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The map label for this gene is lrgA [H]

Identifier: 116492465

GI number: 116492465

Start: 740253

End: 740657

Strand: Direct

Name: lrgA [H]

Synonym: PEPE_0697

Alternate gene names: 116492465

Gene position: 740253-740657 (Clockwise)

Preceding gene: 116492464

Following gene: 116492466

Centisome position: 40.4

GC content: 32.1

Gene sequence:

>405_bases
ATGAAAAAAGATGGGAAGAAAGAAACACCAATCCTTATTCAAATGGGAATATTTATGGCAATTTTATTTGTAGCACAATT
ACTATCGCAGTTATTTCCGCCTAGTTTTGCAGTTCCGACACCCTTAATTGGAATGATTATTTTATATATACTATTAGCGA
CGCACATTATTAAGCTTGAACAGGTAGAAAAACTGGGGGATTCATTGATTGGTTTGATTGCTTTTTTGTTCGTACCATCT
GGAATTCAGTTAGCAGGAAGCTTAGATTTAATTAAGCGTGAAGGCTTACAGGATGTCATTGTGACAATCATTTCAACCAT
TATTTTATTAGTTGTAATCACGTATGTAGGATCGTTTTTCATAAAATTACATCAAAAAATAAATAATAGAAAAGGGGATG
ATTAA

Upstream 100 bases:

>100_bases
TGGTCACTTTATGTGAAAGCGCTAACATAAATGAGCTAATAGCTTAAAATAAGGTTGTGATAAACAGTATTAGATCCATA
AAGGTAGGGAGGAAGCTAAA

Downstream 100 bases:

>100_bases
TATGACAGCAGCCTTGGCAACACCTTTTACAGGTATCTTCATATCGCTTTTGGTATATTTACTGGGGATGTGGCTTTTTA
AGATTAGTAAAGGCTTTTTC

Product: putative effector of murein hydrolase LrgA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MKKDGKKETPILIQMGIFMAILFVAQLLSQLFPPSFAVPTPLIGMIILYILLATHIIKLEQVEKLGDSLIGLIAFLFVPS
GIQLAGSLDLIKREGLQDVIVTIISTIILLVVITYVGSFFIKLHQKINNRKGDD

Sequences:

>Translated_134_residues
MKKDGKKETPILIQMGIFMAILFVAQLLSQLFPPSFAVPTPLIGMIILYILLATHIIKLEQVEKLGDSLIGLIAFLFVPS
GIQLAGSLDLIKREGLQDVIVTIISTIILLVVITYVGSFFIKLHQKINNRKGDD
>Mature_134_residues
MKKDGKKETPILIQMGIFMAILFVAQLLSQLFPPSFAVPTPLIGMIILYILLATHIIKLEQVEKLGDSLIGLIAFLFVPS
GIQLAGSLDLIKREGLQDVIVTIISTIILLVVITYVGSFFIKLHQKINNRKGDD

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. LrgA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005538 [H]

Pfam domain/function: PF03788 LrgA [H]

EC number: NA

Molecular weight: Translated: 14801; Mature: 14801

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKDGKKETPILIQMGIFMAILFVAQLLSQLFPPSFAVPTPLIGMIILYILLATHIIKLE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QVEKLGDSLIGLIAFLFVPSGIQLAGSLDLIKREGLQDVIVTIISTIILLVVITYVGSFF
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
IKLHQKINNRKGDD
HHHHHHHHCCCCCC
>Mature Secondary Structure
MKKDGKKETPILIQMGIFMAILFVAQLLSQLFPPSFAVPTPLIGMIILYILLATHIIKLE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QVEKLGDSLIGLIAFLFVPSGIQLAGSLDLIKREGLQDVIVTIISTIILLVVITYVGSFF
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
IKLHQKINNRKGDD
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]