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The map label for this gene is proC [H]

Identifier: 116493266

GI number: 116493266

Start: 1498419

End: 1499210

Strand: Reverse

Name: proC [H]

Synonym: PEPE_1529

Alternate gene names: 116493266

Gene position: 1499210-1498419 (Counterclockwise)

Preceding gene: 116493267

Following gene: 116493265

Centisome position: 81.82

GC content: 39.14

Gene sequence:

>792_bases
ATGAAAATTGGATTTATTGGTGTAGGTAATATGGCCAAAGCGATTATCAAGGGTTTGTTAAAAAATAATTTTGAAAGCAC
AGATATACTGGTACACAGTGCGCATCAATCAAGTTATGGACCTTTCGCAGAAAAGAATCAACTAATAGCGACAAAATCTA
ACCAAGAACTTGTTAGAAATTCGGATATCATTGTCATAGCGGTTAAACCATACGTAGTAAAAACGGTTATAGACGAAGTC
AGAGATGATTTAAATCATCATCAGTTAGTTGTCTCACTGGCATCAGGAATTAGTATAGAAGATCTACAGACCAGCTTAGA
TGAGCAACAACCTATCTTACGCATTATGCCGAATGTTAACGTTGAAATTGGCGAAGGAATGACAGCGGTCGTTGCTAATG
GTGATCTTAAAATGGAACCATTTCAGTCTGGGGTTAAAATCTTTGAAACTGTTGGAAGTACAATGGAACTTGCTGAAAAA
GACTTTCCAATTTTTTCAGCAATTGCTGGTAGTGCACCTGCCTATGCTTACTTGTTTATTGATGCTCTTTCACGGGCGGG
AGTTAAACATGGATTAACTAAGGCTTCTGCTACAAAGATCGCTGCTCAAATGGTCAAAGGTAGCGCAGAAATGGTTCTGA
AATCCGATGAGATACCGTATGCCTTAATTGATAAAGTATCTTCTCCAGGTGGTACAACAGTAGCGGGACTCCTAGCAATG
GAAGAAGCAGGCTTTTCACCAGCGGTTGTTAAGGGAATCGATGCTACGGTAGCAAAAGAAATCAATCATTAG

Upstream 100 bases:

>100_bases
GGTTTATAGCTTAAATTTTTAATTGGAGGCTTTCAATATTGGCCTAGTTAATGATAGGATAAGGAGAACAAAATGAAATA
ACCAATGGGGGGCTTTTTTT

Downstream 100 bases:

>100_bases
AATCTTGTTTTTTGGTCTATACCGATATATAATGGATTTAGATTAAAAATTTAGGAGGAAAATTCATGAGTACAGTTTTG
CGTCATGCTACTATTTATAC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKIGFIGVGNMAKAIIKGLLKNNFESTDILVHSAHQSSYGPFAEKNQLIATKSNQELVRNSDIIVIAVKPYVVKTVIDEV
RDDLNHHQLVVSLASGISIEDLQTSLDEQQPILRIMPNVNVEIGEGMTAVVANGDLKMEPFQSGVKIFETVGSTMELAEK
DFPIFSAIAGSAPAYAYLFIDALSRAGVKHGLTKASATKIAAQMVKGSAEMVLKSDEIPYALIDKVSSPGGTTVAGLLAM
EEAGFSPAVVKGIDATVAKEINH

Sequences:

>Translated_263_residues
MKIGFIGVGNMAKAIIKGLLKNNFESTDILVHSAHQSSYGPFAEKNQLIATKSNQELVRNSDIIVIAVKPYVVKTVIDEV
RDDLNHHQLVVSLASGISIEDLQTSLDEQQPILRIMPNVNVEIGEGMTAVVANGDLKMEPFQSGVKIFETVGSTMELAEK
DFPIFSAIAGSAPAYAYLFIDALSRAGVKHGLTKASATKIAAQMVKGSAEMVLKSDEIPYALIDKVSSPGGTTVAGLLAM
EEAGFSPAVVKGIDATVAKEINH
>Mature_263_residues
MKIGFIGVGNMAKAIIKGLLKNNFESTDILVHSAHQSSYGPFAEKNQLIATKSNQELVRNSDIIVIAVKPYVVKTVIDEV
RDDLNHHQLVVSLASGISIEDLQTSLDEQQPILRIMPNVNVEIGEGMTAVVANGDLKMEPFQSGVKIFETVGSTMELAEK
DFPIFSAIAGSAPAYAYLFIDALSRAGVKHGLTKASATKIAAQMVKGSAEMVLKSDEIPYALIDKVSSPGGTTVAGLLAM
EEAGFSPAVVKGIDATVAKEINH

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=264, Percent_Identity=31.8181818181818, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI24797095, Length=264, Percent_Identity=31.0606060606061, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI24797097, Length=264, Percent_Identity=31.0606060606061, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=30.3030303030303, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1786585, Length=259, Percent_Identity=37.8378378378378, Blast_Score=168, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=32.0610687022901, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17540664, Length=274, Percent_Identity=33.2116788321168, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=212, Percent_Identity=29.2452830188679, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=32.4626865671642, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24648116, Length=268, Percent_Identity=28.7313432835821, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24647700, Length=159, Percent_Identity=30.8176100628931, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27995; Mature: 27995

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGVGNMAKAIIKGLLKNNFESTDILVHSAHQSSYGPFAEKNQLIATKSNQELVRN
CEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCHHHHHC
SDIIVIAVKPYVVKTVIDEVRDDLNHHQLVVSLASGISIEDLQTSLDEQQPILRIMPNVN
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCC
VEIGEGMTAVVANGDLKMEPFQSGVKIFETVGSTMELAEKDFPIFSAIAGSAPAYAYLFI
EEECCCEEEEEECCCEEECHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHCCCCHHHHHHH
DALSRAGVKHGLTKASATKIAAQMVKGSAEMVLKSDEIPYALIDKVSSPGGTTVAGLLAM
HHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEEEECCCCCHHHHHCCCCCCCCHHHHHHHH
EEAGFSPAVVKGIDATVAKEINH
HHCCCCCHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MKIGFIGVGNMAKAIIKGLLKNNFESTDILVHSAHQSSYGPFAEKNQLIATKSNQELVRN
CEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCHHHHHC
SDIIVIAVKPYVVKTVIDEVRDDLNHHQLVVSLASGISIEDLQTSLDEQQPILRIMPNVN
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCC
VEIGEGMTAVVANGDLKMEPFQSGVKIFETVGSTMELAEKDFPIFSAIAGSAPAYAYLFI
EEECCCEEEEEECCCEEECHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHCCCCHHHHHHH
DALSRAGVKHGLTKASATKIAAQMVKGSAEMVLKSDEIPYALIDKVSSPGGTTVAGLLAM
HHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEEEECCCCCHHHHHCCCCCCCCHHHHHHHH
EEAGFSPAVVKGIDATVAKEINH
HHCCCCCHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]