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The map label for this gene is lpxC

Identifier: 116328216

GI number: 116328216

Start: 1801775

End: 1802680

Strand: Reverse

Name: lpxC

Synonym: LBL_1540

Alternate gene names: 116328216

Gene position: 1802680-1801775 (Counterclockwise)

Preceding gene: 116328220

Following gene: 116328215

Centisome position: 49.87

GC content: 41.5

Gene sequence:

>906_bases
ATGAAAGAAATCCTATATAGAAAATCCATACAAGATAGAGTTAGAATCAAAGGGATTGGGCTTCATTCCGGAAAGGAAGT
GAACTTAACAGCTCATCCTGCCCCCTCTGGTACAGGAATCGTTTTTGAATATCGAAAAGGTTTAGAAAAGGCGTCGATTT
CCGTTGAACTCAGTAATGTAGTTGATACCAGTAATGCAACTACCCTGGGAGATGGTCTTCATAAGATCCAAACCGTGGAA
CATCTATTGGCGGCAATTTACGCACTCGGTCTAACGGATTTGATTTTGGAAATTGATGCCGTGGAAGTCCCGATTATGGA
TGGCTCCTCGCTTCCTTTCTTACAAGCGCTTGAGTCGGCAGGAATTGTAAAATATCCAGAAATTATAGAGCCGATTTACG
TTCAAAACCCTCTTTGGGTTGTAGACGGAGATAAGTATCTGGTTTTACTTCCCAGCGATGAACTCAAAGTAACCTACACG
ATCGACTTCAATCACCCCCTTCTGAAAGGCCAAAATATTACAATTTCCCTAGATAAAGAAACGATCAAGCAAGAGATTCT
CCCAGCAAGAACCTTCGGCTTCTTAAAAGATGTAGAAGCCCTCCAAGCAAAAGGTCTTGCGATGGGCGGCTCTTTGGATA
ATGCAATTGTTTTAACCCAAGACGGATATCTGAACCAACAGCTTCGTTTTGAAAACGAGTGTGTTCGTCATAAAATTTTG
GATCTTTTTGGAGACATATCTATCGCAGGTCGGCCGATTATTGGACATTATCTTGCATCTAAAGCAGGACATGCACTGGA
TATTTCCATGGCTAAACTTGTGATGAGCAGTGTTACCGGAGACGAAATCAGCAAATACAAAAGTCGAAGAATTCCGCTTT
TCAAAAGAAAAGTGGCAGTTGTTTAA

Upstream 100 bases:

>100_bases
GTTTGGATTTTGTCTCTTAATAAATCTGAAAACGAACTTCAAGCCCATAACGACCGTCTTTTTGGTTGAGGGACGTAAAA
AATCAAATATTCAAAAAACT

Downstream 100 bases:

>100_bases
ACTTTCCGATATTTTCGTTTCGATCGATGTAAAAACTGAAACTTTATCTGTTGTAATTCTTACCTAGAAAAGAATTGTCA
GATTCTTCTTTTGGGGAATT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKEILYRKSIQDRVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEYRKGLEKASISVELSNVVDTSNATTLGDGLHKIQTVE
HLLAAIYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIVKYPEIIEPIYVQNPLWVVDGDKYLVLLPSDELKVTYT
IDFNHPLLKGQNITISLDKETIKQEILPARTFGFLKDVEALQAKGLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKIL
DLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSSVTGDEISKYKSRRIPLFKRKVAVV

Sequences:

>Translated_301_residues
MKEILYRKSIQDRVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEYRKGLEKASISVELSNVVDTSNATTLGDGLHKIQTVE
HLLAAIYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIVKYPEIIEPIYVQNPLWVVDGDKYLVLLPSDELKVTYT
IDFNHPLLKGQNITISLDKETIKQEILPARTFGFLKDVEALQAKGLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKIL
DLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSSVTGDEISKYKSRRIPLFKRKVAVV
>Mature_301_residues
MKEILYRKSIQDRVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEYRKGLEKASISVELSNVVDTSNATTLGDGLHKIQTVE
HLLAAIYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIVKYPEIIEPIYVQNPLWVVDGDKYLVLLPSDELKVTYT
IDFNHPLLKGQNITISLDKETIKQEILPARTFGFLKDVEALQAKGLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKIL
DLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSSVTGDEISKYKSRRIPLFKRKVAVV

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=36.8421052631579, Blast_Score=199, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_LEPBJ (Q04T70)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_800658.1
- ProteinModelPortal:   Q04T70
- SMR:   Q04T70
- STRING:   Q04T70
- GeneID:   4410609
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_1315
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   ATDPAKE
- PhylomeDB:   Q04T70
- ProtClustDB:   PRK13186
- BioCyc:   LBOR355277:LBJ_1315-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33101; Mature: 33101

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEILYRKSIQDRVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEYRKGLEKASISVELSNV
CCCHHHHHHHHHCEEEEEEECCCCCEEEEEECCCCCCCEEEEHHHCCCCHHEEEEEEHHE
VDTSNATTLGDGLHKIQTVEHLLAAIYALGLTDLILEIDAVEVPIMDGSSLPFLQALESA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEECCCCCHHHHHHHHC
GIVKYPEIIEPIYVQNPLWVVDGDKYLVLLPSDELKVTYTIDFNHPLLKGQNITISLDKE
CCEECHHHHCCEEECCCEEEEECCEEEEEECCCCEEEEEEEECCCCEECCCEEEEEECHH
TIKQEILPARTFGFLKDVEALQAKGLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKIL
HHHHHHCCHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
DLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSSVTGDEISKYKSRRIPLFKRKVAV
HHHCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHEEC
V
C
>Mature Secondary Structure
MKEILYRKSIQDRVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEYRKGLEKASISVELSNV
CCCHHHHHHHHHCEEEEEEECCCCCEEEEEECCCCCCCEEEEHHHCCCCHHEEEEEEHHE
VDTSNATTLGDGLHKIQTVEHLLAAIYALGLTDLILEIDAVEVPIMDGSSLPFLQALESA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEECCCCCHHHHHHHHC
GIVKYPEIIEPIYVQNPLWVVDGDKYLVLLPSDELKVTYTIDFNHPLLKGQNITISLDKE
CCEECHHHHCCEEECCCEEEEECCEEEEEECCCCEEEEEEEECCCCEECCCEEEEEECHH
TIKQEILPARTFGFLKDVEALQAKGLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKIL
HHHHHHCCHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
DLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSSVTGDEISKYKSRRIPLFKRKVAV
HHHCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHEEC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA