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The map label for this gene is lysP [H]

Identifier: 116493176

GI number: 116493176

Start: 1412383

End: 1413834

Strand: Reverse

Name: lysP [H]

Synonym: PEPE_1438

Alternate gene names: 116493176

Gene position: 1413834-1412383 (Counterclockwise)

Preceding gene: 116493177

Following gene: 116493175

Centisome position: 77.16

GC content: 41.67

Gene sequence:

>1452_bases
ATGGCAGAACAAGGTGGTAGTCAGGTTAAGCGTGCCTTAAAGACGCGACATATTTCAATGATTTCACTGGGTGGAAGTAT
TGGTACAGGACTATTCGTAGCCAGTGGATCGGCAATCTCCACTGCAGGTCCCGGTGGTGCATTATTAGCTTACGTTGGGA
TGGGGGTCATGGTCTATTTCCTCATGACTAGTTTAGGAGAAATGGCGACTTATATGCCGGTTTCGGGTTCGTTTTCAACG
TACGCAACTAAATACGTTGATCCAGCCTTTGGCTTTGCAATGGGATGGAATTACTGGTTTAACTGGGCTATTACGGTTGC
AGTTGATATTAGTACCATTGCCTTGATTATGAAATTCTGGTTTCCTCACGCTCCGGGGTGGATCTGGAGCCTGTTGGCAC
TAGTGCTAGTTTTCTTGGTAAATGCTTTGACGGTTAAAGCTTTTGGTGAGACTGAATATTGGATTGCTTTAATTAAGTTA
GTCACGGTTATTATATTTTTGGTCGTAGGAGTTTTAACCATTGTTGGAATTATGGGAGGTAAAGCCACATATTTAGAAAA
CTTTGTGTATCATAAAGCCCCGTTTGTGGGTGGGATCCCTGCTATTCTTAGTGTTTTCGTTGTGGCTGGTTTCTCGTTTC
AAGGTACAGAATTGATTGGAATTACAGCTGGCGAATCTGAAACACCTGAAACTAGTGTTCCGAAGGCCATTAGCCAAGTA
TTTTGGCGAATTTTACTATTTTACATCTTAGCAATTTTTGTGATTGCTTGTATCATCCCTTATACAAGCCCTAATTTATT
AGGATCATCAGCCCGTGATGTTTCCATTAGTCCATTTACCCTTGTGTTCCGTCGGGCAGGACTAGCAGGAGCAGCTGGGG
TAATGAATGCGGTTATTTTGACCTCAGTACTATCCTCAGCTAATTCGGGGATGTATGCCTCGACTAGAATGTTATATTCG
CTTTCGAAACAAGGATTTGCTGCCAAAATTTTTGGTAAAACTTCGAAGCGAGGAATCCCATACCTGGCCTTACTTGGTAC
AACTATCGTAGGATTGCTAACCTTTATTTCCAGTATTATGGGACCTAAAATTTATATATGGTTAGTTGCTGCCAGTGGAC
TGACTGGCTTTGTGGCTTGGGTCGGTATTGCGATTGCTCATTGGCGGTTCCGTCGGGCTTTTATTAAACAAGGACATGAC
GTGTCAGAACTTAGATATCGTGCAAAATGGTTCCCATTTGGACCACTCTTTGCCTTTGTTCTCAGTATTATTGTGATTGC
GGGACAAGATATTCATTCCATTGCTAATTTCGATTGGCAAGCAATTGGGATTACGTACATGGCAATTCCGCTATTCATTG
TGTTGTATACCTATTATAAAATTAGATATAAAACGAAGTTAATACCGCTGGAAGAAATCGATTTATCGCGTCCAGATATC
ACGAAAGAATAA

Upstream 100 bases:

>100_bases
TTAAACAGTCTTTTTGTGCGTAGGAATGCTCACAAAAAGGCTTTTTATTTTGTTTTTTGAAAATCAACAGCGCCTCTTTT
ATTTTATAGGAGGTTTTCTT

Downstream 100 bases:

>100_bases
TTTTTTCAAGATATTGTTTTGGGGTCGTTTGGTGGTACAATATGTAGTGCTAAAAAACGAAAAAAGAGGTATTTCTTATA
ATGATTGCTTTATCAGGCCC

Product: amino acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MAEQGGSQVKRALKTRHISMISLGGSIGTGLFVASGSAISTAGPGGALLAYVGMGVMVYFLMTSLGEMATYMPVSGSFST
YATKYVDPAFGFAMGWNYWFNWAITVAVDISTIALIMKFWFPHAPGWIWSLLALVLVFLVNALTVKAFGETEYWIALIKL
VTVIIFLVVGVLTIVGIMGGKATYLENFVYHKAPFVGGIPAILSVFVVAGFSFQGTELIGITAGESETPETSVPKAISQV
FWRILLFYILAIFVIACIIPYTSPNLLGSSARDVSISPFTLVFRRAGLAGAAGVMNAVILTSVLSSANSGMYASTRMLYS
LSKQGFAAKIFGKTSKRGIPYLALLGTTIVGLLTFISSIMGPKIYIWLVAASGLTGFVAWVGIAIAHWRFRRAFIKQGHD
VSELRYRAKWFPFGPLFAFVLSIIVIAGQDIHSIANFDWQAIGITYMAIPLFIVLYTYYKIRYKTKLIPLEEIDLSRPDI
TKE

Sequences:

>Translated_483_residues
MAEQGGSQVKRALKTRHISMISLGGSIGTGLFVASGSAISTAGPGGALLAYVGMGVMVYFLMTSLGEMATYMPVSGSFST
YATKYVDPAFGFAMGWNYWFNWAITVAVDISTIALIMKFWFPHAPGWIWSLLALVLVFLVNALTVKAFGETEYWIALIKL
VTVIIFLVVGVLTIVGIMGGKATYLENFVYHKAPFVGGIPAILSVFVVAGFSFQGTELIGITAGESETPETSVPKAISQV
FWRILLFYILAIFVIACIIPYTSPNLLGSSARDVSISPFTLVFRRAGLAGAAGVMNAVILTSVLSSANSGMYASTRMLYS
LSKQGFAAKIFGKTSKRGIPYLALLGTTIVGLLTFISSIMGPKIYIWLVAASGLTGFVAWVGIAIAHWRFRRAFIKQGHD
VSELRYRAKWFPFGPLFAFVLSIIVIAGQDIHSIANFDWQAIGITYMAIPLFIVLYTYYKIRYKTKLIPLEEIDLSRPDI
TKE
>Mature_482_residues
AEQGGSQVKRALKTRHISMISLGGSIGTGLFVASGSAISTAGPGGALLAYVGMGVMVYFLMTSLGEMATYMPVSGSFSTY
ATKYVDPAFGFAMGWNYWFNWAITVAVDISTIALIMKFWFPHAPGWIWSLLALVLVFLVNALTVKAFGETEYWIALIKLV
TVIIFLVVGVLTIVGIMGGKATYLENFVYHKAPFVGGIPAILSVFVVAGFSFQGTELIGITAGESETPETSVPKAISQVF
WRILLFYILAIFVIACIIPYTSPNLLGSSARDVSISPFTLVFRRAGLAGAAGVMNAVILTSVLSSANSGMYASTRMLYSL
SKQGFAAKIFGKTSKRGIPYLALLGTTIVGLLTFISSIMGPKIYIWLVAASGLTGFVAWVGIAIAHWRFRRAFIKQGHDV
SELRYRAKWFPFGPLFAFVLSIIVIAGQDIHSIANFDWQAIGITYMAIPLFIVLYTYYKIRYKTKLIPLEEIDLSRPDIT
KE

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=475, Percent_Identity=55.3684210526316, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI87081708, Length=430, Percent_Identity=39.5348837209302, Blast_Score=321, Evalue=7e-89,
Organism=Escherichia coli, GI48994972, Length=470, Percent_Identity=36.5957446808511, Blast_Score=275, Evalue=7e-75,
Organism=Escherichia coli, GI1786789, Length=414, Percent_Identity=37.9227053140097, Blast_Score=273, Evalue=3e-74,
Organism=Escherichia coli, GI1786302, Length=413, Percent_Identity=36.8038740920097, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1789017, Length=403, Percent_Identity=35.4838709677419, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1786602, Length=407, Percent_Identity=36.6093366093366, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1790653, Length=428, Percent_Identity=35.5140186915888, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081915, Length=409, Percent_Identity=33.7408312958435, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI87081869, Length=422, Percent_Identity=24.8815165876777, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=490, Percent_Identity=38.1632653061225, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6320772, Length=496, Percent_Identity=37.7016129032258, Blast_Score=321, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6322892, Length=490, Percent_Identity=35.7142857142857, Blast_Score=296, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6324990, Length=493, Percent_Identity=34.4827586206897, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6324059, Length=498, Percent_Identity=35.5421686746988, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6321629, Length=492, Percent_Identity=31.0975609756098, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6320717, Length=488, Percent_Identity=30.7377049180328, Blast_Score=265, Evalue=9e-72,
Organism=Saccharomyces cerevisiae, GI6319824, Length=484, Percent_Identity=31.404958677686, Blast_Score=257, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6324553, Length=500, Percent_Identity=32.6, Blast_Score=256, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6320251, Length=509, Percent_Identity=31.237721021611, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6319542, Length=485, Percent_Identity=30.3092783505155, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6324924, Length=495, Percent_Identity=30.5050505050505, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6321053, Length=486, Percent_Identity=32.3045267489712, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6319543, Length=487, Percent_Identity=30.3901437371663, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6322967, Length=482, Percent_Identity=30.7053941908714, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6324981, Length=481, Percent_Identity=30.977130977131, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6319608, Length=497, Percent_Identity=25.9557344064386, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320364, Length=546, Percent_Identity=25.4578754578755, Blast_Score=159, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52582; Mature: 52451

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQGGSQVKRALKTRHISMISLGGSIGTGLFVASGSAISTAGPGGALLAYVGMGVMVYF
CCCCCHHHHHHHHHHHHHHEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHHH
LMTSLGEMATYMPVSGSFSTYATKYVDPAFGFAMGWNYWFNWAITVAVDISTIALIMKFW
HHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHCHHHHEEEEEEEEEHHHHHHHHHHHH
FPHAPGWIWSLLALVLVFLVNALTVKAFGETEYWIALIKLVTVIIFLVVGVLTIVGIMGG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KATYLENFVYHKAPFVGGIPAILSVFVVAGFSFQGTELIGITAGESETPETSVPKAISQV
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
FWRILLFYILAIFVIACIIPYTSPNLLGSSARDVSISPFTLVFRRAGLAGAAGVMNAVIL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
TSVLSSANSGMYASTRMLYSLSKQGFAAKIFGKTSKRGIPYLALLGTTIVGLLTFISSIM
HHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GPKIYIWLVAASGLTGFVAWVGIAIAHWRFRRAFIKQGHDVSELRYRAKWFPFGPLFAFV
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSIIVIAGQDIHSIANFDWQAIGITYMAIPLFIVLYTYYKIRYKTKLIPLEEIDLSRPDI
HHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHCCCCCCCC
TKE
CCC
>Mature Secondary Structure 
AEQGGSQVKRALKTRHISMISLGGSIGTGLFVASGSAISTAGPGGALLAYVGMGVMVYF
CCCCHHHHHHHHHHHHHHEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHHH
LMTSLGEMATYMPVSGSFSTYATKYVDPAFGFAMGWNYWFNWAITVAVDISTIALIMKFW
HHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHCHHHHEEEEEEEEEHHHHHHHHHHHH
FPHAPGWIWSLLALVLVFLVNALTVKAFGETEYWIALIKLVTVIIFLVVGVLTIVGIMGG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KATYLENFVYHKAPFVGGIPAILSVFVVAGFSFQGTELIGITAGESETPETSVPKAISQV
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
FWRILLFYILAIFVIACIIPYTSPNLLGSSARDVSISPFTLVFRRAGLAGAAGVMNAVIL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
TSVLSSANSGMYASTRMLYSLSKQGFAAKIFGKTSKRGIPYLALLGTTIVGLLTFISSIM
HHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GPKIYIWLVAASGLTGFVAWVGIAIAHWRFRRAFIKQGHDVSELRYRAKWFPFGPLFAFV
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSIIVIAGQDIHSIANFDWQAIGITYMAIPLFIVLYTYYKIRYKTKLIPLEEIDLSRPDI
HHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHCCCCCCCC
TKE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]