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The map label for this gene is clcA [H]

Identifier: 116493350

GI number: 116493350

Start: 1600844

End: 1602364

Strand: Direct

Name: clcA [H]

Synonym: PEPE_1622

Alternate gene names: 116493350

Gene position: 1600844-1602364 (Clockwise)

Preceding gene: 116493346

Following gene: 116493351

Centisome position: 87.36

GC content: 38.66

Gene sequence:

>1521_bases
ATGCATTTGAAAATTGAAGATACTCGATTATCTACTTTACTAAACTCTATTTTTATTGGAATTTTGATTGGTTTAATTGT
CAGCACATTTAGACTAGCAATCGAACATCTTCTAGAAATTTCACAATCAATTTATCGACTAGCCAGTTCCAGTTGGCATT
GGTTGGCCCTGATTGTAGTAATTAATATTATTTTAGCAGTGTTGGTAGGATTGTTAGTTAAAACTTCTCCCCAAATATCT
GGCTCAGGAATTCCTCAAATTGAAGGACAATTATCTGGTGAATATGAAGAAAAATGGTGGCCAGTACTTTGGAAAAAGTT
TACTGGTGGGATTTTAGCAATCGGATCTGGCTTGATGCTAGGGCGTGAAGGCCCTTCTATTCAGTTAGGAGCGGTAGTAG
GTCAAGGTTGGAGTGAAACCCTCCACTATAGTGGTTCTCAACGTCGCGTTTTAATCGCTGGTGGAGCCGCAGCTGGCCTT
TCAGCTGCTTTTAATGCTCCTATTGCTAGTACTCTATTCGTTTTGGAAGAAATCTACCATAACTTTTCTCCGTTGGTTTG
GATTAGTGCCCTTACCAGCGCCGTTGTGTCAAACTTTGTTTCTCTTAACTTTTTTGGTTTAACTCCAGTTTTAGCGATTA
GATATCCTCATTCTTTGCCTCTTGGGCTTTACTGGCACCTAATTGCCTTGGGGATTTTATTGGGCCTTTTTGGACGACTA
TATCAGCTTTGTACATTAAATCTAAAAAAATGGTATCAAAAAATTAGCTTTTTACCACGTTGGCTCCATAGTTTAGTGCC
TTTTATAACGATTATTCCCATCGGAATTTTATGGCCATCATATTTAGGTGGTGGAAATTCCATCATTACTGCAATTGCTA
ACAAAAATCCGATTTTTATGACGCTTTTCACCCTATTAATTATTCGATTCATTTTTTCCATGGTATCTTATGGGTCCGGA
TTACCCGGAGGAATTTTTCTTCCAATCCTAACCCTGGGTGCTATATTTGGGGCTTTGTACGTTAGTATCATGGCTAATCT
TAATCTAATTGATATCCATTACTTACCCAACTTTGTGATTTATGCCATGGCTGGCTACTTTGCCGCCATTGGTAAAGCGC
CATTTACTGCAATTCTACTGATTACTGAAATGGTTGGTTCGCTACAACATTTAATGCCACTAGCCGTTGTGGCGCTTACC
GCCTACATTGTATTAGATTTACTCGGCGGTGAACCAATTTATGAATCTTTACTTCATCAATTAGTTCCAACTATTACTGC
TACTCCTAGCGGGCCTCAAGACCGAGTAGAAATTCCAATTGTCGAAGGTTCTAAGCTGGATGGTTTAGCAGTTCGCAATA
TTTCTTGGCCCAAAGAAAGTTTATTAATTAGCATTCGTCGCGGCTCTAATTCAATTATTCCAAGTGGTGATTCAGTAATT
AAACCTGGTGATACGTTGATTGTTACTACTCATCGGGGAAATCGTAAAAAAATCGCTGCCCATTTTGCAAAAATAAACTA
A

Upstream 100 bases:

>100_bases
TTCTATTATACCGTTTTTATTTATCAAATAAATTTGAACATTTTCAGCTTCTTCGTATGATACTATAGAAATAACTACGT
TTGAATAAGGTGTGAAACAA

Downstream 100 bases:

>100_bases
ACCACTAAAGAAGCATCCAACAGCACTTAGCGTGCTGCTTGATGCTTCTTTTTATAGTGAGTTTACGACTAGTTCCTTTA
TTTGTACCAAATAATGATTG

Product: chloride channel protein EriC

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MHLKIEDTRLSTLLNSIFIGILIGLIVSTFRLAIEHLLEISQSIYRLASSSWHWLALIVVINIILAVLVGLLVKTSPQIS
GSGIPQIEGQLSGEYEEKWWPVLWKKFTGGILAIGSGLMLGREGPSIQLGAVVGQGWSETLHYSGSQRRVLIAGGAAAGL
SAAFNAPIASTLFVLEEIYHNFSPLVWISALTSAVVSNFVSLNFFGLTPVLAIRYPHSLPLGLYWHLIALGILLGLFGRL
YQLCTLNLKKWYQKISFLPRWLHSLVPFITIIPIGILWPSYLGGGNSIITAIANKNPIFMTLFTLLIIRFIFSMVSYGSG
LPGGIFLPILTLGAIFGALYVSIMANLNLIDIHYLPNFVIYAMAGYFAAIGKAPFTAILLITEMVGSLQHLMPLAVVALT
AYIVLDLLGGEPIYESLLHQLVPTITATPSGPQDRVEIPIVEGSKLDGLAVRNISWPKESLLISIRRGSNSIIPSGDSVI
KPGDTLIVTTHRGNRKKIAAHFAKIN

Sequences:

>Translated_506_residues
MHLKIEDTRLSTLLNSIFIGILIGLIVSTFRLAIEHLLEISQSIYRLASSSWHWLALIVVINIILAVLVGLLVKTSPQIS
GSGIPQIEGQLSGEYEEKWWPVLWKKFTGGILAIGSGLMLGREGPSIQLGAVVGQGWSETLHYSGSQRRVLIAGGAAAGL
SAAFNAPIASTLFVLEEIYHNFSPLVWISALTSAVVSNFVSLNFFGLTPVLAIRYPHSLPLGLYWHLIALGILLGLFGRL
YQLCTLNLKKWYQKISFLPRWLHSLVPFITIIPIGILWPSYLGGGNSIITAIANKNPIFMTLFTLLIIRFIFSMVSYGSG
LPGGIFLPILTLGAIFGALYVSIMANLNLIDIHYLPNFVIYAMAGYFAAIGKAPFTAILLITEMVGSLQHLMPLAVVALT
AYIVLDLLGGEPIYESLLHQLVPTITATPSGPQDRVEIPIVEGSKLDGLAVRNISWPKESLLISIRRGSNSIIPSGDSVI
KPGDTLIVTTHRGNRKKIAAHFAKIN
>Mature_506_residues
MHLKIEDTRLSTLLNSIFIGILIGLIVSTFRLAIEHLLEISQSIYRLASSSWHWLALIVVINIILAVLVGLLVKTSPQIS
GSGIPQIEGQLSGEYEEKWWPVLWKKFTGGILAIGSGLMLGREGPSIQLGAVVGQGWSETLHYSGSQRRVLIAGGAAAGL
SAAFNAPIASTLFVLEEIYHNFSPLVWISALTSAVVSNFVSLNFFGLTPVLAIRYPHSLPLGLYWHLIALGILLGLFGRL
YQLCTLNLKKWYQKISFLPRWLHSLVPFITIIPIGILWPSYLGGGNSIITAIANKNPIFMTLFTLLIIRFIFSMVSYGSG
LPGGIFLPILTLGAIFGALYVSIMANLNLIDIHYLPNFVIYAMAGYFAAIGKAPFTAILLITEMVGSLQHLMPLAVVALT
AYIVLDLLGGEPIYESLLHQLVPTITATPSGPQDRVEIPIVEGSKLDGLAVRNISWPKESLLISIRRGSNSIIPSGDSVI
KPGDTLIVTTHRGNRKKIAAHFAKIN

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI153252026, Length=423, Percent_Identity=26.7139479905437, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI189217923, Length=429, Percent_Identity=26.8065268065268, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI189217921, Length=429, Percent_Identity=26.8065268065268, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI4557473, Length=429, Percent_Identity=26.8065268065268, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI55770838, Length=422, Percent_Identity=26.5402843601896, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI55770840, Length=422, Percent_Identity=26.5402843601896, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1786350, Length=435, Percent_Identity=30.5747126436782, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI87081943, Length=338, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980824, Length=525, Percent_Identity=24.952380952381, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71980828, Length=525, Percent_Identity=24.952380952381, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71980820, Length=532, Percent_Identity=24.4360902255639, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985148, Length=488, Percent_Identity=23.9754098360656, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985141, Length=486, Percent_Identity=23.6625514403292, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532615, Length=413, Percent_Identity=27.1186440677966, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6322500, Length=396, Percent_Identity=27.020202020202, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24665008, Length=423, Percent_Identity=26.241134751773, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI45551566, Length=404, Percent_Identity=26.7326732673267, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 55073; Mature: 55073

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLKIEDTRLSTLLNSIFIGILIGLIVSTFRLAIEHLLEISQSIYRLASSSWHWLALIVV
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
INIILAVLVGLLVKTSPQISGSGIPQIEGQLSGEYEEKWWPVLWKKFTGGILAIGSGLML
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEE
GREGPSIQLGAVVGQGWSETLHYSGSQRRVLIAGGAAAGLSAAFNAPIASTLFVLEEIYH
CCCCCCEEEEHEECCCHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHH
NFSPLVWISALTSAVVSNFVSLNFFGLTPVLAIRYPHSLPLGLYWHLIALGILLGLFGRL
CCCHHHHHHHHHHHHHHHHHHCEEECCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHH
YQLCTLNLKKWYQKISFLPRWLHSLVPFITIIPIGILWPSYLGGGNSIITAIANKNPIFM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
TLFTLLIIRFIFSMVSYGSGLPGGIFLPILTLGAIFGALYVSIMANLNLIDIHYLPNFVI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
YAMAGYFAAIGKAPFTAILLITEMVGSLQHLMPLAVVALTAYIVLDLLGGEPIYESLLHQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LVPTITATPSGPQDRVEIPIVEGSKLDGLAVRNISWPKESLLISIRRGSNSIIPSGDSVI
HHCCEECCCCCCCCCEEEEEECCCCCCCEEECCCCCCHHHHEEEEECCCCCCCCCCCCEE
KPGDTLIVTTHRGNRKKIAAHFAKIN
CCCCEEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure
MHLKIEDTRLSTLLNSIFIGILIGLIVSTFRLAIEHLLEISQSIYRLASSSWHWLALIVV
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
INIILAVLVGLLVKTSPQISGSGIPQIEGQLSGEYEEKWWPVLWKKFTGGILAIGSGLML
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEE
GREGPSIQLGAVVGQGWSETLHYSGSQRRVLIAGGAAAGLSAAFNAPIASTLFVLEEIYH
CCCCCCEEEEHEECCCHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHH
NFSPLVWISALTSAVVSNFVSLNFFGLTPVLAIRYPHSLPLGLYWHLIALGILLGLFGRL
CCCHHHHHHHHHHHHHHHHHHCEEECCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHH
YQLCTLNLKKWYQKISFLPRWLHSLVPFITIIPIGILWPSYLGGGNSIITAIANKNPIFM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
TLFTLLIIRFIFSMVSYGSGLPGGIFLPILTLGAIFGALYVSIMANLNLIDIHYLPNFVI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
YAMAGYFAAIGKAPFTAILLITEMVGSLQHLMPLAVVALTAYIVLDLLGGEPIYESLLHQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LVPTITATPSGPQDRVEIPIVEGSKLDGLAVRNISWPKESLLISIRRGSNSIIPSGDSVI
HHCCEECCCCCCCCCEEEEEECCCCCCCEEECCCCCCHHHHEEEEECCCCCCCCCCCCEE
KPGDTLIVTTHRGNRKKIAAHFAKIN
CCCCEEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA