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The map label for this gene is gltT [H]

Identifier: 116491857

GI number: 116491857

Start: 36064

End: 37335

Strand: Direct

Name: gltT [H]

Synonym: PEPE_0039

Alternate gene names: 116491857

Gene position: 36064-37335 (Clockwise)

Preceding gene: 116491855

Following gene: 116491861

Centisome position: 1.97

GC content: 39.07

Gene sequence:

>1272_bases
ATGAAAAAAGTTCGGAATTGGAGATTGACGCTGGGGTGGCAAATCCTGATAGGTTTGATTTTAGGAGTGGTTTTAGGTGC
CGTTTTCTACCATAACCAGGTTGCCATTACGGCGATGCAAAATATTGGAACCATGTTTATCCACTTGATTCAAATGATTG
TTCTTCCAATCGTTATATCCTGCTTAACCGTAGGGATTGCGGGAATGGGTGACATTGGAGAATTGGGTCGTGTTGGATTG
AAAACTTTGATTTATTTTGAAATTCTAACCACCATTGCTTTAGTAGTCGGAATGATTTTTGCTAACGTTTTTCATCCAGG
AACTTATATTGATATCCATAGTTTGCAAAGTACGGATATTAGTTCATACGTGGAAACTGCAAAACACGCTAAAGAAAGCA
GTGGCCTATGGTCAACGATTATGAACATTATTCCAACTAATATCTTTAGTTCGTTATCTGAAGGAAACATGATGCCCATC
ATTCTATTTTCAGTTCTTTTTGGATTAGGAATTACGGCAATTGGTAAACAAGGACAAATCTTGATTGATGGCCTTACTGC
TATCCAAGAAGTAATGTTTAAGATTACCAACTGGATTATGCACCTTTCTCCTATTGGGGTTTGCGCTCTAATTGGGGTAA
CAATCGCTCAAATGGGGATTGATGCTCTAAAACCATTAGGATTGTTCATCTTGATTGCCTACGTGGCGATGGTATTCTTT
GTAATTGTGGTACTAGGAATTGTGGCTAAGATTCACCACGTGAAATTCTTCCAGTTACTCAAGGTAATCAAAAATGAATT
GATTTTAGCATTTTCAACAGCCAGTTCAGAGGCTGCACTTCCTAAAATTATTGATAAAATGCAAAAATATGGTGTTAGCC
AAGGGATCGTATCCTTCGTTATTCCAACTGGATACACGTTTAACCTGGACGGATCAGCTATCTATCAAGCAGTTGGGGCA
CTCTTCTTAGCCCAGGCTTATCATATTAATTTAAGTATTGGACAACAAATTACATTGCTAGTAGTATTGATGATTACTTC
TAAAGGGATGGCTGGTGTTCCTGGTGCTTCATTTGTGGTTCTCTTAGCTACTGTTTCTACCATTGGTGTTCCAATGGCTG
GTTTAACGTTTATTGCTGGTGTCGACCGCATTATTGATATGGGTCGAACCGCGGTTAACGTGGTGGGTAACTCACTAGCT
GCAATTATCATGGGCAAGTCGGAAGGCGAGTTCGATGAAGAGAAGCATGCAGAATATGTAAAAAATATTTAG

Upstream 100 bases:

>100_bases
ATTCGTTATTTCTCAAAAGATTTTTGGAATTAACCTATGATTAATTTTTAATTAAAAATATGATAATATAGTAAATAGCA
TAAATTTTAGGGGTGTGAAT

Downstream 100 bases:

>100_bases
AGTATGAAATAAAATACAGCGAAAAAAGGCGACCATGACATTAATGTCATGGTCGCCTTTTTGAATATTTTAACTGCCAA
GTTCATAAGTAAAGTTGATT

Product: Na+/H+-dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKKVRNWRLTLGWQILIGLILGVVLGAVFYHNQVAITAMQNIGTMFIHLIQMIVLPIVISCLTVGIAGMGDIGELGRVGL
KTLIYFEILTTIALVVGMIFANVFHPGTYIDIHSLQSTDISSYVETAKHAKESSGLWSTIMNIIPTNIFSSLSEGNMMPI
ILFSVLFGLGITAIGKQGQILIDGLTAIQEVMFKITNWIMHLSPIGVCALIGVTIAQMGIDALKPLGLFILIAYVAMVFF
VIVVLGIVAKIHHVKFFQLLKVIKNELILAFSTASSEAALPKIIDKMQKYGVSQGIVSFVIPTGYTFNLDGSAIYQAVGA
LFLAQAYHINLSIGQQITLLVVLMITSKGMAGVPGASFVVLLATVSTIGVPMAGLTFIAGVDRIIDMGRTAVNVVGNSLA
AIIMGKSEGEFDEEKHAEYVKNI

Sequences:

>Translated_423_residues
MKKVRNWRLTLGWQILIGLILGVVLGAVFYHNQVAITAMQNIGTMFIHLIQMIVLPIVISCLTVGIAGMGDIGELGRVGL
KTLIYFEILTTIALVVGMIFANVFHPGTYIDIHSLQSTDISSYVETAKHAKESSGLWSTIMNIIPTNIFSSLSEGNMMPI
ILFSVLFGLGITAIGKQGQILIDGLTAIQEVMFKITNWIMHLSPIGVCALIGVTIAQMGIDALKPLGLFILIAYVAMVFF
VIVVLGIVAKIHHVKFFQLLKVIKNELILAFSTASSEAALPKIIDKMQKYGVSQGIVSFVIPTGYTFNLDGSAIYQAVGA
LFLAQAYHINLSIGQQITLLVVLMITSKGMAGVPGASFVVLLATVSTIGVPMAGLTFIAGVDRIIDMGRTAVNVVGNSLA
AIIMGKSEGEFDEEKHAEYVKNI
>Mature_423_residues
MKKVRNWRLTLGWQILIGLILGVVLGAVFYHNQVAITAMQNIGTMFIHLIQMIVLPIVISCLTVGIAGMGDIGELGRVGL
KTLIYFEILTTIALVVGMIFANVFHPGTYIDIHSLQSTDISSYVETAKHAKESSGLWSTIMNIIPTNIFSSLSEGNMMPI
ILFSVLFGLGITAIGKQGQILIDGLTAIQEVMFKITNWIMHLSPIGVCALIGVTIAQMGIDALKPLGLFILIAYVAMVFF
VIVVLGIVAKIHHVKFFQLLKVIKNELILAFSTASSEAALPKIIDKMQKYGVSQGIVSFVIPTGYTFNLDGSAIYQAVGA
LFLAQAYHINLSIGQQITLLVVLMITSKGMAGVPGASFVVLLATVSTIGVPMAGLTFIAGVDRIIDMGRTAVNVVGNSLA
AIIMGKSEGEFDEEKHAEYVKNI

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=474, Percent_Identity=26.5822784810127, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI21314632, Length=429, Percent_Identity=28.2051282051282, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI66773030, Length=475, Percent_Identity=26.9473684210526, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI194239697, Length=478, Percent_Identity=25.9414225941423, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI169790839, Length=446, Percent_Identity=27.1300448430493, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI4827012, Length=268, Percent_Identity=32.4626865671642, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI5032093, Length=376, Percent_Identity=28.1914893617021, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI223468566, Length=250, Percent_Identity=30, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=30, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI262359914, Length=408, Percent_Identity=25.7352941176471, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI301601644, Length=128, Percent_Identity=39.0625, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1790514, Length=426, Percent_Identity=50.2347417840376, Blast_Score=440, Evalue=1e-125,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=38.4615384615385, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1788024, Length=394, Percent_Identity=25.3807106598985, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789473, Length=390, Percent_Identity=20.7692307692308, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=436, Percent_Identity=25.6880733944954, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI193206505, Length=427, Percent_Identity=26.6978922716628, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71996953, Length=472, Percent_Identity=26.6949152542373, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983106, Length=424, Percent_Identity=24.5283018867925, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983099, Length=424, Percent_Identity=24.5283018867925, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17541374, Length=420, Percent_Identity=24.7619047619048, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=419, Percent_Identity=25.0596658711217, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24583025, Length=394, Percent_Identity=25.6345177664975, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI17137668, Length=394, Percent_Identity=25.6345177664975, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24583023, Length=394, Percent_Identity=25.6345177664975, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI281360481, Length=457, Percent_Identity=27.3522975929978, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI281360483, Length=458, Percent_Identity=27.292576419214, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137666, Length=458, Percent_Identity=27.292576419214, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45514; Mature: 45514

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCC
>Mature Secondary Structure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HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]