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The map label for this gene is pdxH

Identifier: 116328761

GI number: 116328761

Start: 2501541

End: 2502185

Strand: Reverse

Name: pdxH

Synonym: LBL_2135

Alternate gene names: 116328761

Gene position: 2502185-2501541 (Counterclockwise)

Preceding gene: 116328762

Following gene: 116328759

Centisome position: 69.23

GC content: 41.86

Gene sequence:

>645_bases
ATGAATTCTAAAATTTCAGAAATTAGAAAAAATTACAGTTTGTCTTCTTTGGACATAGGAGATATCGGAGACGATCCGAT
TTCATTTTTTCAAAAATGGTTTGAGGAAGCCGTCTTGTCGGAAGTTTTGGAAGTTAATGCGATGACTCTTGCTACGGCGA
CCAAGGACGGAAAACCGAACGCAAGAATCGTTCTTCTCAAAGAAATCCTGGAAGACTCGTTCGTCTTTTATACGAATTAC
GAAAGTAAAAAAGGACGGGAATTGGAAGAGAATCCGAGGGCTTGTCTTGTTTTCTTTTGGTCCGAGTTGGAACGTCAGGT
CCGAATCGAAGGGGGAGTAAAGAAAGTTTCTAGGGAAGAATCGAACGTGTACTTTCATTCCAGACCCAGAGGGTCCCAGA
TCGGCGCGGTTGTTTCTCCTCAGAGTTATGAAATTCCGAATCGTAAATTTTTAGAGGAACGTTTTGAAGAATTTTCGAAG
CTATATGAAGGTAAGGAAGTGGATCTTCCGAATCATTGGGGAGGTTATGCGGTTCATCCTAACCGAATCGAATTTTGGCA
GGGACGTTCCAGCCGTTTGCACGATAGAATTGTGTTTGAGAAAGATACGGATTCTTCTTGGAAAAAATTCAGAGTCGCTC
CGTAA

Upstream 100 bases:

>100_bases
TAATACAAACCTTTTGCGGATGAGATCGAACTTCTGAAAAATGCAATTCGAATTTTTTCTTTTACTTTAAAGCCGTTCTT
ATTTTTTGAATTCAATCGAT

Downstream 100 bases:

>100_bases
AATGTGATTTCAAAATCGGAGTCTCCACTGAAATAAAAGCGCTCTTGGTATTTCGGCTAATTGTTTGGCGGTAGAATTCA
ATTTTATTAAAGTTTGTTTC

Product: pyridoxamine-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MNSKISEIRKNYSLSSLDIGDIGDDPISFFQKWFEEAVLSEVLEVNAMTLATATKDGKPNARIVLLKEILEDSFVFYTNY
ESKKGRELEENPRACLVFFWSELERQVRIEGGVKKVSREESNVYFHSRPRGSQIGAVVSPQSYEIPNRKFLEERFEEFSK
LYEGKEVDLPNHWGGYAVHPNRIEFWQGRSSRLHDRIVFEKDTDSSWKKFRVAP

Sequences:

>Translated_214_residues
MNSKISEIRKNYSLSSLDIGDIGDDPISFFQKWFEEAVLSEVLEVNAMTLATATKDGKPNARIVLLKEILEDSFVFYTNY
ESKKGRELEENPRACLVFFWSELERQVRIEGGVKKVSREESNVYFHSRPRGSQIGAVVSPQSYEIPNRKFLEERFEEFSK
LYEGKEVDLPNHWGGYAVHPNRIEFWQGRSSRLHDRIVFEKDTDSSWKKFRVAP
>Mature_214_residues
MNSKISEIRKNYSLSSLDIGDIGDDPISFFQKWFEEAVLSEVLEVNAMTLATATKDGKPNARIVLLKEILEDSFVFYTNY
ESKKGRELEENPRACLVFFWSELERQVRIEGGVKKVSREESNVYFHSRPRGSQIGAVVSPQSYEIPNRKFLEERFEEFSK
LYEGKEVDLPNHWGGYAVHPNRIEFWQGRSSRLHDRIVFEKDTDSSWKKFRVAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=178, Percent_Identity=56.7415730337079, Blast_Score=215, Evalue=2e-56,
Organism=Escherichia coli, GI1787926, Length=211, Percent_Identity=43.6018957345972, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17553712, Length=195, Percent_Identity=44.1025641025641, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6319509, Length=213, Percent_Identity=40.8450704225352, Blast_Score=160, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45551845, Length=180, Percent_Identity=49.4444444444444, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24644901, Length=180, Percent_Identity=49.4444444444444, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24644903, Length=169, Percent_Identity=28.9940828402367, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640564, Length=206, Percent_Identity=23.7864077669903, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_LEPBJ (Q04R37)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801391.1
- ProteinModelPortal:   Q04R37
- SMR:   Q04R37
- STRING:   Q04R37
- GeneID:   4410267
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_2141
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- PhylomeDB:   Q04R37
- ProtClustDB:   CLSK573797
- BioCyc:   LBOR355277:LBJ_2141-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24950; Mature: 24950

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 62-62 BINDING 65-65 BINDING 67-67 BINDING 84-84 BINDING 124-124 BINDING 128-128 BINDING 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKISEIRKNYSLSSLDIGDIGDDPISFFQKWFEEAVLSEVLEVNAMTLATATKDGKPN
CCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCC
ARIVLLKEILEDSFVFYTNYESKKGRELEENPRACLVFFWSELERQVRIEGGVKKVSREE
CEEEEHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCHHHHHCCC
SNVYFHSRPRGSQIGAVVSPQSYEIPNRKFLEERFEEFSKLYEGKEVDLPNHWGGYAVHP
CCEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
NRIEFWQGRSSRLHDRIVFEKDTDSSWKKFRVAP
CCEEEECCCCCCCCCEEEEECCCCCCCCEEECCC
>Mature Secondary Structure
MNSKISEIRKNYSLSSLDIGDIGDDPISFFQKWFEEAVLSEVLEVNAMTLATATKDGKPN
CCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCC
ARIVLLKEILEDSFVFYTNYESKKGRELEENPRACLVFFWSELERQVRIEGGVKKVSREE
CEEEEHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCHHHHHCCC
SNVYFHSRPRGSQIGAVVSPQSYEIPNRKFLEERFEEFSKLYEGKEVDLPNHWGGYAVHP
CCEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
NRIEFWQGRSSRLHDRIVFEKDTDSSWKKFRVAP
CCEEEECCCCCCCCCEEEEECCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA