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The map label for this gene is lpxA [H]

Identifier: 116329231

GI number: 116329231

Start: 3163017

End: 3163796

Strand: Direct

Name: lpxA [H]

Synonym: LBL_2669

Alternate gene names: 116329231

Gene position: 3163017-3163796 (Clockwise)

Preceding gene: 116329230

Following gene: 116329232

Centisome position: 87.51

GC content: 42.69

Gene sequence:

>780_bases
ATGAAAATACATCCGACTGCCGTCATCGACCCGAAAACAGAATTACATGAATCAGTCGAAGTCGGTCCTTACTCCATTAT
CGAAGGAAATGTTTCCATTCAAGAAGGTACCGTAATTGAAAGCCACGTAAAAATTTGCGCGGGTTCGGAGATCGGAAAAT
TCAATCGTTTTCATCAAGGCGCCGTAATCGGAGTAATGCCTCAGGATTTGGGATTTAATCAACAACTTTTAACTCGAACC
GTAATCGGCGACCATAATATTTTCCGAGAATACTCAAATATCCATAAAGGAACCAAAGAGGATTCTCCGACGGTAATCGG
TAATAAAAACTATTTTATGGGAAATTCTCACGTTGGTCACGATTGTATTCTAGGAAATAATAATATTCTTACGCACGGTT
GTGTGTTAGCCGGTCACGTAACTTTGGGTAATTTTGTGTTTATCTCCGGTTTGGCAGCGGTTCATCAGTTTTGTTTTGTC
GGAGACTACGCAATGGTCGCGGGACTTGCAAAGGTCGTCCAGGATGTTCCTCCTTATTCCACGGTCGACGGAAATCCTAG
TACGGTAGTAGGTCTGAACAGCATCGGTTTGAAACGCGCCGGTTTTTCTCCGGAAGTAAGAAACGCAATTAAACAGGCCT
ATAAAATCATTTATCATTCGGGAATGCCGACTAGAAAAGCCTTGGATGAGCTGGAGGTTTCGAGCGACCCGATCGAGGAA
GTAAAGTATATTATAAAATTCTTTAGAGATAGCGATAGAGGAGTGACAAGCCACAGGTGA

Upstream 100 bases:

>100_bases
CTACTTTCCGGTAAACATTACGCCTGTTCAAGACATCTTTAAAAGCTTGAATAAAAAAGCAGAACCGATTTTTGTATTTT
AGAGTCAAAGTGAGGTTTAA

Downstream 100 bases:

>100_bases
GATTACTAATTACGGGGGGTGCAGGTTACATCGGAAGTCATATAGTCGCACTTCTTCTTGAAAAAAAGCACGAAATTTTA
ATCGTAGATAATCTTGAAAA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MKIHPTAVIDPKTELHESVEVGPYSIIEGNVSIQEGTVIESHVKICAGSEIGKFNRFHQGAVIGVMPQDLGFNQQLLTRT
VIGDHNIFREYSNIHKGTKEDSPTVIGNKNYFMGNSHVGHDCILGNNNILTHGCVLAGHVTLGNFVFISGLAAVHQFCFV
GDYAMVAGLAKVVQDVPPYSTVDGNPSTVVGLNSIGLKRAGFSPEVRNAIKQAYKIIYHSGMPTRKALDELEVSSDPIEE
VKYIIKFFRDSDRGVTSHR

Sequences:

>Translated_259_residues
MKIHPTAVIDPKTELHESVEVGPYSIIEGNVSIQEGTVIESHVKICAGSEIGKFNRFHQGAVIGVMPQDLGFNQQLLTRT
VIGDHNIFREYSNIHKGTKEDSPTVIGNKNYFMGNSHVGHDCILGNNNILTHGCVLAGHVTLGNFVFISGLAAVHQFCFV
GDYAMVAGLAKVVQDVPPYSTVDGNPSTVVGLNSIGLKRAGFSPEVRNAIKQAYKIIYHSGMPTRKALDELEVSSDPIEE
VKYIIKFFRDSDRGVTSHR
>Mature_259_residues
MKIHPTAVIDPKTELHESVEVGPYSIIEGNVSIQEGTVIESHVKICAGSEIGKFNRFHQGAVIGVMPQDLGFNQQLLTRT
VIGDHNIFREYSNIHKGTKEDSPTVIGNKNYFMGNSHVGHDCILGNNNILTHGCVLAGHVTLGNFVFISGLAAVHQFCFV
GDYAMVAGLAKVVQDVPPYSTVDGNPSTVVGLNSIGLKRAGFSPEVRNAIKQAYKIIYHSGMPTRKALDELEVSSDPIEE
VKYIIKFFRDSDRGVTSHR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=254, Percent_Identity=42.1259842519685, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI1786376, Length=198, Percent_Identity=25.7575757575758, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28288; Mature: 28288

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHPTAVIDPKTELHESVEVGPYSIIEGNVSIQEGTVIESHVKICAGSEIGKFNRFHQG
CCCCCCEEECCHHHHHHHHCCCCEEEEECCEEECCCCEEHHHHHHHCCCCCHHHHHHHCC
AVIGVMPQDLGFNQQLLTRTVIGDHNIFREYSNIHKGTKEDSPTVIGNKNYFMGNSHVGH
CEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEECCCCEEECCCCCCC
DCILGNNNILTHGCVLAGHVTLGNFVFISGLAAVHQFCFVGDYAMVAGLAKVVQDVPPYS
EEEECCCCEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
TVDGNPSTVVGLNSIGLKRAGFSPEVRNAIKQAYKIIYHSGMPTRKALDELEVSSDPIEE
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHH
VKYIIKFFRDSDRGVTSHR
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKIHPTAVIDPKTELHESVEVGPYSIIEGNVSIQEGTVIESHVKICAGSEIGKFNRFHQG
CCCCCCEEECCHHHHHHHHCCCCEEEEECCEEECCCCEEHHHHHHHCCCCCHHHHHHHCC
AVIGVMPQDLGFNQQLLTRTVIGDHNIFREYSNIHKGTKEDSPTVIGNKNYFMGNSHVGH
CEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEECCCCEEECCCCCCC
DCILGNNNILTHGCVLAGHVTLGNFVFISGLAAVHQFCFVGDYAMVAGLAKVVQDVPPYS
EEEECCCCEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
TVDGNPSTVVGLNSIGLKRAGFSPEVRNAIKQAYKIIYHSGMPTRKALDELEVSSDPIEE
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHH
VKYIIKFFRDSDRGVTSHR
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA