Click here to switch to the map view.

The map label for this gene is mutL

Identifier: 116493021

GI number: 116493021

Start: 1260006

End: 1261943

Strand: Reverse

Name: mutL

Synonym: PEPE_1273

Alternate gene names: 116493021

Gene position: 1261943-1260006 (Counterclockwise)

Preceding gene: 116493022

Following gene: 116493020

Centisome position: 68.87

GC content: 37.0

Gene sequence:

>1938_bases
TTGGCAGAAATACATGAGTTAAGTGAAATTTTAGCGGATCAGATTGCAGCGGGTGAAGTTGTTGAACGTCCAGCTTCAGT
GGTTAAAGAATTAGTTGAAAATGCTATCGATGCTGGTAGTTCTCGAATTGATATTTTGCTTGAAGAGTCTGGGTTAAAGA
TGATTCGAATTATTGACAATGGTAGTGGAATTGATGCAAATCAAGTTGAGATTGCTTTTAAACGACATGCTACGAGTAAG
ATTTCGTCGCGTTCAGACTTATTTAAGGTGGGGACTTTGGGTTTTCGAGGGGAAGCCCTACCTAGTATTGCTTCAATTGC
AGATGTTGAAATGTTGACAGCTACAACTGATGGACCGGGTAAAAAGATTCATTACCGGGGTGGCAAATTAGAAGATAGCG
GTGATGCTCAAAGTCGCCAAGGTACGGATATTACTGTACAGGATCTATTTTTCAATACTCCAGCACGGTTAAAGTACTTA
AAATCGCTCCAAACAGAATTATCTAAAATTACGGATATTGTCAATCGAATTGCACTAAGTTACCCAGAAGTAGCTATCTC
ACTACAAAATAATGAGCGTGAGCTAATGCGAACCTCAGGAAACGGAAATATTCAACAAGTTTTAGCTAACATTTATGGTG
CCAAAAATGCTCAAAAAATGGTACATGTTAAAGAACAAAATATTGACTTTACGATTGATGGTTATATTAGTTTACCAGAA
TTCACTAGGGCAAATCGCAGCTATATCACGGTTCTAGTTAATGGACGGTATATCAAAAATTTCCAAATCAGTAAGGCTAT
TATTGATGGTTATGGTTCAAAATTAATGGTTGGTCGTTATCCAGTAGCAGTTTTGAATATTAAAACTGATCCAATTTTAG
TAGATGTAAATGTGCATCCAACTAAACAAGAGGTGCGCATCAGTGAAGAACAGACACTGTTAGATTTAATTTCCAAAGCC
GTTTTTAATGAACTTGCAGATAAAAATTTGATTCCGGATGCAGTAGACAATTTAAAAAAGTCACGTGTAAAAGTAAGTTC
AAGTGAACAACTTGACTTAGCTCGGATGGCCATATCGGGTTCTTTTGAGATGGAACAGGATCATGTAACGATTCCAGATA
CAGATAACGACGAAGTTGAAAAAGAAGTAAATATCTCGGATCGATATGTGGAACCTGAACCAATTGTTATTAATAGTCGC
CAAGATTTAAAATCTGATACCATTGCCGAATTTAAAACCAAATACGCTAACGATGCAGTAGTTAACAATACGGTTGAAGA
CGGGGATCAGCCTGAATTAAAAGAGAAAGATGCCGTACAACGTTTTCCAACTTTGACTTACATTGGACAAATGCACGGAA
CATATTTGTTTGCCGAAGCTGAGGATGGTCTCTACATTATTGATCAACATGCAGCGCAGGAACGTATTAATTATGAATAT
TATCGAGTTCAAATTGGAGAGGTCAGTGATGATCAACAGGACTTACTAGTGCCAATTTACTTAGATTATTCAACTACGGA
TGCTATCCGAATTAAAGAAAAGCAAACAGTCTTAGAGTCGTGTGGATTGTTTTTAGAAGAATTCGGGAAAAATACGTTTA
TCGTTAGACATCATCCAACGTGGTTCAAAAAAGGGCAAGAGGAAGACACCGTTAAAGAAATGGTTGATTATGTTTTAAAT
GATAGCTCAATGACGGTAGCTAAATTTAGGGAAGCAACCGCCATCATGATGAGTTGTAAACGAGCTATTAAAGCCAATCA
TCATTTAGATGAACCACAAGCTAAACAATTATTAAAAGACATCGCTAAGGCTGAAAATCCATTTAATTGTCCTCATGGTC
GTCCAGTACTAGTACATTTTTCAACGACAGACATGGAGAAAATGTTTAAAAGAATTCAAGATCCACACCATTCTGACTTG
ATGGAAGATGAGATGTGA

Upstream 100 bases:

>100_bases
ACCAACTGGAACAGTTAAATTTAATGGATATGACTCCCATGGAAGTTATGAATCAGTTATATAAATGGCAAAAGAAACTT
CGTAAGTGAGGCGATTATTT

Downstream 100 bases:

>100_bases
TACAATTAACTGAATGCGAACAAACGTTTTGAAATGAGGATTTATAAATGTATGAATATTTAGATGGAGTCGTCGTTAAC
GTTAATCCAGCTTATATTGT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MAEIHELSEILADQIAAGEVVERPASVVKELVENAIDAGSSRIDILLEESGLKMIRIIDNGSGIDANQVEIAFKRHATSK
ISSRSDLFKVGTLGFRGEALPSIASIADVEMLTATTDGPGKKIHYRGGKLEDSGDAQSRQGTDITVQDLFFNTPARLKYL
KSLQTELSKITDIVNRIALSYPEVAISLQNNERELMRTSGNGNIQQVLANIYGAKNAQKMVHVKEQNIDFTIDGYISLPE
FTRANRSYITVLVNGRYIKNFQISKAIIDGYGSKLMVGRYPVAVLNIKTDPILVDVNVHPTKQEVRISEEQTLLDLISKA
VFNELADKNLIPDAVDNLKKSRVKVSSSEQLDLARMAISGSFEMEQDHVTIPDTDNDEVEKEVNISDRYVEPEPIVINSR
QDLKSDTIAEFKTKYANDAVVNNTVEDGDQPELKEKDAVQRFPTLTYIGQMHGTYLFAEAEDGLYIIDQHAAQERINYEY
YRVQIGEVSDDQQDLLVPIYLDYSTTDAIRIKEKQTVLESCGLFLEEFGKNTFIVRHHPTWFKKGQEEDTVKEMVDYVLN
DSSMTVAKFREATAIMMSCKRAIKANHHLDEPQAKQLLKDIAKAENPFNCPHGRPVLVHFSTTDMEKMFKRIQDPHHSDL
MEDEM

Sequences:

>Translated_645_residues
MAEIHELSEILADQIAAGEVVERPASVVKELVENAIDAGSSRIDILLEESGLKMIRIIDNGSGIDANQVEIAFKRHATSK
ISSRSDLFKVGTLGFRGEALPSIASIADVEMLTATTDGPGKKIHYRGGKLEDSGDAQSRQGTDITVQDLFFNTPARLKYL
KSLQTELSKITDIVNRIALSYPEVAISLQNNERELMRTSGNGNIQQVLANIYGAKNAQKMVHVKEQNIDFTIDGYISLPE
FTRANRSYITVLVNGRYIKNFQISKAIIDGYGSKLMVGRYPVAVLNIKTDPILVDVNVHPTKQEVRISEEQTLLDLISKA
VFNELADKNLIPDAVDNLKKSRVKVSSSEQLDLARMAISGSFEMEQDHVTIPDTDNDEVEKEVNISDRYVEPEPIVINSR
QDLKSDTIAEFKTKYANDAVVNNTVEDGDQPELKEKDAVQRFPTLTYIGQMHGTYLFAEAEDGLYIIDQHAAQERINYEY
YRVQIGEVSDDQQDLLVPIYLDYSTTDAIRIKEKQTVLESCGLFLEEFGKNTFIVRHHPTWFKKGQEEDTVKEMVDYVLN
DSSMTVAKFREATAIMMSCKRAIKANHHLDEPQAKQLLKDIAKAENPFNCPHGRPVLVHFSTTDMEKMFKRIQDPHHSDL
MEDEM
>Mature_644_residues
AEIHELSEILADQIAAGEVVERPASVVKELVENAIDAGSSRIDILLEESGLKMIRIIDNGSGIDANQVEIAFKRHATSKI
SSRSDLFKVGTLGFRGEALPSIASIADVEMLTATTDGPGKKIHYRGGKLEDSGDAQSRQGTDITVQDLFFNTPARLKYLK
SLQTELSKITDIVNRIALSYPEVAISLQNNERELMRTSGNGNIQQVLANIYGAKNAQKMVHVKEQNIDFTIDGYISLPEF
TRANRSYITVLVNGRYIKNFQISKAIIDGYGSKLMVGRYPVAVLNIKTDPILVDVNVHPTKQEVRISEEQTLLDLISKAV
FNELADKNLIPDAVDNLKKSRVKVSSSEQLDLARMAISGSFEMEQDHVTIPDTDNDEVEKEVNISDRYVEPEPIVINSRQ
DLKSDTIAEFKTKYANDAVVNNTVEDGDQPELKEKDAVQRFPTLTYIGQMHGTYLFAEAEDGLYIIDQHAAQERINYEYY
RVQIGEVSDDQQDLLVPIYLDYSTTDAIRIKEKQTVLESCGLFLEEFGKNTFIVRHHPTWFKKGQEEDTVKEMVDYVLND
SSMTVAKFREATAIMMSCKRAIKANHHLDEPQAKQLLKDIAKAENPFNCPHGRPVLVHFSTTDMEKMFKRIQDPHHSDLM
EDEM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=332, Percent_Identity=34.3373493975904, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI4505913, Length=338, Percent_Identity=28.4023668639053, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI310128478, Length=338, Percent_Identity=28.4023668639053, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI4505911, Length=318, Percent_Identity=29.874213836478, Blast_Score=127, Evalue=5e-29,
Organism=Homo sapiens, GI189458898, Length=321, Percent_Identity=30.5295950155763, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI189458896, Length=309, Percent_Identity=30.42071197411, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI263191589, Length=238, Percent_Identity=29.4117647058824, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI310128480, Length=305, Percent_Identity=25.9016393442623, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI91992160, Length=347, Percent_Identity=24.7838616714697, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI91992162, Length=347, Percent_Identity=24.7838616714697, Blast_Score=97, Evalue=5e-20,
Organism=Escherichia coli, GI1790612, Length=340, Percent_Identity=40.2941176470588, Blast_Score=225, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI71991825, Length=318, Percent_Identity=32.3899371069182, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=355, Percent_Identity=30.4225352112676, Blast_Score=148, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323819, Length=332, Percent_Identity=33.433734939759, Blast_Score=180, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=349, Percent_Identity=28.080229226361, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325093, Length=421, Percent_Identity=23.5154394299287, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=362, Percent_Identity=26.7955801104972, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17136968, Length=332, Percent_Identity=31.6265060240964, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17136970, Length=347, Percent_Identity=27.9538904899135, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_PEDPA (Q03EQ8)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804756.1
- ProteinModelPortal:   Q03EQ8
- SMR:   Q03EQ8
- STRING:   Q03EQ8
- GeneID:   4417609
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1273
- NMPDR:   fig|278197.10.peg.1115
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   MACKAAV
- PhylomeDB:   Q03EQ8
- ProtClustDB:   PRK00095
- BioCyc:   PPEN278197:PEPE_1273-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 72567; Mature: 72436

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIHELSEILADQIAAGEVVERPASVVKELVENAIDAGSSRIDILLEESGLKMIRIIDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEC
GSGIDANQVEIAFKRHATSKISSRSDLFKVGTLGFRGEALPSIASIADVEMLTATTDGPG
CCCCCCCCEEEEEHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHCEEEEEEECCCCC
KKIHYRGGKLEDSGDAQSRQGTDITVQDLFFNTPARLKYLKSLQTELSKITDIVNRIALS
CEEEECCCCCCCCCCCCCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
YPEVAISLQNNERELMRTSGNGNIQQVLANIYGAKNAQKMVHVKEQNIDFTIDGYISLPE
CCCEEEEECCCCHHHHEECCCCCHHHHHHHHHCCCCCHHEEEEEECCCCEEEECEEECCH
FTRANRSYITVLVNGRYIKNFQISKAIIDGYGSKLMVGRYPVAVLNIKTDPILVDVNVHP
HHCCCCCEEEEEEECEEEECEEHHHHHHHCCCCEEEEECCCEEEEEECCCCEEEEEECCC
TKQEVRISEEQTLLDLISKAVFNELADKNLIPDAVDNLKKSRVKVSSSEQLDLARMAISG
CHHHHEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHCC
SFEMEQDHVTIPDTDNDEVEKEVNISDRYVEPEPIVINSRQDLKSDTIAEFKTKYANDAV
CCEECCCEEECCCCCCCHHHHHCCCCCCCCCCCCEEECCCHHCCHHHHHHHHHHHCCCHH
VNNTVEDGDQPELKEKDAVQRFPTLTYIGQMHGTYLFAEAEDGLYIIDQHAAQERINYEY
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCEEEEEECCCCEEEEECHHHHHHCCCEE
YRVQIGEVSDDQQDLLVPIYLDYSTTDAIRIKEKQTVLESCGLFLEEFGKNTFIVRHHPT
EEEEECCCCCCCCCEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCH
WFKKGQEEDTVKEMVDYVLNDSSMTVAKFREATAIMMSCKRAIKANHHLDEPQAKQLLKD
HHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
IAKAENPFNCPHGRPVLVHFSTTDMEKMFKRIQDPHHSDLMEDEM
HHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure 
AEIHELSEILADQIAAGEVVERPASVVKELVENAIDAGSSRIDILLEESGLKMIRIIDN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEC
GSGIDANQVEIAFKRHATSKISSRSDLFKVGTLGFRGEALPSIASIADVEMLTATTDGPG
CCCCCCCCEEEEEHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHCEEEEEEECCCCC
KKIHYRGGKLEDSGDAQSRQGTDITVQDLFFNTPARLKYLKSLQTELSKITDIVNRIALS
CEEEECCCCCCCCCCCCCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
YPEVAISLQNNERELMRTSGNGNIQQVLANIYGAKNAQKMVHVKEQNIDFTIDGYISLPE
CCCEEEEECCCCHHHHEECCCCCHHHHHHHHHCCCCCHHEEEEEECCCCEEEECEEECCH
FTRANRSYITVLVNGRYIKNFQISKAIIDGYGSKLMVGRYPVAVLNIKTDPILVDVNVHP
HHCCCCCEEEEEEECEEEECEEHHHHHHHCCCCEEEEECCCEEEEEECCCCEEEEEECCC
TKQEVRISEEQTLLDLISKAVFNELADKNLIPDAVDNLKKSRVKVSSSEQLDLARMAISG
CHHHHEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHCC
SFEMEQDHVTIPDTDNDEVEKEVNISDRYVEPEPIVINSRQDLKSDTIAEFKTKYANDAV
CCEECCCEEECCCCCCCHHHHHCCCCCCCCCCCCEEECCCHHCCHHHHHHHHHHHCCCHH
VNNTVEDGDQPELKEKDAVQRFPTLTYIGQMHGTYLFAEAEDGLYIIDQHAAQERINYEY
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCEEEEEECCCCEEEEECHHHHHHCCCEE
YRVQIGEVSDDQQDLLVPIYLDYSTTDAIRIKEKQTVLESCGLFLEEFGKNTFIVRHHPT
EEEEECCCCCCCCCEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCH
WFKKGQEEDTVKEMVDYVLNDSSMTVAKFREATAIMMSCKRAIKANHHLDEPQAKQLLKD
HHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
IAKAENPFNCPHGRPVLVHFSTTDMEKMFKRIQDPHHSDLMEDEM
HHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA