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The map label for this gene is sdhA [H]

Identifier: 116328391

GI number: 116328391

Start: 2012927

End: 2014840

Strand: Direct

Name: sdhA [H]

Synonym: LBL_1728

Alternate gene names: 116328391

Gene position: 2012927-2014840 (Clockwise)

Preceding gene: 116328390

Following gene: 116328392

Centisome position: 55.69

GC content: 45.82

Gene sequence:

>1914_bases
ATGAGTTTAGATTCTAAAATTCCAAACGGCCCGATTGAGAAAAAATGGTCTAATCACAAGGCTAATATCAAGTTAGTCAA
CCCAGCCAACAAAAGAAAATTCAACATCATCGTAGTCGGTTCCGGTTTGGCAGGAGCTTCCGCATCGGCAACTCTCGCAG
AACTCGGTTACAACGTAAAAACATTCTGTTTTCAAGACAGTCCTCGTCGTGCGCATAGTATCGCGGCTCAAGGTGGGATC
AACGCCGCTAAAAACTACCAAAACGACGGTGATTCAGTTTATCGTTTATTCTACGATACAGTGAAAGGCGGCGACTTTCG
CGCAAGAGAAGCGAATGTGCATCGCCTTGCGGAAGTTTCCGTTAACATCATCGATCAGTGTGTCGCCCAAGGAGTTCCTT
TCGCGAGAGAATACGGAGGGCATCTTTCCAACCGTTCTTTCGGCGGGGCTCAAGTTTCCAGAACCTTCTACGCAAAAGGT
CAAACCGGACAACAGCTTCTCTTAGGAGCTTACTCCGCTCTCTCTCGTCAAATCGGGTTGGGTGCGGTAAAGATGTATCC
TAGAACCGAGATGGTGGAACTAATCGTGATTGACGGTCATGCAAAAGGAATCATAGTTCGTGATCTTGTCACCGGAGAAC
TTTCCACTCACATGGCGGATGCAATTGTGCTTGGAACCGGAGGTTACGGAAACGTATTCTTTCTTTCCACGAATGCAAAA
GGTTGTAACGTAACTGCAACTTGGAAAGCTCATAAAAAAGGAGCATACTTTGCTAACCCGTGTTATACGCAAATTCACCC
GACGTGTATTCCTGTTTCCGGAGATCATCAATCCAAACTGACTTTGATGTCCGAGTCCCTTAGAAACGACGGAAGAATCT
GGGTTCCGAAAAATAAAGGAGACAAACGGAGTCCCGCGGACATACCCGAATCGGAAAGAGATTATTATTTGGAAAGAAAA
TACCCAAGTTACGGAAATCTTTCTCCAAGGGACATTGCATCCCGCGCGGCCAAAGAAGCTTGCGACGCAGGACTCGGTGT
GGGAGAATCCGGACAAGGAGTATATTTGGATTTTGCAGACTCGATCAAACGCCTTGGTGAAGACAAAATCCGGGATCGTT
ACGAAAATCTCTTCCAAATGTATGAACAAATCACCGGTGAAAATCCTTACAAACAACCGATGAGAATTTACCCTGCTGTC
CACTATACAATGGGTGGACTTTGGGTGGATTACAATCTAATGAGCAACTTACCCGGTCTGTTTGTAATCGGAGAAGCAAA
CTTTTCCGATCACGGAGCAAACCGCCTCGGAGCGTCCGCTTTGATGCAGGGACTTGCGGACGGATATTTCATTCTTCCTT
ATACGATCGGAAATTATCTCGCAGGAGTGGGATTTAATTCTCATCCCAAAGAAGATCACGCAGAAGCCAAAAAAGCTCTT
TCCGATGCGAAAGAGACCACGAAAAAACTTCTTTCCATCCAAGGAAAAAGAACCGTGGATTCTTTCCATAAGCAACTCGG
GAAACTGATGTGGGACAAATGCGGAATGGCGCGTAATGATAAAGGTCTTAAAGAAGCGTTATCCGAAATTCCTAATATCC
GGGAAGAGTTCTGGAAAAACGTAAATGTTCCCGGAAGTGGAGCCGAGCTCAATCAGTCTCTCGAAAAAGCGGGAAGAGTC
GCGGACTTCCTCGAATTCGCCGAACTTCTTTGTTTAGATGCATTGACTCGGGAAGAATCCTGTGGAGGACATTTCCGAGA
AGAGCACCAAGAAGAAGGAGAAGCGAAACGAAACGACGATAAATTCTGCCACGCAACCGCTTGGGAATTCAACGGAATCG
GTAAAAAACCGACAGAACACAGGGAAAAACTGGAATTCGAAAACGTTCACCTCGCTACAAGGAGTTATAAATAA

Upstream 100 bases:

>100_bases
AGCGATTCTTTTTGCTTTGATCATTTTTATTGGAAACACTTCTATCCCGCTTTCGATTTTGGCGGGATACGTTCACCCGT
AATTCTTTGGAGAAACTTTT

Downstream 100 bases:

>100_bases
TGGATCTGAAGCTCAAAGTTTGGAGACAAAAAAACGGAGAAACAAAGGGAAAGATTGCAGACTATGATGCAAAAGATATT
TCCCCGAACATGTCCTTTTT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MSLDSKIPNGPIEKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVKTFCFQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVSVNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKG
QTGQQLLLGAYSALSRQIGLGAVKMYPRTEMVELIVIDGHAKGIIVRDLVTGELSTHMADAIVLGTGGYGNVFFLSTNAK
GCNVTATWKAHKKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKGDKRSPADIPESERDYYLERK
YPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFADSIKRLGEDKIRDRYENLFQMYEQITGENPYKQPMRIYPAV
HYTMGGLWVDYNLMSNLPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHAEAKKAL
SDAKETTKKLLSIQGKRTVDSFHKQLGKLMWDKCGMARNDKGLKEALSEIPNIREEFWKNVNVPGSGAELNQSLEKAGRV
ADFLEFAELLCLDALTREESCGGHFREEHQEEGEAKRNDDKFCHATAWEFNGIGKKPTEHREKLEFENVHLATRSYK

Sequences:

>Translated_637_residues
MSLDSKIPNGPIEKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVKTFCFQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVSVNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKG
QTGQQLLLGAYSALSRQIGLGAVKMYPRTEMVELIVIDGHAKGIIVRDLVTGELSTHMADAIVLGTGGYGNVFFLSTNAK
GCNVTATWKAHKKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKGDKRSPADIPESERDYYLERK
YPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFADSIKRLGEDKIRDRYENLFQMYEQITGENPYKQPMRIYPAV
HYTMGGLWVDYNLMSNLPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHAEAKKAL
SDAKETTKKLLSIQGKRTVDSFHKQLGKLMWDKCGMARNDKGLKEALSEIPNIREEFWKNVNVPGSGAELNQSLEKAGRV
ADFLEFAELLCLDALTREESCGGHFREEHQEEGEAKRNDDKFCHATAWEFNGIGKKPTEHREKLEFENVHLATRSYK
>Mature_636_residues
SLDSKIPNGPIEKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVKTFCFQDSPRRAHSIAAQGGIN
AAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVSVNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKGQ
TGQQLLLGAYSALSRQIGLGAVKMYPRTEMVELIVIDGHAKGIIVRDLVTGELSTHMADAIVLGTGGYGNVFFLSTNAKG
CNVTATWKAHKKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKGDKRSPADIPESERDYYLERKY
PSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFADSIKRLGEDKIRDRYENLFQMYEQITGENPYKQPMRIYPAVH
YTMGGLWVDYNLMSNLPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHAEAKKALS
DAKETTKKLLSIQGKRTVDSFHKQLGKLMWDKCGMARNDKGLKEALSEIPNIREEFWKNVNVPGSGAELNQSLEKAGRVA
DFLEFAELLCLDALTREESCGGHFREEHQEEGEAKRNDDKFCHATAWEFNGIGKKPTEHREKLEFENVHLATRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=559, Percent_Identity=25.9391771019678, Blast_Score=146, Evalue=6e-35,
Organism=Escherichia coli, GI1790597, Length=571, Percent_Identity=27.6707530647986, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI1788928, Length=589, Percent_Identity=25.2971137521222, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1786942, Length=603, Percent_Identity=26.0364842454395, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17550100, Length=540, Percent_Identity=28.8888888888889, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17505833, Length=543, Percent_Identity=27.8084714548803, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322701, Length=600, Percent_Identity=27.3333333333333, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6322416, Length=620, Percent_Identity=26.7741935483871, Blast_Score=170, Evalue=8e-43,
Organism=Drosophila melanogaster, GI17137288, Length=654, Percent_Identity=27.0642201834862, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24655642, Length=654, Percent_Identity=27.0642201834862, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24655647, Length=654, Percent_Identity=27.0642201834862, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24663005, Length=575, Percent_Identity=25.9130434782609, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70377; Mature: 70246

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDSKIPNGPIEKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVK
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCEE
TFCFQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVS
EEEECCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKGQTGQQLLLGAYSALSRQIGL
HHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHCC
GAVKMYPRTEMVELIVIDGHAKGIIVRDLVTGELSTHMADAIVLGTGGYGNVFFLSTNAK
CEEEECCCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHCCEEEEECCCCCCEEEEECCCC
GCNVTATWKAHKKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKG
CCEEEEEECCCCCCCEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCC
DKRSPADIPESERDYYLERKYPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFAD
CCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHH
SIKRLGEDKIRDRYENLFQMYEQITGENPYKQPMRIYPAVHYTMGGLWVDYNLMSNLPGL
HHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCEEEEEEHHHCCCCE
FVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHAEAKKAL
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHH
SDAKETTKKLLSIQGKRTVDSFHKQLGKLMWDKCGMARNDKGLKEALSEIPNIREEFWKN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHC
VNVPGSGAELNQSLEKAGRVADFLEFAELLCLDALTREESCGGHFREEHQEEGEAKRNDD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC
KFCHATAWEFNGIGKKPTEHREKLEFENVHLATRSYK
CEEEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCC
>Mature Secondary Structure 
SLDSKIPNGPIEKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVK
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCEE
TFCFQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVS
EEEECCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKGQTGQQLLLGAYSALSRQIGL
HHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHCC
GAVKMYPRTEMVELIVIDGHAKGIIVRDLVTGELSTHMADAIVLGTGGYGNVFFLSTNAK
CEEEECCCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHCCEEEEECCCCCCEEEEECCCC
GCNVTATWKAHKKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKG
CCEEEEEECCCCCCCEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCC
DKRSPADIPESERDYYLERKYPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFAD
CCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHH
SIKRLGEDKIRDRYENLFQMYEQITGENPYKQPMRIYPAVHYTMGGLWVDYNLMSNLPGL
HHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCEEEEEEHHHCCCCE
FVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHAEAKKAL
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHH
SDAKETTKKLLSIQGKRTVDSFHKQLGKLMWDKCGMARNDKGLKEALSEIPNIREEFWKN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHC
VNVPGSGAELNQSLEKAGRVADFLEFAELLCLDALTREESCGGHFREEHQEEGEAKRNDD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC
KFCHATAWEFNGIGKKPTEHREKLEFENVHLATRSYK
CEEEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]