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The map label for this gene is yajL [H]

Identifier: 116328289

GI number: 116328289

Start: 1903242

End: 1903778

Strand: Reverse

Name: yajL [H]

Synonym: LBL_1624

Alternate gene names: 116328289

Gene position: 1903778-1903242 (Counterclockwise)

Preceding gene: 116328290

Following gene: 116328288

Centisome position: 52.67

GC content: 45.07

Gene sequence:

>537_bases
ATGCCTAAGGTTTTGGTCCCATTCGCAGAAGGAATGGAAGCGGTTATCATCGTAGATGTTCTCCGCAGAGCGGGGGTGGA
AGTTACGAGTGCTTCCCTAAAGGAAGGACCGGTAAAGGCTTCCAGGGGAATTTACCTTTTAGCCGATACAACTTTAGACG
CGGTAAACTTAAAAGACTTTGATATGATCGTGCTTCCGGGTAGAGCCGGAGGCACCAAGGTTCTAGGAGCAGACCCCAAA
ATAGCCGATTTTCTCCAAGAAGCGAAAAAAGAAAACAAATGGATCGGTGCCATTTGTGCCGCACCTAGTATTTTAGTACA
TCAAAATATACTAACTTCTGAGGATCGTTTTACCGCTTTTCCTGGAATCGTATCCGATACATCGGGTTATACCGGTTCCC
GGTTGGAAATTTCCGGAAAGATCGTTACAAGCATCGGTCCCGGTTCTGCCTTCGAATTTTCTTTAGAGCTCGTAAAAATC
CTATGCGGGAAAGAATCTATGTTGAAAGTGAAATCCGCTCTTCAACTTGCTTTATGA

Upstream 100 bases:

>100_bases
ATTGAATTCGCGATGAAAGAAGGACGATCCGATATCAAACCGGATTGAAATTCAAACGAATCTCCCTCAAGTGAATTTAA
GGTTTCTAAAGGAGAAGTAT

Downstream 100 bases:

>100_bases
AAGAATTCATATCGAAGCATAAGGGTAAATTTCAGAGAATCACTGCAATTTCCGGAGCCGGAATTTCCGCCGAAAGTGGG
ATTCCCACGTTTCGGGGAAG

Product: DJ-1/PfpI family intracellular protease

Products: 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium; 4-Methyl-5-(2-hydroxyethyl)-thiazole

Alternate protein names: NA

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MPKVLVPFAEGMEAVIIVDVLRRAGVEVTSASLKEGPVKASRGIYLLADTTLDAVNLKDFDMIVLPGRAGGTKVLGADPK
IADFLQEAKKENKWIGAICAAPSILVHQNILTSEDRFTAFPGIVSDTSGYTGSRLEISGKIVTSIGPGSAFEFSLELVKI
LCGKESMLKVKSALQLAL

Sequences:

>Translated_178_residues
MPKVLVPFAEGMEAVIIVDVLRRAGVEVTSASLKEGPVKASRGIYLLADTTLDAVNLKDFDMIVLPGRAGGTKVLGADPK
IADFLQEAKKENKWIGAICAAPSILVHQNILTSEDRFTAFPGIVSDTSGYTGSRLEISGKIVTSIGPGSAFEFSLELVKI
LCGKESMLKVKSALQLAL
>Mature_177_residues
PKVLVPFAEGMEAVIIVDVLRRAGVEVTSASLKEGPVKASRGIYLLADTTLDAVNLKDFDMIVLPGRAGGTKVLGADPKI
ADFLQEAKKENKWIGAICAAPSILVHQNILTSEDRFTAFPGIVSDTSGYTGSRLEISGKIVTSIGPGSAFEFSLELVKIL
CGKESMLKVKSALQLAL

Specific function: Involved in biogenesis of ribosomal proteins, probably as a ribosomal protein-folding chaperone. Interacts with ribosomal subunits, ribosomes and polysomes. Confers resistance to oxidative stress [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C56 family [H]

Homologues:

Organism=Homo sapiens, GI183227678, Length=181, Percent_Identity=38.121546961326, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI31543380, Length=181, Percent_Identity=38.121546961326, Blast_Score=101, Evalue=3e-22,
Organism=Escherichia coli, GI87081736, Length=181, Percent_Identity=32.5966850828729, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531319, Length=162, Percent_Identity=38.2716049382716, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17558714, Length=171, Percent_Identity=35.0877192982456, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571932, Length=179, Percent_Identity=38.5474860335196, Blast_Score=116, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24653499, Length=177, Percent_Identity=36.1581920903955, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006287
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: 2.5.1.2

Molecular weight: Translated: 18875; Mature: 18744

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVLVPFAEGMEAVIIVDVLRRAGVEVTSASLKEGPVKASRGIYLLADTTLDAVNLKDF
CCCEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEECCCCEECCCCC
DMIVLPGRAGGTKVLGADPKIADFLQEAKKENKWIGAICAAPSILVHQNILTSEDRFTAF
CEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEHHCCCEEEEECCCCCCCCCEEEC
PGIVSDTSGYTGSRLEISGKIVTSIGPGSAFEFSLELVKILCGKESMLKVKSALQLAL
CCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKVLVPFAEGMEAVIIVDVLRRAGVEVTSASLKEGPVKASRGIYLLADTTLDAVNLKDF
CCEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEECCCCEECCCCC
DMIVLPGRAGGTKVLGADPKIADFLQEAKKENKWIGAICAAPSILVHQNILTSEDRFTAF
CEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEHHCCCEEEEECCCCCCCCCEEEC
PGIVSDTSGYTGSRLEISGKIVTSIGPGSAFEFSLELVKILCGKESMLKVKSALQLAL
CCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: thiamine; pyridine

Specific reaction: thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9592144 [H]