Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 116492647

GI number: 116492647

Start: 879819

End: 880568

Strand: Direct

Name: uppS [H]

Synonym: PEPE_0881

Alternate gene names: 116492647

Gene position: 879819-880568 (Clockwise)

Preceding gene: 116492646

Following gene: 116492648

Centisome position: 48.01

GC content: 37.87

Gene sequence:

>750_bases
ATGAAAATGAATCAAAAACTTGAAACAGAATTAAATGAAAATATTCCAAAGCATGTTGCCATTATTATGGATGGTAACGG
ACGCTGGGCTCAGAAACGATTTATGCCACGTGTTGCTGGTCATAAGCGAGGAATGGAAGTCGTTAAGACTATTACTAAAA
GTGCTAGTAAGTTGGGCGTAAAGGTGTTAACCTTATACGCTTTTTCGACGGAAAACTGGAAACGTCCCCAAGATGAAGTT
TCATTCTTAATGAAATTACCGATTACTTTTTTCAATAAATTTGTTCCAGAATTGATTGAAGAGGGGGTCCAGGTTCGAGT
AACTGGAGATATCGACGGCCTTCCCCAAGCGACTCAAGATGCTGTACGAAAAGCGATCGAGGACACCGCACAAGGTACAA
AGATGATTTTAAATTTTGCTCTTAACTATGGAAGTCGGGACGAAATTACCAAGATGGTCCAGTCAATTGCTCAAGCTGTT
AATACCAAACAATTGGACGTGGATAAAATTGATGAGCAGGTTATTGAAAACCATCTACAAACTAATTTTTTAGGCGAACT
TTCTAATCCAGATGTATTGATTAGGACCAGTGGAGAAGAGCGAATTTCGAACTTCTTACTTTGGCAAATTGCATATAGTG
AGTTAGTCTTTACTGACACACTTTGGCCAGATTTCGACGAAAAAATCTTTATTGAAATGATAAAAGAGTATCAAAAACGT
GATCGACGTTTTGGTGCAATTAAAAAGTGA

Upstream 100 bases:

>100_bases
TGACGTATCTTTAATAGTCGTTGTCCGTTTATTTGTACAGAACAATGATTTTGTAGCTTTTTTTTGGTAAAATAATAACC
ATTAGCTTGGAGGTTTTTTG

Downstream 100 bases:

>100_bases
GGAATTAATTTTGAAGCAAAGAGTAATTACTGCCGTAGTAGCGTTAATAATTTTTATTCCAATTGTCTTTCTTGGAGGAA
CATTAATCGAGATTGCAGCC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MKMNQKLETELNENIPKHVAIIMDGNGRWAQKRFMPRVAGHKRGMEVVKTITKSASKLGVKVLTLYAFSTENWKRPQDEV
SFLMKLPITFFNKFVPELIEEGVQVRVTGDIDGLPQATQDAVRKAIEDTAQGTKMILNFALNYGSRDEITKMVQSIAQAV
NTKQLDVDKIDEQVIENHLQTNFLGELSNPDVLIRTSGEERISNFLLWQIAYSELVFTDTLWPDFDEKIFIEMIKEYQKR
DRRFGAIKK

Sequences:

>Translated_249_residues
MKMNQKLETELNENIPKHVAIIMDGNGRWAQKRFMPRVAGHKRGMEVVKTITKSASKLGVKVLTLYAFSTENWKRPQDEV
SFLMKLPITFFNKFVPELIEEGVQVRVTGDIDGLPQATQDAVRKAIEDTAQGTKMILNFALNYGSRDEITKMVQSIAQAV
NTKQLDVDKIDEQVIENHLQTNFLGELSNPDVLIRTSGEERISNFLLWQIAYSELVFTDTLWPDFDEKIFIEMIKEYQKR
DRRFGAIKK
>Mature_249_residues
MKMNQKLETELNENIPKHVAIIMDGNGRWAQKRFMPRVAGHKRGMEVVKTITKSASKLGVKVLTLYAFSTENWKRPQDEV
SFLMKLPITFFNKFVPELIEEGVQVRVTGDIDGLPQATQDAVRKAIEDTAQGTKMILNFALNYGSRDEITKMVQSIAQAV
NTKQLDVDKIDEQVIENHLQTNFLGELSNPDVLIRTSGEERISNFLLWQIAYSELVFTDTLWPDFDEKIFIEMIKEYQKR
DRRFGAIKK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=227, Percent_Identity=39.647577092511, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI45580738, Length=227, Percent_Identity=39.647577092511, Blast_Score=163, Evalue=1e-40,
Organism=Escherichia coli, GI1786371, Length=248, Percent_Identity=44.3548387096774, Blast_Score=214, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71993029, Length=228, Percent_Identity=35.5263157894737, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6323748, Length=220, Percent_Identity=32.2727272727273, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=35.0230414746544, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18857969, Length=231, Percent_Identity=38.5281385281385, Blast_Score=157, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28670; Mature: 28670

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMNQKLETELNENIPKHVAIIMDGNGRWAQKRFMPRVAGHKRGMEVVKTITKSASKLGV
CCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
KVLTLYAFSTENWKRPQDEVSFLMKLPITFFNKFVPELIEEGVQVRVTGDIDGLPQATQD
HHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHH
AVRKAIEDTAQGTKMILNFALNYGSRDEITKMVQSIAQAVNTKQLDVDKIDEQVIENHLQ
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TNFLGELSNPDVLIRTSGEERISNFLLWQIAYSELVFTDTLWPDFDEKIFIEMIKEYQKR
HHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
DRRFGAIKK
HHHCCCCCC
>Mature Secondary Structure
MKMNQKLETELNENIPKHVAIIMDGNGRWAQKRFMPRVAGHKRGMEVVKTITKSASKLGV
CCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
KVLTLYAFSTENWKRPQDEVSFLMKLPITFFNKFVPELIEEGVQVRVTGDIDGLPQATQD
HHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHH
AVRKAIEDTAQGTKMILNFALNYGSRDEITKMVQSIAQAVNTKQLDVDKIDEQVIENHLQ
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TNFLGELSNPDVLIRTSGEERISNFLLWQIAYSELVFTDTLWPDFDEKIFIEMIKEYQKR
HHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
DRRFGAIKK
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566; 6712246 [H]