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The map label for this gene is lpxD-2 [H]

Identifier: 116329203

GI number: 116329203

Start: 3121681

End: 3122697

Strand: Direct

Name: lpxD-2 [H]

Synonym: LBL_2633

Alternate gene names: 116329203

Gene position: 3121681-3122697 (Clockwise)

Preceding gene: 116329202

Following gene: 116329204

Centisome position: 86.37

GC content: 43.26

Gene sequence:

>1017_bases
ATGAAAGCCAAAGATTTAGCAAAAACGCTCGGAGTAGCACTTAAGGGCAACGGAGAACTGGACGTCAACGGAATCGGAGA
CATTGAAAACCATTCGAACGTTTTACCGGATCGAATTTATTACTTCGAAGCAAAAAAATATTTTAGTTCTAATCCGAAAG
CGAAGCAGGTTCAATTGGCGCTGACCATTCCTTCTTTGGCCGATGAGTTTGCCTCGGCATTGATCGTACCGGAACATGAA
GCAAGACTGAAATTTATCGAGTTACTTTCTCTCTTTGAAAAGAAACCAAAACTCCCCACTACTTTGATCTCAGACAAAGC
GAGTATTCATGAAAGTGCTCGATTAGGAAAAAATGTTACGATCATGGACTTTGTCGTAATCCAGGAAAATGTGGAAATTG
GAGACAATTGCCAAATTTATCCGAACGTCATCGTGGAAAGCGGGGCTAAGATCGGAGAAAACACGGTATTGAAATCGGGA
GTTGTGATTGGTTACAATTGTATTCTTGGAAAACATAACCTCATTCATTCGAATACCGTAATCGGAGCGGACGGTTTCGG
TTTTTATGATCAGGGGGGAGTACGTTATAAAATTCCTCAAATCGGAAATTCCGTAATCGGAGACTATGTGGAAATGGGCG
CTTGTTGTACTGTGGACCGTGCGACAATCGAAACTACAACTGTCGGAAATCATACGAAATTCGACGATCATGTTCATATC
GCTCATAATTGTAGAGTCGGAAACTATGTCTATATTGCCGGTGGCGCAGGTCTTGCCGGTTCTGTTACTCTGGAAGATGG
AGTTATCATAGGAGGTCGTGCGGCGATCATGGGAGGAATCACGATGAAAAAAGGATCGATTCTGATGGGAATGTCCGGTC
TTGGTGAAGATACTGCCGAGAAAGCCGCTTACTTCGGTTTTCCCGCAAAGCCCGCCTTGGAAATGCATAGAATTCACTTC
TCCCTGTCTAAACTTCCCGAACTTGTGAGAGAACATAGGAATCGTTCTAAGAACTAA

Upstream 100 bases:

>100_bases
AATCTTTTATAAAGAACCGTGTCCGTTTTTCATCGTGTAACAAATCTTAAATATAAAAAACGAGTTGAGTCCTTTTTTTA
TATGAGAAAAATTTGATCTT

Downstream 100 bases:

>100_bases
GAACCGGCAAACGACCCATGGAAATGAAGATGATCAAGTTTACAACACCGCTTTTGCGGTGTTGTTTTTGGTTTTTACAC
CGTAGCTATTTTAGAGACTA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N- acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKAKDLAKTLGVALKGNGELDVNGIGDIENHSNVLPDRIYYFEAKKYFSSNPKAKQVQLALTIPSLADEFASALIVPEHE
ARLKFIELLSLFEKKPKLPTTLISDKASIHESARLGKNVTIMDFVVIQENVEIGDNCQIYPNVIVESGAKIGENTVLKSG
VVIGYNCILGKHNLIHSNTVIGADGFGFYDQGGVRYKIPQIGNSVIGDYVEMGACCTVDRATIETTTVGNHTKFDDHVHI
AHNCRVGNYVYIAGGAGLAGSVTLEDGVIIGGRAAIMGGITMKKGSILMGMSGLGEDTAEKAAYFGFPAKPALEMHRIHF
SLSKLPELVREHRNRSKN

Sequences:

>Translated_338_residues
MKAKDLAKTLGVALKGNGELDVNGIGDIENHSNVLPDRIYYFEAKKYFSSNPKAKQVQLALTIPSLADEFASALIVPEHE
ARLKFIELLSLFEKKPKLPTTLISDKASIHESARLGKNVTIMDFVVIQENVEIGDNCQIYPNVIVESGAKIGENTVLKSG
VVIGYNCILGKHNLIHSNTVIGADGFGFYDQGGVRYKIPQIGNSVIGDYVEMGACCTVDRATIETTTVGNHTKFDDHVHI
AHNCRVGNYVYIAGGAGLAGSVTLEDGVIIGGRAAIMGGITMKKGSILMGMSGLGEDTAEKAAYFGFPAKPALEMHRIHF
SLSKLPELVREHRNRSKN
>Mature_338_residues
MKAKDLAKTLGVALKGNGELDVNGIGDIENHSNVLPDRIYYFEAKKYFSSNPKAKQVQLALTIPSLADEFASALIVPEHE
ARLKFIELLSLFEKKPKLPTTLISDKASIHESARLGKNVTIMDFVVIQENVEIGDNCQIYPNVIVESGAKIGENTVLKSG
VVIGYNCILGKHNLIHSNTVIGADGFGFYDQGGVRYKIPQIGNSVIGDYVEMGACCTVDRATIETTTVGNHTKFDDHVHI
AHNCRVGNYVYIAGGAGLAGSVTLEDGVIIGGRAAIMGGITMKKGSILMGMSGLGEDTAEKAAYFGFPAKPALEMHRIHF
SLSKLPELVREHRNRSKN

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=312, Percent_Identity=32.0512820512821, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1786378, Length=203, Percent_Identity=30.5418719211823, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36543; Mature: 36543

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKDLAKTLGVALKGNGELDVNGIGDIENHSNVLPDRIYYFEAKKYFSSNPKAKQVQLA
CCHHHHHHHHCEEEECCCEEEECCCCCCCCCCCCCCCEEEEEEEHHHHCCCCCCEEEEEE
LTIPSLADEFASALIVPEHEARLKFIELLSLFEKKPKLPTTLISDKASIHESARLGKNVT
EECHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHCCCCCE
IMDFVVIQENVEIGDNCQIYPNVIVESGAKIGENTVLKSGVVIGYNCILGKHNLIHSNTV
EEEEEEEECCCCCCCCCEECCCCEEECCCCCCCCCEECCCEEEEEEEEECCCCEEECCEE
IGADGFGFYDQGGVRYKIPQIGNSVIGDYVEMGACCTVDRATIETTTVGNHTKFDDHVHI
EECCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCCEEE
AHNCRVGNYVYIAGGAGLAGSVTLEDGVIIGGRAAIMGGITMKKGSILMGMSGLGEDTAE
EECCEECCEEEEECCCCCCCEEEECCCEEECCCHHEECCEEEECCCEEEECCCCCCCHHH
KAAYFGFPAKPALEMHRIHFSLSKLPELVREHRNRSKN
HHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKAKDLAKTLGVALKGNGELDVNGIGDIENHSNVLPDRIYYFEAKKYFSSNPKAKQVQLA
CCHHHHHHHHCEEEECCCEEEECCCCCCCCCCCCCCCEEEEEEEHHHHCCCCCCEEEEEE
LTIPSLADEFASALIVPEHEARLKFIELLSLFEKKPKLPTTLISDKASIHESARLGKNVT
EECHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHCCCCCE
IMDFVVIQENVEIGDNCQIYPNVIVESGAKIGENTVLKSGVVIGYNCILGKHNLIHSNTV
EEEEEEEECCCCCCCCCEECCCCEEECCCCCCCCCEECCCEEEEEEEEECCCCEEECCEE
IGADGFGFYDQGGVRYKIPQIGNSVIGDYVEMGACCTVDRATIETTTVGNHTKFDDHVHI
EECCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCCEEE
AHNCRVGNYVYIAGGAGLAGSVTLEDGVIIGGRAAIMGGITMKKGSILMGMSGLGEDTAE
EECCEECCEEEEECCCCCCCEEEECCCEEECCCHHEECCEEEECCCEEEECCCCCCCHHH
KAAYFGFPAKPALEMHRIHFSLSKLPELVREHRNRSKN
HHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA