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The map label for this gene is coaB [H]

Identifier: 116329247

GI number: 116329247

Start: 3181697

End: 3182383

Strand: Direct

Name: coaB [H]

Synonym: LBL_2686

Alternate gene names: 116329247

Gene position: 3181697-3182383 (Clockwise)

Preceding gene: 116329246

Following gene: 116329248

Centisome position: 88.03

GC content: 40.47

Gene sequence:

>687_bases
GTGGGATTTTCCAAGGCTATCATTACATCCGGACCGACTAGAGAATGGATCGATCCAGTTCGATATATTTCAAACGCTTC
TTCAGGTAAAATGGGATTTCACATTGCAGAAGAAATCGGGAAATGGATCTCGAATGTTACTTACGTTTACGGCTTAGTTC
AAGAAGAATATAAAAGTCCCATCGGAATCAAAAGAGTTTCCGTGGAAACTACTTTAGAAATGTGTGATATCGTTCTTTCC
GAAATTCGATCCGACACTCTATTGGTTATGGCCGCCGCTCCGGCGGACTTCCGACCGGCCGAGAGTAAAGAAACCAAAAT
CAAAAAAGAGGACGGTCGTGAAACTCTGCTTTTGGAATTTGTAAAAAATCCGGACATTTTGAAGACCGTGAGTTCTAAGA
TTTTGAAAGATACAATCCACGGTTGTTGTTTGGTAGGTTTTGCGGCGGAAACGAATTCACTGGAAGAACACGCCATCGGC
AAGTTAAAAAATAAGAATCTGGATTATATCGTTGGAAACTATGTCGGGAAAAATGAAAAGGGCTTTGGCGAAGGAGAGAC
AAGTGTGATTATTTATTCTTCTTTTGGAAAAGCCGCAGAGATAGGACCTCTTCCAAAAGAAGTTGTTTCGGAAAAGATAG
TTGAGTTCTTGAAAAGGGAAACTTCAAAGACATTCGTAAATTTGTAG

Upstream 100 bases:

>100_bases
TGCGGAGATGAAGGTTATGGAAAGTTAGCCGAAATTTCTGTAATTCAAAAGTTAATTCTGGACGCGCACCAAAAAAATTC
TTAGATACAGAGAAATTTAA

Downstream 100 bases:

>100_bases
TTAGGCGCTATGTTAAAATCAAACTTATACCTTTTAAAGAGTAATTATTCAAAGGTAAAGTAAACATAATATGAGATTGG
ATAACTACGAAACAGCAATT

Product: phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MGFSKAIITSGPTREWIDPVRYISNASSGKMGFHIAEEIGKWISNVTYVYGLVQEEYKSPIGIKRVSVETTLEMCDIVLS
EIRSDTLLVMAAAPADFRPAESKETKIKKEDGRETLLLEFVKNPDILKTVSSKILKDTIHGCCLVGFAAETNSLEEHAIG
KLKNKNLDYIVGNYVGKNEKGFGEGETSVIIYSSFGKAAEIGPLPKEVVSEKIVEFLKRETSKTFVNL

Sequences:

>Translated_228_residues
MGFSKAIITSGPTREWIDPVRYISNASSGKMGFHIAEEIGKWISNVTYVYGLVQEEYKSPIGIKRVSVETTLEMCDIVLS
EIRSDTLLVMAAAPADFRPAESKETKIKKEDGRETLLLEFVKNPDILKTVSSKILKDTIHGCCLVGFAAETNSLEEHAIG
KLKNKNLDYIVGNYVGKNEKGFGEGETSVIIYSSFGKAAEIGPLPKEVVSEKIVEFLKRETSKTFVNL
>Mature_227_residues
GFSKAIITSGPTREWIDPVRYISNASSGKMGFHIAEEIGKWISNVTYVYGLVQEEYKSPIGIKRVSVETTLEMCDIVLSE
IRSDTLLVMAAAPADFRPAESKETKIKKEDGRETLLLEFVKNPDILKTVSSKILKDTIHGCCLVGFAAETNSLEEHAIGK
LKNKNLDYIVGNYVGKNEKGFGEGETSVIIYSSFGKAAEIGPLPKEVVSEKIVEFLKRETSKTFVNL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=191, Percent_Identity=43.979057591623, Blast_Score=130, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 25201; Mature: 25070

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFSKAIITSGPTREWIDPVRYISNASSGKMGFHIAEEIGKWISNVTYVYGLVQEEYKSP
CCCCCCEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IGIKRVSVETTLEMCDIVLSEIRSDTLLVMAAAPADFRPAESKETKIKKEDGRETLLLEF
CCEEEEHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHCHHCCCCHHHHHHH
VKNPDILKTVSSKILKDTIHGCCLVGFAAETNSLEEHAIGKLKNKNLDYIVGNYVGKNEK
HCCCHHHHHHHHHHHHHHHHHHHEEEEHHCCCCHHHHHHHHHCCCCCCEEECCCCCCCCC
GFGEGETSVIIYSSFGKAAEIGPLPKEVVSEKIVEFLKRETSKTFVNL
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GFSKAIITSGPTREWIDPVRYISNASSGKMGFHIAEEIGKWISNVTYVYGLVQEEYKSP
CCCCCEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IGIKRVSVETTLEMCDIVLSEIRSDTLLVMAAAPADFRPAESKETKIKKEDGRETLLLEF
CCEEEEHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHCHHCCCCHHHHHHH
VKNPDILKTVSSKILKDTIHGCCLVGFAAETNSLEEHAIGKLKNKNLDYIVGNYVGKNEK
HCCCHHHHHHHHHHHHHHHHHHHEEEEHHCCCCHHHHHHHHHCCCCCCEEECCCCCCCCC
GFGEGETSVIIYSSFGKAAEIGPLPKEVVSEKIVEFLKRETSKTFVNL
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]