| Definition | Pediococcus pentosaceus ATCC 25745, complete genome. |
|---|---|
| Accession | NC_008525 |
| Length | 1,832,387 |
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The map label for this gene is leuS
Identifier: 116492415
GI number: 116492415
Start: 685858
End: 688275
Strand: Direct
Name: leuS
Synonym: PEPE_0645
Alternate gene names: 116492415
Gene position: 685858-688275 (Clockwise)
Preceding gene: 116492412
Following gene: 116492416
Centisome position: 37.43
GC content: 41.11
Gene sequence:
>2418_bases ATGGCTTATAATCATAAAGATATCGAACAGAAGTGGCAGCAATTCTGGAGCGACAATGAGACTTTTAAGACGGTCGAAGA TGCAGACAAACCCAAATATTATGCATTAGACATGTTCCCTTATCCATCAGGTCAAGGACTCCATGTGGGCCATCCTGAAG GATATACAGCAACAGATATTATGTCACGAATGAAACGTATGCAAGGTTACAAAGTACTTCATCCAATGGGATGGGATGCT TTTGGTCTTCCAGCAGAACAATATGCGATGAAGACGGGTAACAATCCGCGTGATTTTACAGCTAAGAATATTCAAAACTT TAAGCGTCAAATCCAATCACTTGGTTTTTCTTATGACTGGTCGCGAGAAGTTAATACAACTGATCCAGCTTACTACAAGT GGACTCAATGGATTTTTGAGCAACTCTACAAGAAGGGCTTAGCTTATGAAAAAGAAACGCTGGTAAACTGGGCTCCTGAT TTAATGGGTGGAACGGTAGTTGCTAACGAAGAAGTTGTGGATGGTAAGACAGAACGTGGTGGGTTCCCCGTTTATCGTAA ACCAATGAAACAATGGATTCTTAAAATTACAGCTTACGCCGACCGTTTGATTGACGATTTGGACCTGGTAGATTGGCCCG ATAGTATTAAAGAAATGCAAAAAAACTGGATTGGTCGTTCAGTGGGGGCTAGCGTCTTCTTTAATGTTGAAGATAGCGAA AAACAAATTGAAGTATTTACAACGCGTCCAGATACATTATTTGGCGCAACATACTTGGTAATTTCACCAGAACATGACCT CGTTGACCAAATTACAACTCCAGAAAGTAAAGCTGCCGTTGAAGAATACAAGAAAGCTGTTGCAACTAAATCAGATCTTG AACGGACGGATTTGAATAAAGACAAGACGGGAGTCTTCACGGGAGCATACGCGGTTAACCCTGTTAATGGTAAGAAAATT CCAGTTTGGATTAGTGATTACGTATTGGCTTCATACGGAACTGGAGCAGTGATGGCTGTTCCTGCTCATGATGGCCGTGA CTACGAATTTGCTAAGAAATTCAAGATAGATATGGTGCCAGTTTATGAAGGTGGCAATCTTGAAGATGGAGTATTGGACA GCGAAGGCGGGCTAATTAACTCTGGATTCCTAGATGGGATGGATAAGCAGACGGCTATTGATACCATGATTAGCTGGTTG GAAGAACATGGAGTTGGTCATAAGAAGGTTAACTATCGTCTTCGTGACTGGGTCTTCTCTCGCCAACGCTACTGGGGTGA ACCAATCCCTGTAATTCATTGGGAAGATGGAGAAACAACTTTGATTCCTGAAGATGAATTGCCATTGAGACTCCCAGCTG CAACTGACATTCGTCCTTCCGGTACCGGAGAAAGCCCATTAGCTAATTTAGATGATTGGGTAAACGTAGTTGATGAAAAT GGACGTAAGGGTCGCCGGGAAACTAATACAATGCCACAATGGGCGGGTAGTTCATGGTACTTCCTCCGTTACGTTGATCC TAAGAATGATCAAAAGATTGCTGACGAAGATTTACTTAAAGAATGGTTACCAGTCGACTTATATGTTGGTGGAGCTGAAC ATGCGGTACTTCATTTACTTTATGCACGTTTCTGGCACAAAGTTTTATATGATCTAGGAGTTGTACCAACTAAGGAACCA TTCCAAAAATTGGTTAACCAAGGGATGATTCTCGGTAGCAATCATGAGAAGATGTCTAAGTCAAAAGGGAACGTGGTTAA TCCAGATGATATTGTTGAGCGCTTTGGAGCGGATACTTTACGATTATACGAAATGTTCATGGGACCTCTGACAGAATCAG TCGCCTGGAGTGAAGATGGGCTTAACGGAAGTCGTAAGTGGATTGACCGCGTCTGGCGCTTGATGATTGACGACGAAAAC CAATTGCGTGATCATATTGTTACTGAAAATGATGGCAGTTTGGATATGATTTATAACCAAACTGTTAAGAAGGTAACTGA TGATTATGAAAACATGCGCTTTAACACGGCTATTTCACAAATGATGGTCTTTGTTAATGAAGCATACAAGGCTGATAAAC TTCCAGCAGTATATATGGAAGGATTAGTTAAGATGTTAGCTCCAATTATTCCGCACGTTGCTGAAGAACTTTGGAGTTTG CTAGGTCACGAAGGTGGTATTTCATACGCTGAATGGCCAACATATGATGAAAGTAAGTTAGTAGAAGCTACAGTTCAAGT CATTCTACAAGTTAATGGTAAAGTTCGGAGTAAGATTACCGTTGACAAGGATATCGCCAAAGAAGAACTTGAAAAATTAG CGTTAGCTGATGCTAAGATTCAACAATGGACGGCAGATAAGACTGTTCGTAAGGTAATTGTTATTCCTAACAAGATTGTT AATATCGTAGTAGGCTAA
Upstream 100 bases:
>100_bases TGCAAAACATAGGTGGTACCGCGGAACTTTTCGTCCTAAGGATTCTTTTTTAGAATCCTTAGGTTTTTTTTTATCGACAA ATATAATAATGGAGGAAACT
Downstream 100 bases:
>100_bases CTAAATCAAAAGTAGGGTCCAGATGTTTTAACAGCATCGTGGACCCTTTTTTTGTAGAAAAATAGTTTGGAAAATGAACT AATTTTGGGAGTTTGGTGGA
Product: leucyl-tRNA synthetase
Products: NA
Alternate protein names: Leucine--tRNA ligase; LeuRS
Number of amino acids: Translated: 805; Mature: 804
Protein sequence:
>805_residues MAYNHKDIEQKWQQFWSDNETFKTVEDADKPKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRMKRMQGYKVLHPMGWDA FGLPAEQYAMKTGNNPRDFTAKNIQNFKRQIQSLGFSYDWSREVNTTDPAYYKWTQWIFEQLYKKGLAYEKETLVNWAPD LMGGTVVANEEVVDGKTERGGFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSVGASVFFNVEDSE KQIEVFTTRPDTLFGATYLVISPEHDLVDQITTPESKAAVEEYKKAVATKSDLERTDLNKDKTGVFTGAYAVNPVNGKKI PVWISDYVLASYGTGAVMAVPAHDGRDYEFAKKFKIDMVPVYEGGNLEDGVLDSEGGLINSGFLDGMDKQTAIDTMISWL EEHGVGHKKVNYRLRDWVFSRQRYWGEPIPVIHWEDGETTLIPEDELPLRLPAATDIRPSGTGESPLANLDDWVNVVDEN GRKGRRETNTMPQWAGSSWYFLRYVDPKNDQKIADEDLLKEWLPVDLYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEP FQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTLRLYEMFMGPLTESVAWSEDGLNGSRKWIDRVWRLMIDDEN QLRDHIVTENDGSLDMIYNQTVKKVTDDYENMRFNTAISQMMVFVNEAYKADKLPAVYMEGLVKMLAPIIPHVAEELWSL LGHEGGISYAEWPTYDESKLVEATVQVILQVNGKVRSKITVDKDIAKEELEKLALADAKIQQWTADKTVRKVIVIPNKIV NIVVG
Sequences:
>Translated_805_residues MAYNHKDIEQKWQQFWSDNETFKTVEDADKPKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRMKRMQGYKVLHPMGWDA FGLPAEQYAMKTGNNPRDFTAKNIQNFKRQIQSLGFSYDWSREVNTTDPAYYKWTQWIFEQLYKKGLAYEKETLVNWAPD LMGGTVVANEEVVDGKTERGGFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSVGASVFFNVEDSE KQIEVFTTRPDTLFGATYLVISPEHDLVDQITTPESKAAVEEYKKAVATKSDLERTDLNKDKTGVFTGAYAVNPVNGKKI PVWISDYVLASYGTGAVMAVPAHDGRDYEFAKKFKIDMVPVYEGGNLEDGVLDSEGGLINSGFLDGMDKQTAIDTMISWL EEHGVGHKKVNYRLRDWVFSRQRYWGEPIPVIHWEDGETTLIPEDELPLRLPAATDIRPSGTGESPLANLDDWVNVVDEN GRKGRRETNTMPQWAGSSWYFLRYVDPKNDQKIADEDLLKEWLPVDLYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEP FQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTLRLYEMFMGPLTESVAWSEDGLNGSRKWIDRVWRLMIDDEN QLRDHIVTENDGSLDMIYNQTVKKVTDDYENMRFNTAISQMMVFVNEAYKADKLPAVYMEGLVKMLAPIIPHVAEELWSL LGHEGGISYAEWPTYDESKLVEATVQVILQVNGKVRSKITVDKDIAKEELEKLALADAKIQQWTADKTVRKVIVIPNKIV NIVVG >Mature_804_residues AYNHKDIEQKWQQFWSDNETFKTVEDADKPKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRMKRMQGYKVLHPMGWDAF GLPAEQYAMKTGNNPRDFTAKNIQNFKRQIQSLGFSYDWSREVNTTDPAYYKWTQWIFEQLYKKGLAYEKETLVNWAPDL MGGTVVANEEVVDGKTERGGFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSVGASVFFNVEDSEK QIEVFTTRPDTLFGATYLVISPEHDLVDQITTPESKAAVEEYKKAVATKSDLERTDLNKDKTGVFTGAYAVNPVNGKKIP VWISDYVLASYGTGAVMAVPAHDGRDYEFAKKFKIDMVPVYEGGNLEDGVLDSEGGLINSGFLDGMDKQTAIDTMISWLE EHGVGHKKVNYRLRDWVFSRQRYWGEPIPVIHWEDGETTLIPEDELPLRLPAATDIRPSGTGESPLANLDDWVNVVDENG RKGRRETNTMPQWAGSSWYFLRYVDPKNDQKIADEDLLKEWLPVDLYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPF QKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTLRLYEMFMGPLTESVAWSEDGLNGSRKWIDRVWRLMIDDENQ LRDHIVTENDGSLDMIYNQTVKKVTDDYENMRFNTAISQMMVFVNEAYKADKLPAVYMEGLVKMLAPIIPHVAEELWSLL GHEGGISYAEWPTYDESKLVEATVQVILQVNGKVRSKITVDKDIAKEELEKLALADAKIQQWTADKTVRKVIVIPNKIVN IVVG
Specific function: Unknown
COG id: COG0495
COG function: function code J; Leucyl-tRNA synthetase
Gene ontology:
Cell location: Cytoplasm
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family
Homologues:
Organism=Homo sapiens, GI7661872, Length=876, Percent_Identity=32.1917808219178, Blast_Score=451, Evalue=1e-126, Organism=Homo sapiens, GI108773810, Length=277, Percent_Identity=28.5198555956679, Blast_Score=76, Evalue=2e-13, Organism=Homo sapiens, GI94721239, Length=160, Percent_Identity=28.75, Blast_Score=70, Evalue=9e-12, Organism=Homo sapiens, GI94721241, Length=160, Percent_Identity=28.75, Blast_Score=70, Evalue=9e-12, Organism=Escherichia coli, GI1786861, Length=867, Percent_Identity=42.3298731257209, Blast_Score=672, Evalue=0.0, Organism=Escherichia coli, GI1790708, Length=395, Percent_Identity=26.3291139240506, Blast_Score=103, Evalue=5e-23, Organism=Caenorhabditis elegans, GI71997510, Length=823, Percent_Identity=28.3110571081409, Blast_Score=302, Evalue=4e-82, Organism=Caenorhabditis elegans, GI71997517, Length=818, Percent_Identity=28.4841075794621, Blast_Score=300, Evalue=2e-81, Organism=Caenorhabditis elegans, GI212645227, Length=336, Percent_Identity=29.4642857142857, Blast_Score=142, Evalue=7e-34, Organism=Caenorhabditis elegans, GI17541896, Length=405, Percent_Identity=24.9382716049383, Blast_Score=77, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17554638, Length=243, Percent_Identity=27.1604938271605, Blast_Score=76, Evalue=8e-14, Organism=Saccharomyces cerevisiae, GI6323414, Length=830, Percent_Identity=34.8192771084337, Blast_Score=474, Evalue=1e-134, Organism=Saccharomyces cerevisiae, GI6321531, Length=399, Percent_Identity=25.8145363408521, Blast_Score=105, Evalue=4e-23, Organism=Saccharomyces cerevisiae, GI6325097, Length=225, Percent_Identity=26.2222222222222, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6319395, Length=160, Percent_Identity=28.125, Blast_Score=65, Evalue=4e-11, Organism=Drosophila melanogaster, GI21355409, Length=876, Percent_Identity=31.1643835616438, Blast_Score=389, Evalue=1e-108, Organism=Drosophila melanogaster, GI17864482, Length=482, Percent_Identity=23.6514522821577, Blast_Score=101, Evalue=2e-21, Organism=Drosophila melanogaster, GI24653289, Length=482, Percent_Identity=23.6514522821577, Blast_Score=101, Evalue=2e-21, Organism=Drosophila melanogaster, GI28574733, Length=279, Percent_Identity=25.4480286738351, Blast_Score=71, Evalue=3e-12,
Paralogues:
None
Copy number: 800 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): SYL_PEDPA (Q03GG4)
Other databases:
- EMBL: CP000422 - RefSeq: YP_804150.1 - ProteinModelPortal: Q03GG4 - SMR: Q03GG4 - STRING: Q03GG4 - GeneID: 4418531 - GenomeReviews: CP000422_GR - KEGG: ppe:PEPE_0645 - NMPDR: fig|278197.10.peg.573 - eggNOG: COG0495 - HOGENOM: HBG693845 - OMA: ERGNFPV - PhylomeDB: Q03GG4 - ProtClustDB: PRK00390 - BioCyc: PPEN278197:PEPE_0645-MONOMER - GO: GO:0005737 - HAMAP: MF_00049_B - InterPro: IPR001412 - InterPro: IPR002300 - InterPro: IPR002302 - InterPro: IPR014729 - InterPro: IPR009080 - InterPro: IPR013155 - InterPro: IPR009008 - Gene3D: G3DSA:3.40.50.620 - PANTHER: PTHR11946:SF7 - PRINTS: PR00985 - TIGRFAMs: TIGR00396
Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1; SSF47323 tRNAsyn_1a_bind; SSF50677 ValRS_IleRS_edit
EC number: =6.1.1.4
Molecular weight: Translated: 91897; Mature: 91766
Theoretical pI: Translated: 4.88; Mature: 4.88
Prosite motif: PS00178 AA_TRNA_LIGASE_I
Important sites: BINDING 580-580
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAYNHKDIEQKWQQFWSDNETFKTVEDADKPKYYALDMFPYPSGQGLHVGHPEGYTATDI CCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCCCCCCEECCCCCCCCHHHH MSRMKRMQGYKVLHPMGWDAFGLPAEQYAMKTGNNPRDFTAKNIQNFKRQIQSLGFSYDW HHHHHHHCCCEEECCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCC SREVNTTDPAYYKWTQWIFEQLYKKGLAYEKETLVNWAPDLMGGTVVANEEVVDGKTERG CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHCCCEEEECCCCCCCCCCCC GFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSVGASVFFNVEDSE CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCC KQIEVFTTRPDTLFGATYLVISPEHDLVDQITTPESKAAVEEYKKAVATKSDLERTDLNK CEEEEEECCCCCCCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC DKTGVFTGAYAVNPVNGKKIPVWISDYVLASYGTGAVMAVPAHDGRDYEFAKKFKIDMVP CCCCEEECCEEECCCCCCEEEEEEECHHHHCCCCCEEEEEECCCCCCCHHHHHEEEEEEE VYEGGNLEDGVLDSEGGLINSGFLDGMDKQTAIDTMISWLEEHGVGHKKVNYRLRDWVFS EECCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH RQRYWGEPIPVIHWEDGETTLIPEDELPLRLPAATDIRPSGTGESPLANLDDWVNVVDEN HHHHCCCCCCEEEECCCCEEECCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCC GRKGRRETNTMPQWAGSSWYFLRYVDPKNDQKIADEDLLKEWLPVDLYVGGAEHAVLHLL CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCEEEEECCHHHHHHHHH YARFWHKVLYDLGVVPTKEPFQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTL HHHHHHHHHHHCCCCCCHHHHHHHHHCCEEECCCHHHHHHCCCCCCCHHHHHHHHCCHHH RLYEMFMGPLTESVAWSEDGLNGSRKWIDRVWRLMIDDENQLRDHIVTENDGSLDMIYNQ HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEHHHHH TVKKVTDDYENMRFNTAISQMMVFVNEAYKADKLPAVYMEGLVKMLAPIIPHVAEELWSL HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH LGHEGGISYAEWPTYDESKLVEATVQVILQVNGKVRSKITVDKDIAKEELEKLALADAKI HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHH QQWTADKTVRKVIVIPNKIVNIVVG HHHHHHHHHEEEEEECCCCEEEECC >Mature Secondary Structure AYNHKDIEQKWQQFWSDNETFKTVEDADKPKYYALDMFPYPSGQGLHVGHPEGYTATDI CCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCCCCCCEECCCCCCCCHHHH MSRMKRMQGYKVLHPMGWDAFGLPAEQYAMKTGNNPRDFTAKNIQNFKRQIQSLGFSYDW HHHHHHHCCCEEECCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCC SREVNTTDPAYYKWTQWIFEQLYKKGLAYEKETLVNWAPDLMGGTVVANEEVVDGKTERG CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHCCCEEEECCCCCCCCCCCC GFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSVGASVFFNVEDSE CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCC KQIEVFTTRPDTLFGATYLVISPEHDLVDQITTPESKAAVEEYKKAVATKSDLERTDLNK CEEEEEECCCCCCCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC DKTGVFTGAYAVNPVNGKKIPVWISDYVLASYGTGAVMAVPAHDGRDYEFAKKFKIDMVP CCCCEEECCEEECCCCCCEEEEEEECHHHHCCCCCEEEEEECCCCCCCHHHHHEEEEEEE VYEGGNLEDGVLDSEGGLINSGFLDGMDKQTAIDTMISWLEEHGVGHKKVNYRLRDWVFS EECCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH RQRYWGEPIPVIHWEDGETTLIPEDELPLRLPAATDIRPSGTGESPLANLDDWVNVVDEN HHHHCCCCCCEEEECCCCEEECCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCC GRKGRRETNTMPQWAGSSWYFLRYVDPKNDQKIADEDLLKEWLPVDLYVGGAEHAVLHLL CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCEEEEECCHHHHHHHHH YARFWHKVLYDLGVVPTKEPFQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTL HHHHHHHHHHHCCCCCCHHHHHHHHHCCEEECCCHHHHHHCCCCCCCHHHHHHHHCCHHH RLYEMFMGPLTESVAWSEDGLNGSRKWIDRVWRLMIDDENQLRDHIVTENDGSLDMIYNQ HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEHHHHH TVKKVTDDYENMRFNTAISQMMVFVNEAYKADKLPAVYMEGLVKMLAPIIPHVAEELWSL HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH LGHEGGISYAEWPTYDESKLVEATVQVILQVNGKVRSKITVDKDIAKEELEKLALADAKI HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHH QQWTADKTVRKVIVIPNKIVNIVVG HHHHHHHHHEEEEEECCCCEEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA