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The map label for this gene is imdH [H]

Identifier: 116328414

GI number: 116328414

Start: 2040578

End: 2042104

Strand: Reverse

Name: imdH [H]

Synonym: LBL_1754

Alternate gene names: 116328414

Gene position: 2042104-2040578 (Counterclockwise)

Preceding gene: 116328419

Following gene: 116328413

Centisome position: 56.5

GC content: 44.99

Gene sequence:

>1527_bases
ATGTCAAACCAAACTTACCGCGACTCCGAATATTTAGACGGACTATCCGGGGATGAATTATTTAGTCTTCAGATCGGTCT
AACGTACAGAGATTTTCTCGTCCTCCCTGGATTTATCGACTTTCATCCGTCCGAAGTTGAGCTTGAAACCAGACTGACTC
GAAATATAAGACTAAAGAGACCTTTTATAAGCTCTCCGATGGACACGGTAACGGAATCCCAAATGGCGATTGCGCAGGCT
CTCATGGGAGGAATCGGAATCATTCATTACAACAACACGATCGAAGAGCAAGTCGCTCTTGTGGAAAAGGTAAAACGTTT
TGAAAATGGATTCATTACGGATCCCGTAGTTTTAGGACCGAAGAACATTATCCGTGATTTGGATCGGATTAAAGAACACA
AAGGATTTACGGGAATTCCGGTAACCGAAGACGGCACAAGAAATTCTAAACTGATCGGAATCGTTACGAATAGGGACATT
GATTTTGAGAGGAATCGAGAAATCACTCTCGACGAAGTGATGACTAAGAATGTGATCACCGGTAAAGAGGGAATTACTTT
GCAGGATGCGAACGACATCATAAAGAAATCTAAGATCGGAAAGCTTCCGATTGTGGATTCCGATGGAAAATTGGTGTCTC
TTGTGAGCCGTTCCGACTTAAAGAAGAATAAAGAATTTCCGGATGCTTCAAAAGACGAAGGAAAAAGACTTCGTTGCGGC
GCTGCAGTTTCCACTCTTCTGGAATCTAGAGATAGGGTGGCGGCGCTTTATGAAGCGGGAGTCGATGTAATCATCATCGA
TTCCGCGCAAGGGAACTCGAATTATCAGATCGAAATGATTCAGTTCATCAAAAAGGAATTTAAAAATTTGGATATAGTTG
CGGGGAATGTGGTGACTCGTGCACAAGCGGAGAATTTGATTCGAGCCGGCGCAGATGGACTTCGAATCGGAATGGGGCCG
GGATCCATTTGTATCACACAGGATACGATGGCCGTCGGACGAGCTCAGGCGACTGCGGTCTATCAAACCGCAAAACATGC
CGCAAAATACGATGTTCCCGTCATTGCGGACGGGGGAATTTCAAATATCGGTGATATCGCGAATTCTCTCGCAATCGGCG
CTTCTACTTGTATGATGGGATTTATGTTCGCCGGGACCACGGAAGCTCCCGGAGAGTATTTTTATGAGAACGGAATTCGT
CTTAAGAAATATAGGGGAATGGCGTCAATCGAAGCGATGAAAGCAGGCGGTGATAAACGTTACTTTAATGAAGGTCAAAA
GGTAAAGGTCGCTCAAGGTGTCAGCGGGTCGGTCGTGGATAGAGGATCGATTTTGAACTTTATTCCGTATTTATCCCAAG
GTCTTAGGTTGTCCTTTCAAGACATGGGTTATAAATCGATACCTGAAATTCATAAAGCTCTTCGGGAGGGGAAGCTTCGT
TTTGAAAGAAGATCCGAATCCGCACAGGCTCAAGGTTCTGTTCATGGTCTTTATTCTTTCAGCGCGCCGACGATGAGGGC
GGAATAA

Upstream 100 bases:

>100_bases
CTCTCTTTTTTTTCTCTGAATCGTTTCCATAGTTTTTCAAAGCGAACGAGGGGAAATTCTCTTGATCTTAGTTCTCAGTT
TACCTTTTATGTACTAGGTA

Downstream 100 bases:

>100_bases
ATTGGATCGGATTCTTGCGTTTATGGTAGGTCTTTTTGCTCTCACTGTGCTAAGCAAAGAGACAAATTCGCAAGGATCCA
ATGTGAGGATCGCCCAAGAG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSNQTYRDSEYLDGLSGDELFSLQIGLTYRDFLVLPGFIDFHPSEVELETRLTRNIRLKRPFISSPMDTVTESQMAIAQA
LMGGIGIIHYNNTIEEQVALVEKVKRFENGFITDPVVLGPKNIIRDLDRIKEHKGFTGIPVTEDGTRNSKLIGIVTNRDI
DFERNREITLDEVMTKNVITGKEGITLQDANDIIKKSKIGKLPIVDSDGKLVSLVSRSDLKKNKEFPDASKDEGKRLRCG
AAVSTLLESRDRVAALYEAGVDVIIIDSAQGNSNYQIEMIQFIKKEFKNLDIVAGNVVTRAQAENLIRAGADGLRIGMGP
GSICITQDTMAVGRAQATAVYQTAKHAAKYDVPVIADGGISNIGDIANSLAIGASTCMMGFMFAGTTEAPGEYFYENGIR
LKKYRGMASIEAMKAGGDKRYFNEGQKVKVAQGVSGSVVDRGSILNFIPYLSQGLRLSFQDMGYKSIPEIHKALREGKLR
FERRSESAQAQGSVHGLYSFSAPTMRAE

Sequences:

>Translated_508_residues
MSNQTYRDSEYLDGLSGDELFSLQIGLTYRDFLVLPGFIDFHPSEVELETRLTRNIRLKRPFISSPMDTVTESQMAIAQA
LMGGIGIIHYNNTIEEQVALVEKVKRFENGFITDPVVLGPKNIIRDLDRIKEHKGFTGIPVTEDGTRNSKLIGIVTNRDI
DFERNREITLDEVMTKNVITGKEGITLQDANDIIKKSKIGKLPIVDSDGKLVSLVSRSDLKKNKEFPDASKDEGKRLRCG
AAVSTLLESRDRVAALYEAGVDVIIIDSAQGNSNYQIEMIQFIKKEFKNLDIVAGNVVTRAQAENLIRAGADGLRIGMGP
GSICITQDTMAVGRAQATAVYQTAKHAAKYDVPVIADGGISNIGDIANSLAIGASTCMMGFMFAGTTEAPGEYFYENGIR
LKKYRGMASIEAMKAGGDKRYFNEGQKVKVAQGVSGSVVDRGSILNFIPYLSQGLRLSFQDMGYKSIPEIHKALREGKLR
FERRSESAQAQGSVHGLYSFSAPTMRAE
>Mature_507_residues
SNQTYRDSEYLDGLSGDELFSLQIGLTYRDFLVLPGFIDFHPSEVELETRLTRNIRLKRPFISSPMDTVTESQMAIAQAL
MGGIGIIHYNNTIEEQVALVEKVKRFENGFITDPVVLGPKNIIRDLDRIKEHKGFTGIPVTEDGTRNSKLIGIVTNRDID
FERNREITLDEVMTKNVITGKEGITLQDANDIIKKSKIGKLPIVDSDGKLVSLVSRSDLKKNKEFPDASKDEGKRLRCGA
AVSTLLESRDRVAALYEAGVDVIIIDSAQGNSNYQIEMIQFIKKEFKNLDIVAGNVVTRAQAENLIRAGADGLRIGMGPG
SICITQDTMAVGRAQATAVYQTAKHAAKYDVPVIADGGISNIGDIANSLAIGASTCMMGFMFAGTTEAPGEYFYENGIRL
KKYRGMASIEAMKAGGDKRYFNEGQKVKVAQGVSGSVVDRGSILNFIPYLSQGLRLSFQDMGYKSIPEIHKALREGKLRF
ERRSESAQAQGSVHGLYSFSAPTMRAE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=494, Percent_Identity=56.2753036437247, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI34328930, Length=494, Percent_Identity=56.2753036437247, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI34328928, Length=494, Percent_Identity=56.2753036437247, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI156616279, Length=494, Percent_Identity=56.2753036437247, Blast_Score=572, Evalue=1e-163,
Organism=Homo sapiens, GI66933016, Length=494, Percent_Identity=55.0607287449393, Blast_Score=566, Evalue=1e-161,
Organism=Homo sapiens, GI217035148, Length=494, Percent_Identity=55.4655870445344, Blast_Score=563, Evalue=1e-160,
Organism=Homo sapiens, GI217035152, Length=476, Percent_Identity=56.5126050420168, Blast_Score=556, Evalue=1e-158,
Organism=Homo sapiens, GI217035150, Length=494, Percent_Identity=53.0364372469636, Blast_Score=532, Evalue=1e-151,
Organism=Homo sapiens, GI156104880, Length=215, Percent_Identity=36.7441860465116, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI50541956, Length=173, Percent_Identity=40.4624277456647, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI50541954, Length=173, Percent_Identity=40.4624277456647, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI50541952, Length=173, Percent_Identity=40.4624277456647, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI50541948, Length=173, Percent_Identity=40.4624277456647, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1788855, Length=474, Percent_Identity=37.9746835443038, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1786293, Length=212, Percent_Identity=32.0754716981132, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71994385, Length=534, Percent_Identity=47.752808988764, Blast_Score=476, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71994389, Length=456, Percent_Identity=48.0263157894737, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17560440, Length=209, Percent_Identity=33.0143540669856, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323464, Length=498, Percent_Identity=57.2289156626506, Blast_Score=560, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322012, Length=497, Percent_Identity=54.5271629778672, Blast_Score=559, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6323585, Length=497, Percent_Identity=55.3319919517103, Blast_Score=558, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6319352, Length=351, Percent_Identity=53.8461538461538, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319353, Length=146, Percent_Identity=54.7945205479452, Blast_Score=153, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24641071, Length=500, Percent_Identity=55.6, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24641073, Length=500, Percent_Identity=55.6, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=55.7823129251701, Blast_Score=499, Evalue=1e-141,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 55835; Mature: 55703

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQTYRDSEYLDGLSGDELFSLQIGLTYRDFLVLPGFIDFHPSEVELETRLTRNIRLKR
CCCCCCCCHHHHCCCCCCCEEEEEECCEEEHHEEECCEECCCCCCEEHHHHHCCCEEEEC
PFISSPMDTVTESQMAIAQALMGGIGIIHYNNTIEEQVALVEKVKRFENGFITDPVVLGP
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECC
KNIIRDLDRIKEHKGFTGIPVTEDGTRNSKLIGIVTNRDIDFERNREITLDEVMTKNVIT
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHCCC
GKEGITLQDANDIIKKSKIGKLPIVDSDGKLVSLVSRSDLKKNKEFPDASKDEGKRLRCG
CCCCCEEECHHHHHHHHCCCCCCEECCCCCEEEEHHHHHHHHCCCCCCCCCCCCCEEEHH
AAVSTLLESRDRVAALYEAGVDVIIIDSAQGNSNYQIEMIQFIKKEFKNLDIVAGNVVTR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHH
AQAENLIRAGADGLRIGMGPGSICITQDTMAVGRAQATAVYQTAKHAAKYDVPVIADGGI
HHHHHHHHCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
SNIGDIANSLAIGASTCMMGFMFAGTTEAPGEYFYENGIRLKKYRGMASIEAMKAGGDKR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEECCCCHHHHHHHCCCCHH
YFNEGQKVKVAQGVSGSVVDRGSILNFIPYLSQGLRLSFQDMGYKSIPEIHKALREGKLR
HHCCCCEEEEECCCCCCEECCCHHHHHHHHHCCCCEEEHHHCCCCCHHHHHHHHHHCCHH
FERRSESAQAQGSVHGLYSFSAPTMRAE
HHHHCCHHHHCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
SNQTYRDSEYLDGLSGDELFSLQIGLTYRDFLVLPGFIDFHPSEVELETRLTRNIRLKR
CCCCCCCHHHHCCCCCCCEEEEEECCEEEHHEEECCEECCCCCCEEHHHHHCCCEEEEC
PFISSPMDTVTESQMAIAQALMGGIGIIHYNNTIEEQVALVEKVKRFENGFITDPVVLGP
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECC
KNIIRDLDRIKEHKGFTGIPVTEDGTRNSKLIGIVTNRDIDFERNREITLDEVMTKNVIT
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHCCC
GKEGITLQDANDIIKKSKIGKLPIVDSDGKLVSLVSRSDLKKNKEFPDASKDEGKRLRCG
CCCCCEEECHHHHHHHHCCCCCCEECCCCCEEEEHHHHHHHHCCCCCCCCCCCCCEEEHH
AAVSTLLESRDRVAALYEAGVDVIIIDSAQGNSNYQIEMIQFIKKEFKNLDIVAGNVVTR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHH
AQAENLIRAGADGLRIGMGPGSICITQDTMAVGRAQATAVYQTAKHAAKYDVPVIADGGI
HHHHHHHHCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
SNIGDIANSLAIGASTCMMGFMFAGTTEAPGEYFYENGIRLKKYRGMASIEAMKAGGDKR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEECCCCHHHHHHHCCCCHH
YFNEGQKVKVAQGVSGSVVDRGSILNFIPYLSQGLRLSFQDMGYKSIPEIHKALREGKLR
HHCCCCEEEEECCCCCCEECCCHHHHHHHHHCCCCEEEHHHCCCCCHHHHHHHHHHCCHH
FERRSESAQAQGSVHGLYSFSAPTMRAE
HHHHCCHHHHCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]