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The map label for this gene is paaJ-3 [C]

Identifier: 116328648

GI number: 116328648

Start: 2352445

End: 2353563

Strand: Reverse

Name: paaJ-3 [C]

Synonym: LBL_2014

Alternate gene names: 116328648

Gene position: 2353563-2352445 (Counterclockwise)

Preceding gene: 116328652

Following gene: 116328647

Centisome position: 65.12

GC content: 44.59

Gene sequence:

>1119_bases
ATGTCTTCGCCCGTTTTTATTCTCGATTCGGAACTCAGTCCTTTCGGTAAAACTGCACTTGATTATCATTCTCTTTCTTA
TCAAACTGCAATTCAACTTTTGGAAAGAAATCCTGAGTTTGAACCTCAGTTTCTTATTTTTGCTGCAATGGCTCCCGAAA
GATACACGGGAGAGATCTTTCTTTCCGCAAGGATTAAGGAAAGCCTTGGTTTAAAGAATTTATTTACCATTAGAACGGAG
ACCGCTTCTTCATCGGGAGCGAGTGCTTTCCATACCGCCGTTTATTTTTTGCGGTCAGGAGCGTTTCGAAGAGGAATTGT
AATTGCTACCGAAGTGATGAGTCGTTTGGAAAGGGAGCAAAACAATCTTCTTTTAGGGAGCGTTTTGTCCGAGCGTCAAA
AAGGTTTTGCGATGTCCATGGCTCAAGGCGGGGGAATGATAACGACACGTTATCTGCACGAGTACGGATACGGTCGTAAG
GACTTGTATGCTCTTTCCAAGAAGTTGCACGATAACGGTCTGAAGAACGAAAAGGCTCATATTCGAAAGAATATTACAGA
AGAAGAATATTTTAATTCTCCTCTTTTTGCGAGTCCTCTTTGTTTGTATGATATTTCTCCTCTTTCCGACGGGAGTTGTG
CCGTATTACTCGATTCCGAAGAAGCGAAATCTCCCAAACGGCTCGAGGTTCGCGGAATCGGTCACGGGATCGGGGATCTT
TCTTCTCCTCCGAGTTTTTTAAGTTTTCCTTCCAGTGTTTCTGCATTTGCGGGAGCGTATAAAGAAGCTGATTTAAAACC
GGAGCAGATTCGGATTGCCGAGCTTCACGATGCATTTACTCCTTTTGAGTTGATCGGCGCCGAGGATGCGGGACTTTTTC
CAAAAGGGAAGGCTTTGCGTTATGTGCGAGAGGGTAAAACTCATCCTGATGGACAACTGCCGATCAATGCTTCGGGCGGT
TTGAAAACGAGAGGACATCCTGTGGGAGTTTCGGGCCTTGCTCAAATTGCGGAATTACAGACTTGGATGTGTAAAGAGGA
ACGTTTTCAAAACGGTTTGGCTCTTTCGATCGGCGGTTTGGGGATAAACAATTTTGCGACGATTCTCTCCAAAGTTTAG

Upstream 100 bases:

>100_bases
TACAAGGATAGTTTAAAAACTTGAATGAAAAGTCGTCTTACTTGCGTTATTTAATTTTTTTTGATTTTCAATCTCACAAT
TTTAAAAAACATAGACTCCG

Downstream 100 bases:

>100_bases
AACGGAATTTAACAGTGACTGAAAAAATACTACTGGTTCAGACCGCATTTTTAGGAGATCTGATCTTAACGACTCCCTTC
TTTCGGGAAGTCAAAAGAAA

Product: Acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MSSPVFILDSELSPFGKTALDYHSLSYQTAIQLLERNPEFEPQFLIFAAMAPERYTGEIFLSARIKESLGLKNLFTIRTE
TASSSGASAFHTAVYFLRSGAFRRGIVIATEVMSRLEREQNNLLLGSVLSERQKGFAMSMAQGGGMITTRYLHEYGYGRK
DLYALSKKLHDNGLKNEKAHIRKNITEEEYFNSPLFASPLCLYDISPLSDGSCAVLLDSEEAKSPKRLEVRGIGHGIGDL
SSPPSFLSFPSSVSAFAGAYKEADLKPEQIRIAELHDAFTPFELIGAEDAGLFPKGKALRYVREGKTHPDGQLPINASGG
LKTRGHPVGVSGLAQIAELQTWMCKEERFQNGLALSIGGLGINNFATILSKV

Sequences:

>Translated_372_residues
MSSPVFILDSELSPFGKTALDYHSLSYQTAIQLLERNPEFEPQFLIFAAMAPERYTGEIFLSARIKESLGLKNLFTIRTE
TASSSGASAFHTAVYFLRSGAFRRGIVIATEVMSRLEREQNNLLLGSVLSERQKGFAMSMAQGGGMITTRYLHEYGYGRK
DLYALSKKLHDNGLKNEKAHIRKNITEEEYFNSPLFASPLCLYDISPLSDGSCAVLLDSEEAKSPKRLEVRGIGHGIGDL
SSPPSFLSFPSSVSAFAGAYKEADLKPEQIRIAELHDAFTPFELIGAEDAGLFPKGKALRYVREGKTHPDGQLPINASGG
LKTRGHPVGVSGLAQIAELQTWMCKEERFQNGLALSIGGLGINNFATILSKV
>Mature_371_residues
SSPVFILDSELSPFGKTALDYHSLSYQTAIQLLERNPEFEPQFLIFAAMAPERYTGEIFLSARIKESLGLKNLFTIRTET
ASSSGASAFHTAVYFLRSGAFRRGIVIATEVMSRLEREQNNLLLGSVLSERQKGFAMSMAQGGGMITTRYLHEYGYGRKD
LYALSKKLHDNGLKNEKAHIRKNITEEEYFNSPLFASPLCLYDISPLSDGSCAVLLDSEEAKSPKRLEVRGIGHGIGDLS
SPPSFLSFPSSVSAFAGAYKEADLKPEQIRIAELHDAFTPFELIGAEDAGLFPKGKALRYVREGKTHPDGQLPINASGGL
KTRGHPVGVSGLAQIAELQTWMCKEERFQNGLALSIGGLGINNFATILSKV

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI302344760, Length=310, Percent_Identity=26.4516129032258, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI19923233, Length=310, Percent_Identity=26.4516129032258, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI302344767, Length=215, Percent_Identity=29.7674418604651, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI302344762, Length=215, Percent_Identity=29.7674418604651, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537653, Length=229, Percent_Identity=28.82096069869, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19921506, Length=310, Percent_Identity=27.0967741935484, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585051, Length=308, Percent_Identity=26.2987012987013, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 40751; Mature: 40620

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPVFILDSELSPFGKTALDYHSLSYQTAIQLLERNPEFEPQFLIFAAMAPERYTGEIF
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEE
LSARIKESLGLKNLFTIRTETASSSGASAFHTAVYFLRSGAFRRGIVIATEVMSRLEREQ
EEEEHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHH
NNLLLGSVLSERQKGFAMSMAQGGGMITTRYLHEYGYGRKDLYALSKKLHDNGLKNEKAH
CCEEHHHHHHHHHCCCEEEHHCCCCEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHH
IRKNITEEEYFNSPLFASPLCLYDISPLSDGSCAVLLDSEEAKSPKRLEVRGIGHGIGDL
HHHCCCHHHHCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCC
SSPPSFLSFPSSVSAFAGAYKEADLKPEQIRIAELHDAFTPFELIGAEDAGLFPKGKALR
CCCCHHHCCCCHHHHHHHHHHCCCCCHHHEEHHHHHCCCCCHHEECCCCCCCCCCCHHHH
YVREGKTHPDGQLPINASGGLKTRGHPVGVSGLAQIAELQTWMCKEERFQNGLALSIGGL
HHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GINNFATILSKV
CHHHHHHHHHCC
>Mature Secondary Structure 
SSPVFILDSELSPFGKTALDYHSLSYQTAIQLLERNPEFEPQFLIFAAMAPERYTGEIF
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEE
LSARIKESLGLKNLFTIRTETASSSGASAFHTAVYFLRSGAFRRGIVIATEVMSRLEREQ
EEEEHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHH
NNLLLGSVLSERQKGFAMSMAQGGGMITTRYLHEYGYGRKDLYALSKKLHDNGLKNEKAH
CCEEHHHHHHHHHCCCEEEHHCCCCEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHH
IRKNITEEEYFNSPLFASPLCLYDISPLSDGSCAVLLDSEEAKSPKRLEVRGIGHGIGDL
HHHCCCHHHHCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCC
SSPPSFLSFPSSVSAFAGAYKEADLKPEQIRIAELHDAFTPFELIGAEDAGLFPKGKALR
CCCCHHHCCCCHHHHHHHHHHCCCCCHHHEEHHHHHCCCCCHHEECCCCCCCCCCCHHHH
YVREGKTHPDGQLPINASGGLKTRGHPVGVSGLAQIAELQTWMCKEERFQNGLALSIGGL
HHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GINNFATILSKV
CHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]