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The map label for this gene is ymfI [H]

Identifier: 116493028

GI number: 116493028

Start: 1270426

End: 1271151

Strand: Reverse

Name: ymfI [H]

Synonym: PEPE_1280

Alternate gene names: 116493028

Gene position: 1271151-1270426 (Counterclockwise)

Preceding gene: 116493029

Following gene: 116493027

Centisome position: 69.37

GC content: 37.19

Gene sequence:

>726_bases
ATGAAATTTGCATTAATTTGTGGAGCAAGCGGCAATATCGGAACAGCGATTAGCAAAGATTTGGCTCAAAAGGGATGGTC
ACTTTACTTACATTATTATCAAAATGAGGCAACAACTAATCAATTAGCCAATGAGTTACGGGCAGAATATCCTCAGCAAG
ATTTTTTAACCATTCAAGCGAATTTCAGAAGCGAAGACGCTGCTCAAAAAATTAGCCAAAATATTTTTGGGTTGAATGCC
GTGGTTTTTGCTCAAGGAACGACAATCTATCAATTGTTTGATTGTTTTAGTGCCCAACAGTTGGAAAATTTGTGGCAAGA
ACAGTTAAAAACACCCATGTTAGTTATTCAAAAGGTAATTAAAAAAATAAGCAACGCTGAAAATGGAAGAATTGTTTTTA
TTGGTTCAATCTATGGAGCAGTAGGCAGTTCAATGGAGGTACCTTATAGTGCTATTAAGGGGGGGATTAGTAGTTTTGTA
AATGCCTACTCTAAAGAAGTTGCTTCACTAGGAGTTACTGTTAATGCTGTTGCACCAGGGGCAGTTGCCACTAAGATGAA
CGATGAATTTAATCAAACAGAAATTGAAGCAGTTAATGAAGAAATACCGGTGGGACGTTTCGGTGATCCAACAGAGATCA
GTCATATAGTTCAATCAATTATGGATGAACGGGCCTCTTACCTAACTGGTCAAACGATTTATGTTGATGGTGGATGGAAA
AAATAA

Upstream 100 bases:

>100_bases
ATCAAGATATCTCTTTAGACGAAGTAATTAATACTTTCGATACCTTTATGAAAAATGTTGTTATCAGTACGTTTAAAATG
GATAGTGAGCAGGCGAAGAA

Downstream 100 bases:

>100_bases
TGATATACTTATCTTTGATTTAGAAATAAGTTGGGCGGTATACTTATGAGCACTAGAAAATACAAGGAAATTGGTGAGCG
TCTGCAAGATGCTCGTATAA

Product: 3-oxoacyl-acyl carrier protein reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MKFALICGASGNIGTAISKDLAQKGWSLYLHYYQNEATTNQLANELRAEYPQQDFLTIQANFRSEDAAQKISQNIFGLNA
VVFAQGTTIYQLFDCFSAQQLENLWQEQLKTPMLVIQKVIKKISNAENGRIVFIGSIYGAVGSSMEVPYSAIKGGISSFV
NAYSKEVASLGVTVNAVAPGAVATKMNDEFNQTEIEAVNEEIPVGRFGDPTEISHIVQSIMDERASYLTGQTIYVDGGWK
K

Sequences:

>Translated_241_residues
MKFALICGASGNIGTAISKDLAQKGWSLYLHYYQNEATTNQLANELRAEYPQQDFLTIQANFRSEDAAQKISQNIFGLNA
VVFAQGTTIYQLFDCFSAQQLENLWQEQLKTPMLVIQKVIKKISNAENGRIVFIGSIYGAVGSSMEVPYSAIKGGISSFV
NAYSKEVASLGVTVNAVAPGAVATKMNDEFNQTEIEAVNEEIPVGRFGDPTEISHIVQSIMDERASYLTGQTIYVDGGWK
K
>Mature_241_residues
MKFALICGASGNIGTAISKDLAQKGWSLYLHYYQNEATTNQLANELRAEYPQQDFLTIQANFRSEDAAQKISQNIFGLNA
VVFAQGTTIYQLFDCFSAQQLENLWQEQLKTPMLVIQKVIKKISNAENGRIVFIGSIYGAVGSSMEVPYSAIKGGISSFV
NAYSKEVASLGVTVNAVAPGAVATKMNDEFNQTEIEAVNEEIPVGRFGDPTEISHIVQSIMDERASYLTGQTIYVDGGWK
K

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI15277342, Length=249, Percent_Identity=29.3172690763052, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI19923817, Length=248, Percent_Identity=26.6129032258064, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=22.9838709677419, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1787335, Length=238, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=28.2258064516129, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=26.2295081967213, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=28, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=23.6947791164659, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789208, Length=246, Percent_Identity=24.7967479674797, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI2367365, Length=242, Percent_Identity=23.1404958677686, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790717, Length=239, Percent_Identity=24.6861924686192, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789057, Length=253, Percent_Identity=25.296442687747, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=243, Percent_Identity=26.3374485596708, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=26.2096774193548, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=260, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=255, Percent_Identity=25.4901960784314, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=257, Percent_Identity=24.5136186770428, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=256, Percent_Identity=24.21875, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=24.7104247104247, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=23.7903225806452, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508651, Length=249, Percent_Identity=22.0883534136546, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=28.1124497991968, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=27.4509803921569, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=26.953125, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 26429; Mature: 26429

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFALICGASGNIGTAISKDLAQKGWSLYLHYYQNEATTNQLANELRAEYPQQDFLTIQA
CCEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEE
NFRSEDAAQKISQNIFGLNAVVFAQGTTIYQLFDCFSAQQLENLWQEQLKTPMLVIQKVI
CCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHH
KKISNAENGRIVFIGSIYGAVGSSMEVPYSAIKGGISSFVNAYSKEVASLGVTVNAVAPG
HHHCCCCCCEEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
AVATKMNDEFNQTEIEAVNEEIPVGRFGDPTEISHIVQSIMDERASYLTGQTIYVDGGWK
HHEECCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
K
C
>Mature Secondary Structure
MKFALICGASGNIGTAISKDLAQKGWSLYLHYYQNEATTNQLANELRAEYPQQDFLTIQA
CCEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEE
NFRSEDAAQKISQNIFGLNAVVFAQGTTIYQLFDCFSAQQLENLWQEQLKTPMLVIQKVI
CCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHH
KKISNAENGRIVFIGSIYGAVGSSMEVPYSAIKGGISSFVNAYSKEVASLGVTVNAVAPG
HHHCCCCCCEEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
AVATKMNDEFNQTEIEAVNEEIPVGRFGDPTEISHIVQSIMDERASYLTGQTIYVDGGWK
HHEECCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]