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The map label for this gene is hisE

Identifier: 116329179

GI number: 116329179

Start: 3082493

End: 3082771

Strand: Direct

Name: hisE

Synonym: LBL_2606

Alternate gene names: 116329179

Gene position: 3082493-3082771 (Clockwise)

Preceding gene: 116329177

Following gene: 116329180

Centisome position: 85.28

GC content: 39.07

Gene sequence:

>279_bases
ATGGAATTTTTATTACAGTTAGAAAACATTCTGAAAAAAAGAAAACAAGACCTTCCCGATAAATCTTATACCGCGGATTT
GTTTCGAGGCGGAGTGGATCGAATTCTCAAAAAAGTAGGAGAAGAAGCCGGAGAGGTAATCATTGCCGCTAAAAATTCCG
ATAAAAAGGAACTCACTCACGAAGCGGCTGATCTGCTTTTTCATTTACAAGTGTTGCTCGTAGAACAAGAACTTTCTCTA
CAGGACGTCGTAGAAGAACTTCGTAAACGACACTCTTAA

Upstream 100 bases:

>100_bases
AATTCCTTAGCCAGCGTTTTCTTTCGGAAGAACTCAAAAAATACGGTTGTCGGAGAATCGGAGTCCGGGAAAATTAGAGG
CAGATTTTGTAAAGGAAACT

Downstream 100 bases:

>100_bases
AACGATGGATCTTTCGGAAGCCGTCCTTCCCAAAAAAATTTCCAGCAGAATTATCCTCTTTTTTTTATTTCTTCTTTACA
CGGTTCTTTTTTATCATAGC

Product: phosphoribosyl-ATP diphosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 92; Mature: 92

Protein sequence:

>92_residues
MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTHEAADLLFHLQVLLVEQELSL
QDVVEELRKRHS

Sequences:

>Translated_92_residues
MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTHEAADLLFHLQVLLVEQELSL
QDVVEELRKRHS
>Mature_92_residues
MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTHEAADLLFHLQVLLVEQELSL
QDVVEELRKRHS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=53.9325842696629, Blast_Score=93, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_LEPBJ (Q04V97)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_799931.1
- ProteinModelPortal:   Q04V97
- SMR:   Q04V97
- STRING:   Q04V97
- GeneID:   4409373
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_0473
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   KLGEETT
- ProtClustDB:   CLSK575308
- BioCyc:   LBOR355277:LBJ_0473-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 10582; Mature: 10582

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTH
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCEEEECCCCCHHHHHH
EAADLLFHLQVLLVEQELSLQDVVEELRKRHS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTH
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCEEEECCCCCHHHHHH
EAADLLFHLQVLLVEQELSLQDVVEELRKRHS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA