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The map label for this gene is prlC [H]

Identifier: 116328508

GI number: 116328508

Start: 2162769

End: 2164724

Strand: Reverse

Name: prlC [H]

Synonym: LBL_1857

Alternate gene names: 116328508

Gene position: 2164724-2162769 (Counterclockwise)

Preceding gene: 116328512

Following gene: 116328505

Centisome position: 59.89

GC content: 41.82

Gene sequence:

>1956_bases
ATGTTACCGGAATTTAAAACAGATGATCCTGAAGGAACTAAAAATTCGATCTTAAAAAAGATTGAAAAAATTAGGGAGGA
ACTTCCGATTCTCCTTCGAAAAAAGGAAAGAACTTACGATCGCGTCATTCGTCCTTTGAATGATCTTGTGCAAGAGATGC
AGATTGAGTTCACGGTTCTCGCCCATCTCAACAGTGTAAAAAATTCCGAACAAATTCAGGCTCTTTACACCGAAATACTT
CCCGAGATCACTGCTTTTTATTCAGACTTAGGTCAGAACGAGGAATTGAATCTTGTATATCAGGAGATTTTAAAGAATGA
AAACGATACATTGAACGTTCCCCAAAAAAAGGTATTACAGGACGCCGTCACGCAGTTTAAATTGAGTGGAATCGGACTTC
CACCGGAAATAAAAAAAAGAATTCAGGAAATCCAGGTTCGTATTTCCGATCTGGACAATCAGTTCTCTCAGAATTTGCTT
GATGCGACTAATTCCTTCGAACTCGTTTTGGATCGTATTGAGGATGTGGAAGGAATACCCGAATCGGATTTGAATGCGGC
TAAAACGGAGGACGGAAAGTATCGTTTTACACTTCATATGCCGAGTTACATGGCGTATATGACATACGGCCCGAATCGAT
CTATTCGAGAATCCTTATATAAGGCTTATACTACGAGGGCGCCTCAGAACGGAAAACTGATCGAGGACATACTCCGGTTA
AGGAACGAACTTGCAAAATTGCTCGGTTATCGCAATTACGTAGAACTTTCTTTGGCGACCAAGGTGGCCGATTCGGGGAA
GGTGGTTTTGAAATTTTTGAGGGATCTTGCAAAACAGGTGAAGTCGATCGCAGAAAGGGAATTTGTCGATCTTTCGAATT
TTGCGAAGACTTTGGGGATAGATACACTTCAGGCTTACGATACCGCATTCGTGAGTGAAAAATTGATGAAATCCAGATTC
GATTTCGACGAAGAGAAAACCCGTCCTTATTTTGAGAAAGAGAGCGTCGTTTCGGGAACATTCCAATTTTTGAATAAACT
TTTCGGATTGGAATTTCGTAAAACGTTCGCTCAGGTTTGGGAAGAAAAAGTTCAGGTATACGACGTCTATCGATCGGGAA
AACTACTTTCCCGGCTGTATTTGGATTTGGAATCCCGCAAAGATAAACAAGGCGGGGCTTGGATGCACAATTGGCATTCT
AGAAATCGAATCGCAGATAAGGAAGTTCTTCCGACTGCGTTCGTAGTCTGTAACTTTCCGGTTTCTACGAAGGATTCCCC
TTCTCTTTTAAAACACAGGGACGTGGTCACTTTCTTCCATGAGATGGGGCATGCGCTACATCATCTTTGTACGAAAATCG
AAGAACCTCCGGTCAGCGGAATCAACGGTGTCGAATGGGATGCAGTGGAATTTCCTTCCCAGTTTTTGGAGAACTTTGCG
ACTGAAGCGGAAGTTCTAAAGATATTCGGAAAACATCATAAAACCGGAGAAACGATTCCGGATTCCATGATCGTAAAACT
TAAGGAGACTAAAAACTTTCTTTCCGCAATGGGGATCGTAAGACAACTTGAGTTCTCACTTTTCGACATTCTCATTCACG
AAAAAAATTATACCGAAGAAGAGGCGCATTCCATTCTTCAGAATGTTCGCAAAGAGGTTGCGGTAGTGATTCCGCCCGAA
TACAATCGTTTTCAAAACGGATTTTCTCATATTTTCTCCGGAGGTTATGCCGCTGGATATTATAGTTATAAATGGGCCGA
AGTGATGAGCGCGGACGCCTTTTTCGCGTTTGTCGACAAAGGGTTCTTTGATCCGGAACTTTGTAACGCATATTTTACGG
AAATTTTAGAAAAGGGAGGAAGCGAAAACGCGATGATTCTCTTCAAACGACTTTTAGGGCGAGATCCGGAAGTCGGATCT
CTTCTCAAACTTTACGAATTAAAAGAAAGTTATTAG

Upstream 100 bases:

>100_bases
TCGATTTGAAAACATAGATTCGTGTTTTACAATCGGTAGGTTTCCGGTCAAACCTGAAAAAATGGATGAAGTTTCGAAGG
GTGGAGGGAAATTGGCGGAG

Downstream 100 bases:

>100_bases
GAAAGGCTTTTCCTGAAATTTTGAAGGAGAGTTTCCTTTCCTGCCAGGAGAACTTCGACCTGATCCTGATCGATGTTATA
GACGACATTACTACGAAGTG

Product: Zn-dependent oligopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MLPEFKTDDPEGTKNSILKKIEKIREELPILLRKKERTYDRVIRPLNDLVQEMQIEFTVLAHLNSVKNSEQIQALYTEIL
PEITAFYSDLGQNEELNLVYQEILKNENDTLNVPQKKVLQDAVTQFKLSGIGLPPEIKKRIQEIQVRISDLDNQFSQNLL
DATNSFELVLDRIEDVEGIPESDLNAAKTEDGKYRFTLHMPSYMAYMTYGPNRSIRESLYKAYTTRAPQNGKLIEDILRL
RNELAKLLGYRNYVELSLATKVADSGKVVLKFLRDLAKQVKSIAEREFVDLSNFAKTLGIDTLQAYDTAFVSEKLMKSRF
DFDEEKTRPYFEKESVVSGTFQFLNKLFGLEFRKTFAQVWEEKVQVYDVYRSGKLLSRLYLDLESRKDKQGGAWMHNWHS
RNRIADKEVLPTAFVVCNFPVSTKDSPSLLKHRDVVTFFHEMGHALHHLCTKIEEPPVSGINGVEWDAVEFPSQFLENFA
TEAEVLKIFGKHHKTGETIPDSMIVKLKETKNFLSAMGIVRQLEFSLFDILIHEKNYTEEEAHSILQNVRKEVAVVIPPE
YNRFQNGFSHIFSGGYAAGYYSYKWAEVMSADAFFAFVDKGFFDPELCNAYFTEILEKGGSENAMILFKRLLGRDPEVGS
LLKLYELKESY

Sequences:

>Translated_651_residues
MLPEFKTDDPEGTKNSILKKIEKIREELPILLRKKERTYDRVIRPLNDLVQEMQIEFTVLAHLNSVKNSEQIQALYTEIL
PEITAFYSDLGQNEELNLVYQEILKNENDTLNVPQKKVLQDAVTQFKLSGIGLPPEIKKRIQEIQVRISDLDNQFSQNLL
DATNSFELVLDRIEDVEGIPESDLNAAKTEDGKYRFTLHMPSYMAYMTYGPNRSIRESLYKAYTTRAPQNGKLIEDILRL
RNELAKLLGYRNYVELSLATKVADSGKVVLKFLRDLAKQVKSIAEREFVDLSNFAKTLGIDTLQAYDTAFVSEKLMKSRF
DFDEEKTRPYFEKESVVSGTFQFLNKLFGLEFRKTFAQVWEEKVQVYDVYRSGKLLSRLYLDLESRKDKQGGAWMHNWHS
RNRIADKEVLPTAFVVCNFPVSTKDSPSLLKHRDVVTFFHEMGHALHHLCTKIEEPPVSGINGVEWDAVEFPSQFLENFA
TEAEVLKIFGKHHKTGETIPDSMIVKLKETKNFLSAMGIVRQLEFSLFDILIHEKNYTEEEAHSILQNVRKEVAVVIPPE
YNRFQNGFSHIFSGGYAAGYYSYKWAEVMSADAFFAFVDKGFFDPELCNAYFTEILEKGGSENAMILFKRLLGRDPEVGS
LLKLYELKESY
>Mature_651_residues
MLPEFKTDDPEGTKNSILKKIEKIREELPILLRKKERTYDRVIRPLNDLVQEMQIEFTVLAHLNSVKNSEQIQALYTEIL
PEITAFYSDLGQNEELNLVYQEILKNENDTLNVPQKKVLQDAVTQFKLSGIGLPPEIKKRIQEIQVRISDLDNQFSQNLL
DATNSFELVLDRIEDVEGIPESDLNAAKTEDGKYRFTLHMPSYMAYMTYGPNRSIRESLYKAYTTRAPQNGKLIEDILRL
RNELAKLLGYRNYVELSLATKVADSGKVVLKFLRDLAKQVKSIAEREFVDLSNFAKTLGIDTLQAYDTAFVSEKLMKSRF
DFDEEKTRPYFEKESVVSGTFQFLNKLFGLEFRKTFAQVWEEKVQVYDVYRSGKLLSRLYLDLESRKDKQGGAWMHNWHS
RNRIADKEVLPTAFVVCNFPVSTKDSPSLLKHRDVVTFFHEMGHALHHLCTKIEEPPVSGINGVEWDAVEFPSQFLENFA
TEAEVLKIFGKHHKTGETIPDSMIVKLKETKNFLSAMGIVRQLEFSLFDILIHEKNYTEEEAHSILQNVRKEVAVVIPPE
YNRFQNGFSHIFSGGYAAGYYSYKWAEVMSADAFFAFVDKGFFDPELCNAYFTEILEKGGSENAMILFKRLLGRDPEVGS
LLKLYELKESY

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=625, Percent_Identity=29.12, Blast_Score=252, Evalue=1e-66,
Organism=Homo sapiens, GI14149738, Length=632, Percent_Identity=29.4303797468354, Blast_Score=225, Evalue=9e-59,
Organism=Homo sapiens, GI156105687, Length=571, Percent_Identity=25.569176882662, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1789913, Length=670, Percent_Identity=40.7462686567164, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1787819, Length=612, Percent_Identity=28.7581699346405, Blast_Score=229, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI71999758, Length=690, Percent_Identity=23.9130434782609, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI32565901, Length=684, Percent_Identity=21.3450292397661, Blast_Score=93, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319793, Length=496, Percent_Identity=32.0564516129032, Blast_Score=238, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322715, Length=613, Percent_Identity=23.4910277324633, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356111, Length=582, Percent_Identity=24.914089347079, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129717, Length=616, Percent_Identity=24.3506493506494, Blast_Score=143, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 75124; Mature: 75124

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPEFKTDDPEGTKNSILKKIEKIREELPILLRKKERTYDRVIRPLNDLVQEMQIEFTVL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHLNSVKNSEQIQALYTEILPEITAFYSDLGQNEELNLVYQEILKNENDTLNVPQKKVLQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH
DAVTQFKLSGIGLPPEIKKRIQEIQVRISDLDNQFSQNLLDATNSFELVLDRIEDVEGIP
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
ESDLNAAKTEDGKYRFTLHMPSYMAYMTYGPNRSIRESLYKAYTTRAPQNGKLIEDILRL
CCCCCCCCCCCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RNELAKLLGYRNYVELSLATKVADSGKVVLKFLRDLAKQVKSIAEREFVDLSNFAKTLGI
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DTLQAYDTAFVSEKLMKSRFDFDEEKTRPYFEKESVVSGTFQFLNKLFGLEFRKTFAQVW
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
EEKVQVYDVYRSGKLLSRLYLDLESRKDKQGGAWMHNWHSRNRIADKEVLPTAFVVCNFP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHCCCEEEEEECC
VSTKDSPSLLKHRDVVTFFHEMGHALHHLCTKIEEPPVSGINGVEWDAVEFPSQFLENFA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
TEAEVLKIFGKHHKTGETIPDSMIVKLKETKNFLSAMGIVRQLEFSLFDILIHEKNYTEE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
EAHSILQNVRKEVAVVIPPEYNRFQNGFSHIFSGGYAAGYYSYKWAEVMSADAFFAFVDK
HHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GFFDPELCNAYFTEILEKGGSENAMILFKRLLGRDPEVGSLLKLYELKESY
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLPEFKTDDPEGTKNSILKKIEKIREELPILLRKKERTYDRVIRPLNDLVQEMQIEFTVL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHLNSVKNSEQIQALYTEILPEITAFYSDLGQNEELNLVYQEILKNENDTLNVPQKKVLQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH
DAVTQFKLSGIGLPPEIKKRIQEIQVRISDLDNQFSQNLLDATNSFELVLDRIEDVEGIP
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
ESDLNAAKTEDGKYRFTLHMPSYMAYMTYGPNRSIRESLYKAYTTRAPQNGKLIEDILRL
CCCCCCCCCCCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RNELAKLLGYRNYVELSLATKVADSGKVVLKFLRDLAKQVKSIAEREFVDLSNFAKTLGI
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DTLQAYDTAFVSEKLMKSRFDFDEEKTRPYFEKESVVSGTFQFLNKLFGLEFRKTFAQVW
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
EEKVQVYDVYRSGKLLSRLYLDLESRKDKQGGAWMHNWHSRNRIADKEVLPTAFVVCNFP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHCCCEEEEEECC
VSTKDSPSLLKHRDVVTFFHEMGHALHHLCTKIEEPPVSGINGVEWDAVEFPSQFLENFA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
TEAEVLKIFGKHHKTGETIPDSMIVKLKETKNFLSAMGIVRQLEFSLFDILIHEKNYTEE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
EAHSILQNVRKEVAVVIPPEYNRFQNGFSHIFSGGYAAGYYSYKWAEVMSADAFFAFVDK
HHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GFFDPELCNAYFTEILEKGGSENAMILFKRLLGRDPEVGSLLKLYELKESY
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]