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The map label for this gene is liaS [H]

Identifier: 116328919

GI number: 116328919

Start: 2738136

End: 2739962

Strand: Direct

Name: liaS [H]

Synonym: LBL_2313

Alternate gene names: 116328919

Gene position: 2738136-2739962 (Clockwise)

Preceding gene: 116328918

Following gene: 116328926

Centisome position: 75.76

GC content: 40.34

Gene sequence:

>1827_bases
ATGCCCGCAAAGAGAATATTCGTATTTTCTATTTTTATTATATTTACCTTGTTTTCGACGGGATGCAGCTCCAAGAACGA
GCCAATCGCGGAAAAAGGCGTCATCGACCTCAGAAATTTTAATCTCGAAGAAAACATTACTACGCTTAACGGAAACTGGG
AATTTCATTGGAAAGAATCGACACACGGCAATCATCCGATCCCTAAAACCTCGACTTATTTTCCAGTCCCCGGAATTTGG
AGGGACTACGATCCGAACTTCACTCCGGAAGGTTATGCGACCTATCGCCTGCGCGTGTTATGCGATGATCAATATCCCGA
TTTAAAGATCAGAATTCCCAGGCTTCCGGGAGTTTACGAAGTCTATTTCGACGACCATAAAGTTTATTCGAACGGTTTTG
CCGGAACCGGTCCTTTAGATACGGTATTTTCAGCTCATCCATTGATGACGAATATCGTCGTGCCCTCCGAGGATTTTTAT
ATCACCGTAACCGTTTCCACCTTCAAAGGAAATTATCTTAAAGGGGGAATTCGGAAGCCATTCCAAATCGGATCAGGAAA
GGCGATCGATTTGGAGACAAAAAGAGAAGAATGGAGGGAGATGGTTCTAATCGTCGTTATCTTTTCTTTTGGAATCTATC
ACCTCGTATTCTTTTTTTCCTACAGAAAAGATCCGATTCCTCTCTATTTCACCCTGTTTTGTTTTTTAGTTTCCGGATAT
ACTTTCATCACCTCCGAAATTCAATTTATGGCTCTCTCGGATCTTTCCCTGGATCTCAGACTACGAATAAAGTTTTTTTG
TGAGATCGCATTTTTCCCTACTTCTTTCCTGATGCTCCGTAAGATGTTCCCGCTTCAGTTCAACCGGAAATGGATTCAAA
CCGCAATTGGAACAAGTACGATTTTCTTTTTCGGAATTTTCGCTTTCAACGAACGGAATATAGTCTGGTTTTATTCTTGG
TTTATGTATTTCCCCCCGCTTTATGCATTGGTTTTGATTCTAGGCACGGCAAATACGTTTAAAGCCAGAGAACTTTTCAC
CGGCTTTGTTCTGGCGTTTACGATGATGAACGACGGAATTTACGGTTTATACGAGATTTATACTTTATATCCGTACAGCT
TTCCTTTGGGTCTTATCGCTTTTGTTGCGTTAAATTCTTATATTATTTCCTCAAGATTCGCGGAAAATCTGGAAAGAGCA
AAAGAATTCGCACAACTTCAAATCAGATATAACGAACAACTAAAGCTACAAGCACAGGAAAGAGCAAGGATCGCCTCGGA
TATTCACGATTCCATAGGGTCCGAGCTTACAGCGATTCTTTTCGAGTTGGAATCCAAAGATAAAAACGATTCCACATTGA
AAAAACTCAAATCGGAAGTAAATCATCTCATTTCGAATGTAAGAGACATCGTATTTCTCATGCACCATCAGGGAAACAAC
CAAGAACTCGTGGAAGAAGTGATAAAAAGGTACGGGGATAGAATTCAACGCACCGGAACCATAGAAGTTAAAATGGAAAT
TGAAGACGTCTCCAATTTCATACATATGGATCAATGTCTACACGTTCAAAAGATCTTTTTAGAAGTCGCTTCCAATATTC
TCAGACATTCCGAAGCGAAGAAGATACGAATTTCCTGGAAAAAAGAGGGAAAAAATCTGGTTCTAAAAGTGACAGACGAC
GGGAAAAAATTCGAGATCAATCCGGAAGAAGTCTCCGGAATCGGAATGAGCAACATTCGAATGAGATCCGAAAAATTGGG
AGCAAGTTACGTTTTCCATTCCAAAGGTTCGGAAAATTCATTCGAACTAAATATTCCGATTTCCTAA

Upstream 100 bases:

>100_bases
CGAAAAAATTTATAAAAAGATGGAAGTGCATTCCAAATCCGAAGCCATCATCCGAGGAAGAAGAATGGGGATTATACGAG
ACGTTCCAGGATACCCTTAA

Downstream 100 bases:

>100_bases
TAAGAATTTTCCGTCACAAAATTTCACAAAGTTTAAAATCCATATCGCATGCGATTTTCCTAATATTTTTATCGTATGCA
CAAATCGTAAGTTTCTTTTT

Product: Signal transduction histidine kinase of a two component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MPAKRIFVFSIFIIFTLFSTGCSSKNEPIAEKGVIDLRNFNLEENITTLNGNWEFHWKESTHGNHPIPKTSTYFPVPGIW
RDYDPNFTPEGYATYRLRVLCDDQYPDLKIRIPRLPGVYEVYFDDHKVYSNGFAGTGPLDTVFSAHPLMTNIVVPSEDFY
ITVTVSTFKGNYLKGGIRKPFQIGSGKAIDLETKREEWREMVLIVVIFSFGIYHLVFFFSYRKDPIPLYFTLFCFLVSGY
TFITSEIQFMALSDLSLDLRLRIKFFCEIAFFPTSFLMLRKMFPLQFNRKWIQTAIGTSTIFFFGIFAFNERNIVWFYSW
FMYFPPLYALVLILGTANTFKARELFTGFVLAFTMMNDGIYGLYEIYTLYPYSFPLGLIAFVALNSYIISSRFAENLERA
KEFAQLQIRYNEQLKLQAQERARIASDIHDSIGSELTAILFELESKDKNDSTLKKLKSEVNHLISNVRDIVFLMHHQGNN
QELVEEVIKRYGDRIQRTGTIEVKMEIEDVSNFIHMDQCLHVQKIFLEVASNILRHSEAKKIRISWKKEGKNLVLKVTDD
GKKFEINPEEVSGIGMSNIRMRSEKLGASYVFHSKGSENSFELNIPIS

Sequences:

>Translated_608_residues
MPAKRIFVFSIFIIFTLFSTGCSSKNEPIAEKGVIDLRNFNLEENITTLNGNWEFHWKESTHGNHPIPKTSTYFPVPGIW
RDYDPNFTPEGYATYRLRVLCDDQYPDLKIRIPRLPGVYEVYFDDHKVYSNGFAGTGPLDTVFSAHPLMTNIVVPSEDFY
ITVTVSTFKGNYLKGGIRKPFQIGSGKAIDLETKREEWREMVLIVVIFSFGIYHLVFFFSYRKDPIPLYFTLFCFLVSGY
TFITSEIQFMALSDLSLDLRLRIKFFCEIAFFPTSFLMLRKMFPLQFNRKWIQTAIGTSTIFFFGIFAFNERNIVWFYSW
FMYFPPLYALVLILGTANTFKARELFTGFVLAFTMMNDGIYGLYEIYTLYPYSFPLGLIAFVALNSYIISSRFAENLERA
KEFAQLQIRYNEQLKLQAQERARIASDIHDSIGSELTAILFELESKDKNDSTLKKLKSEVNHLISNVRDIVFLMHHQGNN
QELVEEVIKRYGDRIQRTGTIEVKMEIEDVSNFIHMDQCLHVQKIFLEVASNILRHSEAKKIRISWKKEGKNLVLKVTDD
GKKFEINPEEVSGIGMSNIRMRSEKLGASYVFHSKGSENSFELNIPIS
>Mature_607_residues
PAKRIFVFSIFIIFTLFSTGCSSKNEPIAEKGVIDLRNFNLEENITTLNGNWEFHWKESTHGNHPIPKTSTYFPVPGIWR
DYDPNFTPEGYATYRLRVLCDDQYPDLKIRIPRLPGVYEVYFDDHKVYSNGFAGTGPLDTVFSAHPLMTNIVVPSEDFYI
TVTVSTFKGNYLKGGIRKPFQIGSGKAIDLETKREEWREMVLIVVIFSFGIYHLVFFFSYRKDPIPLYFTLFCFLVSGYT
FITSEIQFMALSDLSLDLRLRIKFFCEIAFFPTSFLMLRKMFPLQFNRKWIQTAIGTSTIFFFGIFAFNERNIVWFYSWF
MYFPPLYALVLILGTANTFKARELFTGFVLAFTMMNDGIYGLYEIYTLYPYSFPLGLIAFVALNSYIISSRFAENLERAK
EFAQLQIRYNEQLKLQAQERARIASDIHDSIGSELTAILFELESKDKNDSTLKKLKSEVNHLISNVRDIVFLMHHQGNNQ
ELVEEVIKRYGDRIQRTGTIEVKMEIEDVSNFIHMDQCLHVQKIFLEVASNILRHSEAKKIRISWKKEGKNLVLKVTDDG
KKFEINPEEVSGIGMSNIRMRSEKLGASYVFHSKGSENSFELNIPIS

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR017202 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 70533; Mature: 70402

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKRIFVFSIFIIFTLFSTGCSSKNEPIAEKGVIDLRNFNLEENITTLNGNWEFHWKES
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEECCCCCCCEEEECCCEEEEEECC
THGNHPIPKTSTYFPVPGIWRDYDPNFTPEGYATYRLRVLCDDQYPDLKIRIPRLPGVYE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCEEE
VYFDDHKVYSNGFAGTGPLDTVFSAHPLMTNIVVPSEDFYITVTVSTFKGNYLKGGIRKP
EEECCCEEECCCCCCCCCHHHHHCCCCCCEEEEECCCCEEEEEEEEECCCCCEECCCCCC
FQIGSGKAIDLETKREEWREMVLIVVIFSFGIYHLVFFFSYRKDPIPLYFTLFCFLVSGY
EECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
TFITSEIQFMALSDLSLDLRLRIKFFCEIAFFPTSFLMLRKMFPLQFNRKWIQTAIGTST
CEEECCEEEEEEECCCEEEEEEEEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHH
IFFFGIFAFNERNIVWFYSWFMYFPPLYALVLILGTANTFKARELFTGFVLAFTMMNDGI
EEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
YGLYEIYTLYPYSFPLGLIAFVALNSYIISSRFAENLERAKEFAQLQIRYNEQLKLQAQE
EEEEHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEEEEHHH
RARIASDIHDSIGSELTAILFELESKDKNDSTLKKLKSEVNHLISNVRDIVFLMHHQGNN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
QELVEEVIKRYGDRIQRTGTIEVKMEIEDVSNFIHMDQCLHVQKIFLEVASNILRHSEAK
HHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KIRISWKKEGKNLVLKVTDDGKKFEINPEEVSGIGMSNIRMRSEKLGASYVFHSKGSENS
EEEEEEECCCCEEEEEEECCCCEEECCHHHHCCCCCHHHEEHHHHCCCEEEEECCCCCCC
FELNIPIS
EEEEECCC
>Mature Secondary Structure 
PAKRIFVFSIFIIFTLFSTGCSSKNEPIAEKGVIDLRNFNLEENITTLNGNWEFHWKES
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEECCCCCCCEEEECCCEEEEEECC
THGNHPIPKTSTYFPVPGIWRDYDPNFTPEGYATYRLRVLCDDQYPDLKIRIPRLPGVYE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCEEE
VYFDDHKVYSNGFAGTGPLDTVFSAHPLMTNIVVPSEDFYITVTVSTFKGNYLKGGIRKP
EEECCCEEECCCCCCCCCHHHHHCCCCCCEEEEECCCCEEEEEEEEECCCCCEECCCCCC
FQIGSGKAIDLETKREEWREMVLIVVIFSFGIYHLVFFFSYRKDPIPLYFTLFCFLVSGY
EECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
TFITSEIQFMALSDLSLDLRLRIKFFCEIAFFPTSFLMLRKMFPLQFNRKWIQTAIGTST
CEEECCEEEEEEECCCEEEEEEEEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHH
IFFFGIFAFNERNIVWFYSWFMYFPPLYALVLILGTANTFKARELFTGFVLAFTMMNDGI
EEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
YGLYEIYTLYPYSFPLGLIAFVALNSYIISSRFAENLERAKEFAQLQIRYNEQLKLQAQE
EEEEHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEEEEHHH
RARIASDIHDSIGSELTAILFELESKDKNDSTLKKLKSEVNHLISNVRDIVFLMHHQGNN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
QELVEEVIKRYGDRIQRTGTIEVKMEIEDVSNFIHMDQCLHVQKIFLEVASNILRHSEAK
HHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KIRISWKKEGKNLVLKVTDDGKKFEINPEEVSGIGMSNIRMRSEKLGASYVFHSKGSENS
EEEEEEECCCCEEEEEEECCCCEEECCHHHHCCCCCHHHEEHHHHCCCEEEEECCCCCCC
FELNIPIS
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]