Click here to switch to the map view.

The map label for this gene is mutS2

Identifier: 116493007

GI number: 116493007

Start: 1244098

End: 1246455

Strand: Reverse

Name: mutS2

Synonym: PEPE_1259

Alternate gene names: 116493007

Gene position: 1246455-1244098 (Counterclockwise)

Preceding gene: 116493008

Following gene: 116493006

Centisome position: 68.02

GC content: 38.17

Gene sequence:

>2358_bases
ATGAATAAGAAAATTTTAGATGTTTTAGAGTATGACAAGATTAAACAATCTATTCGGCAGTTTATAGCTACTGAAAATGG
AACAAAAGAGTTACGTGAGCTAGTACCAAGTAGCGATGAAACTGAAGTACGAAACGCCTTAAAACAAACACTAGATGCAG
TTAATATTTATCGTTTAAAGAATGGTATTCCAGTTCCGCGGCTTGAAGATGTGACAGAGGCACTTCAACGTTTGAAGATT
GATGCTGCTTTAAACGGTCAAGAATTGGCTCAAATTGGTAGAATTCTAAGAGCTACACGAACGGTAATTAACTTTTTCGA
TGATTTAGAAAATGAAGAAATTGAAATCATTGCACTAGATCAAGTGATTGAGCAACTAGTAACTATTCCTGAAGTTGAAG
AACGTTTAAGTAATTCAATTGAAGGAAACGGTCATTTGTTGAATTCCGCTTCAAGCGAACTAAGACGGATTCGTGCTTCC
ATTACCCGTATCGAGAGTGATGTGCGTTCACGAATGGAAAAATTCACACGTGGAAATAATGTTAAGTATTTAAGTGAACC
AATCGTGACTATCCGAAACGAACGCTATGTTATTCCAGCTCGTGTTGAATATCGTTCTAAATTTGGTGGAGTAGTCCATG
ATCAAAGTTCATCAGGACAAACATTATACGTTGAACCTGAATCAGTAGTGGATTTGAATAATGAATTACGACAAAACCAA
GTAGCAGAAGTCCATGAAGAGCAACGCATCTTACAAGAACTTAGTGCATTAGTAGCTCCTTACACAGATACATTAAAAGA
TAATAGTCGCATTTTGGGCCATTTAGATTTACTAAATGCTAAGGCCCAGTATGCTCATCAACTAAAAGCAACTGAACCGC
AAATTTCAGCGTCCAATGAAATTAACCTACGAGAAGCAAGGCATCCTTTGATTGACCAAAAAAAGGTAGTTTCCAACGAT
ATTAGACTAGGTGGAGAGTATGAGACACTCGTGATTACTGGACCTAATACCGGTGGTAAGACCATCACCTTAAAAACGGT
GGGACTCCTTCAATTAATGGCACAGTCGGGAATGTTTATTCCAGCTAATGAGAATAGTACGGTTCGGATTTTTGAGGAAA
TATTTGCTGATATTGGGGATGAGCAATCCATCGAACAAAATTTGAGTACGTTCTCTTCCCATATGGATAATACAATTCGA
ATTTTAGGCAATTTAAATGAACGTTCCTTGGCATTATTTGATGAATTGGGTGCCGGAACAGATCCTAAAGAAGGGGCTGC
ACTTGCGATTGCTATTTTAGATAAAGTTCGCAGTACGGGGGCTGTTTCAATGACTACCACCCATTATCCAGAATTAAAGA
CTTATGGATATGAAAGAATGGGTACCATTAATGCTAGTATGGAATTCGATGTTGATACCTTGCAGCCTACCTATAAGTTA
TTATTAGGAATTCCTGGTCAGAGTAACGCTTTTGAAATTTCAAAACGTTTAGGTTTAGATAGTGATATCATCAGTCAAGC
TCGGGGGCTAGTTGACCAAGATAGCCAAGATTTGAACAATATGATTAAAGATTTAACGACTCGTCAAAAACGAGCTCAAA
AAATTAATCAACAAGCTGTGGAATTACTTAAACAAGCCGAGGAGTACCACCAAACCTTGGTCAAGGGAGTCGATAGCCTA
AATTCGCAACGGAGCAATTTAATTGAGAGTGCTAAAGAAGATGCAAACCGAATTGTGAATGATAGTCAGGCCGAAGCAGA
CCGCATTATTAAACGTCTACGTAAGTTAGAACATTCCACAGGAAGTTTTAAGGAAAATGATTTAATCGACGCTAAAAGTA
AAATTAACGCCCTTCATCAGGATACTAACCTTAAACGTAATAAAGTTTTACGACGTGCTAAAGAAGCTCAAAAATTCCAT
GAAAATGATGAAGTAGTGGTCTTAACTTATGGACAACGTGGGGAACTTCTTCGGCAAGTTGATAAAAAACATTGGGAAGT
CCAAATGGGAATTATGAAAATGAAGGTTGCCGTTGATGAACTGGAAAAAGTTAAACCGGATAAGACGGTCAAGCGACGAG
TTCATAACTCAGTTCAAAGAACGGCTTCTGCGGGAGTTAAAACAACCTTAGATTTACGTGGAAAACGTTATGAAGAAGCA
CTGACTGAAACCGATCGCTACATTGATGCTGCTTTGTTAGCAGGTTATGACGAGGTAACGATTGTTCATGGAAAAGGAAC
TGGGGCACTTAGAAGTGGGATTACCAAGTATCTTAAGAATAATCGTCGAATTAAAGCTTTTGAATACGCACCTGCGAATG
CTGGTGGAAATGGTGCCACGATTGTTCATTTTAAATAA

Upstream 100 bases:

>100_bases
AAGACCAAGATTAATTTCCTAGAAACGGTCCTTGTTTGACGATGAGATATTATCTATCGGCGAGCGGGCCGTTTTTGATT
TGAAATGAAATGAGATTGAT

Downstream 100 bases:

>100_bases
TCCTTATAAAATGTAAGCTAATTATTTCATTTGCTACGCAAAGACTGGTATAGTTAACGTAACAAATTGTGAAAGAGGGT
AATTAGAATGGTTGAAGCTA

Product: MutS family ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MNKKILDVLEYDKIKQSIRQFIATENGTKELRELVPSSDETEVRNALKQTLDAVNIYRLKNGIPVPRLEDVTEALQRLKI
DAALNGQELAQIGRILRATRTVINFFDDLENEEIEIIALDQVIEQLVTIPEVEERLSNSIEGNGHLLNSASSELRRIRAS
ITRIESDVRSRMEKFTRGNNVKYLSEPIVTIRNERYVIPARVEYRSKFGGVVHDQSSSGQTLYVEPESVVDLNNELRQNQ
VAEVHEEQRILQELSALVAPYTDTLKDNSRILGHLDLLNAKAQYAHQLKATEPQISASNEINLREARHPLIDQKKVVSND
IRLGGEYETLVITGPNTGGKTITLKTVGLLQLMAQSGMFIPANENSTVRIFEEIFADIGDEQSIEQNLSTFSSHMDNTIR
ILGNLNERSLALFDELGAGTDPKEGAALAIAILDKVRSTGAVSMTTTHYPELKTYGYERMGTINASMEFDVDTLQPTYKL
LLGIPGQSNAFEISKRLGLDSDIISQARGLVDQDSQDLNNMIKDLTTRQKRAQKINQQAVELLKQAEEYHQTLVKGVDSL
NSQRSNLIESAKEDANRIVNDSQAEADRIIKRLRKLEHSTGSFKENDLIDAKSKINALHQDTNLKRNKVLRRAKEAQKFH
ENDEVVVLTYGQRGELLRQVDKKHWEVQMGIMKMKVAVDELEKVKPDKTVKRRVHNSVQRTASAGVKTTLDLRGKRYEEA
LTETDRYIDAALLAGYDEVTIVHGKGTGALRSGITKYLKNNRRIKAFEYAPANAGGNGATIVHFK

Sequences:

>Translated_785_residues
MNKKILDVLEYDKIKQSIRQFIATENGTKELRELVPSSDETEVRNALKQTLDAVNIYRLKNGIPVPRLEDVTEALQRLKI
DAALNGQELAQIGRILRATRTVINFFDDLENEEIEIIALDQVIEQLVTIPEVEERLSNSIEGNGHLLNSASSELRRIRAS
ITRIESDVRSRMEKFTRGNNVKYLSEPIVTIRNERYVIPARVEYRSKFGGVVHDQSSSGQTLYVEPESVVDLNNELRQNQ
VAEVHEEQRILQELSALVAPYTDTLKDNSRILGHLDLLNAKAQYAHQLKATEPQISASNEINLREARHPLIDQKKVVSND
IRLGGEYETLVITGPNTGGKTITLKTVGLLQLMAQSGMFIPANENSTVRIFEEIFADIGDEQSIEQNLSTFSSHMDNTIR
ILGNLNERSLALFDELGAGTDPKEGAALAIAILDKVRSTGAVSMTTTHYPELKTYGYERMGTINASMEFDVDTLQPTYKL
LLGIPGQSNAFEISKRLGLDSDIISQARGLVDQDSQDLNNMIKDLTTRQKRAQKINQQAVELLKQAEEYHQTLVKGVDSL
NSQRSNLIESAKEDANRIVNDSQAEADRIIKRLRKLEHSTGSFKENDLIDAKSKINALHQDTNLKRNKVLRRAKEAQKFH
ENDEVVVLTYGQRGELLRQVDKKHWEVQMGIMKMKVAVDELEKVKPDKTVKRRVHNSVQRTASAGVKTTLDLRGKRYEEA
LTETDRYIDAALLAGYDEVTIVHGKGTGALRSGITKYLKNNRRIKAFEYAPANAGGNGATIVHFK
>Mature_785_residues
MNKKILDVLEYDKIKQSIRQFIATENGTKELRELVPSSDETEVRNALKQTLDAVNIYRLKNGIPVPRLEDVTEALQRLKI
DAALNGQELAQIGRILRATRTVINFFDDLENEEIEIIALDQVIEQLVTIPEVEERLSNSIEGNGHLLNSASSELRRIRAS
ITRIESDVRSRMEKFTRGNNVKYLSEPIVTIRNERYVIPARVEYRSKFGGVVHDQSSSGQTLYVEPESVVDLNNELRQNQ
VAEVHEEQRILQELSALVAPYTDTLKDNSRILGHLDLLNAKAQYAHQLKATEPQISASNEINLREARHPLIDQKKVVSND
IRLGGEYETLVITGPNTGGKTITLKTVGLLQLMAQSGMFIPANENSTVRIFEEIFADIGDEQSIEQNLSTFSSHMDNTIR
ILGNLNERSLALFDELGAGTDPKEGAALAIAILDKVRSTGAVSMTTTHYPELKTYGYERMGTINASMEFDVDTLQPTYKL
LLGIPGQSNAFEISKRLGLDSDIISQARGLVDQDSQDLNNMIKDLTTRQKRAQKINQQAVELLKQAEEYHQTLVKGVDSL
NSQRSNLIESAKEDANRIVNDSQAEADRIIKRLRKLEHSTGSFKENDLIDAKSKINALHQDTNLKRNKVLRRAKEAQKFH
ENDEVVVLTYGQRGELLRQVDKKHWEVQMGIMKMKVAVDELEKVKPDKTVKRRVHNSVQRTASAGVKTTLDLRGKRYEEA
LTETDRYIDAALLAGYDEVTIVHGKGTGALRSGITKYLKNNRRIKAFEYAPANAGGNGATIVHFK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain

Homologues:

Organism=Homo sapiens, GI36949366, Length=368, Percent_Identity=29.0760869565217, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI284813531, Length=304, Percent_Identity=28.9473684210526, Blast_Score=116, Evalue=1e-25,
Organism=Homo sapiens, GI4557761, Length=236, Percent_Identity=30.5084745762712, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI26638666, Length=353, Percent_Identity=28.328611898017, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI4505253, Length=353, Percent_Identity=28.328611898017, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI26638664, Length=354, Percent_Identity=28.2485875706215, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4504191, Length=229, Percent_Identity=29.2576419213974, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI262231786, Length=217, Percent_Identity=32.258064516129, Blast_Score=93, Evalue=9e-19,
Organism=Escherichia coli, GI1789089, Length=326, Percent_Identity=28.2208588957055, Blast_Score=123, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17508445, Length=292, Percent_Identity=25.3424657534247, Blast_Score=111, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17534743, Length=272, Percent_Identity=28.3088235294118, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17508447, Length=360, Percent_Identity=24.1666666666667, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539736, Length=250, Percent_Identity=23.6, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324482, Length=329, Percent_Identity=27.9635258358663, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319935, Length=305, Percent_Identity=31.1475409836066, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321912, Length=333, Percent_Identity=26.4264264264264, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321109, Length=240, Percent_Identity=28.75, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320302, Length=223, Percent_Identity=28.6995515695067, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=237, Percent_Identity=26.1603375527426, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664545, Length=267, Percent_Identity=29.9625468164794, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24584320, Length=280, Percent_Identity=26.7857142857143, Blast_Score=97, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS2_PEDPA (Q03ES2)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804742.1
- STRING:   Q03ES2
- GeneID:   4417119
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1259
- NMPDR:   fig|278197.10.peg.1100
- eggNOG:   COG1193
- HOGENOM:   HBG486560
- OMA:   PGLVHDQ
- BioCyc:   PPEN278197:PEPE_1259-MONOMER
- HAMAP:   MF_00092
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625
- PANTHER:   PTHR11361
- PIRSF:   PIRSF005814
- SMART:   SM00534
- SMART:   SM00533
- SMART:   SM00463
- TIGRFAMs:   TIGR01069

Pfam domain/function: PF00488 MutS_V; PF01713 Smr; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 88236; Mature: 88236

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2; PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKILDVLEYDKIKQSIRQFIATENGTKELRELVPSSDETEVRNALKQTLDAVNIYRLK
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
NGIPVPRLEDVTEALQRLKIDAALNGQELAQIGRILRATRTVINFFDDLENEEIEIIALD
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHH
QVIEQLVTIPEVEERLSNSIEGNGHLLNSASSELRRIRASITRIESDVRSRMEKFTRGNN
HHHHHHHCCHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VKYLSEPIVTIRNERYVIPARVEYRSKFGGVVHDQSSSGQTLYVEPESVVDLNNELRQNQ
CEEECCCCEEECCCCEEEECHHHHHHHHCCEEECCCCCCCEEEECCHHHHCCHHHHHHHH
VAEVHEEQRILQELSALVAPYTDTLKDNSRILGHLDLLNAKAQYAHQLKATEPQISASNE
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHEEHHHHHHHHHHHHHHHHCCCCCCCCCCC
INLREARHPLIDQKKVVSNDIRLGGEYETLVITGPNTGGKTITLKTVGLLQLMAQSGMFI
CCHHHHCCCCCCHHHHHHCCCEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCEEE
PANENSTVRIFEEIFADIGDEQSIEQNLSTFSSHMDNTIRILGNLNERSLALFDELGAGT
ECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCC
DPKEGAALAIAILDKVRSTGAVSMTTTHYPELKTYGYERMGTINASMEFDVDTLQPTYKL
CCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCHHHCEECCCEEECCHHHCHHHHH
LLGIPGQSNAFEISKRLGLDSDIISQARGLVDQDSQDLNNMIKDLTTRQKRAQKINQQAV
HEECCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLKQAEEYHQTLVKGVDSLNSQRSNLIESAKEDANRIVNDSQAEADRIIKRLRKLEHST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
GSFKENDLIDAKSKINALHQDTNLKRNKVLRRAKEAQKFHENDEVVVLTYGQRGELLRQV
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
DKKHWEVQMGIMKMKVAVDELEKVKPDKTVKRRVHNSVQRTASAGVKTTLDLRGKRYEEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEHHHCCHHHHHH
LTETDRYIDAALLAGYDEVTIVHGKGTGALRSGITKYLKNNRRIKAFEYAPANAGGNGAT
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCE
IVHFK
EEEEC
>Mature Secondary Structure
MNKKILDVLEYDKIKQSIRQFIATENGTKELRELVPSSDETEVRNALKQTLDAVNIYRLK
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
NGIPVPRLEDVTEALQRLKIDAALNGQELAQIGRILRATRTVINFFDDLENEEIEIIALD
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHH
QVIEQLVTIPEVEERLSNSIEGNGHLLNSASSELRRIRASITRIESDVRSRMEKFTRGNN
HHHHHHHCCHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VKYLSEPIVTIRNERYVIPARVEYRSKFGGVVHDQSSSGQTLYVEPESVVDLNNELRQNQ
CEEECCCCEEECCCCEEEECHHHHHHHHCCEEECCCCCCCEEEECCHHHHCCHHHHHHHH
VAEVHEEQRILQELSALVAPYTDTLKDNSRILGHLDLLNAKAQYAHQLKATEPQISASNE
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHEEHHHHHHHHHHHHHHHHCCCCCCCCCCC
INLREARHPLIDQKKVVSNDIRLGGEYETLVITGPNTGGKTITLKTVGLLQLMAQSGMFI
CCHHHHCCCCCCHHHHHHCCCEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCEEE
PANENSTVRIFEEIFADIGDEQSIEQNLSTFSSHMDNTIRILGNLNERSLALFDELGAGT
ECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCC
DPKEGAALAIAILDKVRSTGAVSMTTTHYPELKTYGYERMGTINASMEFDVDTLQPTYKL
CCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCHHHCEECCCEEECCHHHCHHHHH
LLGIPGQSNAFEISKRLGLDSDIISQARGLVDQDSQDLNNMIKDLTTRQKRAQKINQQAV
HEECCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLKQAEEYHQTLVKGVDSLNSQRSNLIESAKEDANRIVNDSQAEADRIIKRLRKLEHST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
GSFKENDLIDAKSKINALHQDTNLKRNKVLRRAKEAQKFHENDEVVVLTYGQRGELLRQV
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
DKKHWEVQMGIMKMKVAVDELEKVKPDKTVKRRVHNSVQRTASAGVKTTLDLRGKRYEEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEHHHCCHHHHHH
LTETDRYIDAALLAGYDEVTIVHGKGTGALRSGITKYLKNNRRIKAFEYAPANAGGNGAT
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCE
IVHFK
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA