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The map label for this gene is fba [H]

Identifier: 116493098

GI number: 116493098

Start: 1338606

End: 1339469

Strand: Direct

Name: fba [H]

Synonym: PEPE_1352

Alternate gene names: 116493098

Gene position: 1338606-1339469 (Clockwise)

Preceding gene: 116493088

Following gene: 116493104

Centisome position: 73.05

GC content: 40.97

Gene sequence:

>864_bases
ATGTCATTTATTAATGGTACATCAACATTTGCAGCAGCTCGTAAGGGTGGATACGCTGTAGGTGCTTTTAACACAAACAA
CCTTGAATGGACTCGTGCTATCTTAGCTGCAGGCCAAGAAACACACACACCTATCTTGATCCAATCATCAATGGGTGCTG
CTAAGTACATGGGTGGTTACAAAGCTGTTAAGAACCTCGTTGAAAAACAAGTAGAATCAATGGGTATCACAGTTCCTGTT
ATCATGCATTTAGACCATGGTAACTACGAAGCTGCTAAAGAAGCTATCGCTGCTGGATACAGTTCAGTTATGTTTGATGG
TCATGATCTTGACTTTGAAGATAACCTTCTAAAGACAAAAGAAATCGTTGCTTTGGCACATGCTCAAGGCGTATCAGTTG
AAGCTGAAGTTGGCTCAATTGGTGGTGAAGAAGACGGTATCGTTGGTGCTGGTGAATTAGCTGATGTTGAAGAAGCTAAA
CAACTTGCTGCTACAGGCGTTGACTTCCTTGCTGTTGGTATTGGTAACATCCATGGTGTATACCCTGCTAACTGGACTGG
TTTAAACTTTGACCGTCTACAAGAACTTGCTGATGTTATTAAGACACCACTTGTACTTCATGGTGGTTCAGGAATTCCTA
AGGAACAAATCGTTAAGGCTATTTCAATGGGTATTTCTAAGGTTAACGTTAACACAGAACAACAAATTGCTTGGTCAAAC
GCTGTTCGTAAATACTACGAAGCAGACAATGACAAGAAAGCTAAAGGATTCGATCCTCGTAAAGTTCTTGCTTCAGGTAC
AGAAGCTATCAAGAACACTGTTAAGGAACGTATCGAATGGTTCAACACACCATCAATGTGGTAA

Upstream 100 bases:

>100_bases
AAAAACTCGTATAATATTTTTTAATTTTGTGATAAAATAGATGTGTTGCGAAGAGAAAAGCTCTTTGTTTGTATAAACAA
TATTGGGAGGAACCAGTTTT

Downstream 100 bases:

>100_bases
GATGATCCATGAAAAAAGCTTGGCTTAATGGCCAAGCTTTTTTTGTTGCTCTGGAAAATGTAATTTAAAAGTTGTTCCTT
TTTCTGGAGTACTCTCGACA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSFINGTSTFAAARKGGYAVGAFNTNNLEWTRAILAAGQETHTPILIQSSMGAAKYMGGYKAVKNLVEKQVESMGITVPV
IMHLDHGNYEAAKEAIAAGYSSVMFDGHDLDFEDNLLKTKEIVALAHAQGVSVEAEVGSIGGEEDGIVGAGELADVEEAK
QLAATGVDFLAVGIGNIHGVYPANWTGLNFDRLQELADVIKTPLVLHGGSGIPKEQIVKAISMGISKVNVNTEQQIAWSN
AVRKYYEADNDKKAKGFDPRKVLASGTEAIKNTVKERIEWFNTPSMW

Sequences:

>Translated_287_residues
MSFINGTSTFAAARKGGYAVGAFNTNNLEWTRAILAAGQETHTPILIQSSMGAAKYMGGYKAVKNLVEKQVESMGITVPV
IMHLDHGNYEAAKEAIAAGYSSVMFDGHDLDFEDNLLKTKEIVALAHAQGVSVEAEVGSIGGEEDGIVGAGELADVEEAK
QLAATGVDFLAVGIGNIHGVYPANWTGLNFDRLQELADVIKTPLVLHGGSGIPKEQIVKAISMGISKVNVNTEQQIAWSN
AVRKYYEADNDKKAKGFDPRKVLASGTEAIKNTVKERIEWFNTPSMW
>Mature_286_residues
SFINGTSTFAAARKGGYAVGAFNTNNLEWTRAILAAGQETHTPILIQSSMGAAKYMGGYKAVKNLVEKQVESMGITVPVI
MHLDHGNYEAAKEAIAAGYSSVMFDGHDLDFEDNLLKTKEIVALAHAQGVSVEAEVGSIGGEEDGIVGAGELADVEEAKQ
LAATGVDFLAVGIGNIHGVYPANWTGLNFDRLQELADVIKTPLVLHGGSGIPKEQIVKAISMGISKVNVNTEQQIAWSNA
VRKYYEADNDKKAKGFDPRKVLASGTEAIKNTVKERIEWFNTPSMW

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=283, Percent_Identity=36.7491166077738, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI87082041, Length=273, Percent_Identity=35.5311355311355, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788072, Length=232, Percent_Identity=37.5, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789293, Length=334, Percent_Identity=24.8502994011976, Blast_Score=88, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30786; Mature: 30655

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFINGTSTFAAARKGGYAVGAFNTNNLEWTRAILAAGQETHTPILIQSSMGAAKYMGGY
CCCCCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHH
KAVKNLVEKQVESMGITVPVIMHLDHGNYEAAKEAIAAGYSSVMFDGHDLDFEDNLLKTK
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCHHHEECCCCCCCCCCHHHHH
EIVALAHAQGVSVEAEVGSIGGEEDGIVGAGELADVEEAKQLAATGVDFLAVGIGNIHGV
HHHHHHHCCCCEEEEHHCCCCCCCCCEECCCCHHHHHHHHHHHHCCCHHEEEECCCCCCC
YPANWTGLNFDRLQELADVIKTPLVLHGGSGIPKEQIVKAISMGISKVNVNTEQQIAWSN
CCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCHHEECCCCHHHHHHHH
AVRKYYEADNDKKAKGFDPRKVLASGTEAIKNTVKERIEWFNTPSMW
HHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SFINGTSTFAAARKGGYAVGAFNTNNLEWTRAILAAGQETHTPILIQSSMGAAKYMGGY
CCCCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHH
KAVKNLVEKQVESMGITVPVIMHLDHGNYEAAKEAIAAGYSSVMFDGHDLDFEDNLLKTK
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCHHHEECCCCCCCCCCHHHHH
EIVALAHAQGVSVEAEVGSIGGEEDGIVGAGELADVEEAKQLAATGVDFLAVGIGNIHGV
HHHHHHHCCCCEEEEHHCCCCCCCCCEECCCCHHHHHHHHHHHHCCCHHEEEECCCCCCC
YPANWTGLNFDRLQELADVIKTPLVLHGGSGIPKEQIVKAISMGISKVNVNTEQQIAWSN
CCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCHHEECCCCHHHHHHHH
AVRKYYEADNDKKAKGFDPRKVLASGTEAIKNTVKERIEWFNTPSMW
HHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]