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The map label for this gene is cobB [H]

Identifier: 116328288

GI number: 116328288

Start: 1902514

End: 1903245

Strand: Reverse

Name: cobB [H]

Synonym: LBL_1623

Alternate gene names: 116328288

Gene position: 1903245-1902514 (Counterclockwise)

Preceding gene: 116328289

Following gene: 116328284

Centisome position: 52.66

GC content: 42.76

Gene sequence:

>732_bases
ATGAAAGAATTCATATCGAAGCATAAGGGTAAATTTCAGAGAATCACTGCAATTTCCGGAGCCGGAATTTCCGCCGAAAG
TGGGATTCCCACGTTTCGGGGAAGCGGCGGCCTTTGGAAAAATTTTCGAGCCGAAGATTTAGCAACTCCACAAGCCTTTC
AAAAGGATCCCAAGCTAGTTTGGGAATGGTATCTTTGGAGAAGAAACGTTATCGACACCAAACAACCGAATCGTGGGCAT
CTGGCGCTTGCAGAATTGGAGAAAATACATCCTGATTTTTTTCTAGTCACTCAGAATGTGGACGGGCTTCATATTCGTGC
AGGCTCTAGGAAGTTACTCGAAATGCACGGAAATATTTTTATTAATCGCTGTACATCCTGCAGTCAAGAATCCAATGAGA
AAATCCTCAATGGGGAAGATTTACTTCCCCCGAAGTGTAAATTCTGTGGGAATTTTTTAAGACCGGGGATAGTTTGGTTC
GGCGAAAGTTACGACCAAGAGAAACTGAATTTTTCCATTCAAAGAATGGAAAATACAAATCTATTATTGGTTCTCGGAAC
CTCCGGTCTTGTTAGCATGCCGGTGTATCTAACTCAGGTTGCAAAACGTTCAGGTGCCATTCTTATTGAAATCAATCCGG
AACGTTCTTCCTTCTCCTCTTCCGTGGATCTTTTCATTCAAGGAAAAACGGGGGAAATTCTTCCTGAGTTAGTTTCGGAA
ATCGTAGCGTGA

Upstream 100 bases:

>100_bases
TCGGTCCCGGTTCTGCCTTCGAATTTTCTTTAGAGCTCGTAAAAATCCTATGCGGGAAAGAATCTATGTTGAAAGTGAAA
TCCGCTCTTCAACTTGCTTT

Downstream 100 bases:

>100_bases
TTTACCCGGAAGAGGTCGATTTATTTTTTCATTAGAGTTGTTGAAAAATTCATTTTTCATCCATTTCTGTTTCATAAAAA
CGGTCAATTGAAGTAGTTTT

Product: Sir2 family NAD-dependent protein deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKEFISKHKGKFQRITAISGAGISAESGIPTFRGSGGLWKNFRAEDLATPQAFQKDPKLVWEWYLWRRNVIDTKQPNRGH
LALAELEKIHPDFFLVTQNVDGLHIRAGSRKLLEMHGNIFINRCTSCSQESNEKILNGEDLLPPKCKFCGNFLRPGIVWF
GESYDQEKLNFSIQRMENTNLLLVLGTSGLVSMPVYLTQVAKRSGAILIEINPERSSFSSSVDLFIQGKTGEILPELVSE
IVA

Sequences:

>Translated_243_residues
MKEFISKHKGKFQRITAISGAGISAESGIPTFRGSGGLWKNFRAEDLATPQAFQKDPKLVWEWYLWRRNVIDTKQPNRGH
LALAELEKIHPDFFLVTQNVDGLHIRAGSRKLLEMHGNIFINRCTSCSQESNEKILNGEDLLPPKCKFCGNFLRPGIVWF
GESYDQEKLNFSIQRMENTNLLLVLGTSGLVSMPVYLTQVAKRSGAILIEINPERSSFSSSVDLFIQGKTGEILPELVSE
IVA
>Mature_243_residues
MKEFISKHKGKFQRITAISGAGISAESGIPTFRGSGGLWKNFRAEDLATPQAFQKDPKLVWEWYLWRRNVIDTKQPNRGH
LALAELEKIHPDFFLVTQNVDGLHIRAGSRKLLEMHGNIFINRCTSCSQESNEKILNGEDLLPPKCKFCGNFLRPGIVWF
GESYDQEKLNFSIQRMENTNLLLVLGTSGLVSMPVYLTQVAKRSGAILIEINPERSSFSSSVDLFIQGKTGEILPELVSE
IVA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=254, Percent_Identity=40.9448818897638, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI6912664, Length=265, Percent_Identity=40, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI13787215, Length=231, Percent_Identity=41.991341991342, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI6912662, Length=276, Percent_Identity=30.0724637681159, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI300797577, Length=236, Percent_Identity=30.0847457627119, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI300797597, Length=225, Percent_Identity=29.7777777777778, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI6912660, Length=208, Percent_Identity=34.1346153846154, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI63054862, Length=203, Percent_Identity=33.9901477832512, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI300797705, Length=194, Percent_Identity=31.4432989690722, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI13775602, Length=222, Percent_Identity=31.0810810810811, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI13775600, Length=222, Percent_Identity=31.0810810810811, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI7657575, Length=219, Percent_Identity=26.9406392694064, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI308199517, Length=239, Percent_Identity=38.0753138075314, Blast_Score=150, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71990482, Length=277, Percent_Identity=28.158844765343, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71990487, Length=279, Percent_Identity=27.9569892473118, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17567771, Length=268, Percent_Identity=27.6119402985075, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17541892, Length=210, Percent_Identity=30.4761904761905, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571445, Length=272, Percent_Identity=27.5735294117647, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24648389, Length=189, Percent_Identity=30.6878306878307, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17137536, Length=213, Percent_Identity=27.2300469483568, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571443, Length=220, Percent_Identity=26.8181818181818, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28571441, Length=220, Percent_Identity=26.8181818181818, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24650933, Length=246, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24645650, Length=115, Percent_Identity=34.7826086956522, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27310; Mature: 27310

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEFISKHKGKFQRITAISGAGISAESGIPTFRGSGGLWKNFRAEDLATPQAFQKDPKLV
CHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHCCCHHH
WEWYLWRRNVIDTKQPNRGHLALAELEKIHPDFFLVTQNVDGLHIRAGSRKLLEMHGNIF
HHHHHHHCCCCCCCCCCCCCEEHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHCCCEE
INRCTSCSQESNEKILNGEDLLPPKCKFCGNFLRPGIVWFGESYDQEKLNFSIQRMENTN
EEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHCEEEEEECCCC
LLLVLGTSGLVSMPVYLTQVAKRSGAILIEINPERSSFSSSVDLFIQGKTGEILPELVSE
EEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHH
IVA
HCC
>Mature Secondary Structure
MKEFISKHKGKFQRITAISGAGISAESGIPTFRGSGGLWKNFRAEDLATPQAFQKDPKLV
CHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHCCCHHH
WEWYLWRRNVIDTKQPNRGHLALAELEKIHPDFFLVTQNVDGLHIRAGSRKLLEMHGNIF
HHHHHHHCCCCCCCCCCCCCEEHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHCCCEE
INRCTSCSQESNEKILNGEDLLPPKCKFCGNFLRPGIVWFGESYDQEKLNFSIQRMENTN
EEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHCEEEEEECCCC
LLLVLGTSGLVSMPVYLTQVAKRSGAILIEINPERSSFSSSVDLFIQGKTGEILPELVSE
EEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHH
IVA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA