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The map label for this gene is tmk [H]

Identifier: 116328926

GI number: 116328926

Start: 2744825

End: 2745442

Strand: Direct

Name: tmk [H]

Synonym: LBL_2320

Alternate gene names: 116328926

Gene position: 2744825-2745442 (Clockwise)

Preceding gene: 116328919

Following gene: 116328934

Centisome position: 75.94

GC content: 36.25

Gene sequence:

>618_bases
ATGAAAATCGAAAAACCAATCTTTGTAGTTTTTGAAGGAATCGATGGAAGCGGTAAATCAACTCTTTGCAAATCTCTAAC
CGAAAAACTTACAGAACGGGGAATTCCTTCCGTAAACTTTACCGAACCCACAAACTTTGAAACCGGAAAGTATCTTCGAA
AATTCTTAAGAGGGGAAATCGATCTTGAAAGAAAAGAACAAATCGATGCCTTTTTAAACGATAGAGAAGAATCTTTAAGA
CAAAACATCCTTCCTTCCTTAGAATCCGGAAAAAACGTCTTACTGGATCGTTATATGTATTCCACCGCCGCTTATCAGAG
CGGCGACGATCTTCTTCCCGAAACAATCATCGAAAAAAATCTAAAGAAAAACTTTAAAATCCCGGATCTTCTATTTTATC
TAGATCTTAATCCAGCAATCGCACTCGAAAGACTAAGTCAAAGAAAAGAAAATAAAGAAAGATTCGAAACGTTAGCTCAA
CTTGAAAAAATTCGTTCCGCCTACAATAGAATTCTTCCAAAAGAAACGATCCGAATAGACGGCGTAAAAGGCCCGGACGA
AATCGTTCAGGAATGTCTGGAAATTTTTTTAAGAAACTTCAATAGAAAATTCCTATAA

Upstream 100 bases:

>100_bases
CGAAATTTTCATTGGATTCTCGATTTCCAAAAAAATCCATGTAGATAAAATGATTTCGTATAAATCTCTCTTTGTCAAGA
ATTGAATCGGAACCGTAAAA

Downstream 100 bases:

>100_bases
AATCCGAAAGAAAGCATCACCCGATCCAATTTCAGCGTAAAACCGTCGTTTGGTGAACGTAATTTTTAAGGGCTTCTTGA
TAGCAGTCAATTGCAAACAA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MKIEKPIFVVFEGIDGSGKSTLCKSLTEKLTERGIPSVNFTEPTNFETGKYLRKFLRGEIDLERKEQIDAFLNDREESLR
QNILPSLESGKNVLLDRYMYSTAAYQSGDDLLPETIIEKNLKKNFKIPDLLFYLDLNPAIALERLSQRKENKERFETLAQ
LEKIRSAYNRILPKETIRIDGVKGPDEIVQECLEIFLRNFNRKFL

Sequences:

>Translated_205_residues
MKIEKPIFVVFEGIDGSGKSTLCKSLTEKLTERGIPSVNFTEPTNFETGKYLRKFLRGEIDLERKEQIDAFLNDREESLR
QNILPSLESGKNVLLDRYMYSTAAYQSGDDLLPETIIEKNLKKNFKIPDLLFYLDLNPAIALERLSQRKENKERFETLAQ
LEKIRSAYNRILPKETIRIDGVKGPDEIVQECLEIFLRNFNRKFL
>Mature_205_residues
MKIEKPIFVVFEGIDGSGKSTLCKSLTEKLTERGIPSVNFTEPTNFETGKYLRKFLRGEIDLERKEQIDAFLNDREESLR
QNILPSLESGKNVLLDRYMYSTAAYQSGDDLLPETIIEKNLKKNFKIPDLLFYLDLNPAIALERLSQRKENKERFETLAQ
LEKIRSAYNRILPKETIRIDGVKGPDEIVQECLEIFLRNFNRKFL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=153, Percent_Identity=32.0261437908497, Blast_Score=68, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17535647, Length=188, Percent_Identity=29.2553191489362, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573735, Length=173, Percent_Identity=31.7919075144509, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23869; Mature: 23869

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEKPIFVVFEGIDGSGKSTLCKSLTEKLTERGIPSVNFTEPTNFETGKYLRKFLRGEI
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCC
DLERKEQIDAFLNDREESLRQNILPSLESGKNVLLDRYMYSTAAYQSGDDLLPETIIEKN
CCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LKKNFKIPDLLFYLDLNPAIALERLSQRKENKERFETLAQLEKIRSAYNRILPKETIRID
HHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEC
GVKGPDEIVQECLEIFLRNFNRKFL
CCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKIEKPIFVVFEGIDGSGKSTLCKSLTEKLTERGIPSVNFTEPTNFETGKYLRKFLRGEI
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCC
DLERKEQIDAFLNDREESLRQNILPSLESGKNVLLDRYMYSTAAYQSGDDLLPETIIEKN
CCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LKKNFKIPDLLFYLDLNPAIALERLSQRKENKERFETLAQLEKIRSAYNRILPKETIRID
HHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEC
GVKGPDEIVQECLEIFLRNFNRKFL
CCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA