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The map label for this gene is lrgB [H]

Identifier: 116492466

GI number: 116492466

Start: 740659

End: 741387

Strand: Direct

Name: lrgB [H]

Synonym: PEPE_0698

Alternate gene names: 116492466

Gene position: 740659-741387 (Clockwise)

Preceding gene: 116492465

Following gene: 116492467

Centisome position: 40.42

GC content: 37.59

Gene sequence:

>729_bases
ATGACAGCAGCCTTGGCAACACCTTTTACAGGTATCTTCATATCGCTTTTGGTATATTTACTGGGGATGTGGCTTTTTAA
GATTAGTAAAGGCTTTTTCCTATTTACACCGTTACTGGTGGGAGTTGTTTTAGGAATCTTTATTTTGGCATTATGGGCGA
AAGGGATTGGCTCTACAACTGTGGAAGTCTATAAAAAATTCTTTTTACCGGGTGGTAATATAGTATTTTGGTTTTTAAAT
CCAGCGACCATTGCTTTTGCTATTCCACTTTATCGTCGAAATGATATATTTAAAAAATATTGGATAGATGTAGTATTAAC
TTTATTTGTGGGTGGATTTATTTCACTTTTCGGTATTCATATGGTTTCAAAACTATTTGGACTATCAAAAGTCTCCATTG
CAGCAATGTTACCTCAAGCCGCTACAACGGCGGTGGCAATGCCAATAGCTAAGAGCATTGGAGGTGACCCTGCCGTAACA
GCCATGGTTTGTATCATAAATGCTGTGATTATTTACGCTCTTGCAGAATTTCTTATTAAATTTTTCAAGCTTAAAGAAAT
TTCAAAAGTGGGGTTAGGTTTAGGTTTAGGTACATCTGGGCATACAGTTGGTTCTGCTAAGGCAGTGCAGTTGGGTTCAA
TTCAAGGAGCCATGGCATCTGTTTCAGTAGTAATCGTTGCATTAGCGATGGATATTTTAGTACCGATTTACGCTCGTTTA
TTCCTTTGA

Upstream 100 bases:

>100_bases
ATCATTTCAACCATTATTTTATTAGTTGTAATCACGTATGTAGGATCGTTTTTCATAAAATTACATCAAAAAATAAATAA
TAGAAAAGGGGATGATTAAT

Downstream 100 bases:

>100_bases
AATAAAAGATAAAACAAATAGTTTCTTTAGTTGACATGAGACATAGAATTTGGTATTCTAATAAACGTTGAGAAAAAGCA
GAAGCCACCGCTTCTCGCCT

Product: putative effector of murein hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTAALATPFTGIFISLLVYLLGMWLFKISKGFFLFTPLLVGVVLGIFILALWAKGIGSTTVEVYKKFFLPGGNIVFWFLN
PATIAFAIPLYRRNDIFKKYWIDVVLTLFVGGFISLFGIHMVSKLFGLSKVSIAAMLPQAATTAVAMPIAKSIGGDPAVT
AMVCIINAVIIYALAEFLIKFFKLKEISKVGLGLGLGTSGHTVGSAKAVQLGSIQGAMASVSVVIVALAMDILVPIYARL
FL

Sequences:

>Translated_242_residues
MTAALATPFTGIFISLLVYLLGMWLFKISKGFFLFTPLLVGVVLGIFILALWAKGIGSTTVEVYKKFFLPGGNIVFWFLN
PATIAFAIPLYRRNDIFKKYWIDVVLTLFVGGFISLFGIHMVSKLFGLSKVSIAAMLPQAATTAVAMPIAKSIGGDPAVT
AMVCIINAVIIYALAEFLIKFFKLKEISKVGLGLGLGTSGHTVGSAKAVQLGSIQGAMASVSVVIVALAMDILVPIYARL
FL
>Mature_241_residues
TAALATPFTGIFISLLVYLLGMWLFKISKGFFLFTPLLVGVVLGIFILALWAKGIGSTTVEVYKKFFLPGGNIVFWFLNP
ATIAFAIPLYRRNDIFKKYWIDVVLTLFVGGFISLFGIHMVSKLFGLSKVSIAAMLPQAATTAVAMPIAKSIGGDPAVTA
MVCIINAVIIYALAEFLIKFFKLKEISKVGLGLGLGTSGHTVGSAKAVQLGSIQGAMASVSVVIVALAMDILVPIYARLF
L

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell

COG id: COG1346

COG function: function code M; Putative effector of murein hydrolase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidB/LrgB family. LrgB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788464, Length=205, Percent_Identity=31.219512195122, Blast_Score=91, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007300 [H]

Pfam domain/function: PF04172 LrgB [H]

EC number: NA

Molecular weight: Translated: 25921; Mature: 25790

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CC
>Mature Secondary Structure 
TAALATPFTGIFISLLVYLLGMWLFKISKGFFLFTPLLVGVVLGIFILALWAKGIGSTT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VEVYKKFFLPGGNIVFWFLNPATIAFAIPLYRRNDIFKKYWIDVVLTLFVGGFISLFGIH
HHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVSKLFGLSKVSIAAMLPQAATTAVAMPIAKSIGGDPAVTAMVCIINAVIIYALAEFLIK
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FFKLKEISKVGLGLGLGTSGHTVGSAKAVQLGSIQGAMASVSVVIVALAMDILVPIYARL
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA