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The map label for this gene is serS

Identifier: 116493174

GI number: 116493174

Start: 1410111

End: 1411391

Strand: Reverse

Name: serS

Synonym: PEPE_1436

Alternate gene names: 116493174

Gene position: 1411391-1410111 (Counterclockwise)

Preceding gene: 116493175

Following gene: 116493172

Centisome position: 77.02

GC content: 38.64

Gene sequence:

>1281_bases
ATGTTAGATTTGAAAATGATTCGTAATCATGTAGAAGACGTCAAAGCTAAATTAGCAACTCGGGGCGTAAAACCTGAAGC
AATCGACGATTTATTGGCTAAGGATAATGAACGCCGTGAATTGATTGTAAAGAGTGAAAATTTGAAAAAGCTTCGTAATG
AAGTGTCTGATCAAATTTCACAATTAAAACGTAATAAAGAAGACGCTAACGATAAAATTCAAGAAATGCGTAAAGTGAGC
CAAGATATTAAAGGCTTAGACGAACAACTGGAAAATATTGCCGAAGAAGTTGAAAGCAAAGCTGCTCATCTACCTAATCT
ACCACATGAAGATGTACCGGTTAGTTTAACTGAAGAGGGTAGTGTTGAACAACGTCGTAATGGAACACCACGGACTTTTG
ACTTTACGCCTAAGGCTCACTGGGAAATTGGAGAAGAGCTTGGTATTTTAGACTTTGAACGGGCAGCTAAAGTTGCTGGT
AGTCGTTTTGTATATTATGTTGGGGATGGTGCACGTCTTGAACGAGCAGTTTACAATTTCTTTTTAGATCAAAATAATGC
AGCTGGCTTTACAGAAGAAATCACACCTTACATGGTTAACGATGCATCAATGTTTGGAACTGGTCAATTTCCAAAGTTTA
AAGAAACCCATGCCGGTTATGAAGTAAAAGATGAAGGACTAACTTTAATTCCTACAGCTGAAGTACCTTTGGTAAATTAC
TATCGAGATGAAATCATTGATGAAGAAAAGTTACCAATTAGCGTAACAGCATTATCACCAGCATTCCGTTCAGAAGCAGG
AAGTGCCGGACGAGATACACGTGGTTTGATTCGTATGCATCAATTTAACAAGGTAGAAATGGTCAAGATTGCTAAGCCAG
AACAATCATGGAATGAATTAGAAAAATTAACTACCCATGCTGAAACCCTTCTTCAAAAATTGGGATTGCCTTATCGAGTG
ATTACCCTAACCACTGGGGATATGAGTTTTACGGCAGCCAAGACTTACGATCTTGAAGTGTGGATTCCAGCTCAAGATAA
ATACCGCGAAATTTCAAGTTGTTCAAACTGTACTGATTTCCAAGCTCGTCGTGCACATATTCGTTTCCGCGATGAAAATG
GTAAGTTGCAATACGTACACACCCTAAATGGATCTGGTTTGGCGGTCGGACGTACAGTAGCTGCAATTTTAGAAAACTAT
CAAAATGAAGATGGAACAGTCAACGTTCCGGAAGCTTTAGTACCTTATATGCAAGGGACAACTGTAATTGGTAAAAAGTA
A

Upstream 100 bases:

>100_bases
CGCTTATATAAGCAGGTGAACTTGGGTGGTACCGCGAAAAGAGTCTCTTCGTCCCAATGTGGATAGAGGCTCTTTTTCTA
TATTTAAGGAGGATGTAATT

Downstream 100 bases:

>100_bases
ATAGTTATCTAAAAATAAGAGATCGCATTGAGATCTCTTATTTTTTTATGGAATCCATAAAGGATAAGCCTCTGATTAGA
AATGTTTTTCAGCAAATATG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDLKMIRNHVEDVKAKLATRGVKPEAIDDLLAKDNERRELIVKSENLKKLRNEVSDQISQLKRNKEDANDKIQEMRKVS
QDIKGLDEQLENIAEEVESKAAHLPNLPHEDVPVSLTEEGSVEQRRNGTPRTFDFTPKAHWEIGEELGILDFERAAKVAG
SRFVYYVGDGARLERAVYNFFLDQNNAAGFTEEITPYMVNDASMFGTGQFPKFKETHAGYEVKDEGLTLIPTAEVPLVNY
YRDEIIDEEKLPISVTALSPAFRSEAGSAGRDTRGLIRMHQFNKVEMVKIAKPEQSWNELEKLTTHAETLLQKLGLPYRV
ITLTTGDMSFTAAKTYDLEVWIPAQDKYREISSCSNCTDFQARRAHIRFRDENGKLQYVHTLNGSGLAVGRTVAAILENY
QNEDGTVNVPEALVPYMQGTTVIGKK

Sequences:

>Translated_426_residues
MLDLKMIRNHVEDVKAKLATRGVKPEAIDDLLAKDNERRELIVKSENLKKLRNEVSDQISQLKRNKEDANDKIQEMRKVS
QDIKGLDEQLENIAEEVESKAAHLPNLPHEDVPVSLTEEGSVEQRRNGTPRTFDFTPKAHWEIGEELGILDFERAAKVAG
SRFVYYVGDGARLERAVYNFFLDQNNAAGFTEEITPYMVNDASMFGTGQFPKFKETHAGYEVKDEGLTLIPTAEVPLVNY
YRDEIIDEEKLPISVTALSPAFRSEAGSAGRDTRGLIRMHQFNKVEMVKIAKPEQSWNELEKLTTHAETLLQKLGLPYRV
ITLTTGDMSFTAAKTYDLEVWIPAQDKYREISSCSNCTDFQARRAHIRFRDENGKLQYVHTLNGSGLAVGRTVAAILENY
QNEDGTVNVPEALVPYMQGTTVIGKK
>Mature_426_residues
MLDLKMIRNHVEDVKAKLATRGVKPEAIDDLLAKDNERRELIVKSENLKKLRNEVSDQISQLKRNKEDANDKIQEMRKVS
QDIKGLDEQLENIAEEVESKAAHLPNLPHEDVPVSLTEEGSVEQRRNGTPRTFDFTPKAHWEIGEELGILDFERAAKVAG
SRFVYYVGDGARLERAVYNFFLDQNNAAGFTEEITPYMVNDASMFGTGQFPKFKETHAGYEVKDEGLTLIPTAEVPLVNY
YRDEIIDEEKLPISVTALSPAFRSEAGSAGRDTRGLIRMHQFNKVEMVKIAKPEQSWNELEKLTTHAETLLQKLGLPYRV
ITLTTGDMSFTAAKTYDLEVWIPAQDKYREISSCSNCTDFQARRAHIRFRDENGKLQYVHTLNGSGLAVGRTVAAILENY
QNEDGTVNVPEALVPYMQGTTVIGKK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=403, Percent_Identity=33.0024813895782, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI16306548, Length=445, Percent_Identity=33.2584269662921, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI225579074, Length=337, Percent_Identity=36.7952522255193, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=51.9721577726218, Blast_Score=411, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17539260, Length=466, Percent_Identity=31.5450643776824, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=260, Percent_Identity=33.0769230769231, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=443, Percent_Identity=33.8600451467269, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6321799, Length=404, Percent_Identity=33.4158415841584, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24581334, Length=436, Percent_Identity=31.8807339449541, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI17737985, Length=376, Percent_Identity=31.3829787234043, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_PEDPA (Q03EA5)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804909.1
- ProteinModelPortal:   Q03EA5
- SMR:   Q03EA5
- STRING:   Q03EA5
- GeneID:   4417305
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1436
- NMPDR:   fig|278197.10.peg.1262
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q03EA5
- ProtClustDB:   PRK05431
- BioCyc:   PPEN278197:PEPE_1436-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48124; Mature: 48124

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 286-286 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKMIRNHVEDVKAKLATRGVKPEAIDDLLAKDNERRELIVKSENLKKLRNEVSDQIS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHH
QLKRNKEDANDKIQEMRKVSQDIKGLDEQLENIAEEVESKAAHLPNLPHEDVPVSLTEEG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCC
SVEQRRNGTPRTFDFTPKAHWEIGEELGILDFERAAKVAGSRFVYYVGDGARLERAVYNF
CHHHHCCCCCCEEECCCCCCCCCHHHCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHH
FLDQNNAAGFTEEITPYMVNDASMFGTGQFPKFKETHAGYEVKDEGLTLIPTAEVPLVNY
HHCCCCCCCCHHCCCCEEEECCCCCCCCCCCCCHHHCCCCEECCCCEEEEECCCCCHHHH
YRDEIIDEEKLPISVTALSPAFRSEAGSAGRDTRGLIRMHQFNKVEMVKIAKPEQSWNEL
HHHHHCCCCCCCEEEEECCHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHH
EKLTTHAETLLQKLGLPYRVITLTTGDMSFTAAKTYDLEVWIPAQDKYREISSCSNCTDF
HHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEEEEEECCHHHHHHHHHCCCCCCH
QARRAHIRFRDENGKLQYVHTLNGSGLAVGRTVAAILENYQNEDGTVNVPEALVPYMQGT
HHHEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECHHHHHHHHCCC
TVIGKK
EECCCC
>Mature Secondary Structure
MLDLKMIRNHVEDVKAKLATRGVKPEAIDDLLAKDNERRELIVKSENLKKLRNEVSDQIS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHH
QLKRNKEDANDKIQEMRKVSQDIKGLDEQLENIAEEVESKAAHLPNLPHEDVPVSLTEEG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCC
SVEQRRNGTPRTFDFTPKAHWEIGEELGILDFERAAKVAGSRFVYYVGDGARLERAVYNF
CHHHHCCCCCCEEECCCCCCCCCHHHCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHH
FLDQNNAAGFTEEITPYMVNDASMFGTGQFPKFKETHAGYEVKDEGLTLIPTAEVPLVNY
HHCCCCCCCCHHCCCCEEEECCCCCCCCCCCCCHHHCCCCEECCCCEEEEECCCCCHHHH
YRDEIIDEEKLPISVTALSPAFRSEAGSAGRDTRGLIRMHQFNKVEMVKIAKPEQSWNEL
HHHHHCCCCCCCEEEEECCHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHH
EKLTTHAETLLQKLGLPYRVITLTTGDMSFTAAKTYDLEVWIPAQDKYREISSCSNCTDF
HHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEEEEEECCHHHHHHHHHCCCCCCH
QARRAHIRFRDENGKLQYVHTLNGSGLAVGRTVAAILENYQNEDGTVNVPEALVPYMQGT
HHHEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECHHHHHHHHCCC
TVIGKK
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA