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The map label for this gene is yusP [H]

Identifier: 116492412

GI number: 116492412

Start: 682810

End: 684276

Strand: Direct

Name: yusP [H]

Synonym: PEPE_0642

Alternate gene names: 116492412

Gene position: 682810-684276 (Clockwise)

Preceding gene: 116492411

Following gene: 116492415

Centisome position: 37.26

GC content: 37.01

Gene sequence:

>1467_bases
ATGGAGAAAAAACAAACAAATGTGGTCGTTGTAACAGTCGCTATTTTTGTTGCAACTTTTATGTCGGCGATTGAAGGAAC
AATTGTTTCAACAGCGATGCCGACCATTGTAGGAGATTTACATGGCGTTAGTTTGATGAATTGGGTTATTTCAATTTTCC
TACTAACTAATGCAATATTTACCCCAATTTACGGGAAGTTGTCTGATATTTTCGGTCGTAAACGAGTGTTTATTTTTGGA
ATTATTATATTTTTGATTGGCTCGATGTTAAGTGGGATGGCCCACTCAATGGGTTTCTTGATTTTATGGCGCGCATTGCA
AGGAATCGGGGCTGGATCGATTATGCCGGTTTCTAATACCATTATTGCTGATATTTATCCGATTGAAAAACGGGCCAAGG
TAATGGGACTAAATGGTTCAGCATGGGGAATTGCTTCTATTATTGCTCCGCTATTAGGAGGCTTTATTGTTGATAATCTA
AGTTGGCATTGGATTTTCTTTATCAATTTACCGATTGGAATTATCACCATCTTTTTAATTCAGTTCTTCCTTAAAGAAGA
GGTTAGTGTCCATAGCAAGAAAATTGACTACCTAGGTAGTTTTTGGTTAATGGTAGCTTTACTGGGACTAATGTACGGTT
TCCAATTGATGGGTGAAAGTTCATTCTCATGGATTACATTGGTGATTTCGTTTGTGATTTTCATCGTGGGAGCTGGCTTA
TTTATTCGTCAAGAAAAACGGGCGGAAGATCCCATTATTTTCCTAGATTTGTTTAACAACCGCACATTTGTAATTCAAAA
TGTGGCGACGATGTTGGTCTCTGGTTTGTTGATTGGTTTCGAAGTTTACTTACCAAGCTGGACACAAGGAATTTTAGGAG
TGCCAGCTTCATTAGCTGGATTTGCAGTAACTCCAAGTTCAATTTTATGGATTTTCGGTTCATTCTTAGCAGGACGGATG
ATTGTTAAATTAAAGGCCAATCAGATCTTGACCATTAGTTTATCAATCCTAGCTGTTGGTAGCTTATTATTAGCTTTAGT
ACCGGCTTCAACACCGTTCTTGGCTTTCTTCTTTATTGCAGCTATTTTAGGAGTTGGTTTTGGAATTACAATTACTTCCA
CATTAGTAATTTCACAGCAATTAGTAACTAAAGATCGGATTGGGGTAGCAACTTCCTTTAATACTTTGGCTAAGACACTG
GGCCAAACCATTATGATGTCCGTTTTCGGAATCATTATGAATGGGACGATGAATGCCGGAGTTAAGGCGAACCCTAAAAT
TAATATGGATATGATGAACAAAGTTATCAATCCTCAAACGGCTAAAACTTTACCAGAAACTTTATTGCCAACGTTGAGAA
ATGTTTTATATCAAGCTTTGCATAATATCTACATTGGTTGCTTTATTTTGATTGTGGTTGCTTTAATCATTAATGCGTTT
GACCGTCGCTCAAAAGATAATATTTAA

Upstream 100 bases:

>100_bases
CTTTAAACGACTTTTTTAAAAACTAAAAAATTTGATTAATGGCTGTGTTGATGTCTAAACGGATATTAACACGGCTATTA
TATTGGTTGAGAGGTAATAA

Downstream 100 bases:

>100_bases
AAAAATGGATTTAGAACCTAGCTGAGAGGCTAGCCTTCTAAATCCATTATTTTTTACGCTCAATACACAATAAAATGGGC
GGATTATTAATCTGGTTGAT

Product: major facilitator superfamily permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MEKKQTNVVVVTVAIFVATFMSAIEGTIVSTAMPTIVGDLHGVSLMNWVISIFLLTNAIFTPIYGKLSDIFGRKRVFIFG
IIIFLIGSMLSGMAHSMGFLILWRALQGIGAGSIMPVSNTIIADIYPIEKRAKVMGLNGSAWGIASIIAPLLGGFIVDNL
SWHWIFFINLPIGIITIFLIQFFLKEEVSVHSKKIDYLGSFWLMVALLGLMYGFQLMGESSFSWITLVISFVIFIVGAGL
FIRQEKRAEDPIIFLDLFNNRTFVIQNVATMLVSGLLIGFEVYLPSWTQGILGVPASLAGFAVTPSSILWIFGSFLAGRM
IVKLKANQILTISLSILAVGSLLLALVPASTPFLAFFFIAAILGVGFGITITSTLVISQQLVTKDRIGVATSFNTLAKTL
GQTIMMSVFGIIMNGTMNAGVKANPKINMDMMNKVINPQTAKTLPETLLPTLRNVLYQALHNIYIGCFILIVVALIINAF
DRRSKDNI

Sequences:

>Translated_488_residues
MEKKQTNVVVVTVAIFVATFMSAIEGTIVSTAMPTIVGDLHGVSLMNWVISIFLLTNAIFTPIYGKLSDIFGRKRVFIFG
IIIFLIGSMLSGMAHSMGFLILWRALQGIGAGSIMPVSNTIIADIYPIEKRAKVMGLNGSAWGIASIIAPLLGGFIVDNL
SWHWIFFINLPIGIITIFLIQFFLKEEVSVHSKKIDYLGSFWLMVALLGLMYGFQLMGESSFSWITLVISFVIFIVGAGL
FIRQEKRAEDPIIFLDLFNNRTFVIQNVATMLVSGLLIGFEVYLPSWTQGILGVPASLAGFAVTPSSILWIFGSFLAGRM
IVKLKANQILTISLSILAVGSLLLALVPASTPFLAFFFIAAILGVGFGITITSTLVISQQLVTKDRIGVATSFNTLAKTL
GQTIMMSVFGIIMNGTMNAGVKANPKINMDMMNKVINPQTAKTLPETLLPTLRNVLYQALHNIYIGCFILIVVALIINAF
DRRSKDNI
>Mature_488_residues
MEKKQTNVVVVTVAIFVATFMSAIEGTIVSTAMPTIVGDLHGVSLMNWVISIFLLTNAIFTPIYGKLSDIFGRKRVFIFG
IIIFLIGSMLSGMAHSMGFLILWRALQGIGAGSIMPVSNTIIADIYPIEKRAKVMGLNGSAWGIASIIAPLLGGFIVDNL
SWHWIFFINLPIGIITIFLIQFFLKEEVSVHSKKIDYLGSFWLMVALLGLMYGFQLMGESSFSWITLVISFVIFIVGAGL
FIRQEKRAEDPIIFLDLFNNRTFVIQNVATMLVSGLLIGFEVYLPSWTQGILGVPASLAGFAVTPSSILWIFGSFLAGRM
IVKLKANQILTISLSILAVGSLLLALVPASTPFLAFFFIAAILGVGFGITITSTLVISQQLVTKDRIGVATSFNTLAKTL
GQTIMMSVFGIIMNGTMNAGVKANPKINMDMMNKVINPQTAKTLPETLLPTLRNVLYQALHNIYIGCFILIVVALIINAF
DRRSKDNI

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=406, Percent_Identity=31.2807881773399, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788710, Length=337, Percent_Identity=33.5311572700297, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1790195, Length=328, Percent_Identity=30.7926829268293, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI87081983, Length=409, Percent_Identity=27.6283618581907, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788392, Length=245, Percent_Identity=29.7959183673469, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788509, Length=145, Percent_Identity=31.7241379310345, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790146, Length=155, Percent_Identity=32.258064516129, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081738, Length=131, Percent_Identity=35.1145038167939, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI48994889, Length=166, Percent_Identity=28.3132530120482, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=140, Percent_Identity=31.4285714285714, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=499, Percent_Identity=25.6513026052104, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323735, Length=329, Percent_Identity=25.531914893617, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6319770, Length=387, Percent_Identity=27.1317829457364, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321663, Length=146, Percent_Identity=32.8767123287671, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6325455, Length=166, Percent_Identity=31.9277108433735, Blast_Score=90, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324954, Length=408, Percent_Identity=21.5686274509804, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323935, Length=399, Percent_Identity=25.062656641604, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53300; Mature: 53300

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKQTNVVVVTVAIFVATFMSAIEGTIVSTAMPTIVGDLHGVSLMNWVISIFLLTNAIF
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPIYGKLSDIFGRKRVFIFGIIIFLIGSMLSGMAHSMGFLILWRALQGIGAGSIMPVSNT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCC
IIADIYPIEKRAKVMGLNGSAWGIASIIAPLLGGFIVDNLSWHWIFFINLPIGIITIFLI
CEEEEECHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHH
QFFLKEEVSVHSKKIDYLGSFWLMVALLGLMYGFQLMGESSFSWITLVISFVIFIVGAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCH
FIRQEKRAEDPIIFLDLFNNRTFVIQNVATMLVSGLLIGFEVYLPSWTQGILGVPASLAG
HEECCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCCHHHCC
FAVTPSSILWIFGSFLAGRMIVKLKANQILTISLSILAVGSLLLALVPASTPFLAFFFIA
CCCCHHHHHHHHHHHHHCCEEEEEECCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AILGVGFGITITSTLVISQQLVTKDRIGVATSFNTLAKTLGQTIMMSVFGIIMNGTMNAG
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VKANPKINMDMMNKVINPQTAKTLPETLLPTLRNVLYQALHNIYIGCFILIVVALIINAF
CCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRRSKDNI
HCCCCCCC
>Mature Secondary Structure
MEKKQTNVVVVTVAIFVATFMSAIEGTIVSTAMPTIVGDLHGVSLMNWVISIFLLTNAIF
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPIYGKLSDIFGRKRVFIFGIIIFLIGSMLSGMAHSMGFLILWRALQGIGAGSIMPVSNT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCC
IIADIYPIEKRAKVMGLNGSAWGIASIIAPLLGGFIVDNLSWHWIFFINLPIGIITIFLI
CEEEEECHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHH
QFFLKEEVSVHSKKIDYLGSFWLMVALLGLMYGFQLMGESSFSWITLVISFVIFIVGAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCH
FIRQEKRAEDPIIFLDLFNNRTFVIQNVATMLVSGLLIGFEVYLPSWTQGILGVPASLAG
HEECCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCCHHHCC
FAVTPSSILWIFGSFLAGRMIVKLKANQILTISLSILAVGSLLLALVPASTPFLAFFFIA
CCCCHHHHHHHHHHHHHCCEEEEEECCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AILGVGFGITITSTLVISQQLVTKDRIGVATSFNTLAKTLGQTIMMSVFGIIMNGTMNAG
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VKANPKINMDMMNKVINPQTAKTLPETLLPTLRNVLYQALHNIYIGCFILIVVALIINAF
CCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRRSKDNI
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]