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The map label for this gene is iolS [H]

Identifier: 116493348

GI number: 116493348

Start: 1599095

End: 1600009

Strand: Reverse

Name: iolS [H]

Synonym: PEPE_1620

Alternate gene names: 116493348

Gene position: 1600009-1599095 (Counterclockwise)

Preceding gene: 116493349

Following gene: 116493347

Centisome position: 87.32

GC content: 36.72

Gene sequence:

>915_bases
ATGTTAAATCAAATCAAAATTGGTAAAAGTGCAGTTGAAACTACAACTTTAGGATTAGGGACCAATAAAGTTGGTGGACA
TAACTTGTTTGAAGGGTTAGAAGATCAAGATGGTTACGAAGTAGTTAGAACCGCTTTGGATAGCAACATTAAGTTGTTAG
ATACAGCTTATGCATACGGGTATGGTCGTTCAGAAGAAATCATTGGTGATGTAATTAAAGATTATGACCGTAGTAATATA
ACGATTGCAACTAAGGCAGCTCAGGACGTAAACCATGATTATAAACCTAACAATAATCCGGAATTTTTAACTCAACAAAT
TGATCATGCCTTGAAACGATTAAAAACCGATTATATTGATATTTTTTATATCCACTTTCCAGATGAAACCACTAACAAAG
CAGAAGCAATTGAAGCCTTAGTCAAGGCACGGGATGCGGGTAAGATCAAAGCCATTGGAGTTTCTAACTTTAGTTTAGAG
CAAATTAAAGAGGCCAATGCTGATGATGTTATTGACGTTGTCGAGGATCATTACAGTCTTGTGCATCGTGATGCTGAAAA
AGAATTAATTCCATATTTAAATGAGCGTAATATTACTTTTGTTCCATACTTTCCATTAGCTTCTGGAATTTTGACTGGTA
AATATGCTAAGACAGATAGCGGAAAGTTCAACCAATATTCCCAAGCGGAATTTGATCAAATCATCGATGCCGTTGAAAAG
GTACGTGGAATTGCTGAAAGTAAAGATGCAACGGTAGCTCAAGTAGTGTTGGCATGGTATCTAAAGAACCCCAACCTCGG
CGTTGTAATTCCAGGAGCTCGTAAAGCAGAACAGGTAAAAAGTAACGTTAAAGCTACCGCAATCGAACTAAGCGATCAAG
AATACCATCAAATCGATGCGTGGTTTAAATTTTAA

Upstream 100 bases:

>100_bases
AATGGACACAGTAGATAAACTATAATTTGTCGCATATTGTTAGTTTGTAAAATCGATTTCTGTTATTCTAACCATGTTTA
GATGATAGGAGGAAAGTACA

Downstream 100 bases:

>100_bases
TAACTGAATCAAAAGTCATTAACAAAGATGCTAGTGCCCAAAAAGTTAGACCAAAAATCTAGCTATTGGAAGTCACTACA
GAGATAGGTTAATGGCTTTT

Product: Aryl-alcohol dehydrogenase related enzyme

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLNQIKIGKSAVETTTLGLGTNKVGGHNLFEGLEDQDGYEVVRTALDSNIKLLDTAYAYGYGRSEEIIGDVIKDYDRSNI
TIATKAAQDVNHDYKPNNNPEFLTQQIDHALKRLKTDYIDIFYIHFPDETTNKAEAIEALVKARDAGKIKAIGVSNFSLE
QIKEANADDVIDVVEDHYSLVHRDAEKELIPYLNERNITFVPYFPLASGILTGKYAKTDSGKFNQYSQAEFDQIIDAVEK
VRGIAESKDATVAQVVLAWYLKNPNLGVVIPGARKAEQVKSNVKATAIELSDQEYHQIDAWFKF

Sequences:

>Translated_304_residues
MLNQIKIGKSAVETTTLGLGTNKVGGHNLFEGLEDQDGYEVVRTALDSNIKLLDTAYAYGYGRSEEIIGDVIKDYDRSNI
TIATKAAQDVNHDYKPNNNPEFLTQQIDHALKRLKTDYIDIFYIHFPDETTNKAEAIEALVKARDAGKIKAIGVSNFSLE
QIKEANADDVIDVVEDHYSLVHRDAEKELIPYLNERNITFVPYFPLASGILTGKYAKTDSGKFNQYSQAEFDQIIDAVEK
VRGIAESKDATVAQVVLAWYLKNPNLGVVIPGARKAEQVKSNVKATAIELSDQEYHQIDAWFKF
>Mature_304_residues
MLNQIKIGKSAVETTTLGLGTNKVGGHNLFEGLEDQDGYEVVRTALDSNIKLLDTAYAYGYGRSEEIIGDVIKDYDRSNI
TIATKAAQDVNHDYKPNNNPEFLTQQIDHALKRLKTDYIDIFYIHFPDETTNKAEAIEALVKARDAGKIKAIGVSNFSLE
QIKEANADDVIDVVEDHYSLVHRDAEKELIPYLNERNITFVPYFPLASGILTGKYAKTDSGKFNQYSQAEFDQIIDAVEK
VRGIAESKDATVAQVVLAWYLKNPNLGVVIPGARKAEQVKSNVKATAIELSDQEYHQIDAWFKF

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=320, Percent_Identity=26.875, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4504825, Length=320, Percent_Identity=26.875, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI223718702, Length=275, Percent_Identity=29.0909090909091, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI27436962, Length=317, Percent_Identity=25.5520504731861, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI27436966, Length=304, Percent_Identity=25.9868421052632, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI27436964, Length=317, Percent_Identity=25.5520504731861, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI41152114, Length=275, Percent_Identity=29.0909090909091, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI41327764, Length=264, Percent_Identity=29.9242424242424, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI27436971, Length=322, Percent_Identity=24.5341614906832, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI223718708, Length=126, Percent_Identity=30.952380952381, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI310109922, Length=272, Percent_Identity=26.4705882352941, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI223468663, Length=295, Percent_Identity=26.7796610169492, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788070, Length=311, Percent_Identity=29.5819935691318, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI87081735, Length=316, Percent_Identity=30.6962025316456, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789375, Length=318, Percent_Identity=29.559748427673, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789199, Length=337, Percent_Identity=27.299703264095, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787674, Length=309, Percent_Identity=26.537216828479, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788081, Length=261, Percent_Identity=24.1379310344828, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786400, Length=288, Percent_Identity=26.0416666666667, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082198, Length=264, Percent_Identity=26.1363636363636, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994888, Length=312, Percent_Identity=22.4358974358974, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212645785, Length=293, Percent_Identity=24.9146757679181, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17561300, Length=290, Percent_Identity=25.5172413793103, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561298, Length=300, Percent_Identity=24, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538386, Length=303, Percent_Identity=24.4224422442244, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17566692, Length=313, Percent_Identity=26.1980830670927, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17550248, Length=306, Percent_Identity=25.1633986928105, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=340, Percent_Identity=25.8823529411765, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319958, Length=298, Percent_Identity=22.1476510067114, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323998, Length=321, Percent_Identity=22.7414330218069, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319951, Length=307, Percent_Identity=23.7785016286645, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322615, Length=251, Percent_Identity=23.5059760956175, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644950, Length=304, Percent_Identity=28.2894736842105, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24646155, Length=301, Percent_Identity=24.2524916943522, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646159, Length=169, Percent_Identity=28.9940828402367, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 33995; Mature: 33995

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQIKIGKSAVETTTLGLGTNKVGGHNLFEGLEDQDGYEVVRTALDSNIKLLDTAYAYG
CCCCCCCCCHHHHHEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCEEEEHHHHHC
YGRSEEIIGDVIKDYDRSNITIATKAAQDVNHDYKPNNNPEFLTQQIDHALKRLKTDYID
CCCCHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
IFYIHFPDETTNKAEAIEALVKARDAGKIKAIGVSNFSLEQIKEANADDVIDVVEDHYSL
EEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHH
VHRDAEKELIPYLNERNITFVPYFPLASGILTGKYAKTDSGKFNQYSQAEFDQIIDAVEK
HHCCCHHHHHCCCCCCCEEEEECHHHHCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VRGIAESKDATVAQVVLAWYLKNPNLGVVIPGARKAEQVKSNVKATAIELSDQEYHQIDA
HHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCEEEEEECCCHHHHHHH
WFKF
HCCC
>Mature Secondary Structure
MLNQIKIGKSAVETTTLGLGTNKVGGHNLFEGLEDQDGYEVVRTALDSNIKLLDTAYAYG
CCCCCCCCCHHHHHEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCEEEEHHHHHC
YGRSEEIIGDVIKDYDRSNITIATKAAQDVNHDYKPNNNPEFLTQQIDHALKRLKTDYID
CCCCHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
IFYIHFPDETTNKAEAIEALVKARDAGKIKAIGVSNFSLEQIKEANADDVIDVVEDHYSL
EEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHH
VHRDAEKELIPYLNERNITFVPYFPLASGILTGKYAKTDSGKFNQYSQAEFDQIIDAVEK
HHCCCHHHHHCCCCCCCEEEEECHHHHCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VRGIAESKDATVAQVVLAWYLKNPNLGVVIPGARKAEQVKSNVKATAIELSDQEYHQIDA
HHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCEEEEEECCCHHHHHHH
WFKF
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]