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The map label for this gene is thrS

Identifier: 116492462

GI number: 116492462

Start: 735449

End: 737395

Strand: Direct

Name: thrS

Synonym: PEPE_0694

Alternate gene names: 116492462

Gene position: 735449-737395 (Clockwise)

Preceding gene: 116492461

Following gene: 116492463

Centisome position: 40.14

GC content: 38.52

Gene sequence:

>1947_bases
ATGACAGAAATTAATATTGAATTTCCAGATGGCAGTGTAAAACCTTTTGAACAAGGCGTTTCAATTTTAGATATTGCTAA
GTCAATCAGTACTAGCCTTGCTAAAAAAGCTGTTGCTGGGAAAATTAACGGTGCCTTGGTTCGTTTGGACCAAGCTATTA
ACGAAAACGTAAAAATCGAAATTGTCACAAAAGATTCAGAAGATGGTAACATCGTTAACTGGAATTCGGCAGCCTTAGTT
TTGACTAGTGCTATCGAAAGCATCTATCCTGGAGTTCATTTTGGTGAGATTGGCAACGGAGAACATGGTTTTTACGTTGA
TACAGATAAGGTTGATCAACAAATTTCAGTTGACCAATTACCAGCAATCGAAGATAAGATGAAGGACATTATTAAATCTA
AGATTAGCTTAAAGCATAGTGAAATTAGTGTAGAAGAAGCCCTAGCAAGCGTTGATGGTGACCCATACCAAGCTAAAATC
GTTAAGCGTAACGAAAAAAATGGCAAAGTTAGTGTTTATGACGTTGATGGAAAAATAATTGTTAGTGATAACGTTGCTTT
ACTTAGCACTTCAGATATGAAAGCCGTTAAGTTGTTGTCAGTTGCAGGTGCTTATTGGGAAGGTAAGTCAAGTAATCCGA
TGCTCCAACGGATTTACGGAACATCTTTCTACAAACAAAAAGATCTTGAAGCAGAACTTGAACGCCAAAAGGAAGCTCAC
GAACGTGACCACCGTGTCATTGGAAACAATTTAGACTTGTTCTTCGTTGACCCTAAGGTTGGTGCAGGACTTCCTTACTG
GATGCCAAATGGTGCTACAATTCGTCGTTCCATTGAACGTTACATTATTGATAAGGAAGTTAAGCATGGTTACCAACATG
TTTACACTCCAGTATTGATGAACCTTGATGCATATAAGACTTCTGGTCACTGGCAACACTATCGTGAAGACATGTTCCCA
CCAATGGACATGGGTGATGGCGAAATGCTTGAACTCCGTCCAATGAACTGTCCTTCACATATCCAAGTTTATAAGCACCA
TATTCGTTCATATCGTGAATTACCAATCCGGATTGCTGAATTAGGGATGATGCATCGTTACGAAAAATCCGGTGCTCTTT
CTGGATTACAGCGAGTTCGTGAAATGACGTTGAATGATGGTCATACATTTGTGGCTCCAGACCAAATTCAAGCTGAATTT
AAAAAAGTTCTTCAATTAATGGTTGAAGTTTATCGTGATTTCAATATCACTGACTACACATTCCGCCTAAGTTATCGTGA
TCCTGCTAATACTGAAAAGTATTTTGACGATGATGAAATGTGGAACAAGTCACAATCTATGTTGAAAGCTGCTATGGATG
ATCTTGGCTTAGATTATGTTGAAGCTGAAGGCGAAGCCGCATTCTACGGTCCAAAGCTTGACGTTCAAACTAAGACAGCC
CTTGGAAATGAAGAAACACTTTCAACAATTCAATTAGACTTTATGCTTCCAAAGCAATTTGACCTACATTATGTTGGGGC
TGACGGGGAAGAACATCGTCCAGTAATGATTCACCGTGGATTAGTTTCAACTATGGAACGTTTCACGGCTTACTTGATTG
AAATGTATAAGGGTGCTTTCCCAACTTGGTTAGCTCCTAAGCAAGTTACAATCATTCCTGTTAAAGATGATTTACATGGT
GCTTATGCCGATAAACTTCGTGAAGAAATGGTCGATAAAGACATTCGAGTTGAAGTTGACCACCGTAATGAAAAGATGGG
TTATAAGATTCGTGAAGCTCAAACTCAAAAGATTCCATATATCTTAGTTGTTGGTGATAATGAATTAGAAAATAACTCCG
TTAGTGTACGTCACTACGGTGAAGATGATTCTAAGAATGAAGCTAGTGCTGACTTTATCAACAATATCGTTCGTGAAATT
GAAAGTTACAGTCGCGAAAATGACTAA

Upstream 100 bases:

>100_bases
ACAATTAGGGTGGAACCGCGTGAATAATAAATGACAATCACGTCCCTGGTATTTTTATACCAGGGACTTTTTTTGTACAT
AAATTTAAGGAGAGAGTGTT

Downstream 100 bases:

>100_bases
AATAGTTTAATTAAAATAGGATTTTTAATGGTGTGAATATCATTAAAATCCTATTTTTTTGTAGGCTTTAATAAGGGATG
ACCGTTGAAAGGCTTATAAT

Product: Ser-tRNA(Thr) hydrolase / threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MTEINIEFPDGSVKPFEQGVSILDIAKSISTSLAKKAVAGKINGALVRLDQAINENVKIEIVTKDSEDGNIVNWNSAALV
LTSAIESIYPGVHFGEIGNGEHGFYVDTDKVDQQISVDQLPAIEDKMKDIIKSKISLKHSEISVEEALASVDGDPYQAKI
VKRNEKNGKVSVYDVDGKIIVSDNVALLSTSDMKAVKLLSVAGAYWEGKSSNPMLQRIYGTSFYKQKDLEAELERQKEAH
ERDHRVIGNNLDLFFVDPKVGAGLPYWMPNGATIRRSIERYIIDKEVKHGYQHVYTPVLMNLDAYKTSGHWQHYREDMFP
PMDMGDGEMLELRPMNCPSHIQVYKHHIRSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVAPDQIQAEF
KKVLQLMVEVYRDFNITDYTFRLSYRDPANTEKYFDDDEMWNKSQSMLKAAMDDLGLDYVEAEGEAAFYGPKLDVQTKTA
LGNEETLSTIQLDFMLPKQFDLHYVGADGEEHRPVMIHRGLVSTMERFTAYLIEMYKGAFPTWLAPKQVTIIPVKDDLHG
AYADKLREEMVDKDIRVEVDHRNEKMGYKIREAQTQKIPYILVVGDNELENNSVSVRHYGEDDSKNEASADFINNIVREI
ESYSREND

Sequences:

>Translated_648_residues
MTEINIEFPDGSVKPFEQGVSILDIAKSISTSLAKKAVAGKINGALVRLDQAINENVKIEIVTKDSEDGNIVNWNSAALV
LTSAIESIYPGVHFGEIGNGEHGFYVDTDKVDQQISVDQLPAIEDKMKDIIKSKISLKHSEISVEEALASVDGDPYQAKI
VKRNEKNGKVSVYDVDGKIIVSDNVALLSTSDMKAVKLLSVAGAYWEGKSSNPMLQRIYGTSFYKQKDLEAELERQKEAH
ERDHRVIGNNLDLFFVDPKVGAGLPYWMPNGATIRRSIERYIIDKEVKHGYQHVYTPVLMNLDAYKTSGHWQHYREDMFP
PMDMGDGEMLELRPMNCPSHIQVYKHHIRSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVAPDQIQAEF
KKVLQLMVEVYRDFNITDYTFRLSYRDPANTEKYFDDDEMWNKSQSMLKAAMDDLGLDYVEAEGEAAFYGPKLDVQTKTA
LGNEETLSTIQLDFMLPKQFDLHYVGADGEEHRPVMIHRGLVSTMERFTAYLIEMYKGAFPTWLAPKQVTIIPVKDDLHG
AYADKLREEMVDKDIRVEVDHRNEKMGYKIREAQTQKIPYILVVGDNELENNSVSVRHYGEDDSKNEASADFINNIVREI
ESYSREND
>Mature_647_residues
TEINIEFPDGSVKPFEQGVSILDIAKSISTSLAKKAVAGKINGALVRLDQAINENVKIEIVTKDSEDGNIVNWNSAALVL
TSAIESIYPGVHFGEIGNGEHGFYVDTDKVDQQISVDQLPAIEDKMKDIIKSKISLKHSEISVEEALASVDGDPYQAKIV
KRNEKNGKVSVYDVDGKIIVSDNVALLSTSDMKAVKLLSVAGAYWEGKSSNPMLQRIYGTSFYKQKDLEAELERQKEAHE
RDHRVIGNNLDLFFVDPKVGAGLPYWMPNGATIRRSIERYIIDKEVKHGYQHVYTPVLMNLDAYKTSGHWQHYREDMFPP
MDMGDGEMLELRPMNCPSHIQVYKHHIRSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVAPDQIQAEFK
KVLQLMVEVYRDFNITDYTFRLSYRDPANTEKYFDDDEMWNKSQSMLKAAMDDLGLDYVEAEGEAAFYGPKLDVQTKTAL
GNEETLSTIQLDFMLPKQFDLHYVGADGEEHRPVMIHRGLVSTMERFTAYLIEMYKGAFPTWLAPKQVTIIPVKDDLHGA
YADKLREEMVDKDIRVEVDHRNEKMGYKIREAQTQKIPYILVVGDNELENNSVSVRHYGEDDSKNEASADFINNIVREIE
SYSREND

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=620, Percent_Identity=35.3225806451613, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI38570111, Length=595, Percent_Identity=36.3025210084034, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI20070344, Length=656, Percent_Identity=30.1829268292683, Blast_Score=323, Evalue=2e-88,
Organism=Escherichia coli, GI1788013, Length=642, Percent_Identity=35.202492211838, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71984184, Length=616, Percent_Identity=35.7142857142857, Blast_Score=394, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71984192, Length=616, Percent_Identity=35.7142857142857, Blast_Score=393, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322112, Length=634, Percent_Identity=34.2271293375394, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=35.5, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24583839, Length=616, Percent_Identity=35.8766233766234, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24583842, Length=616, Percent_Identity=35.8766233766234, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI28574141, Length=616, Percent_Identity=35.8766233766234, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_PEDPA (Q03GB7)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804197.1
- ProteinModelPortal:   Q03GB7
- SMR:   Q03GB7
- STRING:   Q03GB7
- GeneID:   4418124
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0694
- NMPDR:   fig|278197.10.peg.618
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   NDETMST
- BioCyc:   PPEN278197:PEPE_0694-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73748; Mature: 73617

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEINIEFPDGSVKPFEQGVSILDIAKSISTSLAKKAVAGKINGALVRLDQAINENVKIE
CCEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCEEEE
IVTKDSEDGNIVNWNSAALVLTSAIESIYPGVHFGEIGNGEHGFYVDTDKVDQQISVDQL
EEEECCCCCCEEECCCHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEHHHCCCCCCHHHC
PAIEDKMKDIIKSKISLKHSEISVEEALASVDGDPYQAKIVKRNEKNGKVSVYDVDGKII
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCEEE
VSDNVALLSTSDMKAVKLLSVAGAYWEGKSSNPMLQRIYGTSFYKQKDLEAELERQKEAH
EECCEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHCCHHHHHHHHHHHH
ERDHRVIGNNLDLFFVDPKVGAGLPYWMPNGATIRRSIERYIIDKEVKHGYQHVYTPVLM
HHHHHEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NLDAYKTSGHWQHYREDMFPPMDMGDGEMLELRPMNCPSHIQVYKHHIRSYRELPIRIAE
CCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHH
LGMMHRYEKSGALSGLQRVREMTLNDGHTFVAPDQIQAEFKKVLQLMVEVYRDFNITDYT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEE
FRLSYRDPANTEKYFDDDEMWNKSQSMLKAAMDDLGLDYVEAEGEAAFYGPKLDVQTKTA
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCEEHHC
LGNEETLSTIQLDFMLPKQFDLHYVGADGEEHRPVMIHRGLVSTMERFTAYLIEMYKGAF
CCCCHHEEEEEEEEECCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCC
PTWLAPKQVTIIPVKDDLHGAYADKLREEMVDKDIRVEVDHRNEKMGYKIREAQTQKIPY
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEHHHHCCCCCE
ILVVGDNELENNSVSVRHYGEDDSKNEASADFINNIVREIESYSREND
EEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TEINIEFPDGSVKPFEQGVSILDIAKSISTSLAKKAVAGKINGALVRLDQAINENVKIE
CEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCEEEE
IVTKDSEDGNIVNWNSAALVLTSAIESIYPGVHFGEIGNGEHGFYVDTDKVDQQISVDQL
EEEECCCCCCEEECCCHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEHHHCCCCCCHHHC
PAIEDKMKDIIKSKISLKHSEISVEEALASVDGDPYQAKIVKRNEKNGKVSVYDVDGKII
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCEEE
VSDNVALLSTSDMKAVKLLSVAGAYWEGKSSNPMLQRIYGTSFYKQKDLEAELERQKEAH
EECCEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHCCHHHHHHHHHHHH
ERDHRVIGNNLDLFFVDPKVGAGLPYWMPNGATIRRSIERYIIDKEVKHGYQHVYTPVLM
HHHHHEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NLDAYKTSGHWQHYREDMFPPMDMGDGEMLELRPMNCPSHIQVYKHHIRSYRELPIRIAE
CCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHH
LGMMHRYEKSGALSGLQRVREMTLNDGHTFVAPDQIQAEFKKVLQLMVEVYRDFNITDYT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEE
FRLSYRDPANTEKYFDDDEMWNKSQSMLKAAMDDLGLDYVEAEGEAAFYGPKLDVQTKTA
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCEEHHC
LGNEETLSTIQLDFMLPKQFDLHYVGADGEEHRPVMIHRGLVSTMERFTAYLIEMYKGAF
CCCCHHEEEEEEEEECCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCC
PTWLAPKQVTIIPVKDDLHGAYADKLREEMVDKDIRVEVDHRNEKMGYKIREAQTQKIPY
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEHHHHCCCCCE
ILVVGDNELENNSVSVRHYGEDDSKNEASADFINNIVREIESYSREND
EEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA