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The map label for this gene is coaBC [H]

Identifier: 116492594

GI number: 116492594

Start: 831191

End: 832384

Strand: Direct

Name: coaBC [H]

Synonym: PEPE_0827

Alternate gene names: 116492594

Gene position: 831191-832384 (Clockwise)

Preceding gene: 116492593

Following gene: 116492595

Centisome position: 45.36

GC content: 39.03

Gene sequence:

>1194_bases
ATGAAAATTTTATTTGTTATTACTGGCGGAATTGCCGAATATAAAGTGGTTGAAGCGGTACGGTTTCAAATCAAAAGTGG
TAATCAAGTCAAGGTAGTGATGACGCAAATGGCCAAAAAATTCGTCACACCATTAACGTTTGCAACACTTACCAATGACC
TTGTCTATGATGATTTTGAAATTAATACGGAAAACCCAGTTGCTCATGTAGCTCTGGCAGACTGGGCAGATAAAATTGTA
ATCGCCCCAGCCACGGCTAATTTTATTGGAAAAATGGCGAATGGAATTGCGGATGATTTTGCTTCAACTGTAGTGATTGC
TTCAACAGCAACTAAGCTGTTGCTACCAGCAATGAATGTTAATATGTGGAATAATCCAGCGGTTCAACGGAATATCGAAC
AATTAAAAGTAGATGGAGTAGTCGTTTTAGAACCAGCTGTTGGAGAGCTGGCTGAAGGTTATTCTGGAAAAGGACGTTTT
CCGGATGCTGAAATCGTAAATGCCTTTATCAGCACGCCCCTTGAAAAGCGGGAAAATCTCTTTAAAGGAACACACATTGT
GGTTACTGCTGGGGGGACGCGTGAAGCGATTGATCCCGTACGTTATATTGGTAATGAATCATCTGGTAAGATGGGGTTTG
CGCTTGCTCAAGTAGCAGAACGGTTAGGAGCGCAGGTTACTTTAATTTCTGGACCTACAAACTTAGTTTTACCAGCGAAA
TCAAGTATTCAACGGATAAATATTAAGAGTGTAGCAGACTTACAGGCCGCTCTTGATACAGCAGTACAAGATGCAGATAT
ATTGATAATGGCCGCAGCAGTTTCAGATTACCGCGTGGCGAAAATAGCAGATCATAAAATGAAAAAAGATGATTTTAATG
GTGAACTGGAAATTAAATTGATTGAAAATCCTGATATTTTAGCGACACTAAAACGTCCAGACTCACTTCGATACGTTGTG
GGGTTTGCTGCGGAGACGAATGATTTAATTGAAAATGCTCAACGTAAAATTCTTAAGAAAAACCTAAATATGATTGTGGC
TAATGATGTAGGTAATCCCCAAATCGGTTTTGAATCTAATCAGAATGCTGTCACCATTCTACGTCCGCACCAAGCTAATA
TAGAATTGAAAAAGAATGATAAATCGATAATTGCTGAACAGATTTTAAAGCTAATCGACCAAGAAATTAATTGA

Upstream 100 bases:

>100_bases
GATGGTGGAGGTTGTCCTCTAGCATCTTTTTTGTTGGATTAATCAATTAGTGGGATTGGTATTCAAGGACTGGTAAAATA
GCAGAAGGAGGTTGTTCGAT

Downstream 100 bases:

>100_bases
AAGGAACGTAACTCATGGCAAAAAAATTTAATGTCATCGTAAATGTCCCAGCTTTACAAACTAATACACCATTTACATAT
ATCGCAAATGATGCCATTAA

Product: phosphopantothenate-cysteine ligase / phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKILFVITGGIAEYKVVEAVRFQIKSGNQVKVVMTQMAKKFVTPLTFATLTNDLVYDDFEINTENPVAHVALADWADKIV
IAPATANFIGKMANGIADDFASTVVIASTATKLLLPAMNVNMWNNPAVQRNIEQLKVDGVVVLEPAVGELAEGYSGKGRF
PDAEIVNAFISTPLEKRENLFKGTHIVVTAGGTREAIDPVRYIGNESSGKMGFALAQVAERLGAQVTLISGPTNLVLPAK
SSIQRINIKSVADLQAALDTAVQDADILIMAAAVSDYRVAKIADHKMKKDDFNGELEIKLIENPDILATLKRPDSLRYVV
GFAAETNDLIENAQRKILKKNLNMIVANDVGNPQIGFESNQNAVTILRPHQANIELKKNDKSIIAEQILKLIDQEIN

Sequences:

>Translated_397_residues
MKILFVITGGIAEYKVVEAVRFQIKSGNQVKVVMTQMAKKFVTPLTFATLTNDLVYDDFEINTENPVAHVALADWADKIV
IAPATANFIGKMANGIADDFASTVVIASTATKLLLPAMNVNMWNNPAVQRNIEQLKVDGVVVLEPAVGELAEGYSGKGRF
PDAEIVNAFISTPLEKRENLFKGTHIVVTAGGTREAIDPVRYIGNESSGKMGFALAQVAERLGAQVTLISGPTNLVLPAK
SSIQRINIKSVADLQAALDTAVQDADILIMAAAVSDYRVAKIADHKMKKDDFNGELEIKLIENPDILATLKRPDSLRYVV
GFAAETNDLIENAQRKILKKNLNMIVANDVGNPQIGFESNQNAVTILRPHQANIELKKNDKSIIAEQILKLIDQEIN
>Mature_397_residues
MKILFVITGGIAEYKVVEAVRFQIKSGNQVKVVMTQMAKKFVTPLTFATLTNDLVYDDFEINTENPVAHVALADWADKIV
IAPATANFIGKMANGIADDFASTVVIASTATKLLLPAMNVNMWNNPAVQRNIEQLKVDGVVVLEPAVGELAEGYSGKGRF
PDAEIVNAFISTPLEKRENLFKGTHIVVTAGGTREAIDPVRYIGNESSGKMGFALAQVAERLGAQVTLISGPTNLVLPAK
SSIQRINIKSVADLQAALDTAVQDADILIMAAAVSDYRVAKIADHKMKKDDFNGELEIKLIENPDILATLKRPDSLRYVV
GFAAETNDLIENAQRKILKKNLNMIVANDVGNPQIGFESNQNAVTILRPHQANIELKKNDKSIIAEQILKLIDQEIN

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=164, Percent_Identity=35.9756097560976, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI87082301, Length=374, Percent_Identity=43.3155080213904, Blast_Score=269, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17560194, Length=173, Percent_Identity=32.9479768786127, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24657262, Length=180, Percent_Identity=31.6666666666667, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43200; Mature: 43200

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILFVITGGIAEYKVVEAVRFQIKSGNQVKVVMTQMAKKFVTPLTFATLTNDLVYDDFE
CEEEEEEECCCHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHCCHHHHHHHCCCEECCEE
INTENPVAHVALADWADKIVIAPATANFIGKMANGIADDFASTVVIASTATKLLLPAMNV
ECCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHEEECCC
NMWNNPAVQRNIEQLKVDGVVVLEPAVGELAEGYSGKGRFPDAEIVNAFISTPLEKRENL
CCCCCCHHHHHHHHEEECCEEEECCCHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHH
FKGTHIVVTAGGTREAIDPVRYIGNESSGKMGFALAQVAERLGAQVTLISGPTNLVLPAK
HCCCEEEEEECCCHHHHCHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEECC
SSIQRINIKSVADLQAALDTAVQDADILIMAAAVSDYRVAKIADHKMKKDDFNGELEIKL
CCCEEECHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEHHHHHHCCCCCCCCEEEEEE
IENPDILATLKRPDSLRYVVGFAAETNDLIENAQRKILKKNLNMIVANDVGNPQIGFESN
ECCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
QNAVTILRPHQANIELKKNDKSIIAEQILKLIDQEIN
CCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKILFVITGGIAEYKVVEAVRFQIKSGNQVKVVMTQMAKKFVTPLTFATLTNDLVYDDFE
CEEEEEEECCCHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHCCHHHHHHHCCCEECCEE
INTENPVAHVALADWADKIVIAPATANFIGKMANGIADDFASTVVIASTATKLLLPAMNV
ECCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHEEECCC
NMWNNPAVQRNIEQLKVDGVVVLEPAVGELAEGYSGKGRFPDAEIVNAFISTPLEKRENL
CCCCCCHHHHHHHHEEECCEEEECCCHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHH
FKGTHIVVTAGGTREAIDPVRYIGNESSGKMGFALAQVAERLGAQVTLISGPTNLVLPAK
HCCCEEEEEECCCHHHHCHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEECC
SSIQRINIKSVADLQAALDTAVQDADILIMAAAVSDYRVAKIADHKMKKDDFNGELEIKL
CCCEEECHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEHHHHHHCCCCCCCCEEEEEE
IENPDILATLKRPDSLRYVVGFAAETNDLIENAQRKILKKNLNMIVANDVGNPQIGFESN
ECCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
QNAVTILRPHQANIELKKNDKSIIAEQILKLIDQEIN
CCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]