Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 116332461

GI number: 116332461

Start: 16394

End: 17743

Strand: Direct

Name: hemN [H]

Synonym: LBJ_4015

Alternate gene names: 116332461

Gene position: 16394-17743 (Clockwise)

Preceding gene: 116332460

Following gene: 116332462

Centisome position: 5.47

GC content: 42.15

Gene sequence:

>1350_bases
ATGACGGTTGAAAAAGAGCTGATTGCAAAATACGATATTCCGGCGCCTCGATACACGAGTTATCCTACCGTACCTTATTG
GTCCGAGGATCCGACCACGGAAGAATGGTTGAATAAGGTGAGGAATCGACTTCGTTCGGAAAACTCTTCCCTTTCCTTGT
ACTTGCATATCCCTTTTTGCGAAACCCTTTGTTCTTTTTGCGGATGTAATACTTCGATTACGAAGAATCATTCCGTAGAA
GATCCTTATGTTGAAACCATTCTAACGGAATATTCCAATTATCTAATTAAAATTCCCGAAATCTCTCAAAGGGAGTTGAA
AGAGATTCATCTGGGCGGAGGAACTCCGACGTATCTTTCTGAGAGAAATTTGGAGGCGCTTCTCCGTTCTATATTAGAAA
GAATGAATGTCTCTTCTGTGCCGGATTTTTCTCTCGAAGTGGATCCTCGTAGGACCAGAGATACGCAGTTGAAGGTTCTC
CATGATTTCGGTTTTAGAAGAATCAGTTTGGGAGTGCAAGACTTCGATCCGGAAGTGCAAAGGTTAGTGAATCGTACTCA
ACCTTTCGAAATGACGGAAAGGATCACAGAACTATCCAGAAAATTGGGATATACATCCGTAAATTTTGATCTCATTTACG
GGCTTCCAAAACAGAATCTGAAAAATATGAAACGGACCGTTGAAAAAACTTTGGAATTGCGTCCGGATCGGATTGCATTC
TACAGTTACGCGCATGTACCTTGGCTCAAAGCGGCGCAAAGATTGTTTACGGAGTCGGATCTTCCTTCCGGTCCTGAAAA
ACGCGAGTTGTATGAGGTTTCCAGAGAGATGTTTTTAAAAGCGGGTTATCTTGAGATCGGAATGGATCATTTTGCTTTGG
AATCGGATTCTCTTTCCCAGGCGGCAAAAAACGGAAATTTACATCGGAACTTTATGGGTTATACTTCTAAAACGACGGAT
TTACTTTTGGGTCTCGGAGTTTCCGCGATTTCGGATAGTTGGGATTGTTTTCACCAAAATGAGAAAATCGTTAAAAAATA
TCAAAAACGTGTCCGGGAAGAAGGGTTTGCCACGTTTAGGGGACATAAGCTTGACGAAGAGGATTTGATACAAAGATCGT
TGATTCTGCAATTATCGACGACGGGAACGGTTATAGTACCGGAGCGAATTTTGCAGGATGTGAAACTGTATTTGGCTTCT
ATGGAGGACGATACTTTAATTAGATGGGAAGGAAATCTTCTCTCTTTGACCGAAAAGGGTCGGCCTTTTCTTCGGAATGT
TTGCACCGGTTTGGATCTCAGATTACGGAGAAAAAGCCCGGAATTGAGGGTTTTTTCAAGGTCAATTTGA

Upstream 100 bases:

>100_bases
AGAGAATTGGTTGGGTTTGCGGACTCGGACACGGGGTCATGCCCAAAACACCCGAAGAGAATGTGAAAAGTTTCGTAGAA
ATTGTAAGAGAGACGTTTCG

Downstream 100 bases:

>100_bases
AATGATCCGGCTTTGGTCAAAAAATCGTCCAAAAAAATATAAGTAAAAAATGACAGTTTTAACAAACAAAAATTGTCGCT
TATCGCGGGAAGGCCTATTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MTVEKELIAKYDIPAPRYTSYPTVPYWSEDPTTEEWLNKVRNRLRSENSSLSLYLHIPFCETLCSFCGCNTSITKNHSVE
DPYVETILTEYSNYLIKIPEISQRELKEIHLGGGTPTYLSERNLEALLRSILERMNVSSVPDFSLEVDPRRTRDTQLKVL
HDFGFRRISLGVQDFDPEVQRLVNRTQPFEMTERITELSRKLGYTSVNFDLIYGLPKQNLKNMKRTVEKTLELRPDRIAF
YSYAHVPWLKAAQRLFTESDLPSGPEKRELYEVSREMFLKAGYLEIGMDHFALESDSLSQAAKNGNLHRNFMGYTSKTTD
LLLGLGVSAISDSWDCFHQNEKIVKKYQKRVREEGFATFRGHKLDEEDLIQRSLILQLSTTGTVIVPERILQDVKLYLAS
MEDDTLIRWEGNLLSLTEKGRPFLRNVCTGLDLRLRRKSPELRVFSRSI

Sequences:

>Translated_449_residues
MTVEKELIAKYDIPAPRYTSYPTVPYWSEDPTTEEWLNKVRNRLRSENSSLSLYLHIPFCETLCSFCGCNTSITKNHSVE
DPYVETILTEYSNYLIKIPEISQRELKEIHLGGGTPTYLSERNLEALLRSILERMNVSSVPDFSLEVDPRRTRDTQLKVL
HDFGFRRISLGVQDFDPEVQRLVNRTQPFEMTERITELSRKLGYTSVNFDLIYGLPKQNLKNMKRTVEKTLELRPDRIAF
YSYAHVPWLKAAQRLFTESDLPSGPEKRELYEVSREMFLKAGYLEIGMDHFALESDSLSQAAKNGNLHRNFMGYTSKTTD
LLLGLGVSAISDSWDCFHQNEKIVKKYQKRVREEGFATFRGHKLDEEDLIQRSLILQLSTTGTVIVPERILQDVKLYLAS
MEDDTLIRWEGNLLSLTEKGRPFLRNVCTGLDLRLRRKSPELRVFSRSI
>Mature_448_residues
TVEKELIAKYDIPAPRYTSYPTVPYWSEDPTTEEWLNKVRNRLRSENSSLSLYLHIPFCETLCSFCGCNTSITKNHSVED
PYVETILTEYSNYLIKIPEISQRELKEIHLGGGTPTYLSERNLEALLRSILERMNVSSVPDFSLEVDPRRTRDTQLKVLH
DFGFRRISLGVQDFDPEVQRLVNRTQPFEMTERITELSRKLGYTSVNFDLIYGLPKQNLKNMKRTVEKTLELRPDRIAFY
SYAHVPWLKAAQRLFTESDLPSGPEKRELYEVSREMFLKAGYLEIGMDHFALESDSLSQAAKNGNLHRNFMGYTSKTTDL
LLGLGVSAISDSWDCFHQNEKIVKKYQKRVREEGFATFRGHKLDEEDLIQRSLILQLSTTGTVIVPERILQDVKLYLASM
EDDTLIRWEGNLLSLTEKGRPFLRNVCTGLDLRLRRKSPELRVFSRSI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=246, Percent_Identity=25.609756097561, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI87082341, Length=454, Percent_Identity=40.0881057268723, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1789325, Length=233, Percent_Identity=29.1845493562232, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52087; Mature: 51956

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEKELIAKYDIPAPRYTSYPTVPYWSEDPTTEEWLNKVRNRLRSENSSLSLYLHIPFC
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHH
ETLCSFCGCNTSITKNHSVEDPYVETILTEYSNYLIKIPEISQRELKEIHLGGGTPTYLS
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHEECCCCCCCHHC
ERNLEALLRSILERMNVSSVPDFSLEVDPRRTRDTQLKVLHDFGFRRISLGVQDFDPEVQ
CCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCEEEECCCCCCCHHHH
RLVNRTQPFEMTERITELSRKLGYTSVNFDLIYGLPKQNLKNMKRTVEKTLELRPDRIAF
HHHHCCCCHHHHHHHHHHHHHCCCCEECEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEE
YSYAHVPWLKAAQRLFTESDLPSGPEKRELYEVSREMFLKAGYLEIGMDHFALESDSLSQ
EEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCHHHCCCCHHHHH
AAKNGNLHRNFMGYTSKTTDLLLGLGVSAISDSWDCFHQNEKIVKKYQKRVREEGFATFR
HHHCCCCCCHHCCCCCCHHHHHHHCCHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCEECC
GHKLDEEDLIQRSLILQLSTTGTVIVPERILQDVKLYLASMEDDTLIRWEGNLLSLTEKG
CCCCCHHHHHHHHHHEEEECCCCEEEHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCC
RPFLRNVCTGLDLRLRRKSPELRVFSRSI
CHHHHHHHCCCCEEEECCCCCEEHHCCCC
>Mature Secondary Structure 
TVEKELIAKYDIPAPRYTSYPTVPYWSEDPTTEEWLNKVRNRLRSENSSLSLYLHIPFC
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHH
ETLCSFCGCNTSITKNHSVEDPYVETILTEYSNYLIKIPEISQRELKEIHLGGGTPTYLS
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHEECCCCCCCHHC
ERNLEALLRSILERMNVSSVPDFSLEVDPRRTRDTQLKVLHDFGFRRISLGVQDFDPEVQ
CCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCEEEECCCCCCCHHHH
RLVNRTQPFEMTERITELSRKLGYTSVNFDLIYGLPKQNLKNMKRTVEKTLELRPDRIAF
HHHHCCCCHHHHHHHHHHHHHCCCCEECEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEE
YSYAHVPWLKAAQRLFTESDLPSGPEKRELYEVSREMFLKAGYLEIGMDHFALESDSLSQ
EEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCHHHCCCCHHHHH
AAKNGNLHRNFMGYTSKTTDLLLGLGVSAISDSWDCFHQNEKIVKKYQKRVREEGFATFR
HHHCCCCCCHHCCCCCCHHHHHHHCCHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCEECC
GHKLDEEDLIQRSLILQLSTTGTVIVPERILQDVKLYLASMEDDTLIRWEGNLLSLTEKG
CCCCCHHHHHHHHHHEEEECCCCEEEHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCC
RPFLRNVCTGLDLRLRRKSPELRVFSRSI
CHHHHHHHCCCCEEEECCCCCEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]