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The map label for this gene is purM [H]

Identifier: 116493198

GI number: 116493198

Start: 1433736

End: 1434785

Strand: Reverse

Name: purM [H]

Synonym: PEPE_1460

Alternate gene names: 116493198

Gene position: 1434785-1433736 (Counterclockwise)

Preceding gene: 116493199

Following gene: 116493197

Centisome position: 78.3

GC content: 40.19

Gene sequence:

>1050_bases
ATGGTAGAAAGTGCTTATGAAAAAGCAGGTGTGAATATTACAGCTGGTGAAGAACTTGTAGCTGATCTAAAGCAAAAATT
AGGTGCTCCAGACCCTCATGTTCTAGGCGGACTTGGCAGTTTTGCTGGATGTTACCAGTTATCAAAAGATCAATTGGATC
AGCCGGTTTTAGTAGCGGGAAGTGATGGAGTGGGAACCAAAGTGCTTTTAGCGGCCCAGTCAGGTCAAGTTGAAACGATT
GGGCAAGATTTGGTTGCCATGTGTGTAAATGACTTATTGGCGCAAGGGGCGTTGCCATTATTCTTTTTAGATTATTTAGC
ACTATCACATTTAGAGAAAAATCAGGTTCAAAAGATTTTAAACGGAATTTTAAAAGCCTGCCAAGCTCAGTCAATCACCC
TGTTAGGCGGAGAGACAGCTGAAATGCCTGGAATTTATCAGAAGCATCATTTTGATTTAGCGGGTTTTGCTGTGGGACTA
ACTGCTAAACGTAATTTACTCCAAGCAAAAAATGTCCACAATGGAGATTATTTAATTGGCCTTCCCTCCAGTGGATTACA
TAGTAATGGTTATTCGTTAGTTCGTAAAATTTTATTTGAAGATCATGATTTCCAATTTGATGATCAGTTGGCAGGATTAA
ATGGTAGTTTGATTGAAGAATTGATGCAACCCACCCGTCTTTACGTCAACGTAATTCGGCCTCTTTTAAAACAAAAATTG
GTCAACGGAATCGCTCACATTACCGGTGGAGGATTATTAGATAACGTTCCGCGAATGTTACAAGATCAGCAACAGGCTGA
ATTTAAGTTGGATAGTTGGGAAAAGCCGACAATTTTTAAAATCCTAGCGGAACTTGGAAAGCTATCCCAGACAGACTGTT
ATGAAACTTTTAACATGGGGATTGGGATGGTACTAGCTGTTAGCCCCGACAATTATGCCAGAGTGGTAGCAGAACTTGAA
CAACAGAAAGAAACATATTTTAAGATTGGTAAAGTAAAAAAACGGGAGAAAGATGCACCAGCGGTTTACCTTTCAGGAGG
GAGCAGATGA

Upstream 100 bases:

>100_bases
AATATCCCACCCCCCTTTATGATTATGAAAAAGATTTTGAGATCCCTAAAACAGCTAACGACTTTACATTATCAGCAATG
GCCCAAGTGGAGGAAAAATA

Downstream 100 bases:

>100_bases
TTAATATTGCAGTTTTTGCATCAGGAACAGGGACTAATTTTATGGCATTATACCAACATATTCGAGAAACAAAAGTTCCC
ATTAAAATTGCATGCTTAAT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MVESAYEKAGVNITAGEELVADLKQKLGAPDPHVLGGLGSFAGCYQLSKDQLDQPVLVAGSDGVGTKVLLAAQSGQVETI
GQDLVAMCVNDLLAQGALPLFFLDYLALSHLEKNQVQKILNGILKACQAQSITLLGGETAEMPGIYQKHHFDLAGFAVGL
TAKRNLLQAKNVHNGDYLIGLPSSGLHSNGYSLVRKILFEDHDFQFDDQLAGLNGSLIEELMQPTRLYVNVIRPLLKQKL
VNGIAHITGGGLLDNVPRMLQDQQQAEFKLDSWEKPTIFKILAELGKLSQTDCYETFNMGIGMVLAVSPDNYARVVAELE
QQKETYFKIGKVKKREKDAPAVYLSGGSR

Sequences:

>Translated_349_residues
MVESAYEKAGVNITAGEELVADLKQKLGAPDPHVLGGLGSFAGCYQLSKDQLDQPVLVAGSDGVGTKVLLAAQSGQVETI
GQDLVAMCVNDLLAQGALPLFFLDYLALSHLEKNQVQKILNGILKACQAQSITLLGGETAEMPGIYQKHHFDLAGFAVGL
TAKRNLLQAKNVHNGDYLIGLPSSGLHSNGYSLVRKILFEDHDFQFDDQLAGLNGSLIEELMQPTRLYVNVIRPLLKQKL
VNGIAHITGGGLLDNVPRMLQDQQQAEFKLDSWEKPTIFKILAELGKLSQTDCYETFNMGIGMVLAVSPDNYARVVAELE
QQKETYFKIGKVKKREKDAPAVYLSGGSR
>Mature_349_residues
MVESAYEKAGVNITAGEELVADLKQKLGAPDPHVLGGLGSFAGCYQLSKDQLDQPVLVAGSDGVGTKVLLAAQSGQVETI
GQDLVAMCVNDLLAQGALPLFFLDYLALSHLEKNQVQKILNGILKACQAQSITLLGGETAEMPGIYQKHHFDLAGFAVGL
TAKRNLLQAKNVHNGDYLIGLPSSGLHSNGYSLVRKILFEDHDFQFDDQLAGLNGSLIEELMQPTRLYVNVIRPLLKQKL
VNGIAHITGGGLLDNVPRMLQDQQQAEFKLDSWEKPTIFKILAELGKLSQTDCYETFNMGIGMVLAVSPDNYARVVAELE
QQKETYFKIGKVKKREKDAPAVYLSGGSR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=341, Percent_Identity=41.6422287390029, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI209869995, Length=341, Percent_Identity=41.6422287390029, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI209869993, Length=341, Percent_Identity=41.6422287390029, Blast_Score=259, Evalue=3e-69,
Organism=Escherichia coli, GI1788845, Length=336, Percent_Identity=43.452380952381, Blast_Score=271, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17567511, Length=337, Percent_Identity=40.3560830860534, Blast_Score=239, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321203, Length=358, Percent_Identity=39.1061452513966, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24582400, Length=285, Percent_Identity=36.4912280701754, Blast_Score=194, Evalue=7e-50,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37939; Mature: 37939

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVESAYEKAGVNITAGEELVADLKQKLGAPDPHVLGGLGSFAGCYQLSKDQLDQPVLVAG
CCCCHHHHCCCEEECHHHHHHHHHHHCCCCCCHHHHCHHHHHHHHHCCHHHCCCCEEEEC
SDGVGTKVLLAAQSGQVETIGQDLVAMCVNDLLAQGALPLFFLDYLALSHLEKNQVQKIL
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
NGILKACQAQSITLLGGETAEMPGIYQKHHFDLAGFAVGLTAKRNLLQAKNVHNGDYLIG
HHHHHHHCCCCEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LPSSGLHSNGYSLVRKILFEDHDFQFDDQLAGLNGSLIEELMQPTRLYVNVIRPLLKQKL
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VNGIAHITGGGLLDNVPRMLQDQQQAEFKLDSWEKPTIFKILAELGKLSQTDCYETFNMG
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCC
IGMVLAVSPDNYARVVAELEQQKETYFKIGKVKKREKDAPAVYLSGGSR
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
>Mature Secondary Structure
MVESAYEKAGVNITAGEELVADLKQKLGAPDPHVLGGLGSFAGCYQLSKDQLDQPVLVAG
CCCCHHHHCCCEEECHHHHHHHHHHHCCCCCCHHHHCHHHHHHHHHCCHHHCCCCEEEEC
SDGVGTKVLLAAQSGQVETIGQDLVAMCVNDLLAQGALPLFFLDYLALSHLEKNQVQKIL
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
NGILKACQAQSITLLGGETAEMPGIYQKHHFDLAGFAVGLTAKRNLLQAKNVHNGDYLIG
HHHHHHHCCCCEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LPSSGLHSNGYSLVRKILFEDHDFQFDDQLAGLNGSLIEELMQPTRLYVNVIRPLLKQKL
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VNGIAHITGGGLLDNVPRMLQDQQQAEFKLDSWEKPTIFKILAELGKLSQTDCYETFNMG
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCC
IGMVLAVSPDNYARVVAELEQQKETYFKIGKVKKREKDAPAVYLSGGSR
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA