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The map label for this gene is trxA [H]

Identifier: 116493006

GI number: 116493006

Start: 1243699

End: 1244010

Strand: Reverse

Name: trxA [H]

Synonym: PEPE_1258

Alternate gene names: 116493006

Gene position: 1244010-1243699 (Counterclockwise)

Preceding gene: 116493007

Following gene: 116493005

Centisome position: 67.89

GC content: 36.54

Gene sequence:

>312_bases
ATGGTTGAAGCTATTACAGATGCAAATTTTGAAGAAAAAACAAATACTGGCGTAACACTAACTGATTTTTGGGCTACATG
GTGTGGACCTTGTCGGATGCAATCACCTGTAGTTGAACAACTTGCTGATGAAATGGGCGATAAAGTTTCATTTTCTAAGA
TGGATGTTGATCAAAACCCTGAAACAGCAAGAAACTTTGGAATTATGAGTATCCCAACACTCTTGGTAAAAAAAGACGGA
GCAGTCGTTGATTCAATCGTGGGATACCATTCTAAAGAACAATTAGCTAAGATTTTAGACCAATACATTTAA

Upstream 100 bases:

>100_bases
TCATTTTAAATAATCCTTATAAAATGTAAGCTAATTATTTCATTTGCTACGCAAAGACTGGTATAGTTAACGTAACAAAT
TGTGAAAGAGGGTAATTAGA

Downstream 100 bases:

>100_bases
TTAAATTGAGGTTAAGTAGAAACCAATTTATCAATAATTGGTTTCTTTTTTTATAGAGTTAGGTGGGTAACATGCTCCCT
TTTTGTACTGAAATTTAGTA

Product: Thiol-disulfide isomerase and thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 103; Mature: 103

Protein sequence:

>103_residues
MVEAITDANFEEKTNTGVTLTDFWATWCGPCRMQSPVVEQLADEMGDKVSFSKMDVDQNPETARNFGIMSIPTLLVKKDG
AVVDSIVGYHSKEQLAKILDQYI

Sequences:

>Translated_103_residues
MVEAITDANFEEKTNTGVTLTDFWATWCGPCRMQSPVVEQLADEMGDKVSFSKMDVDQNPETARNFGIMSIPTLLVKKDG
AVVDSIVGYHSKEQLAKILDQYI
>Mature_103_residues
MVEAITDANFEEKTNTGVTLTDFWATWCGPCRMQSPVVEQLADEMGDKVSFSKMDVDQNPETARNFGIMSIPTLLVKKDG
AVVDSIVGYHSKEQLAKILDQYI

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=84, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082331, Length=98, Percent_Identity=45.9183673469388, Blast_Score=97, Evalue=2e-22,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=40.4761904761905, Blast_Score=75, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=71, Percent_Identity=40.8450704225352, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=67, Percent_Identity=41.7910447761194, Blast_Score=67, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=71, Percent_Identity=38.0281690140845, Blast_Score=64, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639826, Length=85, Percent_Identity=34.1176470588235, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=31, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17648013, Length=81, Percent_Identity=37.037037037037, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583090, Length=81, Percent_Identity=37.037037037037, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24664269, Length=70, Percent_Identity=40, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11460; Mature: 11460

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEAITDANFEEKTNTGVTLTDFWATWCGPCRMQSPVVEQLADEMGDKVSFSKMDVDQNP
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHCCCCCCC
ETARNFGIMSIPTLLVKKDGAVVDSIVGYHSKEQLAKILDQYI
CHHHHCCCHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVEAITDANFEEKTNTGVTLTDFWATWCGPCRMQSPVVEQLADEMGDKVSFSKMDVDQNP
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHCCCCCCC
ETARNFGIMSIPTLLVKKDGAVVDSIVGYHSKEQLAKILDQYI
CHHHHCCCHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]