Click here to switch to the map view.

The map label for this gene is pbuX [H]

Identifier: 116493192

GI number: 116493192

Start: 1426431

End: 1427741

Strand: Reverse

Name: pbuX [H]

Synonym: PEPE_1454

Alternate gene names: 116493192

Gene position: 1427741-1426431 (Counterclockwise)

Preceding gene: 116493194

Following gene: 116493191

Centisome position: 77.92

GC content: 37.15

Gene sequence:

>1311_bases
ATGGAAGATATACAAAAACAAGGTGCCAAAAATGTTGAACTATCAACACCAAAGACGATTTTATTAGCTTTTCAGCATTT
ACTGGCAATGTATGCCGGGGATATATTGGTTCCATTATTAATTGGGGCGGCGCTTAAGTTTAATGCGCAACAGATGACCT
ATTTAATCTCAGTAGATATTTTCATGTGTGGAGTTGCCACTTTTTTACAGGTTAAACGCACTCCACTAACTGGGATTGCT
TTACCAGTTGTTTTAGGATCAGCAGTTGAATACTTGGCACCGATGGAGCACATTGGTAATACAATGGGCTGGGGGTATAT
GTATGGTGGAGTAATTGCAGCCGGAATTTTTGTGTTTTTAATTAGCGGATTATTTGCTAGTTTAAGAAAATTTTTTCCAA
TCGTTGTGACGGGCTCTTTGATTACTTTAATTGGGTTTACCTTAATCCCCGTTGCTTTCCAGAACATTGGTGGTGGAAAC
GTTGCTGATAAAAACTTTGGAAGTTCTTCTAACTTAATTTTAGGATTTTTAACAGCTTTAGTTATTATTTTAATTCAAGT
TTTTGCGCACGGATTCATCAAACGCATTTCAGTTTTGATCGGAATTATCGTTGGCTCAGTGATAGCAGTGGTAATGGGAT
TAATCGATCCTACACCAATCAGCCAAGCTCACTGGATTCAAATTCCAATGCCTTTTTATTTTGCAACTCCCAAATTTGAA
TGGTCCTCAATTTTAACCATGCTCTTGGCAGCAGTAACTTGTATGATTGAATCAACGGGAGTTTACTTTGCTTTAGCAGA
TATTACCAAACGGAATCTGACAGCCGATGATTTAAAACGAGGATATCGTTCAGAAGGAATTGCAGCCATTTTAGGCGGGA
TATTCAATACCTTCCCATATTCAACTTTTTCACAGAATGTGGGAATTGTGCAATTATCTGGAATTAAGAAATTAAAACCA
ATTTATTTCTCTGCTGGAATGCTTTTGATTTTAGGATTGATTCCTAAGTTTAGCGCGATTGCTACATTAATCCCGACATC
TGTATTAGGTGGAGCAATGTTAGTAATGTTTGGGATGGTAGGTGCCCAAGGAATTAAAATGCTAGCTAACGTTAAAATGA
CCGTTAATAATTTATTGGTAATTGCTGTATCGATTGGAATTGGTTTAGGTGTAACTACTCAACCAACGCTCTTCCACATT
TTACCAACCTCAGTTCAAACAATTTTAGATAATGGGATGGTAGTAGGCTGTATCACAGCAATTATTATGAATATTCTATT
GAACGGTAACCAAGCCGTTGATGGAGAATAG

Upstream 100 bases:

>100_bases
TTAAAAATAATAATGTTCGTATTTTTGTTTTAATGAAAAGGTTAATGTGCTAAAATGTTCGTTGTAGCTATCTTAATAAT
TACGTGGAGTTGGAGGAAAT

Downstream 100 bases:

>100_bases
TTTAATTTAAAATATATAATTAAAAACAAGAGATGATACTATTTGGTATGGTCTCTTGTTTTATTTTCTGAGTATAATGG
AAGAAAAACGATGGAGCGGG

Product: xanthine/uracil permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MEDIQKQGAKNVELSTPKTILLAFQHLLAMYAGDILVPLLIGAALKFNAQQMTYLISVDIFMCGVATFLQVKRTPLTGIA
LPVVLGSAVEYLAPMEHIGNTMGWGYMYGGVIAAGIFVFLISGLFASLRKFFPIVVTGSLITLIGFTLIPVAFQNIGGGN
VADKNFGSSSNLILGFLTALVIILIQVFAHGFIKRISVLIGIIVGSVIAVVMGLIDPTPISQAHWIQIPMPFYFATPKFE
WSSILTMLLAAVTCMIESTGVYFALADITKRNLTADDLKRGYRSEGIAAILGGIFNTFPYSTFSQNVGIVQLSGIKKLKP
IYFSAGMLLILGLIPKFSAIATLIPTSVLGGAMLVMFGMVGAQGIKMLANVKMTVNNLLVIAVSIGIGLGVTTQPTLFHI
LPTSVQTILDNGMVVGCITAIIMNILLNGNQAVDGE

Sequences:

>Translated_436_residues
MEDIQKQGAKNVELSTPKTILLAFQHLLAMYAGDILVPLLIGAALKFNAQQMTYLISVDIFMCGVATFLQVKRTPLTGIA
LPVVLGSAVEYLAPMEHIGNTMGWGYMYGGVIAAGIFVFLISGLFASLRKFFPIVVTGSLITLIGFTLIPVAFQNIGGGN
VADKNFGSSSNLILGFLTALVIILIQVFAHGFIKRISVLIGIIVGSVIAVVMGLIDPTPISQAHWIQIPMPFYFATPKFE
WSSILTMLLAAVTCMIESTGVYFALADITKRNLTADDLKRGYRSEGIAAILGGIFNTFPYSTFSQNVGIVQLSGIKKLKP
IYFSAGMLLILGLIPKFSAIATLIPTSVLGGAMLVMFGMVGAQGIKMLANVKMTVNNLLVIAVSIGIGLGVTTQPTLFHI
LPTSVQTILDNGMVVGCITAIIMNILLNGNQAVDGE
>Mature_436_residues
MEDIQKQGAKNVELSTPKTILLAFQHLLAMYAGDILVPLLIGAALKFNAQQMTYLISVDIFMCGVATFLQVKRTPLTGIA
LPVVLGSAVEYLAPMEHIGNTMGWGYMYGGVIAAGIFVFLISGLFASLRKFFPIVVTGSLITLIGFTLIPVAFQNIGGGN
VADKNFGSSSNLILGFLTALVIILIQVFAHGFIKRISVLIGIIVGSVIAVVMGLIDPTPISQAHWIQIPMPFYFATPKFE
WSSILTMLLAAVTCMIESTGVYFALADITKRNLTADDLKRGYRSEGIAAILGGIFNTFPYSTFSQNVGIVQLSGIKKLKP
IYFSAGMLLILGLIPKFSAIATLIPTSVLGGAMLVMFGMVGAQGIKMLANVKMTVNNLLVIAVSIGIGLGVTTQPTLFHI
LPTSVQTILDNGMVVGCITAIIMNILLNGNQAVDGE

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=476, Percent_Identity=25.8403361344538, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI40316845, Length=476, Percent_Identity=25.8403361344538, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI44680145, Length=498, Percent_Identity=25.9036144578313, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI44680143, Length=502, Percent_Identity=25.6972111553785, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI87082181, Length=435, Percent_Identity=37.0114942528736, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1790087, Length=427, Percent_Identity=32.0843091334895, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI87082178, Length=449, Percent_Identity=28.9532293986637, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1788843, Length=381, Percent_Identity=30.4461942257218, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081818, Length=404, Percent_Identity=27.7227722772277, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17542262, Length=434, Percent_Identity=21.4285714285714, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17558856, Length=222, Percent_Identity=27.027027027027, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17541904, Length=430, Percent_Identity=21.3953488372093, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17542260, Length=217, Percent_Identity=24.8847926267281, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71993493, Length=258, Percent_Identity=22.8682170542636, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21356175, Length=425, Percent_Identity=25.4117647058824, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46443; Mature: 46443

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCCCCCCC
>Mature Secondary Structure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HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]