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The map label for this gene is trpC [H]

Identifier: 116328897

GI number: 116328897

Start: 2708626

End: 2709384

Strand: Reverse

Name: trpC [H]

Synonym: LBL_2288

Alternate gene names: 116328897

Gene position: 2709384-2708626 (Counterclockwise)

Preceding gene: 116328898

Following gene: 116328896

Centisome position: 74.96

GC content: 43.35

Gene sequence:

>759_bases
ATGTCCTCATCTCAACTTCACCGGGTCCTCCGGGAAATTATCGCAACGAAACAGAACGAAATCGAAAAAATTCGAAATTG
GGACCCGGTTCCTTATCAAGGACTTGGACTTAGAGAATCTCTGAAAAGTAGAAGTTTTTCCATCATCGCGGAATGTAAGC
GCAAGAGTCCTTCCGCTGGAGAGATTTGTGCCGATTATGATCCCGTTCAAATCGCTAAAACATACGAGGCTTTAGGAGCT
TCCGCGGTTTCCGTTCTTACCGATCGGGATTATTTTGGAGGATCTTTGGAAGATCTGAAAAATGTTTCTTCCGAGTTAAA
AATTCCGATTTTAAGAAAGGATTTTATCCTGAATGAGGTCCAGATTCGGGAAGCGAGAGCATTCGGCGCCTCCGCGATTC
TTTTGATTGTGAGAATCTTAACTCCCGCACAGATCAAAACGTTTTTAAAGTCAGCTTCTTCTTTCGGTATGGATAGTTTG
GTTGAAGTTCACACACCGGATGAGGCGAAACTTGCTTTAGATTGTGGGGCCGAAATCATCGGAATCAATACGAGGGATTT
GGATACGTTTCAGATTCATCAAAATCTTGTCGAAGAAGTAACCGCTTTTTTACCGCGTAACGTAGTAAAAGTGGGAGAAT
CCGGAGTAGGGAGTCGTTCCGATTTGGATCGGTTTCGAAAACTGGTCAACGCGGCCCTGATCGGAACTTATTTTATGGAA
AAGTCGGATATCCGTAAAGCTTGGTTGGAATTATTTTAG

Upstream 100 bases:

>100_bases
AAACCGGCAGTGAAACGGATTTTTGACGTAATCGAACTCACCTCTCTTTTTGACATTCGTGAAACCGAAGATGAGGCTTT
GAAATCTTTCTAAACCTCTG

Downstream 100 bases:

>100_bases
AATTTTCGAATTTATTAATGTATTTCTTTGTTTCTCGGTCATTCAGGATTGTTTGTATAAAATTGGCTTAGGGGCTGTCC
TGAAATCTGAAAAATGTAGG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSSSQLHRVLREIIATKQNEIEKIRNWDPVPYQGLGLRESLKSRSFSIIAECKRKSPSAGEICADYDPVQIAKTYEALGA
SAVSVLTDRDYFGGSLEDLKNVSSELKIPILRKDFILNEVQIREARAFGASAILLIVRILTPAQIKTFLKSASSFGMDSL
VEVHTPDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVTAFLPRNVVKVGESGVGSRSDLDRFRKLVNAALIGTYFME
KSDIRKAWLELF

Sequences:

>Translated_252_residues
MSSSQLHRVLREIIATKQNEIEKIRNWDPVPYQGLGLRESLKSRSFSIIAECKRKSPSAGEICADYDPVQIAKTYEALGA
SAVSVLTDRDYFGGSLEDLKNVSSELKIPILRKDFILNEVQIREARAFGASAILLIVRILTPAQIKTFLKSASSFGMDSL
VEVHTPDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVTAFLPRNVVKVGESGVGSRSDLDRFRKLVNAALIGTYFME
KSDIRKAWLELF
>Mature_251_residues
SSSQLHRVLREIIATKQNEIEKIRNWDPVPYQGLGLRESLKSRSFSIIAECKRKSPSAGEICADYDPVQIAKTYEALGAS
AVSVLTDRDYFGGSLEDLKNVSSELKIPILRKDFILNEVQIREARAFGASAILLIVRILTPAQIKTFLKSASSFGMDSLV
EVHTPDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVTAFLPRNVVKVGESGVGSRSDLDRFRKLVNAALIGTYFMEK
SDIRKAWLELF

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=249, Percent_Identity=35.3413654618474, Blast_Score=134, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6322638, Length=213, Percent_Identity=38.0281690140845, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28076; Mature: 27944

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSQLHRVLREIIATKQNEIEKIRNWDPVPYQGLGLRESLKSRSFSIIAECKRKSPSAG
CCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCC
EICADYDPVQIAKTYEALGASAVSVLTDRDYFGGSLEDLKNVSSELKIPILRKDFILNEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
QIREARAFGASAILLIVRILTPAQIKTFLKSASSFGMDSLVEVHTPDEAKLALDCGAEII
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHEEEECCCCCCEEEHCCCCEEE
GINTRDLDTFQIHQNLVEEVTAFLPRNVVKVGESGVGSRSDLDRFRKLVNAALIGTYFME
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KSDIRKAWLELF
HHHHHHHHHHCC
>Mature Secondary Structure 
SSSQLHRVLREIIATKQNEIEKIRNWDPVPYQGLGLRESLKSRSFSIIAECKRKSPSAG
CHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCC
EICADYDPVQIAKTYEALGASAVSVLTDRDYFGGSLEDLKNVSSELKIPILRKDFILNEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
QIREARAFGASAILLIVRILTPAQIKTFLKSASSFGMDSLVEVHTPDEAKLALDCGAEII
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHEEEECCCCCCEEEHCCCCEEE
GINTRDLDTFQIHQNLVEEVTAFLPRNVVKVGESGVGSRSDLDRFRKLVNAALIGTYFME
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KSDIRKAWLELF
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA