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The map label for this gene is gla [H]

Identifier: 116492997

GI number: 116492997

Start: 1235293

End: 1236024

Strand: Direct

Name: gla [H]

Synonym: PEPE_1249

Alternate gene names: 116492997

Gene position: 1235293-1236024 (Clockwise)

Preceding gene: 116492995

Following gene: 116492999

Centisome position: 67.41

GC content: 39.62

Gene sequence:

>732_bases
ATGGAATATAGTTTTTTTGCCAAGTTAGCAGCTGAATTTCTTGGTACAGCAATTTTAGTTCTTTTAGGTAATGGTTCGGT
TGCTAACGTTGAGCTTAAAGGTACAAAAGGTAACGGTAGTGATTGGTTAGTCATCGCAGTTGGGTACGGATGTGGTGTAA
TGGTCCCTGCATTAATGTTTGGAACTATTTCTGGAGCTCAAATTAATCCTGCTTTCACCATTGGTTTAGCAGTTTCAGGA
ATGTTCTCATGGTCTCAGGTCCTTCCTTTCATTATTGCCCAAATGTTAGGTGCTATTTTCGGACAATTAGTAGTTTATTT
TGCTTACAAGCCTCATTATGATTTAACTACTAATACTGAATCAATTTTAGGTACGTTTAGTACAATTGATGCTAGTCATA
GCTCTTGGAATGGTTTTGCTAACGAATTTATTGGTTCATTCGTCCTCTTCTTTGGGGCTACAGCCTTTACTCATGCTCCT
TATTTCGAGGCTAATAAAGGATCAGTATTTATTGCACTTGGTTTTCTAGTTGGTACTTTGGTTGCTTCACTTGGTGGTGC
TACTGGTCCAGCTTTGAATCCTGCTCGTGACTTAGGTCCCCGTTTAGTTCACGCAATGCTCCCAATCAAACATAAAGGAT
CATCTCAATGGGGTTACGCATCAGTTCCCGTTGTTGCCCCAATCTTAGCTGGTATTTGTGCCGTTGCTTTGTATAAAGGA
CTTTTCCTATAA

Upstream 100 bases:

>100_bases
AAAGCTTTACATATCGCCCTTGCATATTGCCTTTCAAATAAGATATACTCATAAACAGTGTGTTTTACGTAAATTTTATT
TTTAAGGAGTTTTACATAAT

Downstream 100 bases:

>100_bases
CATATAATTAAACAAAAAATCCGCTTCTACCTAATGTAGAAGTGGATTTTTTCTTTTATTTAGTAGATTGTCTGAAGACC
ATATCAAATGGAAGAGTAAT

Product: glycerol uptake facilitator related permease

Products: glycerol [Cytoplasm] [C]

Alternate protein names: Aquaglyceroporin; Glyceroaquaporin [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MEYSFFAKLAAEFLGTAILVLLGNGSVANVELKGTKGNGSDWLVIAVGYGCGVMVPALMFGTISGAQINPAFTIGLAVSG
MFSWSQVLPFIIAQMLGAIFGQLVVYFAYKPHYDLTTNTESILGTFSTIDASHSSWNGFANEFIGSFVLFFGATAFTHAP
YFEANKGSVFIALGFLVGTLVASLGGATGPALNPARDLGPRLVHAMLPIKHKGSSQWGYASVPVVAPILAGICAVALYKG
LFL

Sequences:

>Translated_243_residues
MEYSFFAKLAAEFLGTAILVLLGNGSVANVELKGTKGNGSDWLVIAVGYGCGVMVPALMFGTISGAQINPAFTIGLAVSG
MFSWSQVLPFIIAQMLGAIFGQLVVYFAYKPHYDLTTNTESILGTFSTIDASHSSWNGFANEFIGSFVLFFGATAFTHAP
YFEANKGSVFIALGFLVGTLVASLGGATGPALNPARDLGPRLVHAMLPIKHKGSSQWGYASVPVVAPILAGICAVALYKG
LFL
>Mature_243_residues
MEYSFFAKLAAEFLGTAILVLLGNGSVANVELKGTKGNGSDWLVIAVGYGCGVMVPALMFGTISGAQINPAFTIGLAVSG
MFSWSQVLPFIIAQMLGAIFGQLVVYFAYKPHYDLTTNTESILGTFSTIDASHSSWNGFANEFIGSFVLFFGATAFTHAP
YFEANKGSVFIALGFLVGTLVASLGGATGPALNPARDLGPRLVHAMLPIKHKGSSQWGYASVPVVAPILAGICAVALYKG
LFL

Specific function: Mixed channel protein that transports both water and glycerol [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4826645, Length=254, Percent_Identity=31.496062992126, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI157266307, Length=254, Percent_Identity=31.1023622047244, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI22538420, Length=248, Percent_Identity=32.258064516129, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI4502187, Length=241, Percent_Identity=29.4605809128631, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI4755125, Length=244, Percent_Identity=30.327868852459, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4502181, Length=244, Percent_Identity=30.327868852459, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1790362, Length=249, Percent_Identity=32.1285140562249, Blast_Score=90, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17558372, Length=245, Percent_Identity=26.9387755102041, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71992966, Length=249, Percent_Identity=28.5140562248996, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17544068, Length=246, Percent_Identity=27.2357723577236, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=237, Percent_Identity=27.4261603375527, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531431, Length=237, Percent_Identity=27.4261603375527, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71992961, Length=248, Percent_Identity=26.2096774193548, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994009, Length=240, Percent_Identity=28.3333333333333, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32564052, Length=204, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17533613, Length=204, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=221, Percent_Identity=34.3891402714932, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45550503, Length=200, Percent_Identity=28, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 25461; Mature: 25461

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYSFFAKLAAEFLGTAILVLLGNGSVANVELKGTKGNGSDWLVIAVGYGCGVMVPALMF
CCHHHHHHHHHHHHHHEEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHH
GTISGAQINPAFTIGLAVSGMFSWSQVLPFIIAQMLGAIFGQLVVYFAYKPHYDLTTNTE
HCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
SILGTFSTIDASHSSWNGFANEFIGSFVLFFGATAFTHAPYFEANKGSVFIALGFLVGTL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEHHHHHHHH
VASLGGATGPALNPARDLGPRLVHAMLPIKHKGSSQWGYASVPVVAPILAGICAVALYKG
HHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LFL
CCC
>Mature Secondary Structure
MEYSFFAKLAAEFLGTAILVLLGNGSVANVELKGTKGNGSDWLVIAVGYGCGVMVPALMF
CCHHHHHHHHHHHHHHEEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHH
GTISGAQINPAFTIGLAVSGMFSWSQVLPFIIAQMLGAIFGQLVVYFAYKPHYDLTTNTE
HCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
SILGTFSTIDASHSSWNGFANEFIGSFVLFFGATAFTHAPYFEANKGSVFIALGFLVGTL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEHHHHHHHH
VASLGGATGPALNPARDLGPRLVHAMLPIKHKGSSQWGYASVPVVAPILAGICAVALYKG
HHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LFL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycerol [Periplasm] [C]

Specific reaction: glycerol [Periplasm] = glycerol [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]