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The map label for this gene is yqeC [H]

Identifier: 116493108

GI number: 116493108

Start: 1349110

End: 1350009

Strand: Reverse

Name: yqeC [H]

Synonym: PEPE_1362

Alternate gene names: 116493108

Gene position: 1350009-1349110 (Counterclockwise)

Preceding gene: 116493110

Following gene: 116493107

Centisome position: 73.67

GC content: 38.22

Gene sequence:

>900_bases
ATGAAAATTGGATTGATTGGTTTAGGAAAAATGGGACTCAATTTAGCAGAAAATATGTTAGATAATAATATCGAAGTATT
GGCTTTTGATGTCTTTGACAAAGCTAGAGAGAATGCTGAAAAGCATAACATAATTACTGTAGATAGTATTGAACAGCTAG
TTAAACAACTTGATCAACTGCGAATAATTTGGATAATGGTACCAGCCGGAGCTCCCACTAACGACACTATCGGCCAATTA
AGCAATTTATTAAGCAAAAATGATGTTGTGATTGATGGAGGAAATACATATTATCAAGATTCACTTCATCATAATCAGGT
ACTTAGTAAAGCTGGGATTTATTTCTTCGATGTAGGAACATCTGGAGGGATGTCCGGAGCCCGCCATGGAGGCAATTTTA
TGATTGGCGGAGATAAAGACAAGTTTGGGGAGATTGAACCATTATTTAAAGCTATTGCTGAAAAAGATGGATATCTTTAT
ACAGGCCAAGCTGGTTCAGGGCATTATTTAAAAATGGTCCACAATGGAATCGAATATGGAATGATGCAAGCGATTGGTGA
AGGATTTGAAGTACTTTCTAAAAGTGAATTTGATTATGATAATGAAGCAGTTGCCAAAGTATGGAACCATGGATCGGTTG
TCCGAAGTTGGTTGATGGAACTCGCACAATCAGCCTTTAGTAACGATCCTAACTTGGATGAAATAAAAGGGGTTATGCAT
AGTTCTGGAGAGGGCGCTTGGACGGTCGAAGAGGCGATAAGGTTACACGTCCCAACCCCTGTAATCAGTAGTTCGTTGAT
GATGCGTTATCGTTCTGAAGAAGATGATACGATGACAGGAAAAGTAGTATCTGCCTTAAGAAATGGTTTTGGCGGACATA
AAGTTGATCATAAAGAATAG

Upstream 100 bases:

>100_bases
TATAAGAAAATAATTTTCTTGTAAACGCTTGCAATATGTAACATATTTTCATACAATATAAATATAAATTAAGAGATATA
TGAAGAAATGAGGGAACGTC

Downstream 100 bases:

>100_bases
TTGAGGTACAGAATATGGATTATATGATTGGTGTTGATCTTGGCACTACTAGTACAAAAGTAGTTTTATTTGATATGAAG
GGAAATTCAATTGCCTATGC

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKIGLIGLGKMGLNLAENMLDNNIEVLAFDVFDKARENAEKHNIITVDSIEQLVKQLDQLRIIWIMVPAGAPTNDTIGQL
SNLLSKNDVVIDGGNTYYQDSLHHNQVLSKAGIYFFDVGTSGGMSGARHGGNFMIGGDKDKFGEIEPLFKAIAEKDGYLY
TGQAGSGHYLKMVHNGIEYGMMQAIGEGFEVLSKSEFDYDNEAVAKVWNHGSVVRSWLMELAQSAFSNDPNLDEIKGVMH
SSGEGAWTVEEAIRLHVPTPVISSSLMMRYRSEEDDTMTGKVVSALRNGFGGHKVDHKE

Sequences:

>Translated_299_residues
MKIGLIGLGKMGLNLAENMLDNNIEVLAFDVFDKARENAEKHNIITVDSIEQLVKQLDQLRIIWIMVPAGAPTNDTIGQL
SNLLSKNDVVIDGGNTYYQDSLHHNQVLSKAGIYFFDVGTSGGMSGARHGGNFMIGGDKDKFGEIEPLFKAIAEKDGYLY
TGQAGSGHYLKMVHNGIEYGMMQAIGEGFEVLSKSEFDYDNEAVAKVWNHGSVVRSWLMELAQSAFSNDPNLDEIKGVMH
SSGEGAWTVEEAIRLHVPTPVISSSLMMRYRSEEDDTMTGKVVSALRNGFGGHKVDHKE
>Mature_299_residues
MKIGLIGLGKMGLNLAENMLDNNIEVLAFDVFDKARENAEKHNIITVDSIEQLVKQLDQLRIIWIMVPAGAPTNDTIGQL
SNLLSKNDVVIDGGNTYYQDSLHHNQVLSKAGIYFFDVGTSGGMSGARHGGNFMIGGDKDKFGEIEPLFKAIAEKDGYLY
TGQAGSGHYLKMVHNGIEYGMMQAIGEGFEVLSKSEFDYDNEAVAKVWNHGSVVRSWLMELAQSAFSNDPNLDEIKGVMH
SSGEGAWTVEEAIRLHVPTPVISSSLMMRYRSEEDDTMTGKVVSALRNGFGGHKVDHKE

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=292, Percent_Identity=33.9041095890411, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI23308751, Length=219, Percent_Identity=26.4840182648402, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1788341, Length=320, Percent_Identity=35, Blast_Score=168, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17542558, Length=290, Percent_Identity=35.5172413793103, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321695, Length=290, Percent_Identity=36.551724137931, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321977, Length=286, Percent_Identity=36.3636363636364, Blast_Score=152, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24639279, Length=289, Percent_Identity=36.6782006920415, Blast_Score=148, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32846; Mature: 32846

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGLIGLGKMGLNLAENMLDNNIEVLAFDVFDKARENAEKHNIITVDSIEQLVKQLDQL
CEEEEEECCHHHHHHHHHHHCCCCEEEEEHHHHHHHHCHHHCCCEEHHHHHHHHHHHHCE
RIIWIMVPAGAPTNDTIGQLSNLLSKNDVVIDGGNTYYQDSLHHNQVLSKAGIYFFDVGT
EEEEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCEECCHHHHHHHHHHCCEEEEECCC
SGGMSGARHGGNFMIGGDKDKFGEIEPLFKAIAEKDGYLYTGQAGSGHYLKMVHNGIEYG
CCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHCCHHHH
MMQAIGEGFEVLSKSEFDYDNEAVAKVWNHGSVVRSWLMELAQSAFSNDPNLDEIKGVMH
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SSGEGAWTVEEAIRLHVPTPVISSSLMMRYRSEEDDTMTGKVVSALRNGFGGHKVDHKE
CCCCCCEEHHHHHEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKIGLIGLGKMGLNLAENMLDNNIEVLAFDVFDKARENAEKHNIITVDSIEQLVKQLDQL
CEEEEEECCHHHHHHHHHHHCCCCEEEEEHHHHHHHHCHHHCCCEEHHHHHHHHHHHHCE
RIIWIMVPAGAPTNDTIGQLSNLLSKNDVVIDGGNTYYQDSLHHNQVLSKAGIYFFDVGT
EEEEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCEECCHHHHHHHHHHCCEEEEECCC
SGGMSGARHGGNFMIGGDKDKFGEIEPLFKAIAEKDGYLYTGQAGSGHYLKMVHNGIEYG
CCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHCCHHHH
MMQAIGEGFEVLSKSEFDYDNEAVAKVWNHGSVVRSWLMELAQSAFSNDPNLDEIKGVMH
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SSGEGAWTVEEAIRLHVPTPVISSSLMMRYRSEEDDTMTGKVVSALRNGFGGHKVDHKE
CCCCCCEEHHHHHEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]