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The map label for this gene is murC

Identifier: 116492454

GI number: 116492454

Start: 726040

End: 727350

Strand: Direct

Name: murC

Synonym: PEPE_0686

Alternate gene names: 116492454

Gene position: 726040-727350 (Clockwise)

Preceding gene: 116492453

Following gene: 116492455

Centisome position: 39.62

GC content: 37.45

Gene sequence:

>1311_bases
GTGGATAAAGATTCAACTTATTATTTTATCGGTATTAAGGGGTCAGGGATGAGTTCCCTAGCACTTATTTTGCATGACGA
GGGATACAAAGTAGAAGGATCAGATATTGAGCAATATACCTTTACACAAAAGGGCTTAGAAGCTGCTGGGATTAAGATAT
TACCTTTTGATCCAGCCAACCTACGTGAAGGCTTGACGGTGATTGCTGGAAATGCATTTACTGATGAACATCCTGAAATT
AAAAAAGCTAGAGCAATGGGTCTAAAAGTAATTCGTTACCATGAACTTCTGGGACAAATGCTAGACAAATATACTAGTAT
TGGTGTTGCAGGAACGCATGGTAAGACTAGTACAACAGGATTGCTTGCTCACGTTTTAAGTGGTTTAGACAAGACTAGTT
ATTTAATTGGTGATGGAACCGGTAAGGGTATTCCAGATGCACGATTCTTTGTTTTTGAAGCTGACGAATATCGTCGTCAT
TTTATTGCATACCATCCAGACTATATGATTATGACTAACGTCGATTTTGATCATCCAGATTATTATAAGGATCTCGCCGA
TGTTGAAAGTGCCTTCCAGCAGGTTGCCGATCAAGTTCATAAGGGAATCTTTGCTTGGGGTGAAGATGAAAGCCTTCGTA
AAATCAATACATCTGTTCCAGTTTACTATTATGGAACTAAGGAAAATGATGACTTCCAAGCTACCAATATTAGTCGAACA
ACCACGGGTTCTGAATTTGATGTAATCCATAAGGGTGAAAAGTTAGGTCGATTTACAATTAACCTTTTTGGTGAACACAA
TGTGCTAAATTCCTTGGCTGTAATCGCAGTAGCATACTTTGAAAAAGTTGATTTGGACCTAGTTCAAAAAGAACTTTTAA
CTTATCAAGGTGTTAAACGTCGTTTCTCTAAGGAAGCAGTTGCTGATAATATTTTAATTGATGATTATGCACATCATCCA
TCTGAAATTAAGGCGACATTAGATGCAGCTCGCCAAGAATTTCCTGATAAAAAAATTGTTGCTGTTTTCCAACCACATAC
TTACTCAAGAACTGCCGCTTTGATGGATGGCTTTGCCAAGAGTTTAAGTTTAGCTGATCAAGTTGTTTTAACTGAAATTT
TTGGTTCTGCACGTGAAGATGCCGGGGCTGTTTCATCACAAGACTTAGCAGATAAGATTGGTAATAATACCAAATTGATT
CATCAAGATGATTTATCGGCTATTAGTGATTTACACGATGCGGTATTGGTCTTTATGGGGGCCGGAGATATTACTAAGTA
CGAAAATGCTTATAAGGCATTATTTAAATAA

Upstream 100 bases:

>100_bases
AAGCTCGTGGTTCAAAACCACGGGAAGTTTTTTATGATGGAAACAATAACGAAGTGTAGTGTGGTAAACTAAAAACAATT
TAATTATAGGAGTGGTAAAG

Downstream 100 bases:

>100_bases
TTATTAAGTTTTGATTTGTTTGACTAATTTTGACCTATAACATTAGCCATTTGGGTAGCTTCTTGTTACAATGTGGTAAA
TAATCGAATGGGGGAATTAG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MDKDSTYYFIGIKGSGMSSLALILHDEGYKVEGSDIEQYTFTQKGLEAAGIKILPFDPANLREGLTVIAGNAFTDEHPEI
KKARAMGLKVIRYHELLGQMLDKYTSIGVAGTHGKTSTTGLLAHVLSGLDKTSYLIGDGTGKGIPDARFFVFEADEYRRH
FIAYHPDYMIMTNVDFDHPDYYKDLADVESAFQQVADQVHKGIFAWGEDESLRKINTSVPVYYYGTKENDDFQATNISRT
TTGSEFDVIHKGEKLGRFTINLFGEHNVLNSLAVIAVAYFEKVDLDLVQKELLTYQGVKRRFSKEAVADNILIDDYAHHP
SEIKATLDAARQEFPDKKIVAVFQPHTYSRTAALMDGFAKSLSLADQVVLTEIFGSAREDAGAVSSQDLADKIGNNTKLI
HQDDLSAISDLHDAVLVFMGAGDITKYENAYKALFK

Sequences:

>Translated_436_residues
MDKDSTYYFIGIKGSGMSSLALILHDEGYKVEGSDIEQYTFTQKGLEAAGIKILPFDPANLREGLTVIAGNAFTDEHPEI
KKARAMGLKVIRYHELLGQMLDKYTSIGVAGTHGKTSTTGLLAHVLSGLDKTSYLIGDGTGKGIPDARFFVFEADEYRRH
FIAYHPDYMIMTNVDFDHPDYYKDLADVESAFQQVADQVHKGIFAWGEDESLRKINTSVPVYYYGTKENDDFQATNISRT
TTGSEFDVIHKGEKLGRFTINLFGEHNVLNSLAVIAVAYFEKVDLDLVQKELLTYQGVKRRFSKEAVADNILIDDYAHHP
SEIKATLDAARQEFPDKKIVAVFQPHTYSRTAALMDGFAKSLSLADQVVLTEIFGSAREDAGAVSSQDLADKIGNNTKLI
HQDDLSAISDLHDAVLVFMGAGDITKYENAYKALFK
>Mature_436_residues
MDKDSTYYFIGIKGSGMSSLALILHDEGYKVEGSDIEQYTFTQKGLEAAGIKILPFDPANLREGLTVIAGNAFTDEHPEI
KKARAMGLKVIRYHELLGQMLDKYTSIGVAGTHGKTSTTGLLAHVLSGLDKTSYLIGDGTGKGIPDARFFVFEADEYRRH
FIAYHPDYMIMTNVDFDHPDYYKDLADVESAFQQVADQVHKGIFAWGEDESLRKINTSVPVYYYGTKENDDFQATNISRT
TTGSEFDVIHKGEKLGRFTINLFGEHNVLNSLAVIAVAYFEKVDLDLVQKELLTYQGVKRRFSKEAVADNILIDDYAHHP
SEIKATLDAARQEFPDKKIVAVFQPHTYSRTAALMDGFAKSLSLADQVVLTEIFGSAREDAGAVSSQDLADKIGNNTKLI
HQDDLSAISDLHDAVLVFMGAGDITKYENAYKALFK

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=437, Percent_Identity=29.7482837528604, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1790680, Length=388, Percent_Identity=30.6701030927835, Blast_Score=155, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PEDPA (Q03GC5)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804189.1
- ProteinModelPortal:   Q03GC5
- STRING:   Q03GC5
- GeneID:   4418116
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0686
- NMPDR:   fig|278197.10.peg.610
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YHEFLGD
- PhylomeDB:   Q03GC5
- ProtClustDB:   PRK00421
- BioCyc:   PPEN278197:PEPE_0686-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 48404; Mature: 48404

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKDSTYYFIGIKGSGMSSLALILHDEGYKVEGSDIEQYTFTQKGLEAAGIKILPFDPAN
CCCCCEEEEEEEECCCCCEEEEEEECCCCEECCCCCHHHHHHHHCHHHCCEEEEECCCHH
LREGLTVIAGNAFTDEHPEIKKARAMGLKVIRYHELLGQMLDKYTSIGVAGTHGKTSTTG
HHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHH
LLAHVLSGLDKTSYLIGDGTGKGIPDARFFVFEADEYRRHFIAYHPDYMIMTNVDFDHPD
HHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECHHHCCEEEEECCCEEEEEECCCCCCH
YYKDLADVESAFQQVADQVHKGIFAWGEDESLRKINTSVPVYYYGTKENDDFQATNISRT
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCEEEECCCCCCCEEECCCCCC
TTGSEFDVIHKGEKLGRFTINLFGEHNVLNSLAVIAVAYFEKVDLDLVQKELLTYQGVKR
CCCCCEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RFSKEAVADNILIDDYAHHPSEIKATLDAARQEFPDKKIVAVFQPHTYSRTAALMDGFAK
HHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
SLSLADQVVLTEIFGSAREDAGAVSSQDLADKIGNNTKLIHQDDLSAISDLHDAVLVFMG
HHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHEEEEC
AGDITKYENAYKALFK
CCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDKDSTYYFIGIKGSGMSSLALILHDEGYKVEGSDIEQYTFTQKGLEAAGIKILPFDPAN
CCCCCEEEEEEEECCCCCEEEEEEECCCCEECCCCCHHHHHHHHCHHHCCEEEEECCCHH
LREGLTVIAGNAFTDEHPEIKKARAMGLKVIRYHELLGQMLDKYTSIGVAGTHGKTSTTG
HHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHH
LLAHVLSGLDKTSYLIGDGTGKGIPDARFFVFEADEYRRHFIAYHPDYMIMTNVDFDHPD
HHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECHHHCCEEEEECCCEEEEEECCCCCCH
YYKDLADVESAFQQVADQVHKGIFAWGEDESLRKINTSVPVYYYGTKENDDFQATNISRT
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCEEEECCCCCCCEEECCCCCC
TTGSEFDVIHKGEKLGRFTINLFGEHNVLNSLAVIAVAYFEKVDLDLVQKELLTYQGVKR
CCCCCEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RFSKEAVADNILIDDYAHHPSEIKATLDAARQEFPDKKIVAVFQPHTYSRTAALMDGFAK
HHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
SLSLADQVVLTEIFGSAREDAGAVSSQDLADKIGNNTKLIHQDDLSAISDLHDAVLVFMG
HHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHEEEEC
AGDITKYENAYKALFK
CCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA