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The map label for this gene is kdsA [H]

Identifier: 116328337

GI number: 116328337

Start: 1953499

End: 1954362

Strand: Reverse

Name: kdsA [H]

Synonym: LBL_1674

Alternate gene names: 116328337

Gene position: 1954362-1953499 (Counterclockwise)

Preceding gene: 116328338

Following gene: 116328336

Centisome position: 54.07

GC content: 44.44

Gene sequence:

>864_bases
ATGAGAGACAATACCTGTACTAAAAGAGATTTTCTAAACGGAAGTAAGATTGGAGGAGACGAACCTTTCTTTTTGATCGC
CGGTCCCTGTGTGATGGAGAATCGGGATCTTCTGGACCGTGTTTGTGCGGAGATGATCGAAATCTGCGACGAATTAAAAA
TTTCTTATGTTTTCAAAAGTAGTTTCGATAAGGCGAATCGTTCTTCCGTAAACTCTTATCGCGGGCCGGGACTTACGGAA
GGTATTCAAAATTTAGAATATATCAAAAACAAATACAATGTTCCCGTTCTTACGGATATTCACGAAACACATCAGATCGC
TCCTTTAAAAGACGCGATCGATATCTATCAGATCCCCGCTTTTCTGTGCAGACAGACAGACCTGATAGCCGAGTCGGCCA
AAACCGGAAGATGGGTGAACGTAAAAAAGGGACAATTCCTCGCTCCTTCCGATACGAGGCATATCGCGGTAAAGATGAAG
GAATCGGGGAACGACAAACTGCTTGTGACCGAAAGAGGTACTTCTTTCGGTTACGGTAACTTGATCTTTGACGGAAGAGC
GATTCCGATCATTCACGGATTCGATATTCCTCTTATATTCGATGCGACTCATTCCGCACAACTTCCCGGAGCGGCCGAAA
ATAGCACGGGAGGGCAAAGGGAATTTATTCCGAGCATTCTTCGCTCCGCGGTTTCCCTCGGGATAGAAGGAGTTTTTATG
GAAGTACATCCCGATCCTCAAAAGGCTCTTTCGGATGCGACGACTCAGTATCCTCTCTCCCGGATCAAAGATCTTTTAAA
AGAAATGATCGGTCTAGATCGTTATGTCAAAAAAGAAATTCTCGTTTCCAGAAGCGAATCGTAA

Upstream 100 bases:

>100_bases
TTCAGTTTCATCCCGAATTTCAATCCAGACCTACAAAGCCTCATCCCTTATTTGCTGGATTTATCCGTGCGGCCGTGAAA
TACTCAAAGAAAGGATCATC

Downstream 100 bases:

>100_bases
TCGGATCTGTCATGAAAAACAGGATTAACAATCGGATTTTTTTTCTTCCGGTTGTTTGCGCCTTTTTCATATTAACATTT
TATTATTGTAAAAAGGTAAA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MRDNTCTKRDFLNGSKIGGDEPFFLIAGPCVMENRDLLDRVCAEMIEICDELKISYVFKSSFDKANRSSVNSYRGPGLTE
GIQNLEYIKNKYNVPVLTDIHETHQIAPLKDAIDIYQIPAFLCRQTDLIAESAKTGRWVNVKKGQFLAPSDTRHIAVKMK
ESGNDKLLVTERGTSFGYGNLIFDGRAIPIIHGFDIPLIFDATHSAQLPGAAENSTGGQREFIPSILRSAVSLGIEGVFM
EVHPDPQKALSDATTQYPLSRIKDLLKEMIGLDRYVKKEILVSRSES

Sequences:

>Translated_287_residues
MRDNTCTKRDFLNGSKIGGDEPFFLIAGPCVMENRDLLDRVCAEMIEICDELKISYVFKSSFDKANRSSVNSYRGPGLTE
GIQNLEYIKNKYNVPVLTDIHETHQIAPLKDAIDIYQIPAFLCRQTDLIAESAKTGRWVNVKKGQFLAPSDTRHIAVKMK
ESGNDKLLVTERGTSFGYGNLIFDGRAIPIIHGFDIPLIFDATHSAQLPGAAENSTGGQREFIPSILRSAVSLGIEGVFM
EVHPDPQKALSDATTQYPLSRIKDLLKEMIGLDRYVKKEILVSRSES
>Mature_287_residues
MRDNTCTKRDFLNGSKIGGDEPFFLIAGPCVMENRDLLDRVCAEMIEICDELKISYVFKSSFDKANRSSVNSYRGPGLTE
GIQNLEYIKNKYNVPVLTDIHETHQIAPLKDAIDIYQIPAFLCRQTDLIAESAKTGRWVNVKKGQFLAPSDTRHIAVKMK
ESGNDKLLVTERGTSFGYGNLIFDGRAIPIIHGFDIPLIFDATHSAQLPGAAENSTGGQREFIPSILRSAVSLGIEGVFM
EVHPDPQKALSDATTQYPLSRIKDLLKEMIGLDRYVKKEILVSRSES

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=263, Percent_Identity=42.5855513307985, Blast_Score=240, Evalue=8e-65,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 31971; Mature: 31971

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDNTCTKRDFLNGSKIGGDEPFFLIAGPCVMENRDLLDRVCAEMIEICDELKISYVFKS
CCCCCCCHHHCCCCCCCCCCCCEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
SFDKANRSSVNSYRGPGLTEGIQNLEYIKNKYNVPVLTDIHETHQIAPLKDAIDIYQIPA
HCCCCCHHCCHHCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCHHHHHHHHHHHH
FLCRQTDLIAESAKTGRWVNVKKGQFLAPSDTRHIAVKMKESGNDKLLVTERGTSFGYGN
HHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCEEEEEEECCCCCEEEEEECCCCCCCCC
LIFDGRAIPIIHGFDIPLIFDATHSAQLPGAAENSTGGQREFIPSILRSAVSLGIEGVFM
EEECCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEE
EVHPDPQKALSDATTQYPLSRIKDLLKEMIGLDRYVKKEILVSRSES
EECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRDNTCTKRDFLNGSKIGGDEPFFLIAGPCVMENRDLLDRVCAEMIEICDELKISYVFKS
CCCCCCCHHHCCCCCCCCCCCCEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
SFDKANRSSVNSYRGPGLTEGIQNLEYIKNKYNVPVLTDIHETHQIAPLKDAIDIYQIPA
HCCCCCHHCCHHCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCHHHHHHHHHHHH
FLCRQTDLIAESAKTGRWVNVKKGQFLAPSDTRHIAVKMKESGNDKLLVTERGTSFGYGN
HHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCEEEEEEECCCCCEEEEEECCCCCCCCC
LIFDGRAIPIIHGFDIPLIFDATHSAQLPGAAENSTGGQREFIPSILRSAVSLGIEGVFM
EEECCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEE
EVHPDPQKALSDATTQYPLSRIKDLLKEMIGLDRYVKKEILVSRSES
EECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA