Click here to switch to the map view.

The map label for this gene is yrkA [H]

Identifier: 116329245

GI number: 116329245

Start: 3179784

End: 3181118

Strand: Direct

Name: yrkA [H]

Synonym: LBL_2684

Alternate gene names: 116329245

Gene position: 3179784-3181118 (Clockwise)

Preceding gene: 116329244

Following gene: 116329246

Centisome position: 87.97

GC content: 41.2

Gene sequence:

>1335_bases
ATGGAATTAATCGGCTTTTTTATCATCGTACTACTTATATTCGCCAATGGATTTTTCGTTTCCGCAGAATTCGCTTTGGT
TTCGATTCGTCCATCCCGTTTGGAAGAATTGATTAAGGAAAATAAACCTCTCGCGCTCGTCACAAAACGAGCCGCTCAAA
AATTGAACGATATGTTGTCCGTCTGCCAGGTCGGAATCACAATCGCCAGTCTTTTGTTAGGTTGGGTCGGCGAAGGATAC
GTTTCAAGATGGCTTGTTTTTCTTCTAGAAATGTTCGGGCATTCCTCAAGCGAGGCTACAATTCACGGTTTGGCGATCAC
GATTTCGTTCACGATCATCACGTTTCTTCATATTCTTTTGGGAGAACTTCTTCCTAAAACGATCGCAATTCAGAATACGG
AAACGATCGCTCTTTTTATCAGTATTCCTTTATTCTTCTTTTATTATATATTCTATCCGATCACTTTTTTCTTAAACGAG
TTGACTTCCTTTCTTTTGAGGTTGATGGGAATCCAAGCCAATAAGAGTAGAATGATGCACTCCCCCGAAGAATTGATGAT
TATCATAGAAGAACAAAATAAACAGGGGAAGATCGACCAGGAAGAATTTCAGATCATCCAAAACACGTTCCAGTTTTCAG
AACATCAGGCAAAGGACGTAATGACTCATCGTTTGAGTATCATAGGCATTCCGCACGATACCATGATGGATTCCTTGATT
TCGATCATCGCGGAACATCATTTTTCGAGATATCCGATCTACGAAGGCAACACGGATAAGATCATAGGAATCATTCACGT
TCAAACGTATCTTACTTGGTTATCCAATTCCAAAAAAGGAAGAAAGGAAAAAGTAACGGCTATTATGCAACCTCCAATTT
TCGTCCCCGAGGGTCTTTCGATCGAAAAGGTGATGCAAAAACTCAGAGAAAACAAACAGCATATGGCGATCGTTATCGAC
GAATACGGCGGAGTTTCCGGCCTTCTTACTTTAGAGGATATCATCGAGGAAATTTTCGGACAGATTCGCGATGAAACCGA
CGATCACGAGACGGATCCATTTCCCACACAACATTCCGATAGTTTTACAATCGACGGGGCTGCGGAGTTGGACGATCTGA
AAGAAATTCTCGTAGGTGTTCAAGAAGAAGAGATCAAGGACATCCGCACGATTGCGGGTTTTATTTTAGGTCGTTTAGAA
GATATGCCGGAAGAAGGTTCTACGATTACTTTACAATCAGGAACTCTTACCGTCGAGAAAATGGAAGGGAATAAAATTCT
TTCCGTACGTTTTACAAGAGTCGGCTTAGGCAATAAGGTTCAGTCTAAGAAATAA

Upstream 100 bases:

>100_bases
GTCAGTTCTACACACTCAATTGCCGTTCCTCAAATCCAAAAATAAGGTTCATTCTAAATTCACACTATTTTAAATTTCAT
CTGATCTTTATTCTCCCACA

Downstream 100 bases:

>100_bases
AATCGGATATAATATGTCTATGTCCAATTTCGGAAAAGAAATACTCGTTGCCGTTTCAGGAAGTATAGCGGCCTATAAAG
CCTGCGAACTTGTGCGAAAT

Product: hemolysin C-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MELIGFFIIVLLIFANGFFVSAEFALVSIRPSRLEELIKENKPLALVTKRAAQKLNDMLSVCQVGITIASLLLGWVGEGY
VSRWLVFLLEMFGHSSSEATIHGLAITISFTIITFLHILLGELLPKTIAIQNTETIALFISIPLFFFYYIFYPITFFLNE
LTSFLLRLMGIQANKSRMMHSPEELMIIIEEQNKQGKIDQEEFQIIQNTFQFSEHQAKDVMTHRLSIIGIPHDTMMDSLI
SIIAEHHFSRYPIYEGNTDKIIGIIHVQTYLTWLSNSKKGRKEKVTAIMQPPIFVPEGLSIEKVMQKLRENKQHMAIVID
EYGGVSGLLTLEDIIEEIFGQIRDETDDHETDPFPTQHSDSFTIDGAAELDDLKEILVGVQEEEIKDIRTIAGFILGRLE
DMPEEGSTITLQSGTLTVEKMEGNKILSVRFTRVGLGNKVQSKK

Sequences:

>Translated_444_residues
MELIGFFIIVLLIFANGFFVSAEFALVSIRPSRLEELIKENKPLALVTKRAAQKLNDMLSVCQVGITIASLLLGWVGEGY
VSRWLVFLLEMFGHSSSEATIHGLAITISFTIITFLHILLGELLPKTIAIQNTETIALFISIPLFFFYYIFYPITFFLNE
LTSFLLRLMGIQANKSRMMHSPEELMIIIEEQNKQGKIDQEEFQIIQNTFQFSEHQAKDVMTHRLSIIGIPHDTMMDSLI
SIIAEHHFSRYPIYEGNTDKIIGIIHVQTYLTWLSNSKKGRKEKVTAIMQPPIFVPEGLSIEKVMQKLRENKQHMAIVID
EYGGVSGLLTLEDIIEEIFGQIRDETDDHETDPFPTQHSDSFTIDGAAELDDLKEILVGVQEEEIKDIRTIAGFILGRLE
DMPEEGSTITLQSGTLTVEKMEGNKILSVRFTRVGLGNKVQSKK
>Mature_444_residues
MELIGFFIIVLLIFANGFFVSAEFALVSIRPSRLEELIKENKPLALVTKRAAQKLNDMLSVCQVGITIASLLLGWVGEGY
VSRWLVFLLEMFGHSSSEATIHGLAITISFTIITFLHILLGELLPKTIAIQNTETIALFISIPLFFFYYIFYPITFFLNE
LTSFLLRLMGIQANKSRMMHSPEELMIIIEEQNKQGKIDQEEFQIIQNTFQFSEHQAKDVMTHRLSIIGIPHDTMMDSLI
SIIAEHHFSRYPIYEGNTDKIIGIIHVQTYLTWLSNSKKGRKEKVTAIMQPPIFVPEGLSIEKVMQKLRENKQHMAIVID
EYGGVSGLLTLEDIIEEIFGQIRDETDDHETDPFPTQHSDSFTIDGAAELDDLKEILVGVQEEEIKDIRTIAGFILGRLE
DMPEEGSTITLQSGTLTVEKMEGNKILSVRFTRVGLGNKVQSKK

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=378, Percent_Identity=37.5661375661376, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI94681046, Length=291, Percent_Identity=26.1168384879725, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI40068053, Length=351, Percent_Identity=24.5014245014245, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI40068055, Length=351, Percent_Identity=24.5014245014245, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI145693175, Length=415, Percent_Identity=24.578313253012, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1790664, Length=429, Percent_Identity=22.8438228438228, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786879, Length=248, Percent_Identity=26.6129032258064, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87082033, Length=306, Percent_Identity=22.5490196078431, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788119, Length=264, Percent_Identity=27.6515151515151, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980512, Length=370, Percent_Identity=25.6756756756757, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324512, Length=246, Percent_Identity=23.9837398373984, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 50330; Mature: 50330

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIGFFIIVLLIFANGFFVSAEFALVSIRPSRLEELIKENKPLALVTKRAAQKLNDMLS
CHHHHHHHHHHHHHHCCCEEEEEEEEEEECHHHHHHHHHCCCCEEEHHHHHHHHHHHHHH
VCQVGITIASLLLGWVGEGYVSRWLVFLLEMFGHSSSEATIHGLAITISFTIITFLHILL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHH
GELLPKTIAIQNTETIALFISIPLFFFYYIFYPITFFLNELTSFLLRLMGIQANKSRMMH
HHHCCHHEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
SPEELMIIIEEQNKQGKIDQEEFQIIQNTFQFSEHQAKDVMTHRLSIIGIPHDTMMDSLI
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHH
SIIAEHHFSRYPIYEGNTDKIIGIIHVQTYLTWLSNSKKGRKEKVTAIMQPPIFVPEGLS
HHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
IEKVMQKLRENKQHMAIVIDEYGGVSGLLTLEDIIEEIFGQIRDETDDHETDPFPTQHSD
HHHHHHHHHCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
SFTIDGAAELDDLKEILVGVQEEEIKDIRTIAGFILGRLEDMPEEGSTITLQSGTLTVEK
CEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEE
MEGNKILSVRFTRVGLGNKVQSKK
ECCCEEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MELIGFFIIVLLIFANGFFVSAEFALVSIRPSRLEELIKENKPLALVTKRAAQKLNDMLS
CHHHHHHHHHHHHHHCCCEEEEEEEEEEECHHHHHHHHHCCCCEEEHHHHHHHHHHHHHH
VCQVGITIASLLLGWVGEGYVSRWLVFLLEMFGHSSSEATIHGLAITISFTIITFLHILL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHH
GELLPKTIAIQNTETIALFISIPLFFFYYIFYPITFFLNELTSFLLRLMGIQANKSRMMH
HHHCCHHEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
SPEELMIIIEEQNKQGKIDQEEFQIIQNTFQFSEHQAKDVMTHRLSIIGIPHDTMMDSLI
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHH
SIIAEHHFSRYPIYEGNTDKIIGIIHVQTYLTWLSNSKKGRKEKVTAIMQPPIFVPEGLS
HHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
IEKVMQKLRENKQHMAIVIDEYGGVSGLLTLEDIIEEIFGQIRDETDDHETDPFPTQHSD
HHHHHHHHHCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
SFTIDGAAELDDLKEILVGVQEEEIKDIRTIAGFILGRLEDMPEEGSTITLQSGTLTVEK
CEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEE
MEGNKILSVRFTRVGLGNKVQSKK
ECCCEEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]