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The map label for this gene is tpx [H]

Identifier: 116493040

GI number: 116493040

Start: 1284379

End: 1284870

Strand: Reverse

Name: tpx [H]

Synonym: PEPE_1292

Alternate gene names: 116493040

Gene position: 1284870-1284379 (Counterclockwise)

Preceding gene: 116493041

Following gene: 116493039

Centisome position: 70.12

GC content: 35.77

Gene sequence:

>492_bases
ATGGAAGTATTACGCGGTGGAGAAAAAGTTGAACTCGTTGGAAATCCTCCAATGATTGGAGAACAATTACCCAAATTTAA
AGTTTTTACTGGCGACGGTGAAAAAGTTAAGACACGCGATTTACTGGGTAAACCACTTTTAATTAGTGTTGTTCCAGATT
TAAATACGCCGGTTTGCAGCATGCAAACTAAAAAATTTAACCAAGAAACTGACCAATACTCAGATATTCGATTTGTAACC
ATTTCTAACAATATGCCTAAAGACCAAGTAGCTTGGTGCGCAAATGAAGGCGTTAAGAACATGGAAGTATTGTCAGATCA
TGAGCTATCATTTGGTTATGAGATGAATCTATATATTCCGAATGCTGGTTATCTAGCTCGTAGTATCTTCATTGTTGATG
CTGATGGCAAAATTATTTATCGTGAAATTGTACCAGAAATTCATGACGAACCTGACTATCAAGCTGCACTTGATTTTATC
AATAAAATGTAA

Upstream 100 bases:

>100_bases
GAAGTTTTTGCTGAATTATTGTAAAGGATTTGTATATTGATTGAAATCAGTGAGTGTTTGAGATAAGGTTAACGTAATTT
AAATAAAGGAGCGTACAATT

Downstream 100 bases:

>100_bases
AAACATAATTGACGAACGGACAATTATTCTTTATTATTTATTCTGAAGGTTATGACTAAGAGGAGAGCTGCAAAACTTTT
TTCAGAGAATAGACATTTTT

Product: thiol peroxidase (atypical 2-Cys peroxiredoxin)

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: Superoxide-inducible protein 8; SOI8 [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MEVLRGGEKVELVGNPPMIGEQLPKFKVFTGDGEKVKTRDLLGKPLLISVVPDLNTPVCSMQTKKFNQETDQYSDIRFVT
ISNNMPKDQVAWCANEGVKNMEVLSDHELSFGYEMNLYIPNAGYLARSIFIVDADGKIIYREIVPEIHDEPDYQAALDFI
NKM

Sequences:

>Translated_163_residues
MEVLRGGEKVELVGNPPMIGEQLPKFKVFTGDGEKVKTRDLLGKPLLISVVPDLNTPVCSMQTKKFNQETDQYSDIRFVT
ISNNMPKDQVAWCANEGVKNMEVLSDHELSFGYEMNLYIPNAGYLARSIFIVDADGKIIYREIVPEIHDEPDYQAALDFI
NKM
>Mature_163_residues
MEVLRGGEKVELVGNPPMIGEQLPKFKVFTGDGEKVKTRDLLGKPLLISVVPDLNTPVCSMQTKKFNQETDQYSDIRFVT
ISNNMPKDQVAWCANEGVKNMEVLSDHELSFGYEMNLYIPNAGYLARSIFIVDADGKIIYREIVPEIHDEPDYQAALDFI
NKM

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=155, Percent_Identity=29.0322580645161, Blast_Score=80, Evalue=7e-17,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18430; Mature: 18430

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVLRGGEKVELVGNPPMIGEQLPKFKVFTGDGEKVKTRDLLGKPLLISVVPDLNTPVCS
CCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEHHHHCCCCEEEEEECCCCCCCCC
MQTKKFNQETDQYSDIRFVTISNNMPKDQVAWCANEGVKNMEVLSDHELSFGYEMNLYIP
CHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEEEC
NAGYLARSIFIVDADGKIIYREIVPEIHDEPDYQAALDFINKM
CCCCEEEEEEEEECCCCEEEEECCHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEVLRGGEKVELVGNPPMIGEQLPKFKVFTGDGEKVKTRDLLGKPLLISVVPDLNTPVCS
CCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEHHHHCCCCEEEEEECCCCCCCCC
MQTKKFNQETDQYSDIRFVTISNNMPKDQVAWCANEGVKNMEVLSDHELSFGYEMNLYIP
CHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEEEC
NAGYLARSIFIVDADGKIIYREIVPEIHDEPDYQAALDFINKM
CCCCEEEEEEEEECCCCEEEEECCHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 9298659 [H]