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The map label for this gene is npr [H]

Identifier: 116493347

GI number: 116493347

Start: 1597531

End: 1598901

Strand: Reverse

Name: npr [H]

Synonym: PEPE_1619

Alternate gene names: 116493347

Gene position: 1598901-1597531 (Counterclockwise)

Preceding gene: 116493348

Following gene: 116493345

Centisome position: 87.26

GC content: 40.77

Gene sequence:

>1371_bases
ATGGATAAAGTAAAAGTTATCATTGTTGGGGCATCACATGGAGGGCACGAATCGGCGATTGAGCTATTAGATAAATACGA
TAATGTCGATGTTACGATCTATGAAATGGGAGATTTCGTATCGTTTATGTCGTGTGGGATGCAACTTTATTTAGAAGACC
AAGTTACAGACGTTAATGACGTAAGAAATTTCCGGCCAGAGGATATCACTTCTAAAGGTGGAAAGATTTATAACAATCAT
CAAGTTACAGCAATTGATGTTGATCAAAAACAGGTGACAGTCAAAGACCTGAAAGCAGGTTCAGAAGAACAAGTAGCTTA
TGATAAATTAATTCTTAGTTCAGGAGTAACACCTAAGAATCTACCGGTACCAGGCACAGATCTTAAAAATGTTTATTTAA
TGCGTGGTTATGACTGGGCAACTAAGATTAAAGCTGCCTTGACTGATGATAGCATTAAAAACGTAGCCGTAATTGGTTCA
GGATATATTGGAATTGAAGCAGCTGAAGTATTTGCTAAGAAAGGTAAACACGTCACCTTATTCGATTTCATCGACCGTCC
CCTCGGAAATTACCTAAACCATGAAATGACGGAAATTATTGATAAAACATTAACTGACAATGGTATTCAAGTAGAAATGA
GCCAAAGTATCACTGCATTTAAAGGCGATGATAAAGTTGCCAGTGTAGAAACTAAAAAGGGAAGTTATCCTGCAGATTTG
GTAATTCAAGCTGCGGGTGTCCAACCTAATACAGAATGGCTTAAGGGCGTTGTGGACTTGACTGATCGAGGATTCATCAA
TGTAGATGGATACTTGAGGACCAATGTGCCAGACGTATTCGCCATTGGAGATGCGATCTTACCATTATCGATTCCAGCCG
GAAAACCATCGCCGATTGCCCTAGCTACAACCGCCCGTCGAGAAGCTCAATATGTTGTGAACCATATTTTTGAAAAGAAA
CCAACTCAAATTTTTAAGGGAGTTGTTGGTTCATCAGCCTTACATGTGTTTGACGAACATTTTGCTTCGACCGGTGTAAA
TGAATTTACGGCAGAACGTTCTAATGTTGAAATTGTTAACTCACATTACGTAGATCATATTCGCCCCGCGTATGTTCCCA
AGGCGGAAGGAAATGTGCGCGTTGATGTTGATATCACGTTTGACCCCCATACCCACATTGTTTTAGGCGGCGCGGTACTT
TCGACCGCTGACATGACGGCACAAGGAAATGTTTTAGCTTTGGCAGTGGAACACCGATTGACGGTAGAAGACTTGGCTGA
AGCAGATTTCTTCTTCCAACCAGGCTACGACCGACAATGGAGTTTAATTAATTTAGCTGCGCAACATGCTTTAGGATATG
CACGTTTCTAA

Upstream 100 bases:

>100_bases
GGCTTTTTTTATTTGTAGTTTATAAGCGTTTTAATTGTAAGCGGTTCACAAAAAGAGTTAGACTGTAGACGTAATATTAA
GAAATAGGGGGACAATACAG

Downstream 100 bases:

>100_bases
AGTAGATTCAAAAAAAGTTTGATACGCGATTTTTAATCAAGTATCAAACTTTTTTATTTCATTAGCGAATTTCCATAAAT
TAAATCGGCAATCTTTTGTT

Product: NAD(FAD)-dependent dehydrogenase

Products: NA

Alternate protein names: NPXase; Npx [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MDKVKVIIVGASHGGHESAIELLDKYDNVDVTIYEMGDFVSFMSCGMQLYLEDQVTDVNDVRNFRPEDITSKGGKIYNNH
QVTAIDVDQKQVTVKDLKAGSEEQVAYDKLILSSGVTPKNLPVPGTDLKNVYLMRGYDWATKIKAALTDDSIKNVAVIGS
GYIGIEAAEVFAKKGKHVTLFDFIDRPLGNYLNHEMTEIIDKTLTDNGIQVEMSQSITAFKGDDKVASVETKKGSYPADL
VIQAAGVQPNTEWLKGVVDLTDRGFINVDGYLRTNVPDVFAIGDAILPLSIPAGKPSPIALATTARREAQYVVNHIFEKK
PTQIFKGVVGSSALHVFDEHFASTGVNEFTAERSNVEIVNSHYVDHIRPAYVPKAEGNVRVDVDITFDPHTHIVLGGAVL
STADMTAQGNVLALAVEHRLTVEDLAEADFFFQPGYDRQWSLINLAAQHALGYARF

Sequences:

>Translated_456_residues
MDKVKVIIVGASHGGHESAIELLDKYDNVDVTIYEMGDFVSFMSCGMQLYLEDQVTDVNDVRNFRPEDITSKGGKIYNNH
QVTAIDVDQKQVTVKDLKAGSEEQVAYDKLILSSGVTPKNLPVPGTDLKNVYLMRGYDWATKIKAALTDDSIKNVAVIGS
GYIGIEAAEVFAKKGKHVTLFDFIDRPLGNYLNHEMTEIIDKTLTDNGIQVEMSQSITAFKGDDKVASVETKKGSYPADL
VIQAAGVQPNTEWLKGVVDLTDRGFINVDGYLRTNVPDVFAIGDAILPLSIPAGKPSPIALATTARREAQYVVNHIFEKK
PTQIFKGVVGSSALHVFDEHFASTGVNEFTAERSNVEIVNSHYVDHIRPAYVPKAEGNVRVDVDITFDPHTHIVLGGAVL
STADMTAQGNVLALAVEHRLTVEDLAEADFFFQPGYDRQWSLINLAAQHALGYARF
>Mature_456_residues
MDKVKVIIVGASHGGHESAIELLDKYDNVDVTIYEMGDFVSFMSCGMQLYLEDQVTDVNDVRNFRPEDITSKGGKIYNNH
QVTAIDVDQKQVTVKDLKAGSEEQVAYDKLILSSGVTPKNLPVPGTDLKNVYLMRGYDWATKIKAALTDDSIKNVAVIGS
GYIGIEAAEVFAKKGKHVTLFDFIDRPLGNYLNHEMTEIIDKTLTDNGIQVEMSQSITAFKGDDKVASVETKKGSYPADL
VIQAAGVQPNTEWLKGVVDLTDRGFINVDGYLRTNVPDVFAIGDAILPLSIPAGKPSPIALATTARREAQYVVNHIFEKK
PTQIFKGVVGSSALHVFDEHFASTGVNEFTAERSNVEIVNSHYVDHIRPAYVPKAEGNVRVDVDITFDPHTHIVLGGAVL
STADMTAQGNVLALAVEHRLTVEDLAEADFFFQPGYDRQWSLINLAAQHALGYARF

Specific function: Peroxidase whose active site is a redox-active cysteine- sulfenic acid [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=232, Percent_Identity=28.8793103448276, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI226437568, Length=232, Percent_Identity=28.8793103448276, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI65787454, Length=232, Percent_Identity=28.8793103448276, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1789065, Length=243, Percent_Identity=27.5720164609054, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786307, Length=464, Percent_Identity=23.7068965517241, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081763, Length=183, Percent_Identity=31.1475409836066, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=216, Percent_Identity=31.9444444444444, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI32565766, Length=198, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639257, Length=242, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281359715, Length=245, Percent_Identity=27.3469387755102, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281359713, Length=245, Percent_Identity=27.3469387755102, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24639250, Length=245, Percent_Identity=27.3469387755102, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI18543267, Length=245, Percent_Identity=27.3469387755102, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24639252, Length=245, Percent_Identity=27.3469387755102, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21358499, Length=210, Percent_Identity=29.5238095238095, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585130, Length=249, Percent_Identity=23.2931726907631, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.11.1.1 [H]

Molecular weight: Translated: 50005; Mature: 50005

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKVKVIIVGASHGGHESAIELLDKYDNVDVTIYEMGDFVSFMSCGMQLYLEDQVTDVND
CCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCEEEEEECCCCCHHH
VRNFRPEDITSKGGKIYNNHQVTAIDVDQKQVTVKDLKAGSEEQVAYDKLILSSGVTPKN
HHCCCCCCCCCCCCEEECCCEEEEEECCCCEEEHHHHCCCCHHHHHHHHHHHHCCCCCCC
LPVPGTDLKNVYLMRGYDWATKIKAALTDDSIKNVAVIGSGYIGIEAAEVFAKKGKHVTL
CCCCCCCCCCEEEEECCCHHHHHEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEE
FDFIDRPLGNYLNHEMTEIIDKTLTDNGIQVEMSQSITAFKGDDKVASVETKKGSYPADL
HHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCEEEEECCCCCCCCEE
VIQAAGVQPNTEWLKGVVDLTDRGFINVDGYLRTNVPDVFAIGDAILPLSIPAGKPSPIA
EEEECCCCCCHHHHHHHHHHCCCCEEEECCEEECCCCCEEEECCEEEEEECCCCCCCCEE
LATTARREAQYVVNHIFEKKPTQIFKGVVGSSALHVFDEHFASTGVNEFTAERSNVEIVN
EEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCCEEEEE
SHYVDHIRPAYVPKAEGNVRVDVDITFDPHTHIVLGGAVLSTADMTAQGNVLALAVEHRL
CCCHHCCCCCCCCCCCCCEEEEEEEEECCCCEEEECCCEEECCCCCCCCCEEEEEEECCC
TVEDLAEADFFFQPGYDRQWSLINLAAQHALGYARF
CHHHHHCCCEEECCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDKVKVIIVGASHGGHESAIELLDKYDNVDVTIYEMGDFVSFMSCGMQLYLEDQVTDVND
CCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCEEEEEECCCCCHHH
VRNFRPEDITSKGGKIYNNHQVTAIDVDQKQVTVKDLKAGSEEQVAYDKLILSSGVTPKN
HHCCCCCCCCCCCCEEECCCEEEEEECCCCEEEHHHHCCCCHHHHHHHHHHHHCCCCCCC
LPVPGTDLKNVYLMRGYDWATKIKAALTDDSIKNVAVIGSGYIGIEAAEVFAKKGKHVTL
CCCCCCCCCCEEEEECCCHHHHHEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEE
FDFIDRPLGNYLNHEMTEIIDKTLTDNGIQVEMSQSITAFKGDDKVASVETKKGSYPADL
HHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCEEEEECCCCCCCCEE
VIQAAGVQPNTEWLKGVVDLTDRGFINVDGYLRTNVPDVFAIGDAILPLSIPAGKPSPIA
EEEECCCCCCHHHHHHHHHHCCCCEEEECCEEECCCCCEEEECCEEEEEECCCCCCCCEE
LATTARREAQYVVNHIFEKKPTQIFKGVVGSSALHVFDEHFASTGVNEFTAERSNVEIVN
EEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCCEEEEE
SHYVDHIRPAYVPKAEGNVRVDVDITFDPHTHIVLGGAVLSTADMTAQGNVLALAVEHRL
CCCHHCCCCCCCCCCCCCEEEEEEEEECCCCEEEECCCEEECCCCCCCCCEEEEEEECCC
TVEDLAEADFFFQPGYDRQWSLINLAAQHALGYARF
CHHHHHCCCEEECCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1719212; 12663927; 2501302; 1942054; 8425532; 8756456; 9214307 [H]