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The map label for this gene is hslU [H]

Identifier: 116328185

GI number: 116328185

Start: 1766402

End: 1767835

Strand: Direct

Name: hslU [H]

Synonym: LBL_1509

Alternate gene names: 116328185

Gene position: 1766402-1767835 (Clockwise)

Preceding gene: 116328184

Following gene: 116328186

Centisome position: 48.87

GC content: 41.21

Gene sequence:

>1434_bases
ATGACAGACTACTCCAAAGACCAGGACCTTATGTTGCCGATCGAAGAAGAGCTAACTCCTCGACAAATCGTCGCAAAATT
GGACGAACATATCATCGGCCAGAAAAATGCAAAAAAGGCGGTTGCAATCGCTCTTAGAAATAGAACCAGACGCAAAAAAC
TGGATCTTGAAATGAGAGAAGAAATTTATCCGAAGAATATTATCATGATCGGACCTACCGGAGTCGGTAAAACGGAAATT
GCTAGAAGACTCTCTAAACTCTGCGGAGCTCCATTTTTAAAAGTAGAAGCCACAAAATACACCGAAGTCGGTTATGTCGG
AAGAGACGTTGAATCCATGATTCGGGATCTCGCAGTTATATCGATGAATCTTGTGAAACAGGAATTTAGAACCAAGGTAG
AAGAAACCGCAAAACAAAAGGCGGAAGAAGCTTTGCTTGATATTCTTCTTCCATTTCCTGTTGAGAATAAATATAATCCC
GGGCAAGCCGCCGACTTTAAGACTTCTTCTACGGATGAAGAAGAAAGAAAAACTCATTTTTTCGAAACTAGAGAATTTAT
GAGAAAAAAATTAAAAACGGGAAAACTAGACGATCAGGAAGTAGAATTGGATCTTCCAAACCCAAGCGTGTCTCAGATTC
CGATGCTTCAGGTTTTTGGAGCGGGAAATTTGGACGATTTAGACAATCAACTTCAGAATGTTTTGGGAGATTTGCTTCCC
AAAAAAAATAAAAAACGTAAACTCAAAATTCCAGAAGCCATTAAGACATTAGAAGAATTCGAAGCGGATAAACTTTTGGA
TCCGGATAAGGTACAAAGAGAAGCTCTACGAAGAGTTGAGGAAATGGGAATCATATTTCTGGATGAGATCGATAAGATAG
CGGGAAGAGAAGGAAAAAACGGAGCAGACGTTTCCAGAGAAGGGGTTCAAAGAGACCTTCTTCCGATCGTGGAAGGAGCG
ACAGTGAACACAAAAATCGGTCCCGTAAAAACCGATCATATTCTTTTTATAGCCGCGGGTGCGTTTCACATGACGAAACC
TTCCGACCTCATTCCGGAACTTCAGGGAAGATTTCCGATCCGCGTAGAACTTGAAAAACTTTCAAGGGAGGATTTTGAAA
AAATCCTGACGGCCCCTCGCTCTTCTCTCGCCAGACAATACGAGGCTTTGCTTTTTACGGACGGAATTCAGTTGGAGTTT
TCTTCGGACGGAATTCAAGAAATCGCAAGAATTGCATACGATATGAACGAGAAACACGAGAATATCGGAGCCAGAAGACT
CAACACGATTTTGGAACGCCTTCTTGAGGAAGTAAGTTTTGAAGGCCCCGATCTTCCGGAAAATCAAAAGAATATAAAAA
TCGACGGAAAGTATGTTATGGATCGTTTGCAAGGTGTGATTCAAGATAAGGATCTCAGTCAGTATATTCTCTAA

Upstream 100 bases:

>100_bases
GAGAGAAATTGTAGAATCATCCATGAAAATCGCAGCAAACATTTGTATTTATACGAACGATCACATTACCCTAGAAGAAA
TTCTTTAAAGATAAAAATAT

Downstream 100 bases:

>100_bases
AAAAACATTTAACGGTTCTTTCTATTTTTTCAAATTGAGAATCTGAATTCTTATCGAGAACTTGTTCCAAAACTTTAGAA
TGTAGGAATTCCAACGAGAG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MTDYSKDQDLMLPIEEELTPRQIVAKLDEHIIGQKNAKKAVAIALRNRTRRKKLDLEMREEIYPKNIIMIGPTGVGKTEI
ARRLSKLCGAPFLKVEATKYTEVGYVGRDVESMIRDLAVISMNLVKQEFRTKVEETAKQKAEEALLDILLPFPVENKYNP
GQAADFKTSSTDEEERKTHFFETREFMRKKLKTGKLDDQEVELDLPNPSVSQIPMLQVFGAGNLDDLDNQLQNVLGDLLP
KKNKKRKLKIPEAIKTLEEFEADKLLDPDKVQREALRRVEEMGIIFLDEIDKIAGREGKNGADVSREGVQRDLLPIVEGA
TVNTKIGPVKTDHILFIAAGAFHMTKPSDLIPELQGRFPIRVELEKLSREDFEKILTAPRSSLARQYEALLFTDGIQLEF
SSDGIQEIARIAYDMNEKHENIGARRLNTILERLLEEVSFEGPDLPENQKNIKIDGKYVMDRLQGVIQDKDLSQYIL

Sequences:

>Translated_477_residues
MTDYSKDQDLMLPIEEELTPRQIVAKLDEHIIGQKNAKKAVAIALRNRTRRKKLDLEMREEIYPKNIIMIGPTGVGKTEI
ARRLSKLCGAPFLKVEATKYTEVGYVGRDVESMIRDLAVISMNLVKQEFRTKVEETAKQKAEEALLDILLPFPVENKYNP
GQAADFKTSSTDEEERKTHFFETREFMRKKLKTGKLDDQEVELDLPNPSVSQIPMLQVFGAGNLDDLDNQLQNVLGDLLP
KKNKKRKLKIPEAIKTLEEFEADKLLDPDKVQREALRRVEEMGIIFLDEIDKIAGREGKNGADVSREGVQRDLLPIVEGA
TVNTKIGPVKTDHILFIAAGAFHMTKPSDLIPELQGRFPIRVELEKLSREDFEKILTAPRSSLARQYEALLFTDGIQLEF
SSDGIQEIARIAYDMNEKHENIGARRLNTILERLLEEVSFEGPDLPENQKNIKIDGKYVMDRLQGVIQDKDLSQYIL
>Mature_476_residues
TDYSKDQDLMLPIEEELTPRQIVAKLDEHIIGQKNAKKAVAIALRNRTRRKKLDLEMREEIYPKNIIMIGPTGVGKTEIA
RRLSKLCGAPFLKVEATKYTEVGYVGRDVESMIRDLAVISMNLVKQEFRTKVEETAKQKAEEALLDILLPFPVENKYNPG
QAADFKTSSTDEEERKTHFFETREFMRKKLKTGKLDDQEVELDLPNPSVSQIPMLQVFGAGNLDDLDNQLQNVLGDLLPK
KNKKRKLKIPEAIKTLEEFEADKLLDPDKVQREALRRVEEMGIIFLDEIDKIAGREGKNGADVSREGVQRDLLPIVEGAT
VNTKIGPVKTDHILFIAAGAFHMTKPSDLIPELQGRFPIRVELEKLSREDFEKILTAPRSSLARQYEALLFTDGIQLEFS
SDGIQEIARIAYDMNEKHENIGARRLNTILERLLEEVSFEGPDLPENQKNIKIDGKYVMDRLQGVIQDKDLSQYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=95, Percent_Identity=38.9473684210526, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790366, Length=462, Percent_Identity=53.030303030303, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1786642, Length=100, Percent_Identity=45, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319704, Length=108, Percent_Identity=37.037037037037, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24648291, Length=245, Percent_Identity=30.6122448979592, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648289, Length=245, Percent_Identity=30.6122448979592, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR011704
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF07724 AAA_2; PF07728 AAA_5; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 54338; Mature: 54207

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYSKDQDLMLPIEEELTPRQIVAKLDEHIIGQKNAKKAVAIALRNRTRRKKLDLEMRE
CCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
EIYPKNIIMIGPTGVGKTEIARRLSKLCGAPFLKVEATKYTEVGYVGRDVESMIRDLAVI
HCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCCHHHHHHHHHHH
SMNLVKQEFRTKVEETAKQKAEEALLDILLPFPVENKYNPGQAADFKTSSTDEEERKTHF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
FETREFMRKKLKTGKLDDQEVELDLPNPSVSQIPMLQVFGAGNLDDLDNQLQNVLGDLLP
HHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHCCHHEEECCCCHHHHHHHHHHHHHHHCC
KKNKKRKLKIPEAIKTLEEFEADKLLDPDKVQREALRRVEEMGIIFLDEIDKIAGREGKN
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
GADVSREGVQRDLLPIVEGATVNTKIGPVKTDHILFIAAGAFHMTKPSDLIPELQGRFPI
CCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCE
RVELEKLSREDFEKILTAPRSSLARQYEALLFTDGIQLEFSSDGIQEIARIAYDMNEKHE
EEEHHHHCHHHHHHHHHCCHHHHHHHHHHHHEECCEEEEECCCHHHHHHHHHHHHHHHHH
NIGARRLNTILERLLEEVSFEGPDLPENQKNIKIDGKYVMDRLQGVIQDKDLSQYIL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
TDYSKDQDLMLPIEEELTPRQIVAKLDEHIIGQKNAKKAVAIALRNRTRRKKLDLEMRE
CCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
EIYPKNIIMIGPTGVGKTEIARRLSKLCGAPFLKVEATKYTEVGYVGRDVESMIRDLAVI
HCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCCHHHHHHHHHHH
SMNLVKQEFRTKVEETAKQKAEEALLDILLPFPVENKYNPGQAADFKTSSTDEEERKTHF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
FETREFMRKKLKTGKLDDQEVELDLPNPSVSQIPMLQVFGAGNLDDLDNQLQNVLGDLLP
HHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHCCHHEEECCCCHHHHHHHHHHHHHHHCC
KKNKKRKLKIPEAIKTLEEFEADKLLDPDKVQREALRRVEEMGIIFLDEIDKIAGREGKN
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
GADVSREGVQRDLLPIVEGATVNTKIGPVKTDHILFIAAGAFHMTKPSDLIPELQGRFPI
CCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCE
RVELEKLSREDFEKILTAPRSSLARQYEALLFTDGIQLEFSSDGIQEIARIAYDMNEKHE
EEEHHHHCHHHHHHHHHCCHHHHHHHHHHHHEECCEEEEECCCHHHHHHHHHHHHHHHHH
NIGARRLNTILERLLEEVSFEGPDLPENQKNIKIDGKYVMDRLQGVIQDKDLSQYIL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA