| Definition | Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_008508 |
| Length | 3,614,446 |
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The map label for this gene is coaC [H]
Identifier: 116329246
GI number: 116329246
Start: 3181138
End: 3181680
Strand: Direct
Name: coaC [H]
Synonym: LBL_2685
Alternate gene names: 116329246
Gene position: 3181138-3181680 (Clockwise)
Preceding gene: 116329245
Following gene: 116329247
Centisome position: 88.01
GC content: 47.51
Gene sequence:
>543_bases ATGTCCAATTTCGGAAAAGAAATACTCGTTGCCGTTTCAGGAAGTATAGCGGCCTATAAAGCCTGCGAACTTGTGCGAAA TCTCACAAAAGAAGGTTACCCTGTCGGCGTGATTATGACCGCACACGCGACTCAGTTTGTCGGTCCGATTACGTTCGAAG CAATGACAGGCAAAAAAGTTCGAGTCGACGAATACGAACAAGGAATGGCTCATATCGATGCAAAAAATTCCGCCTCCGTG ATCGCAGTGGTTCCCGCGACCGCGAACATCATCGGTAAGATGGCAAATGGAATTGCGGACGATCTCGTAACTTCCGCGTA TCTTGCGGCAACTTGTCCGGTGATCGTCGCTCCAGCGATGAATCCTTTTATGTACGCACATCCGGCGGTTCAGAGAAATT TAAAACGTTTAGCGGACGACGGAGTGATTCTCGCGGATCCTTCCGAAGGTGTGGTCGTTTGCGGAGATGAAGGTTATGGA AAGTTAGCCGAAATTTCTGTAATTCAAAAGTTAATTCTGGACGCGCACCAAAAAAATTCTTAG
Upstream 100 bases:
>100_bases GAGAAAATGGAAGGGAATAAAATTCTTTCCGTACGTTTTACAAGAGTCGGCTTAGGCAATAAGGTTCAGTCTAAGAAATA AAATCGGATATAATATGTCT
Downstream 100 bases:
>100_bases ATACAGAGAAATTTAAGTGGGATTTTCCAAGGCTATCATTACATCCGGACCGACTAGAGAATGGATCGATCCAGTTCGAT ATATTTCAAACGCTTCTTCA
Product: phosphopantothenoylcysteine decarboxylase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 180; Mature: 179
Protein sequence:
>180_residues MSNFGKEILVAVSGSIAAYKACELVRNLTKEGYPVGVIMTAHATQFVGPITFEAMTGKKVRVDEYEQGMAHIDAKNSASV IAVVPATANIIGKMANGIADDLVTSAYLAATCPVIVAPAMNPFMYAHPAVQRNLKRLADDGVILADPSEGVVVCGDEGYG KLAEISVIQKLILDAHQKNS
Sequences:
>Translated_180_residues MSNFGKEILVAVSGSIAAYKACELVRNLTKEGYPVGVIMTAHATQFVGPITFEAMTGKKVRVDEYEQGMAHIDAKNSASV IAVVPATANIIGKMANGIADDLVTSAYLAATCPVIVAPAMNPFMYAHPAVQRNLKRLADDGVILADPSEGVVVCGDEGYG KLAEISVIQKLILDAHQKNS >Mature_179_residues SNFGKEILVAVSGSIAAYKACELVRNLTKEGYPVGVIMTAHATQFVGPITFEAMTGKKVRVDEYEQGMAHIDAKNSASVI AVVPATANIIGKMANGIADDLVTSAYLAATCPVIVAPAMNPFMYAHPAVQRNLKRLADDGVILADPSEGVVVCGDEGYGK LAEISVIQKLILDAHQKNS
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=170, Percent_Identity=34.1176470588235, Blast_Score=86, Evalue=2e-17, Organism=Escherichia coli, GI87082301, Length=168, Percent_Identity=42.2619047619048, Blast_Score=121, Evalue=2e-29, Organism=Saccharomyces cerevisiae, GI6322762, Length=186, Percent_Identity=27.9569892473118, Blast_Score=75, Evalue=7e-15, Organism=Drosophila melanogaster, GI24657262, Length=184, Percent_Identity=29.3478260869565, Blast_Score=85, Evalue=3e-17,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 18976; Mature: 18845
Theoretical pI: Translated: 6.09; Mature: 6.09
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.7 %Cys (Translated Protein) 3.9 %Met (Translated Protein) 5.6 %Cys+Met (Translated Protein) 1.7 %Cys (Mature Protein) 3.4 %Met (Mature Protein) 5.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSNFGKEILVAVSGSIAAYKACELVRNLTKEGYPVGVIMTAHATQFVGPITFEAMTGKKV CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCEEEEECCCCEE RVDEYEQGMAHIDAKNSASVIAVVPATANIIGKMANGIADDLVTSAYLAATCPVIVAPAM ECCHHHCCHHEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCC NPFMYAHPAVQRNLKRLADDGVILADPSEGVVVCGDEGYGKLAEISVIQKLILDAHQKNS CCHHHCCHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCC >Mature Secondary Structure SNFGKEILVAVSGSIAAYKACELVRNLTKEGYPVGVIMTAHATQFVGPITFEAMTGKKV CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCEEEEECCCCEE RVDEYEQGMAHIDAKNSASVIAVVPATANIIGKMANGIADDLVTSAYLAATCPVIVAPAM ECCHHHCCHHEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCC NPFMYAHPAVQRNLKRLADDGVILADPSEGVVVCGDEGYGKLAEISVIQKLILDAHQKNS CCHHHCCHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9534248; 9384377 [H]