Click here to switch to the map view.

The map label for this gene is hemCD [H]

Identifier: 116332455

GI number: 116332455

Start: 9914

End: 11542

Strand: Direct

Name: hemCD [H]

Synonym: LBJ_4009

Alternate gene names: 116332455

Gene position: 9914-11542 (Clockwise)

Preceding gene: 116332454

Following gene: 116332456

Centisome position: 3.31

GC content: 43.59

Gene sequence:

>1629_bases
TTGTCCCGCGTTCTAAAGATCGCTTCCCGTAAAAGCGCTCTCGCAAAACTCCAAACCTATCTTGTACTCGACGCTCTAAA
AAAAAAATTTCCGAATATCCAAATCGAACTTCATTTTCGAGAAGCTTCGGGAGATCTGGATCTGCAGACTCCTCTCTGGA
AAATGGGAACGAGAGGTGTTTTTACACAAGATCTCACAAAGGATCTCGTGGAAAAAAAAGTGGATCTCGTGATCCATTCT
TGGAAGGACTTGGATCTGGAAGGCCATTCCGGAACGACAATCGTAGGCGTGTTGGATCGTGCCGATCAAAGAGACGTCCT
TCTTTGGAAAAAATCTTCCCTTTCTAAAAATTTTCCCTCGGAACTGAAAATTCAAACCTCTTCTCCGAGAAGGGAATATA
ATTTAAAAAAATTCTTAAATAATTCCCTTCCCTCCCGTTATAAAAATTCTTCGCTTATTTTTTTGCCGGTTCGGGGTAAT
ATTCAAACGAGAATCCGCAAATGGGGAAACTCCGATTCGGACGGTCTTGTGCTTGCCAAGGCGGCTTTGGATCGTCTTTT
GTCGGAAGATTTTTTGAATTCGAACGAATTAGAATATCAAGAAATACGAAAGTTCTTGAAAGAGATCTTAGAGGAATCGA
TCTTTCAGGTTCTTCCTCTTTCCTTAAGCCCTTCCGCTCCCGCACAGGGTGCGATCGCGGCGGAGGTGAGAACGGATGAC
GAGTGGGCTTTGAGTTTTGTCCGGGCTCTAAGTAAGCCTGAAGTCGTTTCCGCGGTGGAAGAGGAAAGAAATACCTTAAA
ACGTTTTGGCGGAGGTTGTCATCAAAAGATAGGCGTTTCGGTTCTTTACAAATCCTATGGAAAAATTTTATACCAAAAAG
GACTTACGGATTCCGGCGAAATTTTGGAAATCGAGGAACAATTCTCCGATACTTTTTTTCCTCCGGTCGAATCCGTTACA
AAAGCTTATCCGGTACCGGGAGAAGCGGTCAAACAAAAACGAATTCCCTTGGATTCTTCTCAAGGATTTGTTCTTTCCAG
GGACGGTAAAGAAGACAAGGTCATTCTTCCCGAAGAATTGATCCTAAAAGATTGGCTCGTAACCCGAGGTAATGCGTTTC
CGAATTTGGATCCATCCTTAAGGCACCAAGGTATTGTTTGGACTTCCGGCTTGAAAACTTGGTACCAACTCGCCGAAAGA
GATATTTGGGTTCATGGTTCCTTGGATGCTCTCGGAGAAGAGGAACTTCCCAAACATTCCATTTTTGGAATGTCCTTGGA
TTTCGTAAAATGTACACACGTAGGTTCCACGGAGATCGTTTCGGGTCTTGCGCGGATTCTTACGTATCGGACGCAACCTA
TGGAAGATCATCCCGATCTTTCCGAAAAAACTCATTTTTTTTGGATGAGTGCGTCTCAGTTCGACAAAGCGTTGTCTCTT
TTTCCTGGAATTCGGGATCGGTTTCACGCTTGCGGACCGGGAATTACTTCTTCCCATATCCGAAAAGTTCTGGGAGAATC
GGCGAACTTATCCGTTTTTGTACACTATGAGTCTTGGCTACAAAGTCTCGGACTTAAAGAATTCAAAGGAAAAGAGCTTG
GAAACCAAACAAAGAAGAATTCGCCTTAA

Upstream 100 bases:

>100_bases
CTTTGCAAATTCGAGAAAAAATCGGACCCGCTCTGAATGAGCTCGTCGAAGAGCGGGAATTTGAAACTCGGCAATTTATT
TTCGGTTGGGAAGATCTGAC

Downstream 100 bases:

>100_bases
TGTAGGACTCAGAGATCTTGCGTCTTCGGAGAGTCTGAATTCAAAAAAACTAATACAACCTCTTTTTATCGCAGAAGGTT
TAAAAGAAAAAGAGAAGATG

Product: bifunctional porphobilinogen deaminase/uroporphyrinogen synthase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGVFTQDLTKDLVEKKVDLVIHS
WKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPSELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGN
IQTRIRKWGNSDSDGLVLAKAALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD
EWALSFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGVSVLYKSYGKILYQKGLTDSGEILEIEEQFSDTFFPPVESVT
KAYPVPGEAVKQKRIPLDSSQGFVLSRDGKEDKVILPEELILKDWLVTRGNAFPNLDPSLRHQGIVWTSGLKTWYQLAER
DIWVHGSLDALGEEELPKHSIFGMSLDFVKCTHVGSTEIVSGLARILTYRTQPMEDHPDLSEKTHFFWMSASQFDKALSL
FPGIRDRFHACGPGITSSHIRKVLGESANLSVFVHYESWLQSLGLKEFKGKELGNQTKKNSP

Sequences:

>Translated_542_residues
MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGVFTQDLTKDLVEKKVDLVIHS
WKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPSELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGN
IQTRIRKWGNSDSDGLVLAKAALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD
EWALSFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGVSVLYKSYGKILYQKGLTDSGEILEIEEQFSDTFFPPVESVT
KAYPVPGEAVKQKRIPLDSSQGFVLSRDGKEDKVILPEELILKDWLVTRGNAFPNLDPSLRHQGIVWTSGLKTWYQLAER
DIWVHGSLDALGEEELPKHSIFGMSLDFVKCTHVGSTEIVSGLARILTYRTQPMEDHPDLSEKTHFFWMSASQFDKALSL
FPGIRDRFHACGPGITSSHIRKVLGESANLSVFVHYESWLQSLGLKEFKGKELGNQTKKNSP
>Mature_541_residues
SRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGVFTQDLTKDLVEKKVDLVIHSW
KDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPSELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNI
QTRIRKWGNSDSDGLVLAKAALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDDE
WALSFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGVSVLYKSYGKILYQKGLTDSGEILEIEEQFSDTFFPPVESVTK
AYPVPGEAVKQKRIPLDSSQGFVLSRDGKEDKVILPEELILKDWLVTRGNAFPNLDPSLRHQGIVWTSGLKTWYQLAERD
IWVHGSLDALGEEELPKHSIFGMSLDFVKCTHVGSTEIVSGLARILTYRTQPMEDHPDLSEKTHFFWMSASQFDKALSLF
PGIRDRFHACGPGITSSHIRKVLGESANLSVFVHYESWLQSLGLKEFKGKELGNQTKKNSP

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=319, Percent_Identity=29.153605015674, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI20149500, Length=319, Percent_Identity=29.153605015674, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI48994974, Length=278, Percent_Identity=32.0143884892086, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319996, Length=342, Percent_Identity=26.3157894736842, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI20130425, Length=284, Percent_Identity=31.6901408450704, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 61186; Mature: 61054

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHCCCCC
FTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCC
ELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNIQTRIRKWGNSDSDGLVLAK
CEEEECCCCCHHHHHHHHHCCCCCCHHCCCCEEEEECCCCHHHHHHHCCCCCCCCEEEHH
AALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCH
EWALSFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGVSVLYKSYGKILYQKGLTDSGE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
ILEIEEQFSDTFFPPVESVTKAYPVPGEAVKQKRIPLDSSQGFVLSRDGKEDKVILPEEL
EEEEHHHHCCCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCEECHHHH
ILKDWLVTRGNAFPNLDPSLRHQGIVWTSGLKTWYQLAERDIWVHGSLDALGEEELPKHS
HHHHHHHHCCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHCCEEEECCHHHCCCCCCCCCC
IFGMSLDFVKCTHVGSTEIVSGLARILTYRTQPMEDHPDLSEKTHFFWMSASQFDKALSL
CCCCEECEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHH
FPGIRDRFHACGPGITSSHIRKVLGESANLSVFVHYESWLQSLGLKEFKGKELGNQTKKN
CCCHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEHHHHHHHCCCHHHCCCHHCCCCCCC
SP
CC
>Mature Secondary Structure 
SRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHCCCCC
FTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCC
ELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNIQTRIRKWGNSDSDGLVLAK
CEEEECCCCCHHHHHHHHHCCCCCCHHCCCCEEEEECCCCHHHHHHHCCCCCCCCEEEHH
AALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCH
EWALSFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGVSVLYKSYGKILYQKGLTDSGE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
ILEIEEQFSDTFFPPVESVTKAYPVPGEAVKQKRIPLDSSQGFVLSRDGKEDKVILPEEL
EEEEHHHHCCCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCEECHHHH
ILKDWLVTRGNAFPNLDPSLRHQGIVWTSGLKTWYQLAERDIWVHGSLDALGEEELPKHS
HHHHHHHHCCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHCCEEEECCHHHCCCCCCCCCC
IFGMSLDFVKCTHVGSTEIVSGLARILTYRTQPMEDHPDLSEKTHFFWMSASQFDKALSL
CCCCEECEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHH
FPGIRDRFHACGPGITSSHIRKVLGESANLSVFVHYESWLQSLGLKEFKGKELGNQTKKN
CCCHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEHHHHHHHCCCHHHCCCHHCCCCCCC
SP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]