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The map label for this gene is upp

Identifier: 116493074

GI number: 116493074

Start: 1315566

End: 1316195

Strand: Reverse

Name: upp

Synonym: PEPE_1326

Alternate gene names: 116493074

Gene position: 1316195-1315566 (Counterclockwise)

Preceding gene: 116493075

Following gene: 116493073

Centisome position: 71.83

GC content: 38.41

Gene sequence:

>630_bases
ATGGGTAAGTTTGAGGTTCTCGATCATCCGTTAATTCAACATAAGTTAACTTTGATTAGAGATAAACACTGTAGTACAAA
AGAATTTAGAGAAATCGTCAATGAAATCTCAACATTAATGGCATATGAAGTATCACGAGATATGCCACTGATGGATGTTG
AAATTGAAACACCAATTGGTAAATCAATTCAAAAACAGATTTCAGGTAAAAAAGTGGCGATTGTTCCAATTCTACGTGCT
GGTTTAGGTATGGTTGATGGAATGGCCGAGTTATTACCAGTTGCTCGTATTGGTCACATCGGAATGTATCGTGACGAAGA
AACATTAAAGCCAACTGAATACTTTGTAAAATTACCAAGTGATATCAGTGAACGTCAAGTATTCGTTGTTGATCCAATGC
TTGCTACTGGTGGATCAGCCATTATGGCTGTGGATGCATTGAAAAAACGTGGTGCTAAAGACATCCGTTTCTGTAGCTTA
GTAGCTGCTCCTGAAGGGGTTAAAGCATTACAAGAAGCTCATCCAGACATCGATATTTACACAGCTGCTCTAGATGAAAA
GCTTAATGAAGATGGTTACATCGTCCCAGGATTAGGGGATGCTGGTGATCGCTTATTCGGTACAAAATAA

Upstream 100 bases:

>100_bases
CAAACTAACTGAAAAGTACCCTATTGATTAAATTAGTCCTAGTTTTTTTATGTTTTTTTAGCTACAATTGATAAGGAATT
TGAAAGGAGCGAGTTTAGTC

Downstream 100 bases:

>100_bases
ATCTTTAAAAAGAAGGCCATTGGCCTTCTTTTTTTGTATGTTATTAGTATTAAAACGAACTAAGCTTTATTATTAGTAAT
ATAGTAAAAATTCGGGGGAA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGKFEVLDHPLIQHKLTLIRDKHCSTKEFREIVNEISTLMAYEVSRDMPLMDVEIETPIGKSIQKQISGKKVAIVPILRA
GLGMVDGMAELLPVARIGHIGMYRDEETLKPTEYFVKLPSDISERQVFVVDPMLATGGSAIMAVDALKKRGAKDIRFCSL
VAAPEGVKALQEAHPDIDIYTAALDEKLNEDGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_209_residues
MGKFEVLDHPLIQHKLTLIRDKHCSTKEFREIVNEISTLMAYEVSRDMPLMDVEIETPIGKSIQKQISGKKVAIVPILRA
GLGMVDGMAELLPVARIGHIGMYRDEETLKPTEYFVKLPSDISERQVFVVDPMLATGGSAIMAVDALKKRGAKDIRFCSL
VAAPEGVKALQEAHPDIDIYTAALDEKLNEDGYIVPGLGDAGDRLFGTK
>Mature_208_residues
GKFEVLDHPLIQHKLTLIRDKHCSTKEFREIVNEISTLMAYEVSRDMPLMDVEIETPIGKSIQKQISGKKVAIVPILRAG
LGMVDGMAELLPVARIGHIGMYRDEETLKPTEYFVKLPSDISERQVFVVDPMLATGGSAIMAVDALKKRGAKDIRFCSLV
AAPEGVKALQEAHPDIDIYTAALDEKLNEDGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=33.6633663366337, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=33.6633663366337, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI21450816, Length=168, Percent_Identity=32.1428571428571, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI87082118, Length=201, Percent_Identity=56.7164179104478, Blast_Score=241, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17539892, Length=207, Percent_Identity=29.4685990338164, Blast_Score=109, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17539894, Length=207, Percent_Identity=29.4685990338164, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=42.1875, Blast_Score=144, Evalue=7e-36,
Organism=Drosophila melanogaster, GI45550449, Length=208, Percent_Identity=33.6538461538462, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=33.0049261083744, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=33.0049261083744, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=33.0049261083744, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21358379, Length=197, Percent_Identity=27.4111675126904, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_PEDPA (Q03EK5)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804809.1
- ProteinModelPortal:   Q03EK5
- SMR:   Q03EK5
- STRING:   Q03EK5
- GeneID:   4417013
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1326
- NMPDR:   fig|278197.10.peg.1164
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- PhylomeDB:   Q03EK5
- ProtClustDB:   PRK00129
- BioCyc:   PPEN278197:PEPE_1326-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23005; Mature: 22874

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKFEVLDHPLIQHKLTLIRDKHCSTKEFREIVNEISTLMAYEVSRDMPLMDVEIETPIG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
KSIQKQISGKKVAIVPILRAGLGMVDGMAELLPVARIGHIGMYRDEETLKPTEYFVKLPS
HHHHHHHCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEECCC
DISERQVFVVDPMLATGGSAIMAVDALKKRGAKDIRFCSLVAAPEGVKALQEAHPDIDIY
CCCCCEEEEECCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCEEE
TAALDEKLNEDGYIVPGLGDAGDRLFGTK
HHHHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GKFEVLDHPLIQHKLTLIRDKHCSTKEFREIVNEISTLMAYEVSRDMPLMDVEIETPIG
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
KSIQKQISGKKVAIVPILRAGLGMVDGMAELLPVARIGHIGMYRDEETLKPTEYFVKLPS
HHHHHHHCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEECCC
DISERQVFVVDPMLATGGSAIMAVDALKKRGAKDIRFCSLVAAPEGVKALQEAHPDIDIY
CCCCCEEEEECCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCEEE
TAALDEKLNEDGYIVPGLGDAGDRLFGTK
HHHHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA