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The map label for this gene is hemE [H]

Identifier: 116332460

GI number: 116332460

Start: 15375

End: 16397

Strand: Direct

Name: hemE [H]

Synonym: LBJ_4014

Alternate gene names: 116332460

Gene position: 15375-16397 (Clockwise)

Preceding gene: 116332459

Following gene: 116332461

Centisome position: 5.13

GC content: 41.94

Gene sequence:

>1023_bases
ATGCCAAGTAAACGATATTCGAACGCTATCAGCGGAGTCGCTCAGAAAATTCCTCCCGTATGGATGATGAGGCAGGCGGG
CCGTTATCATAAACACTACCAAACTCTCAGACAAAAATATACGTTTGAAGAACTTTGTAAAAATCCGGAATTGGCGGCGG
AAGTTGCCTTTGGTCCCGTAGACGAATTTGATTTTGACGTTGCGATTCTTTTTTCCGATATTCTTTTCTCATTGGAAGCT
TTGGGAATGGGACTTAGATACACGGATGCGGGACCGGTTTTGAATTTTTCGATCCGATCCGAAAAGGATTTGAAGAAGTT
AAAGCCTGTGGAAGATTCAATTTCTTTTATGCAGTTTCAAAAGAAGGCGATGCATTTAACCCGGGAAAGGATCCCCGAGG
ACAAATCAGTCATCGGATTCGTGGGCGGACCTTGGACTTTGTTCACGTATGCGGTTTCCGGAAAACATGAAGGAAATCTT
TCGCTTCCGAAAATTCTTACCGATGTTCGGAATGAATTTTTGGAAAAAATAATCCGATTTCTAAGAGAGAACATCTCTCT
TCAATTGGAAGGTGGAGCCGAGTTGGTCATGATCTTTGATACCGCGGGAGGAGATCTTTCTCCCGAATTGTTTCGTGAAA
TCGTAATTCCCGGAATAAAAATCTTAGCCGATAGTTATCCAGGCAAGGTCGGATATTATGGAAAAGGAACGACGTCTCCG
CATTTTCAAGCGGTTCAAAGGATTCCGACTCTTGCAGGTTTTGGATTCGATCATAGGTGGGATCTAAAGGAAATTTTTAA
AAATGAAAAAAGAATGGTTCAAGGAAATTTCGATCAAAACTTATTATTTATGGAGAAAGAGGAATTTAAGAGAACTCTCA
AGAGTTATTTAATGCCGTATCGGGATCTTTCACCCGAAGAGAGAATTGGTTGGGTTTGCGGACTCGGACACGGGGTCATG
CCCAAAACACCCGAAGAGAATGTGAAAAGTTTCGTAGAAATTGTAAGAGAGACGTTTCGATGA

Upstream 100 bases:

>100_bases
AATTCGATCGTAAGACTTAGGCATGCCTTTGGCAAGGAAGGGGAAAGGGTGATTCGATCCGTCAGGGGCGTCGGTTATCA
ATGGACCGGAGAAATCAAAG

Downstream 100 bases:

>100_bases
CGGTTGAAAAAGAGCTGATTGCAAAATACGATATTCCGGCGCCTCGATACACGAGTTATCCTACCGTACCTTATTGGTCC
GAGGATCCGACCACGGAAGA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MPSKRYSNAISGVAQKIPPVWMMRQAGRYHKHYQTLRQKYTFEELCKNPELAAEVAFGPVDEFDFDVAILFSDILFSLEA
LGMGLRYTDAGPVLNFSIRSEKDLKKLKPVEDSISFMQFQKKAMHLTRERIPEDKSVIGFVGGPWTLFTYAVSGKHEGNL
SLPKILTDVRNEFLEKIIRFLRENISLQLEGGAELVMIFDTAGGDLSPELFREIVIPGIKILADSYPGKVGYYGKGTTSP
HFQAVQRIPTLAGFGFDHRWDLKEIFKNEKRMVQGNFDQNLLFMEKEEFKRTLKSYLMPYRDLSPEERIGWVCGLGHGVM
PKTPEENVKSFVEIVRETFR

Sequences:

>Translated_340_residues
MPSKRYSNAISGVAQKIPPVWMMRQAGRYHKHYQTLRQKYTFEELCKNPELAAEVAFGPVDEFDFDVAILFSDILFSLEA
LGMGLRYTDAGPVLNFSIRSEKDLKKLKPVEDSISFMQFQKKAMHLTRERIPEDKSVIGFVGGPWTLFTYAVSGKHEGNL
SLPKILTDVRNEFLEKIIRFLRENISLQLEGGAELVMIFDTAGGDLSPELFREIVIPGIKILADSYPGKVGYYGKGTTSP
HFQAVQRIPTLAGFGFDHRWDLKEIFKNEKRMVQGNFDQNLLFMEKEEFKRTLKSYLMPYRDLSPEERIGWVCGLGHGVM
PKTPEENVKSFVEIVRETFR
>Mature_339_residues
PSKRYSNAISGVAQKIPPVWMMRQAGRYHKHYQTLRQKYTFEELCKNPELAAEVAFGPVDEFDFDVAILFSDILFSLEAL
GMGLRYTDAGPVLNFSIRSEKDLKKLKPVEDSISFMQFQKKAMHLTRERIPEDKSVIGFVGGPWTLFTYAVSGKHEGNLS
LPKILTDVRNEFLEKIIRFLRENISLQLEGGAELVMIFDTAGGDLSPELFREIVIPGIKILADSYPGKVGYYGKGTTSPH
FQAVQRIPTLAGFGFDHRWDLKEIFKNEKRMVQGNFDQNLLFMEKEEFKRTLKSYLMPYRDLSPEERIGWVCGLGHGVMP
KTPEENVKSFVEIVRETFR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=339, Percent_Identity=30.9734513274336, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI2367337, Length=350, Percent_Identity=30.5714285714286, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320252, Length=345, Percent_Identity=27.8260869565217, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI19921920, Length=338, Percent_Identity=28.4023668639053, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI221330099, Length=338, Percent_Identity=28.4023668639053, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38965; Mature: 38833

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00906 UROD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSKRYSNAISGVAQKIPPVWMMRQAGRYHKHYQTLRQKYTFEELCKNPELAAEVAFGPV
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCCCC
DEFDFDVAILFSDILFSLEALGMGLRYTDAGPVLNFSIRSEKDLKKLKPVEDSISFMQFQ
CCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCHHHHHHHCCHHHHHHHHHHH
KKAMHLTRERIPEDKSVIGFVGGPWTLFTYAVSGKHEGNLSLPKILTDVRNEFLEKIIRF
HHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
LRENISLQLEGGAELVMIFDTAGGDLSPELFREIVIPGIKILADSYPGKVGYYGKGTTSP
HHHCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCH
HFQAVQRIPTLAGFGFDHRWDLKEIFKNEKRMVQGNFDQNLLFMEKEEFKRTLKSYLMPY
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEECCCCCCCEEEECHHHHHHHHHHHCCCC
RDLSPEERIGWVCGLGHGVMPKTPEENVKSFVEIVRETFR
CCCCHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSKRYSNAISGVAQKIPPVWMMRQAGRYHKHYQTLRQKYTFEELCKNPELAAEVAFGPV
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCCCC
DEFDFDVAILFSDILFSLEALGMGLRYTDAGPVLNFSIRSEKDLKKLKPVEDSISFMQFQ
CCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCHHHHHHHCCHHHHHHHHHHH
KKAMHLTRERIPEDKSVIGFVGGPWTLFTYAVSGKHEGNLSLPKILTDVRNEFLEKIIRF
HHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
LRENISLQLEGGAELVMIFDTAGGDLSPELFREIVIPGIKILADSYPGKVGYYGKGTTSP
HHHCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCH
HFQAVQRIPTLAGFGFDHRWDLKEIFKNEKRMVQGNFDQNLLFMEKEEFKRTLKSYLMPY
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEECCCCCCCEEEECHHHHHHHHHHHCCCC
RDLSPEERIGWVCGLGHGVMPKTPEENVKSFVEIVRETFR
CCCCHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA