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The map label for this gene is purE [H]

Identifier: 116328699

GI number: 116328699

Start: 2428106

End: 2428594

Strand: Direct

Name: purE [H]

Synonym: LBL_2071

Alternate gene names: 116328699

Gene position: 2428106-2428594 (Clockwise)

Preceding gene: 116328698

Following gene: 116328700

Centisome position: 67.18

GC content: 46.42

Gene sequence:

>489_bases
TTGAGCGCAAAAGTGGCAATCATAATGGGAAGTCATTCCGATTGGGAAACGATGAGAGAAACCGAATCGATCTTAAAAGA
ATTCGGCGTATCCTTCCATAAAGAAATCGTGTCCGCGCATAGATCTCCCGAACATATGTTAGAATTTTCTAAATCGGCAA
AACAAAACGGTTATTCCGTAATCATCGCAGGGGCCGGGGGAGCCGCTCATCTTCCGGGAATGGTCGCTTCGATGACTACG
CTTCCCGTCCTCGGAGTTCCCATACAAAGCAAAACGTTAAACGGCTTAGACAGCCTTCTTTCCATTGTTCAAATGCCGGG
AGGCGTTCCTGTCGGAACTCTTGCAATCGGGACCGCCGGTGCAAAAAACGCGGCTCTACTCGCGATAAGAATCCTTTCTC
TTCAAGATTCTGAACTTTCCGAAAAACTCGAACAGTATCGAAACCAAATTAGAGAGGATGCTCTTTCAAAAAACAAGGAC
CTCTTGTGA

Upstream 100 bases:

>100_bases
CCTCGCGCGGAATTCAATTGGAGCGCTTCGTAGATTCTCTTTCTGTTTAATACTTGCAATCACTACGATCGAAGGAAATA
TCTTGAACAGGAGAAAAGAC

Downstream 100 bases:

>100_bases
AGAATAACGATGTTTTAACTCCAGGTTCGAAGCTTGGGGTAATGGGGGCCGGACAACTCGCGAGAATGTTCTGCTTGGAA
GCAATCCCTTTCGGATACGA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MSAKVAIIMGSHSDWETMRETESILKEFGVSFHKEIVSAHRSPEHMLEFSKSAKQNGYSVIIAGAGGAAHLPGMVASMTT
LPVLGVPIQSKTLNGLDSLLSIVQMPGGVPVGTLAIGTAGAKNAALLAIRILSLQDSELSEKLEQYRNQIREDALSKNKD
LL

Sequences:

>Translated_162_residues
MSAKVAIIMGSHSDWETMRETESILKEFGVSFHKEIVSAHRSPEHMLEFSKSAKQNGYSVIIAGAGGAAHLPGMVASMTT
LPVLGVPIQSKTLNGLDSLLSIVQMPGGVPVGTLAIGTAGAKNAALLAIRILSLQDSELSEKLEQYRNQIREDALSKNKD
LL
>Mature_161_residues
SAKVAIIMGSHSDWETMRETESILKEFGVSFHKEIVSAHRSPEHMLEFSKSAKQNGYSVIIAGAGGAAHLPGMVASMTTL
PVLGVPIQSKTLNGLDSLLSIVQMPGGVPVGTLAIGTAGAKNAALLAIRILSLQDSELSEKLEQYRNQIREDALSKNKDL
L

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=158, Percent_Identity=58.2278481012658, Blast_Score=159, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6324702, Length=157, Percent_Identity=54.140127388535, Blast_Score=163, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17267; Mature: 17136

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKVAIIMGSHSDWETMRETESILKEFGVSFHKEIVSAHRSPEHMLEFSKSAKQNGYSV
CCCEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEE
IIAGAGGAAHLPGMVASMTTLPVLGVPIQSKTLNGLDSLLSIVQMPGGVPVGTLAIGTAG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHEEECCCC
AKNAALLAIRILSLQDSELSEKLEQYRNQIREDALSKNKDLL
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SAKVAIIMGSHSDWETMRETESILKEFGVSFHKEIVSAHRSPEHMLEFSKSAKQNGYSV
CCEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEE
IIAGAGGAAHLPGMVASMTTLPVLGVPIQSKTLNGLDSLLSIVQMPGGVPVGTLAIGTAG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHEEECCCC
AKNAALLAIRILSLQDSELSEKLEQYRNQIREDALSKNKDLL
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9311113; 11427726 [H]