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The map label for this gene is hldE [H]

Identifier: 116328339

GI number: 116328339

Start: 1956083

End: 1956559

Strand: Reverse

Name: hldE [H]

Synonym: LBL_1676

Alternate gene names: 116328339

Gene position: 1956559-1956083 (Counterclockwise)

Preceding gene: 116328340

Following gene: 116328338

Centisome position: 54.13

GC content: 44.44

Gene sequence:

>477_bases
ATGGATTTGAAGACCCGTATTGTTCCTTGGGAAAACGTGGCGATTTTTGCGAACCGAATTCGAGAAAATCGAAGAATTGT
TTTCACCAATGGATGTTTCGATTTGATTCACAGGGGTCACATTACGTATCTTTCCCAGGCTCGAGAACTCGGGGATTTTC
TCTGGATAGGGCTTAATGCGGATTCTTCCGTAAAACGTCTGAAAGGAGAACAAAGACCGGTGGTCCCTGAAGACGACCGA
GCGATTCTTCTTTCCAATCTAAGATTTGTGGACGCGGTGACTATTTTTTCTCAGGAAACACCGCTCGAACTGATCCGTCT
CATCAAACCTGCGATTCACGTAAAAGGGGGGGATTATAAGGTAGAAGATTTGCCTGAAACGTCGATTGTCCGCGAATTCG
GCGGAAAAGTCGAAATATTACCTTTCGTACCCGGAAAATCCACTTCACTTCTAATCGAGAAAATCCTGAAACTCTAA

Upstream 100 bases:

>100_bases
CTGCGGCGGGAGTTGTAATCGCAAAATTAGGAGCGGAAACCGTGACTCCCGAAGAATTAGATCTTTCTTTGCAATCTATG
GGAAGTTTTCAAAAGTAAAG

Downstream 100 bases:

>100_bases
AACGTATCGTCCCATTTTTTTAGAGACAGAATTCTTGGAAATTCCGGTTTGAATTTCAAGAAACACTAAAAAACTCTGTT
CTTAAAAGGCGGGAGTACAA

Product: ADP-heptose synthase, adenylyltransferase component

Products: diphosphate; CDPglycerol

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MDLKTRIVPWENVAIFANRIRENRRIVFTNGCFDLIHRGHITYLSQARELGDFLWIGLNADSSVKRLKGEQRPVVPEDDR
AILLSNLRFVDAVTIFSQETPLELIRLIKPAIHVKGGDYKVEDLPETSIVREFGGKVEILPFVPGKSTSLLIEKILKL

Sequences:

>Translated_158_residues
MDLKTRIVPWENVAIFANRIRENRRIVFTNGCFDLIHRGHITYLSQARELGDFLWIGLNADSSVKRLKGEQRPVVPEDDR
AILLSNLRFVDAVTIFSQETPLELIRLIKPAIHVKGGDYKVEDLPETSIVREFGGKVEILPFVPGKSTSLLIEKILKL
>Mature_158_residues
MDLKTRIVPWENVAIFANRIRENRRIVFTNGCFDLIHRGHITYLSQARELGDFLWIGLNADSSVKRLKGEQRPVVPEDDR
AILLSNLRFVDAVTIFSQETPLELIRLIKPAIHVKGGDYKVEDLPETSIVREFGGKVEILPFVPGKSTSLLIEKILKL

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=143, Percent_Identity=46.8531468531469, Blast_Score=125, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI115533408, Length=112, Percent_Identity=31.25, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193209647, Length=112, Percent_Identity=31.25, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.7.39

Molecular weight: Translated: 18005; Mature: 18005

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKTRIVPWENVAIFANRIRENRRIVFTNGCFDLIHRGHITYLSQARELGDFLWIGLNA
CCCCCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHCCCHHHHHHHHHCCCEEEEEECC
DSSVKRLKGEQRPVVPEDDRAILLSNLRFVDAVTIFSQETPLELIRLIKPAIHVKGGDYK
CCHHHHHCCCCCCCCCCCCCEEEECCCHHHHHEEECCCCCHHHHHHHHHHHEEECCCCEE
VEDLPETSIVREFGGKVEILPFVPGKSTSLLIEKILKL
CCCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDLKTRIVPWENVAIFANRIRENRRIVFTNGCFDLIHRGHITYLSQARELGDFLWIGLNA
CCCCCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHCCCHHHHHHHHHCCCEEEEEECC
DSSVKRLKGEQRPVVPEDDRAILLSNLRFVDAVTIFSQETPLELIRLIKPAIHVKGGDYK
CCHHHHHCCCCCCCCCCCCCEEEECCCHHHHHEEECCCCCHHHHHHHHHHHEEECCCCEE
VEDLPETSIVREFGGKVEILPFVPGKSTSLLIEKILKL
CCCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; sn-glycerol 3-phosphate

Specific reaction: CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA